#TWiNPP From Baldi et al., baseline network alignment may be a useful biomarker for optimizing TMS outcomes in depression and anxiety / @shansiddiqi.bsky.social www.nature.com/articles/s41...

I always assumed that brain function had to line up with cytoarchitectonics. It turns out I was wrong. Human cortex, especially PFC, is tiled by chains of functional patches that subdivide and interlink architectonic areas into parallel processing streams. www.biorxiv.org/content/10.6...

We often treat functional connectivity as if it’s an established measure of TMS target engagement. I’m not so sure. Check out our new paper by Samantha Baldi in @npp-journal.bsky.social on rsfMRI data from a head-to-head TMS trial. free link: rdcu.be/feIya full link: lnkd.in/eSdthbSg

A wave of new papers discuss the merits and limitations of lesion network mapping. #neuroskyence By @avaskham.bsky.social www.thetransmitter.org/brain-imagin...

New paper in Molecular Psychiatry: In patients with anxiety + depression, targeting a novel “anxiosomatic” circuit (dmPFC) outperforms standard dlPFC for anxiety—and is equally effective for depression. Free link: rdcu.be/faL22 Full link: lnkd.in/e4WZTncu But the bigger story is the pipeline 1/n

BraSSS starts today at 9am ET! ZOOM: mgb-org.zoom.us/j/86743220335 Passcode: 362150 Agenda here: www.eventbrite.com/e/brain-stim...

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

The methodological foundations of lesion network mapping remain sound https://www.biorxiv.org/content/10.64898/2026.02.24.707529v1

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

Is generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:

Out now in Brain A distinct pattern of brain damage intensifies political involvement, regardless of whether you're liberal, conservative, Democrat, or Republican. With coauthors S.Balters,S. Cohen-Zimerman,G.Zamboni,J.Grafman academic.oup.com/brain/advanc... @braincircuits.bsky.social

Looking toward to our ANPA symposium on interventional neuropsychiatry - kicked off w a brilliant talk & overview on TMS by Nick Trapp.

I think the theoretical limit of explainable variance in a model should be less than the product of the test-retest reliabilities of the input variables. If the explained variance in a study exceeds that value (as it often does in the psychiatric literature), the model must be overfit.

Out now in Brain Stimulation Towards accredited training in brain stimulation: proceedings from the Brain Stimulation Subspecialty Summits (BraSSS) with co-host Nolan Williams and 23 other awesome co-authors including some from @braincircuits.bsky.social www.brainstimjrnl.com/article/S193...

Finally … this also means I am recruiting – big time! Please email me in case you know somebody that might be interested (PhD/Postdoc positions). Please RT for reach! 🙏🙏

My cat has developed a penchant for ⁦‪Kraepelin‬⁩. Last couple of days she just sits next to this old book (first edition English translation) and tries to read it.

jamanetwork.com/journals/jam... Thread below👇

Can damage to a specific brain circuit cause psychosis? New paper out today by @andrewpines.bsky.social @shansiddiqi.bsky.social says Yes! Hub of the circuit is in the hippocampus - great alignment with NMDA encephalitis. @braincircuits.bsky.social

Do lesions that cause psychosis fall into a common brain network? Exciting new work by @andrewpines.bsky.social, @shansiddiqi.bsky.social and colleagues – tweetorial below by the first author, paper here: jamanetwork.com/journals/jam...

What brain regions are involved in causing psychotic symptoms? Take a moment away from the existential dread about the future of science, and join me in this summary of some incredibly cool stuff that could help patients! 1/n🧵

When the Nazis took power, I've of their most effective actions was to destroy the universities.

Super cool to finally meet @shansiddiqi.bsky.social this morning and hear about his lesion network mapping data for schizophrenia - and their consilience with our computational work in primates and paranoia! #MDThalamus

I get it, bsky is great, but I find it harder to get motivated when there’s no vitriol to fight. I need a troll.

Anybody have experience with a successful R33 application? There's no budget limit, so I'm trying to figure out what kind of budget might be perceived as excessive.

ECT, TMS, and ketamine outperform other options for treatment resistant depression. Should we be offering these options to patients earlier in the course of illness? www.nature.com/articles/s41...

We are launching a new Harvard Medical School Continuing Medical Education Course Brain Medicine: Integrating the Clinical Neurosciences Live Virtual Course w On Demand Viewing for 30 days February 7th, 2025 Registration Details Below (Join Us!): cmecatalog.hms.harvard.edu/brain-medici...

🚨Interested in Dystonia?🚨 @braincircuits.bsky.social GPi DBS for dystonia is effective. More recently, STN DBS has been investigated, as an alternative. In what enfolded like a stunning thriller to me, Konstantin Butenko tells a tale of two networks… www.pnas.org/doi/10.1073/...

New use for ChatGPT: help me figure out how to respond to this reviewer comment without throwing off the overall flow of the paper.

Happy to share Bryan Jenkins' latest work published in @psychopharmacology.bsky.social: Cannabidiol potentiates physiological and behavioral markers of hypothalamic–pituitary–adrenal (HPA) axis responsivity in female and male mice link.springer.com/article/10.1.... Bryan truly led this project!

Instead of listing my publications, as the year draws to an end, I want to shine the spotlight on the commonplace assumption that productivity must always increase. Good research is disruptive and thinking time is central to high quality scholarship and necessary for disruptive research.

Don't miss out on "Neuropsychiatry of Magic," the 1075th meeting of the Boston Society of Neurology, Neurosurgery, and Psychiatry, featuring Daniel Roy's neuroscience-inspired magic performance! Join us Thurs, Jan 16 at 6pm for an unforgettable evening. RSVP: www.eventbrite.com/e/neuropsych...

The effect of spherical projections on spin tests for brain maps | biorxiv.org/content/10.1... Spin tests are the de facto null model for map-to-map comparisons in brain imaging. Why don't they perfectly control false positives? @vincebaz.bsky.social explores ⤵️

Happy for this to arrive just in time to add to my holiday book pile: Conversations in Critical Psychiatry by @awaisaftab.bsky.social. I'm looking forward to this one.

Occasionally, I'm working on a problem and realize that it just requires more cognitive steps than what my own brain can handle. Take that to the nth power - there must be problems that require more cognitive steps than our brains can collectively handle? Is brain function one of those problems?

Link to the paper: www.nature.com/articles/s44...

Apparently I’m here

Check out our lab's latest work, finding a common network that unites atrophy patterns in schizophrenia. Also, hello bsky!