I’m happy to share our new preprint on stem cell regeneration in the human colon! Using new CRISPR knockins in organoids, we show that after stem cell loss, non-stem cells rapidly regenerate them. This process is normally inhibited by the stem cells themselves. Manuscript link: tinyurl.com/3ky4ccxf

📢 New preprint 🔥 1/ Stem cell regeneration is often viewed as an actively induced process, triggered by damage. But what if plasticity is actively suppressed by the stem cells themselves? We explored plasticity with 'new' cell type ablation tech in normal human colon organoids tinyurl.com/3ky4ccxf

Check out this very cool new preprint by our lab on how intestinal tuft cells differentiate! 🤩 @julian-buissant.bsky.social @hugosnippert.bsky.social