It’s been a pleasure working with @apdaria.bsky.social, Julie Heffler, and the Prosser Lab on this study, supported by the Leducq Foundation and the National Institutes of Health (NIH). This research is one step to get us closer to an effective treatment for cardiac #laminopathies and #LMNA-DCM.

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

Odell, J et al. (@lammerdinglab.bsky.social lab) A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites. bioRxiv posted 2 September 2025 doi:10.1101/2025.09.01.673543. www.biorxiv.org/content/10.1...

Final call to register and submit abstracts for the @faseborg.bsky.social conference on the Mechanobiology of the Cell Nucleus (#MBNSRC) to be considered for platform presentations. The conference takes place in Melbourne, FL, Oct. 26-30, 2025. See more info at: events.faseb.org/event/Mechan...

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

FOMO no more: NOMO and Calmin extend #mechanobiology to the ER. Julie Heffler and Jan Lammerding @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) & @hennelab.bsky.social (doi.org/10.1016/j.ce...), in Spotlight: rupress.org/jcb/article/...

Interested in #mechanobiology of the cell nucleus? The submission deadline for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus is August 31, 2025. Submit your abstract to be considered for a platform presentation. #MBNSRC events.faseb.org/event/Mechan...

Last chance to register and submit an abstract to be considered for a platform presentation. If you are interested in nuclear #mechano Ta

Heffler and @LammerdingLab.bsky.social discuss recent studies from the @schliekerlab.bsky.social (doi.org/10.1083/jcb....) and @hennelab.bsky.social (doi.org/10.1016/j.ce...) that identify two proteins serving as crucial mechanical elements in the endoplasmic reticulum. rupress.org/jcb/article/...

Please submit your abstracts by August 31st to be considered for a platform presentation! We look forward to an exciting and stimulating meeting! Please share!

Happy #FluorescenceFriday! Our #CellLineOfTheWeek is MLC-2a - illuminating sarcomeric thick filaments! 💪🧫 Our high-quality stem cell lines & plasmids are available for just the cost of shipping to reduce the barriers to discovery. 📦 Dist. by @coriellinstitute.bsky.social & @addgene.bsky.social.

The Anne West lab at Duke is hiring a postdoc to work on nuclear cell biology in neurogenesis. Please help me spread the word! Applications to [email protected].

What allows lamins A and C to confer much stronger mechanical stability to the nuclei than lamin B? We show that even though all lamins can protect the nucleus from small cell intrinsic forces, only lamin A/C protect the nucleus from large deformations: www.biorxiv.org/content/10.1... 1/n

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Join us for the first Mechanobiology of the Nucleus conference supported by @faseborg.bsky.social. Co-organized with @lammerdinglab.bsky.social, @katemiro.bsky.social and Verena Ruprecht, the amazing program is here: events.faseb.org/event/Mechan... Opportunities for talks! Abstracts by Aug. 31st.

If you know anyone with Emery-Dreifuss Muscular Dystrophy (#EDMD) or want to support research on this disease, a patient family we have been working with for many years has started a new foundation, cureEDMD, to raise awareness for this devastating disease: www.cureedmd.org Please share widely!

Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way! #notforprofit

Interested in nuclear #mechanobiology? Join us for the first ever FASEB Science Research Conference on the Mechanobiology of the Nucleus #MBNSRC. Find more information and register at: events.faseb.org/event/Mechan... Submit abstracts by August 31, 2025. Please share and see you in October!

I'm a current Harvard graduate student and I found out today that I had my NSF GRFP terminated without notification. I was awarded this individual research fellowship before even choosing Harvard as my graduate school

The entire nation should protesting this utterly unwarranted, unprecedented, & probably illegal on-going attack on a university. It's right out of the authoritarian playbook. It's an assault on possibility free speech, free thought, & dissent. Fascism is coming small step by small step, not at once.

"We need the whole country to appreciate that by investing in university research and educating the next generation of explorers and innovators, the country has reaped, and will continue to reap, tremendous rewards in new cures, treatments, and inventions, and in new industries, companies, and jobs"

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...

New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇

If biotech wants to continue to recruit highly talented, energetic, and creative PhDs they need to help us to advocate for stable funding for young scientists in academia to prevent a brain drain and loss of scientific innovation. We discuss this on this week's Night Science Podcast with David Baker

Celebrating 140 Years of Women in Engineering at Cornell @cornellengineering.bsky.social and their amazing achievements. Hosted by @mchvdm.bsky.social and Lara Estroff, trailblazers in their own right.

Our first 2025 paper! We discuss in @natrevmcb.bsky.social how epithelial stem cells mechanically sculpt tissues, and how these forces are altered in cancer. Great work from our former and current tumor mechanobiology experts Vince Fiore & @jorgealmagro.bsky.social 👏 www.nature.com/articles/s41...

In their Review, Julien Morival, Anna Hazelwood and Jan Lammerding @lammerdinglab.bsky.social discuss new insights and technological advances in understanding nuclear mechanotransduction. journals.biologists.com/jcs/article/...

Interested in nuclear mechanobiology, and how advanced genomic tools can shed light on how the cell nucleus might sense mechanical forces? Read our latest review by excellent Julien Morival and Anna Hazelwood, now published @jcellsci.bsky.social: journals.biologists.com/jcs/article-...

Second, women make terrific leaders. They tend to be organized and prepared. They also tend to be more empathic as they have often experienced more challenges and setbacks than men in similar positions. They tend to be more courageous, particularly when the stakes are high. 36/n

What a surreal experience. #standupforscience2025 is the honor of my lifetime. I am just speechless. So grateful to the hundreds of volunteers, thousands of attendees, and countless inspirational speakers across rallies. My heart is full. @standupforscience.bsky.social 1/2

Extending my grant update this morning. Here are data limited to new and competitive renewal applications. The Pause is dead, Long live the Pause...

Great opportunity: applications are open for the Weill Institute Emerging Scholars Symposium @Cornell! Senior PhD students and postdocs interested in networking & presenting their work in cell & molecular biology should apply by Apr 14. wicmb.cornell.edu/emerging-schol… Please repost!

@aamctoday.bsky.social @aaup.bsky.social @asm.org Many grad programs are pausing and reducing admissions in response to NIH funding pauses and pending EO’s on indirect cost reductions. These workforce reductions have the potential to imminently and irreversibly harm research labs & grad programs

Thank you @nplb.bsky.social for speaking out in defense of patients, the US economy and our citizenship. Encouraged to see biopharma and investors among patients, health care providers, scientists and policy makers. www.nopatientleftbehind.org/defending-th...

We have to fight now for research that we know benefits all of humanity, we have to stand up for our colleagues at the NIH, we can’t lie down and take it, we stand against this madness #standupforscience2025

Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...

This is catastrophic for US research universities as it ignores the real cost of doing research. The US academic-gov’t partnership forged post-WWII is the greatest creator of knowledge in history and is critical to US economic and technological competitiveness.

A Primer on Indirect Cost Rates

Research universities are often the largest employers in their region. They are often the primary health care providers to communities. This funding shift will not only reduce US research leadership, it will put working people out of work and reduce healthcare access.

Terribly sad to learn of Dr. Michael Sheetz's passing. Mike was a foundational figure in mechanobiology and a strong advocate for the field. He also made us all better by holding himself and others to the highest intellectual standards. Condolences and best wishes to Mike's family and friends.

The NIH diversity supplement pages have all been pulled down. What is a diversity supplement and why should the public care? A diversity supplement is funding to help diversify the research workforce. You may be wondering, “so what?”. Let me explain. www.nigms.nih.gov/Pages/PageNo...

The dark side of fluorescent protein tagging: the impact of protein tags on biomolecular condensation www.biorxiv.org/content/10.1...

PhD students: it’s a waste to just try to impress your committee at the meeting. Bring them problems, ask for suggestions, and generally think of it as a session in which new ideas can emerge.

Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development. Details below 👇👇 Please Repost !!! @ijmonod.bsky.social @cnrs.bsky.social

Exciting work by Martin Beck’s group @mpibp.bsky.social providing further evidence for nuclear pores responding to mechanical stress. The work includes some nice modeling estimating the fluid flow across nuclear pores as a function of (osmotic) pressure. www.cell.com/molecular-ce...

My latest Research Highlight is now online @natrevmcb.bsky.social! The Brangwynne lab uncovers how chromatin heterogeneity influences condensate formation during #CellMigration, revealing intriguing insights into nuclear mechanics. 🔗 go.nature.com/3ZpwGH7 OG Paper: go.nature.com/3Baxpnn

Are you interested in learning about how engineering and physics can be applied to study the motions of #plants, #invertebrates, and #animals? Here's a non-exhaustive list of Comparative Biomechanists to get started! 🦋 🐟 🦎 🌿 🧪 go.bsky.app/HvHFgvB Apologies for any that I may have been missed.

#FluorescenceFriday Witness the magic: Our homebrewed mStayGold live-cell imaging probe for enhancer nucleosomes at 300ms temporal resolution Designed and imaged by this PI (yep, me 😂). Hot damn, these dynamics are mind-blowing—like watching a realtime chromatin dance #Microscopy #ChromatinArtistry

Just because its fun~ This is one of my favorite videos I've taken in my PhD! Here is 60x imaging of neutrophils swarming to attack yeast targets in blue :)