Excited to see BEstimate out - a computational tool for base editing guide RNA design for screening, disease modelling and correction of pathogenic variants. It's SNP-aware, so you can parse non-reference genomes, and reports off-target sites. paper: link.springer.com/article/10.1...

Fully funded postdoc position in my team. CRUK and Wellcome Sanger Institute. Want to work on lung cancer + functional genomics? Only 1 more week to apply!💥

Our paper on genetic mediators of cancer cell susceptibility to T cell killing is out today online: www.cell.com/cell-reports... These genes could serve as biomarkers of sensitivity to immunotherapy - they modulate IFN-g and TNF-a response and are lost in some tumours Thread below on our preprint👇

New biomarkers for cancer immunotherapy have been identified. 🔎 Researchers found that loss of two genes, CHD1 and MAP3K7, makes tumours more likely to respond to immunotherapy. The findings could help support more personalised cancer treatment 👇 bit.ly/4sMBTq2

new year, new job?! Exciting postdoc position opening in my lab at the Wellcome Sanger Institute. Fully funded by CRUK sanger.wd103.myworkdayjobs.com/en-US/Wellco... find out more at www.coelho-lab.com

Looking to start your lab in generative biology / AI? Come join us at the @sangerinstitute.bsky.social Sanger is core-funded so you can generate data at scale to train the next generation of models and understanding. Design/Engineering/Chemistry/Proteins/Pathways! pls RT tinyurl.com/GenGenFaculty

WRN inhibitors are being tested in patients with MSI cancers. How do tumours adapt to WRN inhibition, and can therapy stay ahead of resistance? Our latest preprint investigates how MSI tumours evolve under pressure from WRN inhibition. Highlights below.

Very neat idea to increase precision of base editors by modifying guide design, plus directed evolution!

A pleasure to talk about our research today with the amazing volunteers at St John’s ambulance in aid of @cancerresearchuk.org

Apply for Multiplex Assays of Variant Effects training by 18 August! ⏰ Join our experts to learn how to strengthen your genetic disease research or clinical work using MAVE data. 🧬 Financial assistance available💸 📎Find out more: bit.ly/3EW3lh4 #MAVE25 #VariantInterpretation

Coming up in September! ➡️Christina Kajba @ckajba.bsky.social & Michael Herger @michaelherger.bsky.social — pooled prime editing screens in haploid human cells ➡️Jon Acosta — multiplexed in vivo base editing screens #GeneticVariants #PrimeEditing ℹ️https://www.varianteffect.org/seminar-series/

Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets www.nature.com/articles/s41...

Looking to combine ML and functional genomics to tackle cancer drug resistance? Exciting job opening at the Sanger! sanger.wd103.myworkdayjobs.com/en-US/Wellco...

@mattcoelho.bsky.social at #VariantEffect25

🚨 Excited to share our latest preprint! @mgarnett.bsky.social @mattcoelho.bsky.social We introduce BEstimate, a flexible, comprehensive tool for designing and interpreting CRISPR-based editing experiments. #CRISPR #BEstimate #BaseEditor

Magdalena Strauss at #VariantEffect25

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!

Excited to announce our preprint today @biorxivpreprint.bsky.social Using functional genomics, we map the genetic determinants cancer cell sensitivity to tumour-reactive T cells: www.biorxiv.org/content/10.1...

less than one week remaining to apply 👇

New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le.... Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.

Excited to announce that we're recruiting a Staff scientist at the Sanger Institute to investigate drug resistance mechanisms in cancer using gene editing. Interested? Apply here: sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Thrilled to share new work led by @jieyang437.bsky.social in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre rdcu.be/eci1U

Today in BJC Reports, we summarise the outcomes from a multidisciplinary workshop focused on addressing cancer drug resistance. www.nature.com/articles/s44...

Thrilled to share our first dive into generative models, integrating 7 distinct omics to generate a complete Synthetic Cancer Dependency Map for +1,500 cancer cell lines! Excited for what’s ahead. rdcu.be/d1TgQ #GarnettLab #CMRI #ProCan #INESC-ID #IST @naturecomms.bsky.social

last couple days to apply (for free! from anywhere in the world!) to the Sanger 2025 PhD Programme — Deadline: 28th November 2024 (09:00 GMT) For more info, visit www.sanger.ac.uk/about/study/...

Applications are now open for the Sanger prize! A 3 month placement - undergraduates from low and middle income countries encouraged to apply www.sanger.ac.uk/about/the-sa...