Marcelino and Al-Fatly et al. report literature-based lesion network mapping of dyskinetic cerebral palsy. Grey matter lesions are the most common MRI finding; the motor thalamus is a converging node of a wide functional network. Read at buff.ly/IyRv0E0.

Take a look at our new work, providing explanations for the mechanisms of deep brain stimulation, with insights into the modulation of motor- premotor cortex activity from mouse-based and translatable research methodologies for future therapy solutions shorturl.at/5Atjh

Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.

This was a huge team effort - combining datasets across disorders, continents, and methods. We hope this work helps advance neuromodulation toward guided, symptom-specific treatment. Full paper: www.nature.com/articles/s41...

New research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor www.nature.com/articles/s41...

"Ultra-high field MRI provides high-resolution maps of various aspects of the underlying neurodegenerative process which reflect individual motor impairment in #Parkinsons" - research use 7 tesla MRI; N=43 PD & 24 controls www.nature.com/articles/s41...

New insights on tremor therapeutic sweetspot and tract this time in FUS thalamotomy, congrats @andreashorn.org and team

movementdisorders.onlinelibrary.wiley.com/doi/10.1002/... Happy to share our work in @movedisorder.bsky.social We compared outcomes of bilateral #HIFU and #DBS in essential tremor, identified thalamic hotspots using probabilistic mapping. @fusfoundation.bsky.social @alfonsofasano.bsky.social

🚨Interested in Dystonia?🚨 @braincircuits.bsky.social GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… www.pnas.org/doi/10.1073/...

Do we need to stimulate different circuits to improve different dystonia symptoms with STN DBS? Work by Konstantin Butenko, @andreashorn.org @braincircuits.bsky.social out today in @PNAS says yes: Engaging dystonia networks with subthalamic stimulation | PNAS www.pnas.org/doi/10.1073/...

Mapping neuropeptide signaling in the human brain | doi.org/10.1101/2024... Neuropeptides are among the functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it brain function 🧩 🧠 ⤵️

Is it critical to stimulate @ndosenbach.bsky.social's SCAN and CON networks for clinical improvements of Tourette's patients that undergo DBS? Carlos Baldermann says yes in a cool new paper out in @natureportfolio.bsky.social comms today! www.nature.com/articles/s41...

Do you know the actual tic networks in Gilles de la Tourette Syndrome? Juan Carlos Baldermann and a whole host of colleagues explore this in a new article in Nature Communications. Dosenbach and Gordon sparked this group to action after the DBSThinkTank.

New paper finds that aberrant relative brain hyperperfusion (amount of blood flowing to the brain), independent of striatal dopamine depletion, is associated with baseline & longitudinal motor deficits & progression of neurodegeneration in #Parkinsons www.neurology.org/doi/10.1212/...

Analysis of 39 cases of focused ultrasound subthalamotomy for #Parkinsons highlights the functional anatomy of the subthalamic nucleus & the pathophysiology of cardinal features of PD; Reduced bradykinesia & rigidity associated with ablation of rostral motor STN www.science.org/doi/10.1126/...

Our paper entitled “Neuroimaging-based analysis of DBS outcomes in pediatric dystonia: insights from the GEPESTIM registry” is now out in Neuroimage Clinical sciencedirect.com/science/articl…

It is a pleasure to be in #BrainStimConf to present this new study and very happy to have been awarded a travel grant by #IBROTavelGrant Many thanks to #IBRO and my coauthors @andreashorn_ @AA_Kuhn @foxmdphd @MichaelOkun and many others not on Twitter #Neurology

Happy to have passed the European Board of Neurology 2022 Exam, I recommend it to all #Neurology fellows, many thanks to @EANeurology for the organizing and giving this opportunity to have in depth knowledge in neurology, have to say a bit tough but doable 😃

Nice overview from @HSiebner on targeting brain circuitry using personalized noninvasive brain stimulation approaches @Retune_CRC

Lesions in the tremor circuit can induce tremor (1st img), similar lesions can treat an "existing" tremor (2nd img) -In this case, DBS/lesioning surgery require a pre-existing pathological oscillation to work, can DBS still enhance functionality in normal brain?

Very happy about this successful multicenter "european" collaboration spearheaded by Andreas Nowacki & Sabry Barlatey on mapping beneficial effect of DBS in Essential Tremor in 119 pts @andreashorn_ @DembekTill @AA_Kuhn @VVV_Cologne @leaddbs @netstim_org onlinelibrary.wiley.com/doi/10.1002/an…

Excited to share our new study about mapping beneficial effect of STN-DBS on Quality of Life in PD thanks to Günther Deuschl for this amazing opportunity together with Inken Tödt & @andreashorn_, read more in threads🔽 …mentdisorders.onlinelibrary.wiley.com/doi/10.1002/md…

Lesion and dbs network mapping of tics, a very fruitful first coauthorship with the one and only @ChristosGanos, amazingly supervised by @AA_Kuhn and @andreashorn_ and a great multicenter collaboration and with @foxmdphd (the pioneer of lesion network mapping), such an honor t.co/5iqCBjnXvk

#FSL users, any hint on how to use #FSL topup on two phase encoded #DTI scans each with 63 directions and 1 b0, the data is actually from PPMI dataset (PD patients) and am trying to correct for susceptibility distortion using topup. Thanx #neuroimaging #neuroscience

I really love this schematic, the way it relays the information is wonderful. The cerebellum (dentate) and basal ganglia synapses at separate thalamic nuclei but cross-talk at overlapping cortical level (Nieuwenhuys/TheHumanCentralNervousSystem) @andreashorn_ @neumann_wj

A great dbs-sweetsoot calculation methods comparison paper by @DembekTill et al t.co/5pfeZHlUPI

Congrats @petryschmelzer @DembekTill @VVV_Cologne and other coworkers on this amazing work, really honored for the first use of tremor DBS-suppression tract from our work in@andreashorn_ @leaddbs t.co/Tq6KoZU5VP doi.org/10.1093/brain/…

#dbs folks, which way to go? sweet spot (A)? or sweet cluster/volume (B)? or sweet tract/bundle (C)? or sweet connectome (D)? @leaddbs

Prefrontal-Subthalamic Hyperdirect Pathway Modulates Movement Inhibition in Humans cell.com/neuron/fulltex…

A very rewarding experience, our poster has been selected by Dr Peter Bain for guided posters tour at #MDSCongress @andreashorn_ @SiobhanEwert