Calling for protocols on Tissue Machanics Basics: - (soft) PAA gels - strech/compression - indentation - advanced/high throughout tissue microscopy - force inference methods (shape, beads, ...) - tweezers - micropipette aspiration for a JoVE collection (they do the filming!) DM for more info!

The crowd has left the room for their last coffee break at the fantastic #CellExit, the first meeting on cell #extrusion.. Here's to many more meetings to come! 🥂 Huge thanks to you @magalisuzanne.bsky.social and @levayerr.bsky.social for getting this off the ground and for an impeccable first round

Calling for protocols on The Basics: get a protocol recorded and peer reviewed, and help a colleague learn the tips and tricks by *seeing how it's done* You don't need to include new results and it does not have to be your original protocol. Just cite well and share the know-how 💕🔥 Get in touch!

Tissue mechanics and synth morphogenesis folks, bump on this: Would you or someone in your lab be up for a video of a protocol you use getting recorded? The tips and tricks, the hard-to-explain-without-seeing-it-done? In the name of standardization and reproducibility in the field: get in touch! 🫀

Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

Tissue mechanics and synth morphogenesis folks! Would you or someone in your lab be up for recording a video of a protocol you use? Something hard to explain without seeing it done? In the limbo hours 🌀 between today and 2026🌟, if something comes to mind -get in touch! #JoVE organizes the filming 🤳

Record and get peer-reviewed a video-protocol of an experimental method in tissue mechanics research✨ Welcoming classics like gel making or pipette aspiration, but also ongoing blue sky trials! Abstract submission by March 2026🗓️ #JoVETissueMech #ReproducibleTissueMech 🎁 Learn by replaying it 🤳🎞️▶️

I am putting together a collection of video-protocols we (will) use in tissue mechanics research🌀 I hope to help consolidate established methods, but also showcase a few up-and-coming ones in our blooming field. Abstract submission by March 2026! Get in touch✨ #JoVETissueMech #ReproducibleTissueMech

You know that sinking feeling 🥶 when it was all going well, but this past month your cells stopped attaching to their protein patterns? Could it be the change of season...? 🫠 Don't know what I mean and it all works? Help a friend! Get your protocol on video🎄🎁 #JoVETissueMech #ReproducibleTissueMech

You know that sinking feeling 🥶 when you learn in a conference coffee break that your gel polymerization might have worked if you had stirred the mix for 10 seconds, rather than 1 or 20? #LabUrbanLegends If only you could replay the day when they first taught you how to do it #ReproducibleTissueMech

You know that sinking feeling 🥶 when you AFM the PAA gels you've been working with for a year, and their stiffness is waaay off? 🥶 Join me in this series of unfortunate events from day-to-day tissue mechanics research. Share or send yours, too, get some closure.. 🥲 It all ends well, I promise! 🌞🎄🎁

Intestinal villus cells extrude living, following a calcium pulse. Unlike from extruding apoptotic cells, Ca2+ messaging stops at the first neighbors! #FluorescenceFriday Part of our TrepatLab preprint: www.biorxiv.org/content/10.1... Video by @ronjahoutekamer.bsky.social @gloerichlab.bsky.social

They are a REMARKABLE supporter of scientists and the community. In addition to their five journals, they support dozens of scientific meetings each year, and provide travel grants and other support 2/n www.biologists.com/grants/

On cell extrusion in the #intestine! After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report: 3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look! www.biorxiv.org/content/10.1...

Scientific collaborations come in many flavors & are fun because they expose you to new areas of science. That was definitely the case for this paper, out today. We were definitely in the passenger seat but it was fun to go along for the ride 1/n rdcu.be/euiZB.

How to turn a layer of fibroblasts into a tulip 🌷? Check out our new pre-print on shape-programmable living surfaces. Led by @pauguillamat.bsky.social‬ www.biorxiv.org/content/10.1...

Beautiful story from the Krndija lab, tackling the unexpected challenges of complex epithelia. They show side-effects (or are they?) of building an epithelium out of distinct cell types, with junctional fractures at the heterotypic interface. Is there any reinforcement of 3CJunctions?

... and a few minutes ago our Chart-Checklist came out in @natcellbio.nature.com 🥳🎉 Gift link for #TCTeAC: rdcu.be/eqPpi www.nature.com/articles/s41...

Very useful thread from the best fan club @epimechfc.bsky.social on different (newish) image analysis software. Have a look, add the ones you use! Is it time for a review article?

It's been 2 mere months since the magnificent #CellBio24 @ascbiology.bsky.social @embo.org in San Diego and my first ever trip to the US. It's hard to believe the amount of chaos that's happened since then.. Throwback with @paulinastrzyz.bsky.social Karina Pombo-Garcia, Chris Schmied, Jeff Woodruff

We have a new #stopdoing #science meme, courtesy of Miquel Bosch Padros from the @xaviertrepat.bsky.social lab. Late for #mechanobiology Monday, but here to stay on your lab meme boards forever.

"Politics aside (ha! as if!)", I don't think these will ever get old for me, but they do shine extra bright these days. "..." Stolen from @harmitmalik.bsky.social #biology #stopdoing #science

Please welcome @scadsai.bsky.social on bluesky! We at ScaDS.ai are a federally funded artificial intelligence research center with headquarters in Dresden and Leipzig, Germany!

Beautiful findings, showing that at a critical tissue density, YAP is heterogeneously expressed in intestinal cells, leading to all sorts of responses that help regeneration. Well done Connie @cschwayer.bsky.social and all ✨

See you in San Diego old and new friends! Join me and my talk in the organoid subgroup on Wednesday at 9:15 AM for a dive into the elements that drive intestinal cell extrusion. It's a very pretty, fundamental story ✨

I think this will be fun and very useful! Writing well is thinking well #devbiolwriteclub