Tobias Kletter
@tobiaskletter.bsky.social
📤 175
📥 305
📝 8
PostDoc at the i3S in Porto. Interested in the spatial and temporal dynamics of cell division.
pinned post!
Thrilled to share our newly published work in
@natcellbio.nature.com
. We found that differentiating cells tune the size and architecture of mitotic organelles through changes in cytoplasmic density. Many thanks to my fantastic co-authors! 💥
add a skeleton here at some point
5 months ago
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I'm very grateful and honoured to be on this list! Looking forward to finally visiting Heidelberg again!
add a skeleton here at some point
24 days ago
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reposted by
Tobias Kletter
Nadja M. Hümpfer
about 1 month ago
Now out on bioRxiv. 🥳My research on
#cytokinesis
, averaging thousands of
#ExM
images🔬, creating a dynamic atlas of cytokinesis 🦠⏳. Here's an animated sneak peek of what we found. Better resolution on bioRxiv😄
#PSFoftheGIF
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reposted by
Tobias Kletter
Max Planck Institute for Infection Biology
about 2 months ago
📃 New paper alert! The Zychlinsky Lab and
@raunser-lab.bsky.social
identified the first protein that converts chromatin into an immune effector: Myeloperoxidase transforms chromatin into neutrophil extracellular traps. Now published in
@nature.com
:
www.nature.com/articles/s41...
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Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature
Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.
https://www.nature.com/articles/s41586-025-09523-9
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reposted by
Tobias Kletter
Jorge Ferreira
2 months ago
New preprint from the lab! Please check it out. 🚨 Have you ever wondered how cells decide when it’s time to divide? So did we!
www.biorxiv.org/content/10.1...
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Chromosome condensation mechanically primes the nucleus for mitosis
Timely and accurate transition into mitosis is essential to preserve genome integrity and avoid chromosome segregation errors. This transition depends on spatial and temporal activity patterns of the ...
https://www.biorxiv.org/content/10.1101/2025.09.01.673438v1
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reposted by
Tobias Kletter
Simone Reber
3 months ago
FINALLY! Challenging to publish but we believe it is an important discovery:
rdcu.be/eATFz
💚 Thanks to the team @biswashere.bsky.social, Omar Muñoz, ✨Q✨ C. Hoege, B. Lorton, R. Nikolay @matthewkraushar.bsky.social
@dshechter.bsky.social
@gucklab.bsky.social
@vasilyzaburdaev.bsky.social
💚
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Conserved nucleocytoplasmic density homeostasis drives cellular organization across eukaryotes
Nature Communications - Cells can regulate their mass density. Here, the authors demonstrate how eukaryotes establish and maintain a lower density in the nucleus than in the cytoplasm via pressure...
https://rdcu.be/eATFz
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reposted by
Tobias Kletter
Ana Almeida
3 months ago
🔎New preprint! We reveal a physiological role for tubulin autoregulation, fine-tuning microtubule dynamics and preserving 3D cellular architecture. Big thanks to
@ivanagasic.bsky.social
and team! Link below for all
#cytoskeleton
&
#spheroid
enthusiasts👇(1/5)
www.biorxiv.org/content/10.1...
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Tubulin autoregulation tunes microtubule dynamics to support multicellular architecture and viability
Alpha- and beta-tubulin heterodimers dynamically assemble into microtubules, key cytoskeletal elements involved in intracellular trafficking, cell adhesion and division. The availability of free tubul...
https://www.biorxiv.org/content/10.1101/2025.07.28.667019v1
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reposted by
Tobias Kletter
Manuel Thery
3 months ago
EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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Head of the Cell Biology and Biophysics Unit
The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/job/Heidelberg/Head-of-the-Cell-Biology-and-Biophysics-Unit_JR2042
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reposted by
Tobias Kletter
Simone Reber
4 months ago
Thanks to the Heald lab
@berkeleymcb.bsky.social
for a very nice News & Views on our paper on cytoplasmic density & spindle architecture! 💚
rdcu.be/ewpa1
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Cytoplasmic control of spindle architecture
Nature Cell Biology - Dense crowding of macromolecules in the cytoplasm is a fundamental property of cells. A study now identifies a pathway by which cytoplasmic dilution in differentiating neurons...
https://rdcu.be/ewpa1
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Thrilled to share our newly published work in
@natcellbio.nature.com
. We found that differentiating cells tune the size and architecture of mitotic organelles through changes in cytoplasmic density. Many thanks to my fantastic co-authors! 💥
add a skeleton here at some point
5 months ago
1
23
5
reposted by
Tobias Kletter
Simone Reber
6 months ago
✨We are looking for a PhD student interested in physical cell bio, imaging 🔬, biochemistry,
#Xenopus
🐸 &
#microtubules
✨ Join us @mpiib-berlin.mpg.de!
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reposted by
Tobias Kletter
Abin Biswas
6 months ago
Beautiful work by
@mctwo.bsky.social
investigating the spatio-temporal dynamics of the cytoplasm using label-free tools and 🐸 extracts! 🐸 + 🔬 + 📈 = ✨ w.
@gucklab.bsky.social
,
@simonereber.bsky.social
,
@vasilyzaburdaev.bsky.social
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.05.08.652886v1
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reposted by
Tobias Kletter
Granada Lab
7 months ago
New work out in
@naturephysics.bsky.social
Led by @NicaGutu & Malthe Nordentoft + great collaborators. We show that circadian synchrony shapes cell growth. When coordination is lost, clock–cell cycle coupling breaks down. May help explain paradoxes in circadian cancer biology. 📖
rdcu.be/efNaY
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reposted by
Tobias Kletter
Binyam Mogessie ቢንያም ሞገሴ
8 months ago
Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem.
www.biorxiv.org/content/10.1...
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A versatile cohesion manipulation system reveals CENP-A dysfunction accelerates female reproductive age-related egg aneuploidy.
Female reproductive aging is accompanied by a dramatic rise in the incidence of egg aneuploidy. Premature loss of chromosome cohesion proteins and untimely separation of chromosomes is thought to unde...
https://www.biorxiv.org/content/10.1101/2025.02.27.640570v1
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reposted by
Tobias Kletter
Olga Afonso
9 months ago
New paper alert! ‼️‼️ Super happy to share that my postdoc paper is finally out! 1/3 We looked at scaling of chromosome separation during anaphase in zebrafish embryos.
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reposted by
Tobias Kletter
Journal of Cell Science
10 months ago
Ana Almeida, Helder Rocha, Maximilian Raas, Geert Kops, Reto Gassmann, Helder Maiato
@i3suporto.bsky.social
, et al. dissect the relationship between kinetochore size & CENP-E dependence for chromosome alignment.
journals.biologists.com/jcs/article/...
journals.biologists.com/jcs/article/...
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reposted by
Tobias Kletter
Simone Reber
10 months ago
How did microtubules adapt to support life across 🐸 species at divergent thermal niches? Now online & OA
@currentbiology.bsky.social
Thanks to Ella, Luca,
@biswashere.bsky.social
& Carolyn
@mpiib-berlin.mpg.de
@BirkbeckUoL 🙌 Enjoy reading! 👉
www.cell.com/current-biol...
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Mechanistic basis of temperature adaptation in microtubule dynamics across frog species
Despite tubulin’s evolutionary conservation, microtubule dynamics are highly temperature sensitive. Troman et al. use natural tubulin variants from closely related Xenopus species to show that a decrease in tubulin’s apparent activation energy and weakening of lateral lattice contacts stabilize microtubules in cold-adapted frogs.
https://www.cell.com/current-biology/fulltext/S0960-9822(24)01690-7
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reposted by
Tobias Kletter
Nicolas Minc
10 months ago
Our lab has multiple open positions for post-docs to study the regulation and function of cytoplasm mechanics during embryo development. Details below 👇👇 Please Repost !!!
@ijmonod.bsky.social
@cnrs.bsky.social
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reposted by
Tobias Kletter
Gabriel Neurohr
11 months ago
Did you ever wonder how cytoplasmic properties influence mitotic spindle architecture? Come join us for an exciting seminar next Wednesday by
@simonereber.bsky.social
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reposted by
Tobias Kletter
Simone Reber
12 months ago
Two positions in our lab 🐸🐛🔬
#malaria
#xenopus
#microtubules
#biophysics
#imaging
#PhDlife
add a skeleton here at some point
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Thrilled to share our latest preprint! We've discovered how cells tune spindle architecture through changes in cytoplasmic material properties. Huge thanks to
@simonereber.bsky.social
, the amazing lab team, and our brilliant collaborators. Check it out!
biorxiv.org/content/10.1...
over 1 year ago
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3
0
reposted by
Tobias Kletter
bioRxiv Cell Biology
almost 2 years ago
Torques within and outside the human spindle balance twist at anaphase https://www.biorxiv.org/content/10.1101/2023.12.10.570990v1
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Torques within and outside the human spindle balance twist at anaphase https://www.biorxiv.org/content/10.1101/2023.12.10.570990v1
At each cell division, nanometer-scale motors and microtubules give rise to the micron-scale spindle
https://www.biorxiv.org/content/10.1101/2023.12.10.570990v1
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reposted by
Tobias Kletter
Guillaume Jacquemet
about 2 years ago
Do you work with cell migration data? Or do you track objects from microscopy video? You may be interested in my latest project: CellTracksColab, A platform for compiling, analyzing, and exploring tracking data
www.biorxiv.org/content/10.1...
github.com/guijacquemet...
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reposted by
Tobias Kletter
bioRxiv Cell Biology
about 2 years ago
CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on microtubule attachments close to centrosomes https://www.biorxiv.org/content/10.1101/2023.10.19.563150v1
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CENP-E initiates chromosome congression by opposing Aurora kinases to promote end-on microtubule attachments close to centrosomes https://www.biorxiv.org/content/10.1101/2023.10.19.563150v1
Chromosome congression to the spindle equator, which recurrently fails in cancer cells leading to an
https://www.biorxiv.org/content/10.1101/2023.10.19.563150v1
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1
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reposted by
Tobias Kletter
bioRxiv Cell Biology
about 2 years ago
Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction https://www.biorxiv.org/content/10.1101/2023.10.16.562637v1
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Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction https://www.biorxiv.org/content/10.1101/2023.10.16.562637v1
Accurate chromosome segregation requires sister kinetochores to biorient, attaching to opposite spin
https://www.biorxiv.org/content/10.1101/2023.10.16.562637v1
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Owld but gowld. #inktober
about 2 years ago
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