Spatial-proteomics reveals recombinant human laminin-111 restores adhesion-signaling to laminin-α2 deficient muscle insight.jci.org/articles/vie...

FHL2 enhances ITGB1-mediated ECM remodeling and cellular stiffness to promote radioresistance in non-small cell lung cancer www.nature.com/articles/s41...

from abstract: 'Degrading cell-surface αv integrins, rather than merely blocking their interactions with the extracellular matrix (ECM), produces a stronger anti-proliferative effect by more robustly modulating oncogenic signaling pathways.'

Bi-functional integrin degraders cause stronger anti-proliferative effects than a blocking antibody by modulating distinct downstream signaling www.tandfonline.com/doi/full/10....

Ligand and integrin-independent mechano-sensitive EGFR activation in lung cancer cells journals.biologists.com/jcs/article/...

A critical role of FAK signaling in Rac1-driven melanoma cell resistance to MAPK pathway inhibition www.nature.com/articles/s41...

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells advanced.onlinelibrary.wiley.com/doi/10.1002/...

Very pleased to see this published and to have played a (minor) role. Congrats to all authors and in particular corresponding author Prof Tris McKay @manmetuni.bsky.social

CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival www.nature.com/articles/s41...

Mechanochemical waves in focal adhesions during cell migration www.science.org/doi/full/10....

Piezo1 regulates the mechanotransduction of soft matrix viscoelasticity www.nature.com/articles/s41...

Drak is a potential mechanotransduction partner of Filamin www.biorxiv.org/content/10.1...

Spatial Regulation of Endocytosis and Adhesion Formation Governs Breast Cancer Cell Migration Under Confinement www.mdpi.com/2306-5354/12...

Extracellular matrix-driven metabolic control of pancreatic endocrine lineage allocation www.embopress.org/doi/full/10....

Sex, drugs and the conscious brain: Francis Crick beyond the double helix paging @matthewcobb.bsky.social www.nature.com/articles/d41...

A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels www.nature.com/articles/s41...

Strained Actin Binding by the Prickle2 LIM Domains and their Regulation in the Full-Length Protein www.molbiolcell.org/doi/abs/10.1...

John Gurdon obituary: Biologist who made cloning possible www.nature.com/articles/d41...

ZO-1,cell-cell and cell-matrix interactions...

The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...

Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology. bit.ly/Dynamic-Cell-VI

Get out your calendars! The motors are out of quarantine and we plan to assemble in person on 8th May 2026 at University of Warwick Campus for a fun day on motors and the filaments they walk along. Livestream is planned too. More details on registration, travel bursaries etc. will be revealed soon.

“The bad review will come from your list of suggested reviewers”

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

For years Roland has worked tirelessly to inform BBC listeners about societally-relevant science. This is exactly the WRONG time, BBC, to be letting him go! 😠

For 61 years the #BBCWorldService has been broadcasting the latest in science via its weekly Science in Action programme. That dies in the next half hour, with this final edition, reflecting on the fall in trust in expertise driven by malign interests over recent years.

USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

Depressingly there is more talk in many places about race and ethnicity, and how certain visible characteristics - most obviously skin colour - define people. This is squarely in the identity discussion; ie, people defining their own identity via these visible characteristics

Cell plasticity as a mechanism to evade KRAS inhibition in colorectal cancer. #KRAS #CellPlasticity #CancerStemCell 🧪

The hypoxic ECM and neutrophils in MIBC immunotherapy resistance www.nature.com/articles/s41...

Oscillatory and elevated flow distinctly regulate gene expression in human coronary artery endothelial cells https://www.biorxiv.org/content/10.1101/2025.10.10.681055v1

Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cell Adhesion to Bioactive Hydrogels pubs.acs.org/doi/10.1021/...

Experimental models of pancreas cancer: what has been the impact for precision medicine? www.jci.org/articles/vie...

The Roadmap of the Human Liver Cell Atlas is out in @natrevgastrohep.nature.com laying out the scope and goals of our Human Liver Cell Atlas emerging from the @cziscience.bsky.social funded Liver Seed Network. www.nature.com/articles/s41...

Just flagging up this conference that I'm helping with. There will be fantastic speakers in sessions covering Melanoma evolution, microenvironment, host cell interactions, precision immunotherapy, emerging therapeutics and clinical trials / real-world data. Scan the QR code for full details.

Excited to present at the @metastasisresearch.bsky.social webinar soon. Registration is free!

We are highlighting Arnoud Sonnenberg, a distinguished cell biologist who served as a @jcellsci.bsky.social Editor for 19 years, as an extraordinary biologist. #100biologists @asonnenberg.bsky.social

Lab-grown human embryo model produces blood cells www.theguardian.com/science/2025...

new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

A human pan-disease blood atlas of the circulating proteome | Science www.science.org/doi/10.1126/...

Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice www.jci.org/articles/vie...

🌟Ready to apply? 16 fully funded PhD positions are open in ProtAIomics Doctoral Network! Join 16 labs across Europe to advance AI-powered proteomics and drive discoveries in health & biotechnology. 👉 Apply here: www.protaiomics.eu #Proteomics #ArtificialIntelligence #MSCA #PhDOpportunities

Our group has a PhD position open in this Doctoral network. Our topic is around combining proteomics AI and protein structures. Look through the website below to look at all of the projects/groups and apply.

John Gurdon, former Group Leader and Head of @cellbiol-mrclmb.bsky.social has died. Despite calling himself a "total non-intellectual” his work to reprogramme somatic cells to pluripotent stem cells transformed the field of developmental biology. More: www2.mrc-lmb.cam.ac.uk/john-gurdon-... #LMBNews

Epithelial-mesenchymal transition www.cell.com/cell/fulltex...