📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky

I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf

👋 Hello Bluesky community! We are the Swiss Young Immunologists Society, a network of young immunologists across CH🇨🇭 to connect, support each other, and boost our visibility on national and European levels. ✨👉 Follow us and stay tuned for updates on events, opportunities, and all things immunology!

Exciting data on oral tolerance induction are just out from several groups! I had the pleasure of writing a commentary www.science.org/stoken/autho... on the elegant study from @chrysothemisbrown.bsky.social. Don’t miss it if you're interested in mucosal immunology www.science.org/doi/10.1126/...

Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO. #FastandFairPeerReview #PeerReview #ScientificPublishing

Not sure if this works to trick LLMs, but this illustrates well how ineffective the peer-review enterprise is. Hacking the system.

About intestinal immune tolerance: Weaning sparks a wave of IL-10⁺, T-bet⁺ Tr1 CD4⁺ T cells in the small-intestinal. Surprise: they’re fueled by diet, not microbiota, via a cDC1→IL-27 axis, arming the gut with microbiota-independent, suppressive immunity. www.biorxiv.org/content/10.1...

Every cell is a stem cell! Even ‘terminal’ enterocytes can hit reset: Gut damage triggers a YAP/TAZ-driven fetal program → stress-proof “revival” stem cells → Lgr5⁺ CBC stem cells, rebuilding crypts from scratch and make organoids. #StemCellPlasticity #Organoids #Gut

Agreed! But even if we would solve that research assessment problem, discriminating ‘good research’ from ‘bad research’ in bulk (e.g. when screening CV’s) will still need a metric that allows for ‘quick screening’ I.e., a context-rich metric that reflects the merits of the research. What metric?

On cell extrusion in the #intestine! After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report: 3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look! www.biorxiv.org/content/10.1...

A ‘simple’ experiment but an amazing gem of a reference! Just stimulate blood, observe and describe… #ImmunoSky

This is WILD! “Cumulative evidence suggests a … previously unknown intergenerational inheritance mechanisms that propagate through the gut–germline–placenta axis in males, thru which the father’s gut microbiome influences offspring health & disease susceptibility.” www.science.org/doi/10.1126/...

1-0 for transparency! Transparant peer reviews at all @nature.com publications! www.nature.com/articles/d41...

Its honestly quite shocking. Cancer cell lines are sub-optimal systems due to genomic instability, mutations and potentially strange phenotypes. Thats known, but to see these anomalies quantified is a good moment to realize this once again. #Celllines #ImmunoSky #Jurkat

✨ Incredibly happy!! To receive the 2025 Stimulering prize from the Dutch Coeliac Disease Association! 🙌 Huge Thanks to all NCV members for your trust💚 Excited to continue our mini-gut & gut-on-a-chip research at @umcgroningen.bsky.social 💚 #coeliakie #research #minigut

Amazing idea for your next poster!

IL-27 released by licensed Kupffer cells can reboot exhausted liver CD8⁺ T cells in chronic HBV— No lymph-node priming needed, just IL-27 addition does the trick! Would a similar relay exist for intestinal CD8⁺ T cells guard attacking epithelium in auto-immunity? #Autoimmunity #Liver #HBV

Vascularized organoids! Balancing BMP signaling enables co-differentiation of mesoderm + endoderm in a single spheroid → organ-specific endothelium + vascularized gut & lung organoids! Ever increasing organoid complexity👏 #Organoids #StemCells

Funny to think we drag ourselves through life day after day… all to one day upload a PDF to the internet. #Academia #phdchat #Science

Hello, Bluesky! I'm Akshaya, research associate at the Christian Medical College, Vellore. Currently studying the gut microbiome and its role in undernutrition in children, and focusing on translational work to integrate evidence-based medicine and public health.

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!

Very interesting thought experiment. And one can imagine that the threshold of this risk upon (re-)infections is lower earlier in life, as immune regulation/tolerance has acquired less checks and balances?

Here it is! Bonsai. Now there is really no more excuse for using t-SNE/UMAP. Bonsai not only makes cool pictures of your data. It actually rigorously preserves its structure. No tunable parameters. Incredible work by @dhdegroot.bsky.social. I'm so excited about this! www.biorxiv.org/content/10.1...

Suuuper proud!!

A heartfelt thank you to the University of Groningen, which is now a supporter of PCI 🙏 ! You can find more details at www.rug.nl/library/open...

🎉 We're very excited that our Chief Science and Strategic Officer, @richardsever.bsky.social, is included on this year's #TIME100HEALTH list! time.com/collections/... This recognition helps demonstrate the impact preprints in #bioRxiv & #medRxiv have on global health. #Time100Health #preprints

Excited to attend and present at the Organoid Engineering @KeystoneSymp next week in Whistler! I’ll share an update on our work developing advanced intestine models. Looking forward to great science and new connections—will I see you there? #KSOrganoids25 #organoids

CRISPR screens + organoids > new discoveries! Read all about it here: www.annualreviews.org/content/jour... It was a great honor for our lab (w/ @bartegiani.bsky.social) to write a piece for @annualreviews.bsky.social We discuss both novel discoveries and organoid-specific considerations.

As an academic what excites me most is creating a highly versatile in-vitro system that captures full complexity of biology/disease. Yet, for the system to be useful/translational, simplicity & applicability is key. I think these can go together! #MPS #OrgansOnChips

FDA 🤝 Organs-on-Chips The @fda.gov recently published its Roadmap to Reducing Animal Testing in Preclinical Safety Studies. This is an exciting step forward in emphasizing the adoption of New Approach Methodologies (NAMs), focusing on human-derived in vitro and in silico models.

Self-experimentation is not recommended for good reasons. But it CAN lead to amazing discoveries: Man Bitten by Snakes Hundreds of Times, Now Has Unique Antibodies www.cell.com/cell/fulltex...

Microbiome researchers incoming! @jingyuan-fu.bsky.social joins the BlueSky party! #microbiome #Medsky #ImmunoSky

Intestinal homeostasis and gdT cells: Numbers of gdT cells decline before onset ileal inflammation. Suggesting a compromised gdTcell controlled homeostasis to precede the inflammation! #immunosky

No, you will not remember it. Write it down!!!

This paper is your occasional reminder that post transcriptional regulation is important in immunology and autoinflammation😊 The integrated stress response pathway controls cytokine production in tissue-resident memory CD4+ T cells www.nature.com/articles/s41... #ImmunoSky #IDSky

Cheering for everyone standing up for science today! 👏👏👏

Reaching out to the #immunosky — would you want us to discuss your preprint? Tag us! We would be happy to provide feedback. 📝

PLOS has issued a statement on recent US Executive Orders and scientific integrity. We are determined to stand firmly behind our mission, our values and our principles, and against any attempt at censorship or undermining of the core principles of scientific inquiry. plos.io/3D4O8cH

Seems obvious, but apparently, no one has really dived into it like this(?)👇 🧬 Epigenetic variation in iPSCs staged is mostly tied to genetic variation, but as cells differentiate, this dilutes out quickly: Cell type matters more than genetics. #StemCells www.nature.com/articles/s41...

“The world’s a shit show, so why not put 💩 on a chip? Scientists created an iPSC-derived intestine-on-a-chip with fecal microbiota—uncovering epithelium-specific biomarkers & microbial factors linked to melanoma outcomes. Cutting-edge #OrganOnChip tech! #ImmunoSky #MedSky”

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵 Read more: www.nature.com/articles/s41...

Finally out! 🎉 Really happy to share my first co-author paper! It was wonderful to work with @aliperri.bsky.social , and huge thanks to @xaviertrepat.bsky.social for the opportunity to be part of this project. Grateful to the whole team for making this happen! www.nature.com/articles/s41...

NEW @preprintclub.bsky.social Journal Club of @biorxiv-immuno.bsky.social paper by @makris1.bsky.social @actonlab.bsky.social showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization

IL27 enters the cytotoxicity party! #ImmunoSky #MedSky www.nature.com/articles/s41...

If any American immunologists want to write an op-ed for @immunolcellbiol.bsky.social on the impact of the new executive orders, please contact me

Incredible work! A study years in the making published in Nature. I’ve been waiting for this one. Engineered heart muscle patches from iPSC improve cardiac function in non-human primates…and are stable/show evidence for remuscularization in a human patient! Wow! ❤️ www.nature.com/articles/s41...

Its stories like this that makes me incredibly excited! A gut immune–epithelial circuit regulating tolerance to food: Goblet cell protein RELMβ disrupts tolerance by depleting microbiome-derived indoles needed for protective Tregs. #microbiome #immunity #ImmunoSky www.nature.com/articles/s41...

Great to see the European Organ-on-Chip Society represented on @bsky.app. Activity will ramp up in the coming period, but for now, please follow @euroocs.bsky.social #ooc #mps #microphysiological

Organoids in physiologically relevant culture systems (MPS/OoC) with realtime measurements of cellular responses. How far off are we of this becoming reality and also, of becoming the standard?