STOP WITH WHATEVER IT IS YOURE DOING AND READ THIS NOW!

We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain: arxiv.org/abs/2511.04820 Strain: direct.mit.edu/qss/article/... Oligopoly: direct.mit.edu/qss/article/...

Are authors fairly judged by assessing the #journals in which their work is published? @bihutchins.bsky.social &co reveal that most influential papers are published in lower tier journals, and more authors would be better recognized with #ArticleLevelMetrics #ALMs @plosbiology.org 🧪 plos.io/4oV58Ed

🚀 New preprint! The Human Cytokine Dictionary - 9.7M cells, 12 donors, 90 cytokines - our largest human single-cell perturbation atlas yet. Users can map cytokine activity in their own data. Huge thanks to Lukas, Sören, Larsen, Parse Bio & Seelig lab! 🔗 www.biorxiv.org/content/10.6...

Cells can sense the geometry of their environment, from tiny subcellular features to whole-tissue patterns. How can we engineer environments to systematically probe these responses? 🧵 I'm @lhinderling.bsky.social from @olivierpertz.bsky.social lab, let’s do a short tour on microfabrication!

Do not miss the latest episode of The Stem Cell Report Podcast - Guests discuss their research on cultural conditions effects on PSC-derived intestinal epithelial cells. Listen to the episode: tinyurl.com/3s4pkj34 @jorammooiweer.bsky.social @isscr.org

How to deal with an error in science? — This is how. Great example of clearly owning, investigating, and communicating an error - with high integrity and respect. The error analysis immediately available as a preprint👏 Kudos to the authors for this courageous move. Excited to see the new data!

Totally psyched that our paper is out in @stemcellreports.bsky.social! For human iPSC–based gut #NAMs, which platform would you trust to behave most like real intestinal tissue? We put #organoids, Transwells and @emulatebio.bsky.social intestine-chip head to head. Spoiler: the chip wins. 🧵&🔗👇

THANK YOU!!! #ImmunoSky www.nature.com/articles/s41...

Proud to share our work now out in Cell. We hope what we learned about IgA immune responses to rotavirus can be translated into better vaccines. Congratulations Dr. Kei Haniuda, an amazing PDF. TY @uoftmedicine.bsky.social for covering. temertymedicine.utoronto.ca/news

Yes!!! This is the way forward for fairer science evaluation: (“high-impact”) journals give stamps of interest/impact on peer-reviewed preprints (i.e. still add value). In parallel, societies can use a similar ‘approval stamp’ especially to highlight excellent work in less “sexy” fields.

1/17 🧵 🙌Thrilled to share our first hard-core immunology paper out today in Nature Genetics! 👇 ➡️We unravel how TGFβ suppresses the innate and adaptive immune system in microsatellite stable colorectal cancer (MSS CRC). Very proud of the team and efforts behind it. www.nature.com/articles/s41...

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Big New! @elife.bsky.social @genetics-gsa.bsky.social #G3journal are joining editorial forces with @reviewcommons.org - bringing not just field-specific expertise to the process but also making #PreprintPeerReview a truly collaborative effort!🎉👏 Read more to find out👇 www.embo.org/features/pub...

Genetically editing iPSCs is challenging. But here’s thoroughly expedited how to do it anyway 👇

Online now: TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells

Excited to share a preprint from my postdoc @theGarrettLab- now on bioRxiv! Oral acetoacetate (AcAc) suppresses tumor growth by expanding and activating MAIT cells… and the mechanism was a surprise 🧵👇 (1/10) www.biorxiv.org/content/10.1...

Stop 👏 judging 👏 science 👏 with 👏 bad 👏 metrics 👏!!!!!

It’s unbelievable how side quests somehow take over your whole week. But hey; every day eventually becomes 6 PM, and you can finally start the thing you were actually supposed to do!

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now! events.ibecbarcelona.eu/embl-ibec-co...

Restoring Oral tolerance in 🐭 Continuous oral antigen exposure + CD28 blockade (CTLA4-Ig) = generation of CD101⁺ Tregs that enforce antigen-specific tolerance. Even in primed hosts. So pTregs can be reprogrammed into durable peacekeepers! #immunology #Tregs #immunosky

Back to back commentaries in @natureportfolio.nature.com today. Clearly NAMs are causing a stir!

As a researcher at the start of its career, I find this very frightening… www.nature.com/articles/d41...

Very excited to share the latest work from our lab, which was published today in Nature! nature.com/articles/s41... PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

In the light of “#mTOR regulates everything,” HDAC5 just gave it access to your mucus factory. Microbes → HDAC5 → 14-3-3 → mTOR → translation → mucus. Neat way to link energy status to an energy-costly process — only making #mucus when it’s worth it 🦠🧫 www.biorxiv.org/content/10.1...

CD74 — once thought of as a marker of antigen-presenting or regulatory cells — marks and even supports cytotoxic T cell function! www.biorxiv.org/content/10.1...

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program kcl-mrcdtp.com/project/deco... Applications opening soon! #gdTcells #IBD #gut #organoids

Our lab just completed a +6 year #marathon, describing for the first time that the #microbiome is critical for #exercise - induced increases in antitumor CD8 T cell immunity and improved of #cancer #immunotherapy. www.cell.com/cell/fulltex...

FFS

Excited to share our new study: Single-cell multiomics reveals archetypal regulatory programs shared across CD4 and CD8 T cell subsets in viral infection bioRxiv: doi.org/10.1101/2025... 🧵 Key findings below 👇

📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky

I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf

👋 Hello Bluesky community! We are the Swiss Young Immunologists Society, a network of young immunologists across CH🇨🇭 to connect, support each other, and boost our visibility on national and European levels. ✨👉 Follow us and stay tuned for updates on events, opportunities, and all things immunology!

Exciting data on oral tolerance induction are just out from several groups! I had the pleasure of writing a commentary www.science.org/stoken/autho... on the elegant study from @chrysothemisbrown.bsky.social. Don’t miss it if you're interested in mucosal immunology www.science.org/doi/10.1126/...

Phase II of our Fast & Fair peer review experiment is testing scalability. Results so far are promising. Read more at bit.ly/41N31tO. #FastandFairPeerReview #PeerReview #ScientificPublishing

Not sure if this works to trick LLMs, but this illustrates well how ineffective the peer-review enterprise is. Hacking the system.

About intestinal immune tolerance: Weaning sparks a wave of IL-10⁺, T-bet⁺ Tr1 CD4⁺ T cells in the small-intestinal. Surprise: they’re fueled by diet, not microbiota, via a cDC1→IL-27 axis, arming the gut with microbiota-independent, suppressive immunity. www.biorxiv.org/content/10.1...

Every cell is a stem cell! Even ‘terminal’ enterocytes can hit reset: Gut damage triggers a YAP/TAZ-driven fetal program → stress-proof “revival” stem cells → Lgr5⁺ CBC stem cells, rebuilding crypts from scratch and make organoids. #StemCellPlasticity #Organoids #Gut

Agreed! But even if we would solve that research assessment problem, discriminating ‘good research’ from ‘bad research’ in bulk (e.g. when screening CV’s) will still need a metric that allows for ‘quick screening’ I.e., a context-rich metric that reflects the merits of the research. What metric?

On cell extrusion in the #intestine! After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report: 3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look! www.biorxiv.org/content/10.1...

A ‘simple’ experiment but an amazing gem of a reference! Just stimulate blood, observe and describe… #ImmunoSky

This is WILD! “Cumulative evidence suggests a … previously unknown intergenerational inheritance mechanisms that propagate through the gut–germline–placenta axis in males, thru which the father’s gut microbiome influences offspring health & disease susceptibility.” www.science.org/doi/10.1126/...

1-0 for transparency! Transparant peer reviews at all @nature.com publications! www.nature.com/articles/d41...

Its honestly quite shocking. Cancer cell lines are sub-optimal systems due to genomic instability, mutations and potentially strange phenotypes. Thats known, but to see these anomalies quantified is a good moment to realize this once again. #Celllines #ImmunoSky #Jurkat

✨ Incredibly happy!! To receive the 2025 Stimulering prize from the Dutch Coeliac Disease Association! 🙌 Huge Thanks to all NCV members for your trust💚 Excited to continue our mini-gut & gut-on-a-chip research at @umcgroningen.bsky.social 💚 #coeliakie #research #minigut

Amazing idea for your next poster!

IL-27 released by licensed Kupffer cells can reboot exhausted liver CD8⁺ T cells in chronic HBV— No lymph-node priming needed, just IL-27 addition does the trick! Would a similar relay exist for intestinal CD8⁺ T cells guard attacking epithelium in auto-immunity? #Autoimmunity #Liver #HBV

Vascularized organoids! Balancing BMP signaling enables co-differentiation of mesoderm + endoderm in a single spheroid → organ-specific endothelium + vascularized gut & lung organoids! Ever increasing organoid complexity👏 #Organoids #StemCells

Funny to think we drag ourselves through life day after day… all to one day upload a PDF to the internet. #Academia #phdchat #Science