Paulina Strzyz
@paulinastrzyz.bsky.social
š¤ 92
š„ 181
š 17
Deputy Editor at Advanced Science
Ever wondered what a scientific editor actually does? I recently shared my perspective on this in a written interview for the Academic Life Substack: š
shorturl.at/vqGxU
#CareersOutsideAcademia
#ScientificEditing
#AdvancedScience
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The Other Side of the Desk: Science Editors and Submissions
The Academic Life newsletter by Christina Gessler, Ph.D.
https://shorturl.at/vqGxU
about 6 hours ago
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New in
#AdvancedScience
@wileylifesci.bsky.social
Cells can export the tumor suppressor
#p53
in
#exosomes
and share it with neighbors. The transferred p53 remains functionalāactivating protective programs in recipient cells. In this way cells might collaborate to prevent cancer. š
shorturl.at/veeKj
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Endocytic Control of CellāAutonomous and NonāCellāAutonomous Functions of p53
NUMB Ex3-containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells an...
https://doi.org/10.1002/advs.202513765
8 days ago
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New in
#AdvancedScience
@wileylifesci.bsky.social
Human brain
#organoids
from
#Alzheimer's
patients now faithfully reproduce disease pathology. Even better: a new
#autophagy
drug candidate reverses the damage. A step toward testing treatments in human tissue, not just mice šhttps://shorturl.at/HvAKn
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Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSCāDerived Cortical Organoids
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid-beta and phospho-Tau aggregation, neuronal hyperexcitab...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202514783
8 days ago
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#VitaminD
does more than support bonesāit fine-tunes sense of
#smell
! New work in
#AdvancedScience
@wileylifesci.bsky.social
shows vitamin D controls synaptic proteins in the olfactory bulb, using both gene regulation and
#mTOR
. Nutrition meets
#neuroscience
! š
shorturl.at/3ubBn
#Olfaction
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Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTORāDependent Translational Control of Synaptic Proteins
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor-dependent transcriptional and translational mechanisms. VitD regulates ....
https://doi.org/10.1002/advs.202507181
about 2 months ago
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New research in
#AdvancedScience
@wileylifesci.bsky.social
TBK1 phosphorylation drives optineurin to form filaments that phase separate with poly
#ubiquitin
and LC3, organizing cargo for selective
#autophagy
. New insight into autophagy and
#neurodegeneration
. š
shorturl.at/HzkK8
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TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane-anchored LC3 partitions into these condensates, suggesting that...
https://doi.org/10.1002/advs.202509927
about 2 months ago
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New in Advanced Science: BrillouināRaman microscopy on-a-chip reveals how mechanical stress rewires breast tumor spheroidsāboosting ATF3 and invasion. New tool for cancer mechanobiology. š
doi.org/10.1002/advs...
#cancer
#mechanobiology
#biophotonics
@wileylifesci.bsky.social
@lab-scita.bsky.social
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Brillouin Microscopy of Breast tumor Spheroids OnāaāChip: Mechanical and Transcriptional Responses to MicrofluidicāInduced Rapid Deformations
Brillouin-Raman Microspectroscopy on-a-Chip (BRmS) enables real-time analysis of breast tumor spheroids in microfluidic channels. Following cyclical deformations, MCF10.DCIS.com spheroids are capture...
https://doi.org/10.1002/advs.202513153
about 2 months ago
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New review in
#AdvancedScience
:
#Amyloids
arenāt just disease markersāin bacteria, theyāre dynamic, functional protein assemblies with roles in biofilms, catalysis, and more. Ripe for
#biomaterials
innovation! š
shorturl.at/wPAQb
#microbiology
#SyntheticBiology
@wileylifesci.bsky.social
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The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek-key...
https://doi.org/10.1002/advs.202517090
2 months ago
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New in
#AdvancedScience
: Dual-humanized mouse model with cryopreserved human lung tissue lets researchers study common cold
#coronaviruses
&
#SARS-CoV-2
in a human-relevant way. Opens doors for testing
#antivirals
and exploring immune responses. š
shorturl.at/CYJZU
@wileylifesci.bsky.social
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A LungāImmune DualāHumanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses
Cryopreserved lung-humanized mice overcome the dependency to fresh tissues and permit head-to-head profiling of all four human common cold coronaviruses versus SARS-CoV-2 infection; the model validat...
https://doi.org/10.1002/advs.202512097
2 months ago
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New in
#AdvancedScience
@wileylifesci.bsky.social
: Zhang et al. reveal how ERK, PKA, YAP/TAZ & SHH signaling shape cortical radial glia fateāoffering fresh insight into brain development and evolution.
#Neuroscience
#RadialGlia
#BrainScience
#BrainEvolution
shorturl.at/Z0isZ
3 months ago
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New work in
#AdvancedScience
Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis
@ucsantabarbara.bsky.social
#Morphogenesis
#ECM
#Biomaterials
#TissueEngineering
#CellBiology
#Mechanobiology
Read full OA article
shorturl.at/RxQIh
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Extracellular Matrix Viscoelasticity Regulates Mammary Branching Morphogenesis
This study shows that mammary branching morphogenesis is regulated by extracellular matrix (ECM) stress relaxation. Slow stress-relaxing matrices promote branching through focal adhesion signaling, c...
https://shorturl.at/RxQIh
3 months ago
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Glyco-STORM: Nanoscale Mapping of the Subcellular Glycosylation Landscape by
@majaklevanski.bsky.social
published in
#AdvancedScience
Read full OA article here:
shorturl.at/4GvlM
@wileylifesci.bsky.social
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Nanoscale Mapping of the Subcellular Glycosylation Landscape
Using multiplexed super-resolution imaging with fluorophore-labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending ...
https://shorturl.at/4GvlM
3 months ago
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reposted by
Paulina Strzyz
bioRxivpreprint
3 months ago
Phospho-eIF2B-epsilon links stress response-driven translation to amyloidogenesis in Alzheimer's disease
https://www.biorxiv.org/content/10.1101/2025.11.03.686297v1
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reposted by
Paulina Strzyz
Andreas Linkermann
6 months ago
Happy to start at Bluesky with a post on our recent manuscript at
@nature.com
:
www.nature.com/articles/s41...
Great collaboration with cool scientists such as
@theprattgroup.bsky.social
,
@fedorovalab.bsky.social
and many who do not (yet) have a Bluesky account.
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Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature
17Ī²-oestradiol establishes an anti-ferroptotic state in female kidney tubules.
https://www.nature.com/articles/s41586-025-09389-x
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š§¬ Just published in Advanced Science: New work from
@linkermannlab.bsky.social
showing that secondary necrosis can occur without Gasdermin E. A clear step forward in decoding regulated necrosis.
#CellDeath
#SecondaryNecrosis
#GSDME
#CaspaseInhibition
#AdvancedScience
#EditorPick
shorturl.at/ITJe6
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Secondary Necrosis Following CaspaseāActivation can Occur Independently of Gasdermin E
Secondary necrosis follows apoptosis, but its mechanism is unclear. This study shows that although gasdermin E is cleaved during this process, it is not required for membrane rupture. Across multiple...
https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202507381
3 months ago
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New in Advanced Science: Cells regulate membraneless organelles using a shared proteostasis network. HSP70 chaperones act broadly, while co-chaperones provide organelle-specific control. Vendruscolo-Morimoto labs collaboration š
shorturl.at/v0TeH
#Proteostasis
#MembranelessOrganelles
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Organization of the Proteostasis Network of Membraneless Organelles
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specifi...
https://shorturl.at/v0TeH
8 months ago
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New in Advanced Science: Apoptotic vesicles from mesenchymal stem cells selectively induce CD8āŗ T cell apoptosis via calcium overloadāoffering a novel strategy to treat type IV hypersensitivity
#Immunotherapy
#ExtracellularVesicles
#Nanomedicine
#CD8Tcells
#Hypersensitivity
š
doi.org/10.1002/advs...
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Apoptotic Vesicles Derived from Mesenchymal Stem Cells Ameliorate Hypersensitivity Responses via Inducing CD8+ T Cells Apoptosis with Calcium Overload and Mitochondrial Dysfunction
The therapeutic potential of ApoVs derived from stem cells from human exfoliated deciduous teeth (SHED-ApoVs) in the treatment of CD8+ T cell-mediated hypersensitivity reactions is noteworthy. SHED-A...
https://doi.org/10.1002/advs.202407446
8 months ago
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Don't miss this fantastic
#Review
! I still feel partly responsible, having commissioned it ;) ā¤ļønrmcb!
add a skeleton here at some point
about 1 year ago
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reposted by
Paulina Strzyz
Jan Lammerding - Lab
about 1 year ago
Exciting work by Martin Beckās group
@mpibp.bsky.social
providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure.
www.cell.com/molecular-ce...
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Nuclear pore permeability and fluid flow are modulated by its dilation state
Hoffmann etĀ al. describe within cells how the Dictyostelium discoideum nuclear pore complex structure constricts and dilates as a consequence of osmotic stress. Based on their experimental findings, they propose a hydrodynamics model and quantify fluid flow across nuclear pore complexes under conditions when nuclei change their volume rapidly.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(24)00993-6
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reposted by
Paulina Strzyz
Juan C. Landoni
about 1 year ago
Stoked to share TWO preprints on mitochondrial pearling! š We uncover how spontaneous
#mitochondria
pearling drives
#mtDNA
nucleoid distribution (
doi.org/10.1101/2024...
), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (
doi.org/10.1101/2024...
). Details below! š¬š§µš§Ŗ
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reposted by
Paulina Strzyz
Wallace Marshall
about 1 year ago
Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint,
@gavsturm.bsky.social
investigates how mitochondria transiently adopt a beads-on-a-string morphology
www.biorxiv.org/content/10.1...
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Amazing initiative for peer-reviewing and curating preprints:
noteforms.com/forms/dsdc-p...
. Currently trialling in cancer and immunology.
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Discovery Stack Pilot Participant Signups
https://noteforms.com/forms/dsdc-participant-signups-p2d1ya
about 1 year ago
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Congrats
@marija-matejcic.bsky.social
for a killer talk at the ASCB
#CellBio2024
š
#Mechanobiology
4eva
about 1 year ago
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