Now it's official! Our DFG funded Collaborative Research Center on Membrane Complexes will be funded for another round! 🥳🥳🥳 For our lab that means more exciting work on TRP channels and their role as cellular signaling hubs 😍 @crc1507.bsky.social www.dfg.de/de/aktuelles...

Internship / MSc for #engineering, #photoswitch & #optogenetics fans: Like LEDs, soldering, simple PCBs and optics? Join the Thorn-Seshold lab at @tudresden.bsky.social & help build next-gen light engines for #photopharmacology & cellular control. PIs please repost! @poldresden.bsky.social

Proof of principle vs. translational reality check: Can we accumulate nano-formulated drugs inside solid tumours by transiently disrupting tumour vasculature? Yes, in principle, but with a translational catch 👇 #GO-Bio #BMFTR @lmu.de; #ChemBio bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

GBM Lunch on May 6, 2026, 12:30 Speaker: Youjun Yang (East China University of Science and Technology) Title: "Early Ferroptosis Detection Targeting Lipid Hydrogen Abstraction” Chair: @oliverthornseshold.bsky.social Organizer: Joint Study Group "Chemical Biology" #GBMLunch #ChemicalBiology

This week’s Essential Read in #chembio - my vote: what actually happens to diazirine photolabels? @nadlerlab.bsky.social strikes again. Enjoy #photopharma and caveat N2or! pubs.acs.org/doi/10.1021/...

Youjun Yang and coworkers did a great chemical probe design paper: Fluorogenicity cleverly triggered by H-atom abstraction. Congrats to all! #chembio #fluorescencefriday #realtimechem pubs.acs.org/doi/10.1021/...

Understanding the thioredoxin system is key to understanding cellular RedOx homeostasis. Congratulations to @lzeisel.bsky.social on being awarded one of the @gdchbiochem.bsky.social Young Scientist Awards for his work in the @thornsesholdlab.bsky.social in this field. pubs.acs.org/doi/abs/10.1...

We are excited that we could today award four Young Scientist Awards for outstanding publications and dissertations over the last two years. The awardees are Johannes Morstein, Sarah Emmert, Frederik Schmidt and Lukas Zeisel. Congratulations to all awardees! (1/3) #Biochemistry #ChemSky #ChemBio

Excited to share our new Perspective in @natchembio.nature.com with @Yang_J_lab. How do we move from isolated cysteine modifications to a systems-level understanding of redox signaling? We outline a unified chemical framework for decoding the cysteine redoxome. Read here: t.co/6XY1FCdtN6

Chemical biology PhDs/postdocs: don't miss out! Liz New is hiring a 2-year postdoc position on making & using fluorophores, in Sydney, Australia. A great group in a great city. #chembio #postdoc hunters - check out the @lizjnew.bsky.social lab for more. usyd.wd105.myworkdayjobs.com/en-US/USYD_E...

Important paper alert #molswitches & #photopharma! Thorough, clear, fundamental mechanistics. Congratulations to @screspi.bsky.social @nadjasimeth.bsky.social and all involved!

#chembio and #bioorganic crowd: Registration to ESBOC is open. Join us on 27th-29th May for the oldest meeting in chemical biology in Europe, at the awesome Schlosshotel Pillnitz in Dresden! Check out www.esboc.org.uk or register directly at eveeno.com/esboc2026!

Thank you @compoundchem.com for recognizing the women of chemistry! A few years back you featured >180 present day women chemists, including me. www.compoundchem.com/women-in-che... You are the best!

🎨 „Colourful Chemistry" – unter diesem Motto lädt das JCF der GDCh vom 10.–13. März nach Köln. 400 junge Forschende, Plenarvorträge, Workshops und erstmals der JCF Best Supervisor Award. Erste Preisträgerin: Prof. Lena Daumann. gdch.app/article/colo...

#photoswitches: How should we determine errors on PSS distributions, and the absorption spectrum of the metastable isomer? We have been discussing this for years and have finally written a manuscript, including a python code to fit your data without human bias. chemrxiv.org/doi/full/10....

Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime

🧪If you love lipids,cell biology & chemical bioloy and wonder about the fundamental mechanisms of life, you'll be in for a treat! 🤩🥳 Don't miss the next @gbmev.bsky.social Lunch Seminar by @nadlerlab.bsky.social & Kristin Böhlig! #ChemBio #LipidLove Preregister for free @gfg-chembio.bsky.social

Join us for the GBM Lunch on January 28 at 12:30 PM (CET)! André Nadler & Kristin Böhlig @nadlerlab.bsky.social (@mpi-cbg.de) will speak on “Quantifying Intracellular Lipid Transport.” Chair: Oliver Thorn-Seshold (TU Dresden) Organizer: Joint Study Group "Chemical Biology" #GBMLunch #ChemicalBiology

A new paper by @thornsesholdlab.bsky.social reports photoswitchable ligands with wavelength-dependent, and concentration-independent, control of TRPC4/5 channels in live tissues www.nature.com/articles/s41...

Pick a color to control TRP channels - Check out the associated News & Views by Jana Volaric and Wiktor Szymanski on photoswitchable compounds that can agonize or antagonize TRPC4/5 channels depending on the color of light used www.nature.com/articles/s41...

Colour me happy!

"It’s also, @georgwinter.bsky.social says, grounds for looking very closely at the proteome-wide effects of any compound in development, no matter its putative mechanism." PREACH #biotech #chemsky

Interesting paper by the groups of @zhizhou1619.bsky.social and Xiang Sheng in @natcomms.nature.com. They developed a system, with which thiophenols can be fed to cells, converted into non-canonical amino acids and used for genetic code expansion in protein engineering.

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!

Video compilation from our #türenauf mit der Maus Tag today! #outreach #chemsky @hhu.de @sophieguti.bsky.social @joguti.bsky.social @markussuta.bsky.social @chemiehhu.bsky.social

What can HaloTag do for you? Triggered fluorogenic labelling? Molecular recording? Photo-Chemically Induced Dimerisation? Philipp Mauker's CHalo motif lets reagents do all three, and more. Read the preprint here - doi.org/10.1101/2025... #chembio #fluorescence #cellbio #SLP

Molecular Recording with HaloTag? H2O2, GSH, Trx, LAP? → multiplexable reagents record diverse enzyme activities ratiometrically, without signal loss @biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025... CHalo Crew again programming with HaloTag! #chembio #fluorescence #wednesday

Photocaged HaloTag Ligation with red fluorogenic SiR labels: → on-demand HaloTag visualisation and tracking @biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025... Congrats Philipp Mauker, Joyce Meiring, & the CHalo Crew for again programming with HaloTag! #chembio #fluorescence #wednesday

Chemically Induced Dimerisation, modular & on-demand: => Fast, stepwise reagents for HaloTag-to-SNAP-tag heterodimerisation without a hook effect Now preprinted: doi.org/10.1101/2025... Congratulations to Philipp Mauker & the CHalo Crew for programming with HaloTag! #chembio #fluorescence #friday

We boosted tumour-selective delivery of nano-formulated chemotherapeutics by transiently shaking up tumour blood vessels. The catch? You only get one shot at this ☝️ This #BMBF funded work, driven by a predominantly female team @lmumuenchen.bsky.social is available on the @biorxivpreprint.bsky.social

🔍 Chemie studieren - eine Formel für die Zukunft! Ihr kennt jemanden, der überlegt Chemie zu studieren, aber sich nicht sicher ist? Ein Chemiestudium bietet spannende Möglichkeiten. Auf www.chemie-studieren.de finden sich alle Infos rund um Studiengänge, Ausbildungen und Berufe in der Chemie.

Join our GBM Redox Meeting 2025 in Saarbrücken! We put together an exciting program covering diverse aspects of Redox Regulation in Life. Check out the Programm and register until Feb 28! redox-gbm-meeting-2025.uni-koeln.de #redox #redoxbiology #gbm @gbmev.bsky.social

For ion-specific photocurrents across membranes: just let ionophores intermingle with photolipids. A fully modular approach with easy access to large currents. Stoked that this years-long sleuthing effort led by Peter Pohl is finally out! doi.org/10.1101/2025... #photopharma #ChemBio #lipidtime

The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), consider nominating them. #chemsky #ChemBio en.gdch.de/network-s...

Congrats to our new Doctor Markus! @m-markus.bsky.social pioneered chromocontrol by ideal efficacy photoswitching (doi.org/10.1101/2024...), TRPC5 photopharma (doi.org/10.1002/anie...), & switch-based photoacoustic imaging (doi.org/10.1002/anie... & doi.org/10.26434/che...) : a tour de force summa!

Gregorio Weber is a giant in our field, and I am deeply honored to receive this award in his name. I want to acknowledge all my collaborators over the years—especially @dyerfulchymist.bsky.social—and the place that made everything possible: @hhmijanelia.bsky.social

Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!

The RSC Chemical Biology and Bioorganic Group is now on Bluesky and delighted to be here! We're really looking forward to keeping you all updated with the latest events and news from our community, across the UK and internationally. Spread the word to those you know, and give us a follow! #chembio

You don´t find your people? Check blueskystarterpack.com and search for your community! #organicchemistry #Chemicalbiology #MedChem #naturalproductchemistry

Misogeny and sexism is not always easy to recognise, but it's systematic and it paves the way for inequality, hate and violence. Took me painfully long to become angry enough about this. Feminism, and make it intersectional, is good for EVERYONE. #StopViolenceAgainstWomen #TagGegenGewaltAnFrauen

@thornsesholdlab.bsky.social set up a feed, that will show all posts with #ChemBio. If you are interested in the feed, click this link, click "Pin to Home" and it will be added as feed to your home screen: bsky.app/profile/did...#ChemBio.I will use this hashtag in all relevant posts.

Thanks Stephan! Feed is ordered like this: (1) prioritises recent posts hashtagged #ChemBio or #ChemicalBiology (not case sensitive) (2) then other recent posts with "chembio", "chemical biology" etc (not as hashes) (3) then the "best 5%HN" of recent #ChemSky, #realtimechem, #FluorescenceFriday etc

reposting #ChemBio @hellmichgroup.bsky.social @lipid.bsky.social TRP fans!

This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation

📯📯NEW Chemical Biology Feed bsky.app/profile/did:... 📯List: >200 chemical biologists (probes, OC, PC, imaging): bsky.app/profile/did:... 📯Women in ChemBio Pack: bsky.app/starter-pack... 📯General #ChemBio Pack: bsky.app/starter-pack... 📯 #Photopharma: bsky.app/profile/trac... #chemsky 🧪 🔬

attn to new #chemsky #ChemBio #realtimechem #SciSky 🧪 🔬 #photopharma community members…

📯Chemical Biology Starter Pack ＃2: Probes Aficionadas👩‍🔬 go.bsky.app/DEjVGEn as generalist ChemBio Pack ＃1 go.bsky.app/KLrTWoj is full 🚩Feed reposting #ChemBio: bsky.app/profile/trac... 🚩 #Photoswitch: bsky.app/profile/trac... 🚩 #FluorescenceFriday: bsky.app/profile/trac... #chemsky #realtimechem

📯📯Photopharmacology and Switches communities📯📯 Here is a Feed reposting #molswitch #photoswitch #photopharma bsky.app/profile/did:... #chemsky #chembio #scisky 🧪

📯 Chemical Biology starter pack No.1: now with 📯 #chembio Feed 📯 (also gets #chemicalbiology) #ChemBio feed: bsky.app/profile/did:... Pack covers 150 groups posting primary research in chemical biology: go.bsky.app/KLrTWoj 📬 Please Repost !📬 #realtimechem #FluorescenceFriday #chemsky #scisky