Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social . rdcu.be/eVrxX

Hana Polášek-Sedláčková @hanasedlackova.bsky.social from our Institute of Biophysics is one of 28 group leaders who just became @embo.org Young Investigators for the next four years. #LifeSciences www.avcr.cz/en/media/pre... Details ➡️ www.embo.org/press-releas...

Thrilled to be selected as one of the 28 EMBO Young Investigators for 2026! It is an incredible honor, and I am especially proud to be the second scientist from Czechia chosen since the programme began in 2001. Happy to join Tomas Pluskal in representing our country in the EMBO YIP.

Truly delighted to host @agagambus.bsky.social next week in Brno for an IBP Guest Lecture! Her groundbreaking work and genuinely human approach to science have always been a great inspiration to me. Come and join us for her lecture at IBP 👇

📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.

A comprehensive genetic catalog of human double-strand break repair | Science www.science.org/doi/10.1126/...

@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read. www.nature.com/articles/s41...

ICYMI: New online: Returning home: there and back again in Czechia

📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...

🧑‍🔬🎙️ When you publish with JCB, you can reach more of your community by submitting a short video! Want to promote your research in your own voice? 🎦 See our guidelines: rupress.org/jcb/pages/vi... ▶️ Watch video summaries from our authors: www.youtube.com/@JCellBiol

Another reason to consider HaloTag as an alternative to GFP for tagging

We're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...

A Biotin-HaloTag ligand enables efficient affinity capture of protein variants from live cells. New tools developed by Anoop Kumar Yadav, Abhijeet Jadhav, Hana Polasek-Sedlackova @hanasedlackova.bsky.social and colleagues: rupress.org/jcb/article/... #Technology #Chromatin #epigenetics #CellCycle

Thank you, Melina, for the interview!

📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @jcb.org! Full link here: rupress.org/jcb/article-...

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

In @jcb.org, the @hanasedlackova.bsky.social lab presents a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

Apply to our PhD program!!

Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling www.nature.com/articles/s41... Thank you Steffi and Veselin.

This review discusses the cellular pathways mediating Targeted Protein Degradation approaches and points to some gaps in our understanding of the biology of novel therapeutic tools such as PROTACs. doi.org/10.1038/s420...

This editorial details why we think it's a good idea to standarise reporting of microscopy data and what we are doing towards that. I also feel that it is both important and a step towards helping the community. www.nature.com/articles/s41...

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

If you are interested in working on chromatin and oogenesis in the mouse in beautiful Copenhagen, we are recruiting a postdoc! jobportal.ku.dk/videnskabeli... Please share!

📣Check out our recent review (written with Martina Huranova lab) on converging mechanisms controlling #cilia #dynamics during #cell #cycle, #cell #signaling, and cross-talk of ciliary modules. rdcu.be/epVDc

So excited to share that we @natsmb.nature.com are hiring a new editor! If you are interested about working with an intelligent, compassionate and funny team helping scientists publish great research, please consider applying. Deadline June 20th. springernature.wd3.myworkdayjobs.com/SpringerNatu...

Next Tuesday's webinar will feature @agagambus.bsky.social and @chowdhurylab.bsky.social. Join us on June 3rd at 5PM Rome / 11AM NYC for a lively discussion on DNA replication and repair! Zoom link: uniroma1.zoom.us/j/95149984403 Become part of our community: docs.google.com/forms/d/e/1F...

Oh wow. Starting grant 0-10 years post PhD from 2027, Consolidator 5-15

Lastly, many thanks to Sarah Aitken (@s-j-aitken.bsky.social) and Emma Reilly for writing a great News & Views article that summarizes our findings and puts them into perspective. You can find it here: doi.org/10.1038/d415...

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Exciting PhD project available in our lab (time sensitive)! 👇

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Also in Issue 8: - Research Highlights on tracking leukocytes, trap formation and pluripotency transitions - Interview with @hanasedlackova.bsky.social - In memoriam – Angelika Noegel - Epithelial cell extrusion at a glance journals.biologists.com/jcs/issue/13...

We are looking for a motivated postdoc to study genomic imprinting in barley. @apecinka.bsky.social @beata-strej.bsky.social

Truly honored that my career path and laboratory were featured in the 'Cell Scientist to Watch' interview series. A huge thank you to Sara Morais da Silva and @jcellsci.bsky.social for this wonderful opportunity 🙏

(jobs.ie-freiburg.mpg.de/jobposting/4...)

Our new preprint is now on bioRxiv! 📄 We introduce qAID, an AI-based workflow for automated analysis of DNA replication dynamics. Glad to have contributed a small part to this study.

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading. www.biorxiv.org/content/10.1... Brief teaser:

How are chromosome breaks repaired and how is their repair influenced and facilitated by nuclear and genome dynamics? Fantastic initiative and collaboration with @karimmekhail.bsky.social, @chiololab.bsky.social, and @lablegube.bsky.social. @natrevmcb.bsky.social Link to article: rdcu.be/edViW

Exciting seminar series from Genome integrity italian Network (GiiN), chaired by myself and Raffaella Di Micco! Short talks (2x30’), at convenient time for EU/USA attendees. Big shots and raising stars in an expanding field. See flyers + link to receive email alerts. Please repost to your network!👇

Had an absolutely fantastic time in Essen! Thank you so much, Dominik Boos, for kind invitation and the inspiring discussions that sparked many ideas💡Hemmo Meyer, Michael Ehrmann, Boris Pfander, Simon Popsel, @hellerschmiedlab.bsky.social & students & postdocs 💚 I appreciated every moment 🙏

Join us tomorrow, February 18, for an exciting @crc1430.bsky.social seminar at @unidue.bsky.social! We’re happy to welcome @hanasedlackova.bsky.social, who will present on 'Molecular Homeostasis of DNA Replication Origins in Human Cells.' #DNAreplication #ResearchCollaboration

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection! institute-genetics-cancer.ed.ac.uk/igc-graduate...

Dead line is approaching. Have a look on the prg.

Please RT. Join the sixth edition of our Training Unit @institut_curie international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...

Look forward to welcoming all participants in Frankfurt for some exciting science, building networks and having a good time 🤗🍀

I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.

Three must read papers for PhD students. #scisky #PhD #science #research #academicsky 1. The importance of stupidity in scientific research Open Access journals.biologists.com/jcs/article/...