Read our new paper in Nature Comms: SPIED-DIA = spike-in enhanced DIA phosphoproteomics -> Boosts detection of key phosphosites -> Reveals JNK activation upon MEK inhibition in CRC cells -> Dual MEK/JNK targeting impairs growth 🔗 rdcu.be/enPF2 #proteomics #DIA #cancer

Excited to share our preprint on multiplexed DVP! mxDVP extends CODEX to DVP family, revealing spatial heterogeneity in human pancreatic islets with 12 endocrine sub-types including rare polyhormonal cells. Fantastic team effort #LundbergLab biorxiv.org/content/10.1101/2025.04.27.650857v1

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights: www.nature.com/articles/s41...

📢Register for the Berlin symposium #Biology_of_Health Towards a Molecular Approach to Preventive Medicine! 🗓️ 19-20 May 2025 🎤 Inspiring line-up of speakers! Keynotes by Amos Tanay, Elvira Mass, Aleksejs Sazonovs, and Nikolaus Rajewsky ✏️Register & full program: rb.gy/kos81 📌 Registration: 12 May 2025

Alternative splicing (AS) is common, but its impact on the proteome remains debated, especially in primary cells. What determines which AS isoforms result in abundant proteins ? We find that proteoform-specific ... 🧵 www.biorxiv.org/content/10.1...

What happens to all those alternative transcripts? 👉 Many are translated. 👉 Proteolytic processing adds even more diversity. Integrated mRNA & protein isoform landscape now out on bioRxiv! 🔗 doi.org/10.1101/2025... #proteomics #transcriptomics #systemsbiology