In #DeepBrainStimulation the two major developments across the last decade have been 1. Adaptive DBS and 2. Connectomic DBS In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask: Could the two be united into a common framework? www.nature.com/articles/s41... A 🧵

From Adaptive DBS to Adaptive Circuit Targeting 👇👇

Next steps ahead for DBS! 👇👇

One of our "bigger visions" for the next years summarized in a neat perspective paper out now 👇👇

How should we best model recruitment of axons by deep brain stimulation? Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications: academic.oup.com/braincomms/a...

Konstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇

Sending off 2 of our best research assistants ‬to graduate programs that are lucky to have them. Congrats Grace and Jessy and we look forward to your ongoing success! @braincircuits.bsky.social

Honored to highlight our work @braincircuits.bsky.social @massgenbrigham.bsky.social Neuro Research Day. Thank you @shansiddiqi.bsky.social @fredschaper.bsky.social Sheena Baratano and Sam Snider for sharing your experience.

Is there a brain circuit target for restoring consciousness after brain injury? New work by @rolstonjohn.bsky.social @braincircuits.bsky.social says yes!

How may traveling waves in the brain impact seizure focus detection in functional neurosurgery? How does RNS for epilepsy really work? Are we ready for stem cell therapy in PD? DBS for disorders of consciousness? Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇

We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇 stimulatingbrains.org/72-john-rols...

Massive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇

🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...

Can a brain injury lead someone to commit a crime? Brain imaging is increasingly introduced as evidence in criminal trials but it remains unclear which structural injuries play a causal role in criminal behavior. @braincircuits.bsky.social @foxmdphd.bsky.social www.nature.com/articles/s41...

Thrilled our ADHD network mapping work is now out in Annals of the Child Neurology Society, and honored to be featured on the cover! 🔗 Full article: onlinelibrary.wiley.com/doi/full/10.... @childneurosoc.bsky.social @bostonchildrens.bsky.social @simonwarfield.bsky.social @braincircuits.bsky.social

We are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested! lnkd.in/eEbnXByJ

10,000! 🎂🍰 💯x💯!

What a number! 🔜 🎉🥳🎊🍾 @foxmdphd.bsky.social!

Hard to keep track about all the great things our labmembers have achieved recently:

Happening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively. Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET Register here: partners.zoom.us/webinar/regi...

Join us today! 👇👇

Are we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?

Can brain injury cause the loss of visual imagination? We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social www.medrxiv.org/content/10.1...

Is there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor www.nature.com/articles/s41...

Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.

Curious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇

Patient selection for Deep Brain Stimulation (DBS) is crucial. Are there ways to improve it? In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response - and serve as an additional marker for DBS outcomes. doi.org/10.1002/acn3... A thread. 🧵

Is there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation? @lukasgoede.bsky.social says yes – new study here: onlinelibrary.wiley.com/doi/10.1002/... A 🧵 @netstim.org @braincircuits.bsky.social @lead-dbs.org

First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇

New insights on tremor therapeutic sweetspot and tract this time in FUS thalamotomy, congrats @andreashorn.org and team

MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...

When modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...

It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...

Tune in here for a fantastic primer on ECT – and so much more! Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!

Truly inspiring episode about a life lived in neurosurgery across 🇨🇦 and the 🇺🇸, from ventriculography- & frame-based procedures including ablative lesions in neuro & psych to intraoperative MRI all the way to carrying out over 600 lesions using MR guided focused ultrasound. Tune in below 👇👇

We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...

Very hard to say goodbye to these fantastic people. I will miss you guys! @braincircuits.bsky.social!

Probably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!! Out at @natcomms.nature.com: www.nature.com/articles/s41...

Was fun to do a podcast about our recent paper on creativity and brain disease with Dr Norman Swan @abcnewsbot.bsky.social @braincircuits.bsky.social @foxmdphd.bsky.social @harvardmed.bsky.social www.abc.net.au/listen/progr...

It's been pure joy to see Barbara grow over the years and I am very excited about her next steps as a post-doc at @braincircuits.bsky.social under supervision of none else than @foxmdphd.bsky.social – could not think of a better mentor for next steps in your career, Barbara!

Follow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band. Happy to be part of it!

🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--

Research defined the optimal DBS response network in STN-DBS for Parkinson’s Disease in a spatial domain. Other research defined physiomarkers for DBS response locally, in a temporal domain. However, nobody has analyzed these two concepts simultaneously. Enter @bahnebahners.bsky.social 👇👇

We had a wonderful conversation with Dr. Terry Sanger from CHOC who is a very inspirational figure and innovator in the field of DBS – with a special focus on treating pediatric forms dystonia / cerebral palsy. Tune in here 👇👇 stimulatingbrains.org/69-terrence-...

I learned so much from a very sharp mind in this conversation. Equipped w an undergrad mathematics at Harvard, Medschool at Harvard, PhD at MIT, Terry has begun deeply thinking about dystonia and neuromodulation early on and has come up with a very unique sEEG based approach to treat tough cases.

Lesions causing epilepsy map to a brain circuit, but what about generalized epilepsy? Great new paper (and thread) by @fredschaper.bsky.social identifies this circuit with implications for #DBS. @braincircuits.bsky.social

New @braincircuits.bsky.social Paper out 👇👇

Can brain damage change your political opinions? “No significant neuroanatomical circuit was associated with political ideology or party affiliation, but a distinct circuit was associated with intensity of political involvement” Work by @shansiddiqi.bsky.social @braincircuits.bsky.social

Huge thank you to first author Gongjun Ji for leading this study, to @foxmdphd.bsky.social for his invaluable mentorship at @braincircuits.bsky.social, and all collaborators for their support and generous sharing of their data: