Prof. Vladimir Litvak (@vlitvak.bsky.social)

We have released a subset of our simultaneous MEG and subthalamic LFP recordings from people with Parkinson’s with clinical metadata. The data cover rest and movement tasks, medication on and off states, and include MEG‑derived virtual electrodes for SMA and bilateral M1. doi.org/10.6084/m9.f...

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Sumultaneous subthalamic local field potentials and MEG-derived cortical activity in Parkinson's patients ON and OFF dopaminergic medication This dataset contains simultaneous magnetoencephalography and subthalamic local field potential recordings acquired during deep brain stimulation surgery for Parkinson’s disease. Acquisition and preprocessing procedures are detailed in Litvak et al., Brain 2011 (doi:10.1093/brain/awq332) and Litvak et al., Journal of Neuroscience 2012 (doi:10.1523/JNEUROSCI.0767-12.2012). All files are provided in FieldTrip raw format as defined in the FieldTrip data specification. Data from a subset of the original cohort are available due to ethical restrictions on data sharing.Recordings were obtained in two clinical states for each participant: after overnight withdrawal of dopaminergic medication and while receiving their usual medication. Clinical characteristics and medication doses are listed in subject_details.csv. Pre-operative motor scores were collected using standard clinical assessments.Experimental conditionsParticipants completed the following tasks:R: rest.SL: simple left-hand movement comprising a simultaneous button press with digits 2 to 4.SR: simple right-hand movement with the same gesture.CL: complex left-hand sequence consisting of successive presses of digits 2, 4 and 3.CR: complex right-hand sequence with the same pattern.Event timings for button presses are stored in the event channel.Recorded signalsThe dataset includes:Bipolar subthalamic local field potentials.Electro-oculography.Electromyography from the bilateral first dorsal interosseous muscles.Virtual electrode time series reconstructed from MEG for the supplementary motor area and bilateral primary motor cortices. Virtual electrode coordinates are reported in MNI space and were affine transformed to individual anatomy: SMA [−2 −10 59], left M1 [−37 −25 62], right M1 [37 −25 62]. https://doi.org/10.6084/m9.figshare.31254136