Fig. 6: Mathematical model

Der #Forschungsausschuss des Bundestags tagt nicht mehr öffentlich — das war’s dann mit Tranzparenz wissenschaftspolitischen Handelns auf Bundesebene! Erschwert die Arbeit von Journalist_innen ebenso wie unsere für #IchBinHanna uvm. massiv. @wpk.bsky.social fordert in 1 offenen Brief, das zu ändern:

Die Charité-Chefs haben am Montag im Berliner Wissenschaftsausschuss die Folgen der Kürzungen für die Uniklinik skizziert. "Drittmittel werden sinken, Ambulanzen müssen schließen“, fasste Dekan Joachim Spranger es zusammen. (T+) www.tagesspiegel.de/wissen/chari...

Welcome our new colleagues: Prof. Flasche aus Ede and Prof. Geschirrschwämme! Looking forward to working with you!

I always wanted to join the editorial board for an agricultural journal. Clearly my expertise. Will be a great journal 🤡 #scientificspam

Berlin’s senate invests >12 mio EUR for 3 NFL games in Berlin, at a time where they cut millions at the universities that are already underfunded, with collapsing buildings. They definitely seems to have priorities that are not mine. www.tagesspiegel.de/berlin/senat...

“Stands out … for its contribution to the society in the field to finance”???? Maybe the most bizarre spam email I ever received…

⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation. 👉 We discover how sex and development signals are decoded at a single gene locus. www.nature.com/articles/s41... 👇 Bluetorial

When I was at NIH and shutdowns loomed, it was discovered that the administration was planning to shut down PubMed. The head of NCBI called the powers that be and pointed out that this would threaten patient safety Who knows what will happen now Just in case, remember Euruope-PMC (europepmc.org )

The Ärzteblatt asked me about the instability of Pubmed (Why my? Don't know...). Not sure if I agree with the colleagues that we should build up national resources, I rather think we should strengthen existing European ones (e.g. EuropePMC, ENA, EGA...)... www.aerzteblatt.de/archiv/wisse...

Nicky McGranahan kicking off the last day showing the evolutionary history of metastasis. Amazing data and analysis.

Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!

Great talks from PhD students Tancredi Massimo Pentimalli, Adila Apsara: and Siddharth Annaldasula!

Efrat Shema kicking off today’s program with a lecture on epigenetics and single cell methods.

Final session for today: Sven Nelander discusses how patient specific models combined with advanced molecular biology and large scale computation allow for a better understanding of CNS cancers.

We continue with Ido Amit who shows how single cell approaches allow to improve immune therapy and Anton Henssen introducing us to the world of extrachromosomal DNA and how this relates to tumor heterogeneity. Fascinating!

First session: Uli Keilholz of the comprehensive cancer center on how complex data and models are now used in the clinics, and Heiko Enderling on modeling approaches. Both show excellent examples on how computation already now is impotent for clinical decisions, and how it will be in future.

Kicking off today’s Late Summer School on tumor heterogeneity and treatment resistance with an amazing program. Great to see a huge turnout!

Very harmonious and inspiring collaboration with Niels Gehring, @volkerboehm.bsky.social and team at Uni Köln, and colleagues at @mdc-berlin.bsky.social . Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell www.cell.com/molecular-ce...

Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU

Spatenstich für den Forschungsneubau Optobiologie an der #HumboldtUni. Gemeinsam mit der Charité und der @berlinualliance.bsky.social entsteht ein Zentrum für interdisziplinäre Spitzenforschung. Auf rund 3.800 m² entstehen Laborflächen für 110 Wissenschaftler*innen 👉 www.hu-berlin.de/de/pr/nachri...

Why do kids respond differently to a new virus than adults? Lev has the answer… it is differences in Stat signaling. Happy that we (mainly @astaburuaga-garcia.bsky.social ) could contribute a bit. Congratulations @sawitzkilab.bsky.social and @woodenrobo.bsky.social to this great paper!

Very moving obituary by Stas Svartsman for Benny Shilo. I met Benny a few years ago at the WiKo in Berlin and enjoyed our very inspiring conversations about signaling dynamics and patterning. Glad that I met him. www.cell.com/developmenta...

Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19! 🧵 Explainer thread by the first author Lev Petrov linked below ⬇️

Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen. #KHAG @spdfraktion.de #CDUCSU

Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025

Happy to chair a session on cell and pathway engineering at ICSB2025.com featuring e.g. an inspiring talk by @olivierpertz.bsky.social on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October! #ICSB2025

Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?

Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...

Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust www.science.org/doi/10.1126/...

Dear Professor [Last Name]...

I studied physics, theoretical biophysics and was involved in the emerging field (around 2005) of systems biology - this paradigm of @proffeynman.bsky.social always astonished me. Still.

Join ICSB2025 in Dublin: The late-breaking abstract deadline has been extended to August 1st (for oral presentation) and September 1st (for posters). Hope to see you in Dublin! icsb2025.com

Vom 23. bis 29. Juni streicht die #FUBerlin das "E", um zu zeigen, was fehlt, wenn Substanz gestrichen wird. Allein für 2025 sollen die Kürzungen rund 37 Million n uro betragen. D r B rlin r S nat g fährd t damit L hr, Forschung und Zukunftssich rh it. All Infos ➡️ tinyurl.com/aktionswoche...

Tomorrow (Wednesday) is abstract deadline, so send your abstract quickly!

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

5 more days to submit abstracts for International Conference on Systems Biology #ICSB2024! Hope to meet you in Dublin!

I wrote a new piece on how much progress has been made in treating childhood leukemia. The answer is: quite a lot! Before the 1970s, fewer than 10% of children diagnosed survived 5 years after diagnosis. Now most are cured and around 85% survive that long. ourworldindata.org/childhood-le...

Read our new paper in Nature Comms: SPIED-DIA = spike-in enhanced DIA phosphoproteomics -> Boosts detection of key phosphosites -> Reveals JNK activation upon MEK inhibition in CRC cells -> Dual MEK/JNK targeting impairs growth 🔗 rdcu.be/enPF2 #proteomics #DIA #cancer

Ganz ohne Trump 😅

Good radio interview with Charité's dean Jochen Spranger, highlighting the lack of support by the local Government. He particularly points out how the illegal breach of existing financing contracts likely led to loss of excellent clusters. Cannot agree more. www.inforadio.de/rubriken/int...

Berlin’s local government is ruining the city’s scientific landscape, by further cuts into the under-financed Universities. www.tagesspiegel.de/wissen/kurzu...

join us at ISMB iscb.bsky.social & @dreamchallenges.bsky.social - benchmarking foundation models w. @anshulkundaje.bsky.social @oldbap.bsky.social G. Stolovitzky @bowang87.bsky.social @mariabrbic.bsky.social K. Kalantar, J. Guinney supported by @ebi.embl.org @cziscience.bsky.social Tempus AI

speaker list is now expanded! sessions on cancer, evolution, metabolic disease, multi-omics, AI. speakers include @epetsalaki.bsky.social @ciriellolab.bsky.social @juliosaezrod.bsky.social @molsysbio.bsky.social @inesthiele.bsky.social @profjochen.bsky.social @renskevroomans.bsky.social +tons more

Definitely the most professional equipment for photographing the eclipse. And clearly the best photo…

Hier nochmal aus unserem Archiv eine ebenso aufwendige wie durchaus realitätsnahe Visualisierung, die den Unterschied zwischen einer partiellen und einer totalen Sonnenfinsternis zeigt.

Happy birthday to Canadian medical researcher & #biochemist Maud Menten (1879-1960). 🧪🐡👩🏼‍🔬 #histscj Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of 🧵

📣 Job alert! 📣 We are are looking for a talented bioinformatician to join us at the Berlin Institute of Health at Charité to analyze multiomics data in post-COVID-19 and ME/CSF syndrome research. Please share and come join us! ⬇️ #ImmunoSky #Bioinformatics #Immunology #ComputationalBiology #MedSky

Exciting line-up for our CompCancer colloquium for spring/summer 2025: - March 26th: Helen Byrne, Oxford - April 30th: Altuna Akalin, Berlin - May 14th: Florian Markowetz, Cambridge - June 16th: Sohrab Shah, New York 4pm, Maud Menten room, 3rd floor, House 18, Philippstr. 13, 10115 Berlin