New preprint from the lab !! Loop extrusion may provide mechanical robustness to chromatin. Great work by Hossein Salari. @cnrs.fr @lbmcinlyon.bsky.social www.biorxiv.org/content/10.1...

Join us at the Hubrecht Institute in Utrecht to start your research group! Fantastic scientific environment, strong support, and nice colleagues :) Apply and please share broadly in your network.

One of the core missions of EMBO is to grow and connect talents. Karin Dumstrei, head of the EMBO Fellowship Programme, tells us about how EMBO has been supporting scientists’ international mobility for more than five decades: www.embo.org/features/sup... 🧪 #research #funding #LifeSciences

Some (+)ve news to lighten another heavy weekend: our latest preprint (c/o Mattiroli + Ramani labs) is up! www.biorxiv.org/content/10.1... A tour-de-force by 1st authors Bruna Eckhardt & @palindromephd.bsky.social, focusing on chromatin replication. RTs welcome; tweetorial in 3,2...(1/n)

A significant conceptual advance in the field of DNA recombination… great work by the labs of @brookscrickard1.bsky.social and Michelle Wang

👵🏻⏰👴🏻 Is aging a programmed process? Check out this perspective article in Nature Aging by our two #CRC1678 members @meyerdh.bsky.social and @bjornschumacher.bsky.social. Congratulations! 🥳

Our chromatin scaling paper is now out in its peer-reviewed form! 🎉 We added some controls, statistics, and a new introduction to better contextualise our findings. Overall a much-improved version we hope! (see my earlier thread for the preprint background) www.sciencedirect.com/science/arti...

📢 Lancement de la campagne ATIP-Avenir 2026 @cnrsbiologie.bsky.social et @inserm.fr ouvre la campagne ATIP-Avenir 2026, destinée à soutenir des projets de recherche innovants portés par de jeunes chercheuses et chercheurs. 📅 Toutes les informations : buff.ly/5DH6mpd

Meet George Garinis, professor at the University of Crete #Greece, affiliated group leader at imbb-forth.bsky.social and EMBO Member. “For me EMBO is all about connection,” he says, grateful for the role EMBO plays in facilitating #networking to other parts of #Europe: www.embo.org/people/creat... 🧪

Checkout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team

Supporting the #LifeSciences community through different programmes and schemes, scientific #publishing, #policy as well as #innovation, EMBO champions scientific excellence throughout #Europe and worldwide. This week’s feature: #Greece www.embo.org/the-embo-com... 🧪 #research #opportunities

Now accepting applications for our 2026 Cancer Biology & Cancer Engineering programs. Aspiring scientists & engineers will solve fundamental problems in biology & conduct research & develop technology that will help understand, diagnose & treat cancer. bit.ly/3WUiuo1

New Online! Learning about break-induced replication from bacteriophages

New important opportunity for young PI recruitment at our Institute! Please spread the news. Interested candidates should carefully check their eligibility for the indicated SNSF funding schemes, before submitting their application 👍 👇 www.imcr.uzh.ch/dam/jcr:3d1f... www.imcr.uzh.ch/en.html

Tomorrow (Tue 9th) at 5 PM CET. Don't miss it!

🔬 Division cellulaire : comment une modification épigénétique protège nos chromosomes. L’équipe du Dr Daniele Fachinetti ( @institutcurie.bsky.social / @cnrs.fr), en collaboration avec l'université Stanford, révèle le rôle clé de la méthylation de l’ADN dans l’organisation des centromères.

Co-organizing a one day FREE conference on Genome Instability- Discovery to Personalized Medicine 11/1/25. Please join us! Short talks available. https//noncredit.t...

📢Deadline extended! Our 2nd Spatial Genome Organisation Conference deadline has been extended to 25 Sep, dont miss out on joining our fantastic line up of speakers, alongside Karim, Matthias and Irene in what is set to be a fantastic meeting this October! #SGO25 Final slots ➡️https://bit.ly/3JJzYR4

▶️ Pour en savoir plus ⏩ Lire l'actu : curie.fr/actualite/di... ⏩ Lire la publication : www.nature.com/articles/s41...

We’re back! Registration is NOW OPEN for the 6th Annual Meeting on Advances in Nuclear Topology & 3D Chromatin Architecture in Cancer. Don’t miss insights from leading experts in the field. Join us online on Nov 25, 2025—register for free: bit.ly/chromatin-2025 #chromatin2025

Excited to share our new paper from the Buhrlage lab & Chowdhury labs! 🎉 We designed CAS-010, a selective, low nanomolar USP28 inhibitor that reduces p53 transcriptional activity, mimics p53 loss & disrupts 53BP1-USP28 binding, offering new insights into USP28 function. www.cell.com/cell-chemica...

#New-Paper Rass laboratory reveal DNA2 to be a gatekeeper to homologous recombination at stalled DNA replication forks, rrequired to stave off cellular senescence. Their findings provide a molecular explanation for the association of DNA2 with primordial dwarfism and cancer. doi.org/10.1038/s415...

Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...

The Maria Leptin | EMBO Science Journalism Fellowships support life scientists pursuing a career in #ScienceJournalism and science journalists who wish to further their scientific education. Apply now: www.embo.org/funding/fell... #LifeSciences #ScienceCommunication #SciComm #Funding 🧪

🍂The 2025 Fall Session of GIIN webinars is here! Join us on the 1st Tuesday of each month at 5 PM CET (Rome) / 11 AM DET (NYC). No pre-registration needed, just click to join via Zoom: uniroma1.zoom.us/j/95149984403 Subscribe here for webinar reminders: docs.google.com/forms/d/e/1F...

New review about DNA double-strand break resection during meiosis, with @alhajijoker.bsky.social and Soonjoung Kim. Please check it out: www.sciencedirect.com/science/arti...

#NEW_PAPER In this study, the Chan Lab uncover the molecular mechanisms by which human cells safeguard centromeric chromatin during mitosis, via tight dynamic control of the Bloom Syndrome complex (BTRR). rdcu.be/eCGxF

📅 Apply by Sept 14 to our International Course “Multiscale integration in Biological Systems” in partnership with @normalesup.bsky.social 👉 Open to MSc/PhD students, postdocs & researchers: training.institut-curie.org/courses/mult...

Mark your calendar (September 9th) for two more exciting virtual seminars of the Genome Integrity Italian Network (GiiN). Full schedule for the Fall season also provided just below. No registration required, just come and join us with a click! 👇

New topology Pre-print from: @alengronne.bsky.social Condensin and topoisomerases cooperate to relieve topological stress at stalled replication forks: biorxiv.org/content/earl...

👏 Congratulations to Dr. Leïla Perié, team leader at @institutcurie.bsky.social who's been awarded an #ERC #ProofofConcept Grant for her project "VisioWell", the 1st accessible ex-vivo single-cell live-cell imaging device designed to analyse the dynamics of non-adherent cells. #CellBio @cnrs.fr

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

Two major events today on our campus! 🚴‍♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social! 🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!

Less than two weeks left to apply! Postdoc positions in my lab to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists & structural biologists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

🚀 Une année riche de nouveaux espoirs contre le #cancer ! 📽️ Retrouvez en vidéo les temps forts qui ont marqué l’année 2024 à l’Institut Curie, à l’occasion de la sortie de son rapport annuel.

Sussex is the host for this year's South West Structural Biology Consortium meeting [we snuck in... !]. Looking forward to hearing talks from Universities of Bath, Bristol, Cardiff, Exeter, Portsmouth, Southampton and of course, Sussex!

Ready for #Yeast2025 in Paris tomorrow. Looking forward to the science and to seeing colleagues and friends.

This seems like a really important paper comparing chromosome tracing methods, demonstrating that classical denaturing DNA-FISH and chromosome tracing leads to substantial distortion of 3D genome structure, likely due to the high-temperatures involved (70-90C): www.nature.com/articles/s41...

Our paper is now out in Molecular Cell! Check the thread in this former post: www.cell.com/molecular-ce...

🔥🔥🔥 Read now our latest article: The Somatic Impact on Inheritance and the Germline Control of the Soma | Annual Reviews - www.annualreviews.org/content/jour...

Are you a #PhD student in #Chile and want to develop your #SoftSkills? Learn about #ScienceCommunication, #ethics, #creativity, #career #opportunities and more at the EMBO PhD Course in Chile! 🧪 Deadline extended to 27 July! Apply now: meetings.embo.org/event/embo-p...

Participez au #MarathondeParis 2026 tout en accélérant la recherche contre le cancer ! L’Institut Curie propose 100 dossards solidaires: 95€ d’inscription + une collecte de 420€ = un engagement sportif et solidaire au bénéfice des patients. 👉 marathon-paris.dossards-solidaires.org/project/cour...

🔬 The Multiscale Integration in Biological Systems course with @normalesup.bsky.social will explore how physical tools address biological complexity across scales. Open to MSc/PhD students, postdocs & researchers in biology, physics & related fields. 👉 training.institut-curie.org/courses/mult...

we're hiring!

The surprise came from trans-sister maps: contacts above the diagonal - lower-coordinate loci on Sister 1 vs higher-coordinate loci on Sister 2 - outnumber the reverse. An asymmetric/biased matrix implies a genome-wide register shift between sisters in the 5->3 direction of inherited strands!! 5/

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Don't miss out – Deadline today for India | EMBO Lecture Course "Structure, function, and quality control of proteins in cell #organelles" in Hyderabad, India, 10–14 November 2025. meetings.embo.org/event/25-org... #EMBOorganelles #EMBOevents 🧪

I may be biased by my career stage, but I don't understand how anyone can look at the European academia (DACH, particularly) and conclude that we need even more centralization of research.

Apply to our PhD program!!

Congratulations to @hyardimci.bsky.social on receiving a £2.3m @wellcometrust.bsky.social Discovery Award to study how cells faithfully duplicate their genetic material when under stress. 🥳 www.crick.ac.uk/news-and-fea...