Nils Blüthgen
@molsysbio.bsky.social
📤 1072
📥 824
📝 73
Charité and Humboldt University Berlin, Computational Modelling, Cancer, Signaling
reposted by
Nils Blüthgen
Markus Landthaler
11 days ago
Very harmonious and inspiring collaboration with Niels Gehring,
@volkerboehm.bsky.social
and team at Uni Köln, and colleagues at
@mdc-berlin.bsky.social
. Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome: Molecular Cell
www.cell.com/molecular-ce...
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Rapid UPF1 depletion illuminates the temporal dynamics of the NMD-regulated human transcriptome
UPF1 depletion inhibits nonsense-mediated mRNA decay (NMD) and stabilizes direct target transcripts within hours. Boehm et al. use conditional protein degradation and advanced transcriptomics to map t...
https://www.cell.com/molecular-cell/fulltext/S1097-2765%2825%2900700-2
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Join us for our first CompCancer seminar this fall on Thursday, 4pm with Chris Sander (Harvard): „Catch Cancer Early with the Help of AI Tools“. Maud Menten Room, House 18, Campus Nord HU
14 days ago
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Nils Blüthgen
28 days ago
Spatenstich für den Forschungsneubau Optobiologie an der
#HumboldtUni
. Gemeinsam mit der Charité und der
@berlinualliance.bsky.social
entsteht ein Zentrum für interdisziplinäre Spitzenforschung. Auf rund 3.800 m² entstehen Laborflächen für 110 Wissenschaftler*innen 👉
www.hu-berlin.de/de/pr/nachri...
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Why do kids respond differently to a new virus than adults? Lev has the answer… it is differences in Stat signaling. Happy that we (mainly
@astaburuaga-garcia.bsky.social
) could contribute a bit. Congratulations
@sawitzkilab.bsky.social
and
@woodenrobo.bsky.social
to this great paper!
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about 1 month ago
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Very moving obituary by Stas Svartsman for Benny Shilo. I met Benny a few years ago at the WiKo in Berlin and enjoyed our very inspiring conversations about signaling dynamics and patterning. Glad that I met him.
www.cell.com/developmenta...
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Ben-Zion Shilo (1951–2025)
Ben-Zion Shilo, a distinguished Israeli geneticist (Figure 1), passed away this April at the age of 73 at his home in Rehovot. Benny, as he was known to his friends and colleagues around the world, ma...
https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00470-8
about 1 month ago
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Nils Blüthgen
Sawitzki Lab
about 1 month ago
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Nils Blüthgen
Sawitzki Lab
about 1 month ago
Excited to share our new study on how age-related changes in STAT signaling impact antiviral responses and hyperinflammation in COVID-19! 🧵 Explainer thread by the first author Lev Petrov linked below ⬇️
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Rewired type I IFN signaling is linked to age-dependent differences in COVID-19
Petrov et al. identify an age-dependent shift in interferon signaling during SARS-CoV-2 infection, with older individuals favoring a STAT3-driven inflammatory response. This mechanistic insight helps ...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00358-1
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Leif Erik Sander 🇪🇺🇺🇦
about 2 months ago
Wollen Sie mit einer komplizierten Infektion von Infektionsspezialisten behandelt werden oder soll das einfach irgendwer nebenbei "mitmachen"? Die Politik meint: Letzteres muss reichen in Deutschland. Anders ist die Abschaffung der LG Infektiologie nicht zu verstehen.
#KHAG
@spdfraktion.de
#CDUCSU
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Nils Blüthgen
Happy to chair a session on cell and pathway engineering at
ICSB2025.com
featuring e.g. an inspiring talk by
@olivierpertz.bsky.social
on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October!
#ICSB2025
about 2 months ago
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Happy to chair a session on cell and pathway engineering at
ICSB2025.com
featuring e.g. an inspiring talk by
@olivierpertz.bsky.social
on pathway dynamics, cell fates and optical tools. Contributed talk deadline is today, Sept 1st for poster abstracts. Hope to see you in Dublin in October!
#ICSB2025
about 2 months ago
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Maybe they recently contacted a different {{Last Name))? Maybe they should consider using Latin alphabet in the subject line?
about 2 months ago
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Nils Blüthgen
Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust
www.science.org/doi/10.1126/...
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Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer
A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.
https://www.science.org/doi/10.1126/scisignal.adr3738
2 months ago
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Different modes of resistance to RAS inhibitors unveiled by dual Erk reporters that monitor erk activity in the nucleus and the cytoplasm. Cool new paper led by Markus Morkel and Oleksandra Aust
www.science.org/doi/10.1126/...
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Reporter-based screening identifies RAS-RAF mutations as drivers of resistance to active-state RAS inhibitors in colorectal cancer
A cell-sorting approach reveals distinct modes of cancer resistance to active-state RAS inhibitors.
https://www.science.org/doi/10.1126/scisignal.adr3738
2 months ago
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Dear Professor [Last Name]...
3 months ago
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Nils Blüthgen
Stephan Beirer
3 months ago
I studied physics, theoretical biophysics and was involved in the emerging field (around 2005) of systems biology - this paradigm of
@proffeynman.bsky.social
always astonished me. Still.
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Join ICSB2025 in Dublin: The late-breaking abstract deadline has been extended to August 1st (for oral presentation) and September 1st (for posters). Hope to see you in Dublin!
icsb2025.com
3 months ago
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Nils Blüthgen
Freie Universität Berlin
3 months ago
Vom 23. bis 29. Juni streicht die
#FUBerlin
das "E", um zu zeigen, was fehlt, wenn Substanz gestrichen wird. Allein für 2025 sollen die Kürzungen rund 37 Million n uro betragen. D r B rlin r S nat g fährd t damit L hr, Forschung und Zukunftssich rh it. All Infos ➡️
tinyurl.com/aktionswoche...
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Tomorrow (Wednesday) is abstract deadline, so send your abstract quickly!
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3 months ago
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Simone Reber
3 months ago
✨Thanks to amazing students
@tobiaskletter.bsky.social
, postdocs
@biswashere.bsky.social
& collaborators
@vasilyzaburdaev.bsky.social
& ALMF
@embl.org
✨ 👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today
@natcellbio.nature.com
rdcu.be/eqPr8
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Cell state-specific cytoplasmic density controls spindle architecture and scaling
Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...
https://rdcu.be/eqPr8
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5 more days to submit abstracts for International Conference on Systems Biology
#ICSB2024
! Hope to meet you in Dublin!
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3 months ago
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Nils Blüthgen
Saloni
4 months ago
I wrote a new piece on how much progress has been made in treating childhood leukemia. The answer is: quite a lot! Before the 1970s, fewer than 10% of children diagnosed survived 5 years after diagnosis. Now most are cured and around 85% survive that long.
ourworldindata.org/childhood-le...
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Nils Blüthgen
Selbach Lab
4 months ago
Read our new paper in Nature Comms: SPIED-DIA = spike-in enhanced DIA phosphoproteomics -> Boosts detection of key phosphosites -> Reveals JNK activation upon MEK inhibition in CRC cells -> Dual MEK/JNK targeting impairs growth 🔗
rdcu.be/enPF2
#proteomics
#DIA
#cancer
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Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells
Nature Communications - Kinase inhibitors are key in cancer therapy, but resistance limits their efficacy. Here, the authors develop SPIED-DIA, a phosphoproteomics method enhancing detection of key...
https://rdcu.be/enPF2
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Nils Blüthgen
Clean Air
4 months ago
Ganz ohne Trump 😅
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Good radio interview with Charité's dean Jochen Spranger, highlighting the lack of support by the local Government. He particularly points out how the illegal breach of existing financing contracts likely led to loss of excellent clusters. Cannot agree more.
www.inforadio.de/rubriken/int...
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Charité-Dekan Joachim Spranger fordert mehr Förderung
Die Charité begrüßt die zusätzlichen Fördergelder von Bund und Ländern. Joachim Spranger, Dekan der Charité, fordert dennoch, die Wissenschaft in der Hauptstadt stärker zu fördern.
https://www.inforadio.de/rubriken/interviews/2025/05/23/charite-dekan-joachim-spranger-zu-exzellenzcluster.html
4 months ago
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Berlin’s local government is ruining the city’s scientific landscape, by further cuts into the under-financed Universities.
www.tagesspiegel.de/wissen/kurzu...
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Kürzungen bei den Berliner Hochschulen: Einsparungen 2025 fallen noch deutlich höher aus
Zur Sparsumme für die Berliner Hochschulen gibt es nun erstmals eine Zahl, wie groß das Minus im laufenden Jahr werden soll. Sie liegt deutlich über dem bisher bekannten Betrag von 107 Millionen.
https://www.tagesspiegel.de/wissen/kurzungen-bei-den-berliner-hochschulen-einsparungen-2025-fallen-noch-deutlich-hoher-aus-13717615.html
4 months ago
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Nils Blüthgen
Julio Saez-Rodriguez
4 months ago
join us at ISMB
iscb.bsky.social
&
@dreamchallenges.bsky.social
- benchmarking foundation models w.
@anshulkundaje.bsky.social
@oldbap.bsky.social
G. Stolovitzky
@bowang87.bsky.social
@mariabrbic.bsky.social
K. Kalantar, J. Guinney supported by
@ebi.embl.org
@cziscience.bsky.social
Tempus AI
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Nils Blüthgen
Colm Ryan
5 months ago
speaker list is now expanded! sessions on cancer, evolution, metabolic disease, multi-omics, AI. speakers include
@epetsalaki.bsky.social
@ciriellolab.bsky.social
@juliosaezrod.bsky.social
@molsysbio.bsky.social
@inesthiele.bsky.social
@profjochen.bsky.social
@renskevroomans.bsky.social
+tons more
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Definitely the most professional equipment for photographing the eclipse. And clearly the best photo…
6 months ago
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Nils Blüthgen
DLR-next
6 months ago
Hier nochmal aus unserem Archiv eine ebenso aufwendige wie durchaus realitätsnahe Visualisierung, die den Unterschied zwischen einer partiellen und einer totalen Sonnenfinsternis zeigt.
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Ele Willoughby
6 months ago
Happy birthday to Canadian medical researcher &
#biochemist
Maud Menten (1879-1960). 🧪🐡👩🏼🔬
#histscj
Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of 🧵
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Nils Blüthgen
Sawitzki Lab
6 months ago
📣 Job alert! 📣 We are are looking for a talented bioinformatician to join us at the Berlin Institute of Health at Charité to analyze multiomics data in post-COVID-19 and ME/CSF syndrome research. Please share and come join us! ⬇️
#ImmunoSky
#Bioinformatics
#Immunology
#ComputationalBiology
#MedSky
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Computational Scientist (d/f/m) in Translational Immunology
Vollzeit | 16.04.2025 | BIH Berlin Mitte
https://www.bihealth.org/de/karriere/arbeiten-am-bih/aktuelle-stellenangebote/stellenangebot/computational-scientist-dfm-in-translational-immunology
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Nils Blüthgen
CompCancer PhD programme
7 months ago
Exciting line-up for our CompCancer colloquium for spring/summer 2025: - March 26th: Helen Byrne, Oxford - April 30th: Altuna Akalin, Berlin - May 14th: Florian Markowetz, Cambridge - June 16th: Sohrab Shah, New York 4pm, Maud Menten room, 3rd floor, House 18, Philippstr. 13, 10115 Berlin
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Come and join our seminar series!
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7 months ago
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Nils Blüthgen
CompCancer PhD programme
7 months ago
3 more days to apply!!!
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Opening of a new exhibition in Charite’s medical history museum: Erfindungswahn, telling the story of patient in the psychiatry in 1908 from his medical records with all its facets and from many different angles. Extremely well done, worth visiting!
bmm-charite.de/ausstellunge...
7 months ago
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Nils Blüthgen
Pedro Beltrao
7 months ago
Sad to know about the passing of Béla Novák. This review from Tyson, Chen and Novak was such a revelation for me as an introduction to control theory in biological systems. A classic that will remain relevant for many years to come.
www.sciencedirect.com/science/arti...
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👇Join us and do cool stuff!
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7 months ago
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We will have an exciting research building next door! Looking forward to many collaborations and exciting science!
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7 months ago
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Nils Blüthgen
CompCancer PhD programme
7 months ago
Join CompCancer for a PhD! Call now open, apply until 7th of March! About the programme: comp-cancer.de Apply here:
karriere.charite.de/stellenangeb...
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Wissenschaftliche Mitarbeiterin / Wissenschaftlicher Mitarbeiter / Doktorandin / Doktorand (d/w/m) Institut für Pathologie DM.39.25
Teilzeit | 07.03.2025 | Campus Charité Mitte
https://karriere.charite.de/stellenangebote/detail/4229
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See you in Dublin in October for the ICSB2024! Early registration is open at:
ICSB2025.com
. I will chair an exciting session on "Cell Engineering & Pathway Engineering".
7 months ago
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Good morning!
8 months ago
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Yesterdays cuts in more detail: - Support for students (Studierendenwerk): -32% - Einsteinstiftung: -18% - Budget for building costs: -80% - Invest for Universities: -20% - Support to update technical infrastructure at Charite: -48% - Invests in Buildings -40% This is how you ruin the future.
9 months ago
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Nils Blüthgen
Steffen Mau
9 months ago
Anbiederei first, Bedenken second.
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Nils Blüthgen
Andrew Plested
9 months ago
Huge noisy crowd outside the Berlin House of Representatives protesting proposed budget cuts that would hit universities hard
#savebraincity
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Nils Blüthgen
Kirstin Drenkhahn
9 months ago
Berlin hatte immer nur Techno und Wissenschaft. Ab 1.1.2025 haben wir nix mehr.
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Good to see thousands on the street to protest against terrible cuts into Berlin‘s university. The planned 10% cuts in the budget will definitely cause major and sustaining damage to research and education!
9 months ago
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Nils Blüthgen
Beate Krickel
9 months ago
Es ist zum Heulen. 😔
#SaveBrainCity
#berlin
#sparpolitik
www.jmwiarda.de/https-www.jm...
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Exzellenzstrategisches Harakiri
Bis vor kurzem galt die Berliner Wissenschaftsförderung bundesweit als Vorbild. Mit dem am Mittwoch beschlossenen Sparhaushalt reißt der CDU-SPD-Senat ein, was seine Vorgänger mühsam aufgebaut haben.
https://www.jmwiarda.de/https-www.jmwiarda.de-2024-12-12-exzellenzstrategisches-harakiri/
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Nils Blüthgen
9 months ago
📢
#SaveBrainCity
:
#Aufruf
zur
#Kundgebung
der Landeskonferenz der Rektor*innen und Präsident*innen der Berliner Hochschulen (LKRP) mit
@bbaw.bsky.social
, Berlin Research 50 & Verdi Berlin-Brandenburg gegen die
#Sparpolitik
des Berliner Senats am 19. Dezember! 👉
www.lkrp-berlin.de/aktuelles/24...
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🎉 New paper alert! Our new method "RUCova" to normalise CyTOF data is finally out in Bioinformatics!
dx.doi.org/10.1093/bioi...
10 months ago
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🎉 New paper alert! Our new method "RUCova" to normalise CyTOF data is finally out in Bioinformatics!
dx.doi.org/10.1093/bioi...
10 months ago
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