I’m constantly thinking this guy is a genius and then realising that all he is doing is identifying problems people care about and offering to do something about it. Is that really such a revolutionary idea? Yet it doesn’t seem to have ever occurred to the existing Democratic establishment

Trump's actions mean that everyone gets behind the Belgian football team. Farage's actions mean that everyone gets behind Count Binface.

Exactly this

Did you know that on Manhattan Island, New York, there is still a naturally regenerating forest that has been untouched for thousands of years No human activity until the indigenous population used the rock shelters a few hundred years ago for a short period Inwood Hill Park

This is huge! Triple Negative Breast Cancers (TNBCs) are aggressive & disproportionately strike younger women. Historically, TNBCs have limited treatment options. Trodelvy, which targets Trop-2 is now approved in the US for first line treatment of metastatic TNBC. 🧪 www.gilead.com/news/news-de...

Ah, I remember O-level revision!

The 250th anniversary is obviously a one-off celebration and it is a shame the President isn't using the occasion to bring the whole country together. But then again, divide and conquer has always been his strategy.

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A comprehensive assessment of the safety of mRNA vaccines thelancet.com/journals/lan...

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Do better, antibody companies. And scientists shouldn't trust the advertising, do the proper experiments and controls. Great work by David Sholto on uncovering some of the most agregious behaviour. Antibodies per se aren't the problem - their misprepresentation is.

GOOD NEWS! A personalized mRNA vaccine, known as mRNA-4157, has shown promise in keeping melanoma, a deadly skin cancer, from returning. FIVE years later, NEARLY 70% of people in the vaccine group are CANCER-FREE. The vaccine also cut a person’s risk of the cancer metastasizing by NEARLY 60%.

Supreme Court rejects Trump's appeal of E Jean Carroll's sexual abuse case

Wow. The whole country moved 5mm!

💥💥💥 www.bbc.co.uk/news/live/cg...

Incredible

Will the Mamdani effect make 2028 the year of the leftwing president?

Genius. Stop the bully.

Advice for Life from Mel Brooks - (thanks @scientits.bsky.social )

We got a big bump in traffic yesterday when people learned about us on NPR. Thank you to @npr.org for covering our launch and bringing our story to people's attention! And thank you to all our new followers. We can do this together! 🌍️🧪💪 #ClimateAction #ClimateForUs #ProtectScience

“I felt two sudden jolts, as if someone was trying to lift me out of bed.” https://scim.ag/4g9cDGJ

When you show up for the qualifying exam without even having read the first page of the paper to be discussed…

A fifth of Leave voters have died.

Congrats and thanks to Steve White and everyone @martinhumphries.bsky.social who contributed to this work. Really pleased to have been able to make a contribution.

How do donated tissue samples help shape future cancer treatments? Our latest blog explores the work of the MCRC Biobank, which has collected more than 230,000 samples from nearly 30,000 patients to support cutting-edge cancer research. Read more: https://ow.ly/ozuS50Z5EsS

80%!

"In summary, neighborhood socioeconomics represent the principal axis shaping brain organization during childhood and beyond, potentially through sleep and stress."

This is brilliant news - a new GCSE in Natural History will bring #nature and its benefits to new generations of young adults in the UK 🍎 www.theguardian.com/education/20...

If you happen to bump into Farage, Johnson or Gove, shove these charts in their faces, will you. www.theguardian.com/politics/202...

In their Cell Science at a Glance article, @zeinabrekad.bsky.social Stavroula Mili, Ellen Van Obberghen-Schilling & Delphine Ciais highlight the ways in which RBPs & local RNA regulation impact adhesion-dependent processes, & the effect of their dysregulation. journals.biologists.com/jcs/article/...

Congratulations Henry!

History Job Klaxon. Join us at the University of Manchester!

Cryo-EM: the revolution continues doi.org/10.1107/S205...

1/10 For decades, cellular aggregation was considered an evolutionary dead end. Cells could come together temporarily. But complex multicellular organisms like animals? Our study, led by JP Gerdt, with Ruibao & @jennahed.bsky.social suggests it may be time to rethink that🧵 #ProtistsOnSKy

Speed of response is everything, and it's still lagging far behind. Essential explainer on the Congo Ebola outbreak from @JeremyKonyndyk. www.nytimes.com/interactive/...

Brexit was an act of “sabotage” that has made Britain up to £30bn a year worse off, former foreign secretary David Miliband has claimed. He said the loss of income caused by leaving the EU is equivalent to imposing “a punishing tax every day” on the UK. #RejoinEU #BrexitDisaster

Wow

1/ Our new crystal structure is now available in the PDB (9SR0). It is the structure of the widely used A50I vinculin mutant bound to talin. Which is slightly awkward, because A50I is supposed to be a talin-binding-null mutant. rcsb.org/structure/9SR0

A reminder: All of us are “foreign-born” almost anywhere on this planet.

This should be blindingly obvious. Does anyone who is serious/honest really believe the UK can prosper on its own? So why waste time?

Rank 1 in a 143 year time series.

Key results of the randomized trial: —At 5-years, 69% of patients getting vaccine plus pembrolizumab (Keytruda) were cancer free compared with 49% in the pembrolizumab group alone, —Distant metastasis was also reduced by 59% by vaccine addition —Overall survival 92 vs 71% (vaccine vs no vaccine)

Imagine what the effect would be with earlier stage disease

Magnolias evolved before bees existed. 95 million years ago, their ancestors shared the planet with the dinosaurs of the Cretaceous, but no bees. So they made a messy partnership with beetles that continues today & it explains why they're such unusual flowering plants. Let's talk about it.

If you're interested in the hot (yet complex) field of cancer immunotherapies with >2,000 approved or in the works, I've done a rundown and future outlook erictopol.substack.com/p/the-remark...

Hear, hear! Far too many paper titles now with "mapping", "profiling" and "landscape" in them. An abundance of data doesn't equate to a discovery.