This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

SMC and recombination enthusiasts: we updated our work describing the loop extrusion properties of budding yeast condensin and its function in biasing donor usage for mating-type switching. Lots of cool new data, check it out! www.biorxiv.org/content/10.1...

The famous CNRS "concours" competition for tenured research positions is open 👇

1/I’m proud to that our NHMRC Ideas Grant was successful and will support ongoing research in how DNA repair influences cancer cell fate. This project builds on pioneering work by @szmyd-radoslaw.bsky.social and @radoncdocgee.bsky.social, supported by @cmri.bsky.social and @sydney.edu.au

📢 Telomere community: Registration and abstract submission are now open for the EMBO Workshop “Telomere function and maintenance in health and disease”, May 25–30, 2026, in Lazise, Italy 🇮🇹. Looking forward to an exciting meeting! Please re-post. meetings.embo.org/event/26-tel...

Congratulations 👍

🚨 Exciting news! Our latest study is out in Nature Communications! We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair. 🔗 rdcu.be/eT1R9 #CancerResearch #BRCA2 #Genomics

Explore advances in telomere biology and its involvement in organism homeostasis and disease in EMBO Workshop "Telomere function and maintenance in health and disease" in Lazise, IT, 25–30 May 2026. Deadline: 10 Feb https://meetings.embo.org/event/26-telomere #EMBOTelomereMaintenance #EMBOevents 🧪

Sophie Polo has been awarded an Impulscience grant from the Bettencourt Schueller Foundation to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab! We thank the Foundation for their support.

Congrats to Dr. Raphaël Ceccaldi named 2025 #Impulscience laureate by the Fondation Bettencourt Schueller 👏 This award will enable his team to push further their investigations into DNA repair during mitosis, a key process for understanding the vulnerabilities of certain tumors.

#Yeast RNase H1 responds to unscheduled, stress-inducing #RNA-DNAhybrids. Overexpressed Rnh1 leaves wt cells unaffected, but clears dysregulated RNA–DNA hybrids in mutants and promotes #DNAreplication at transcription-replication conflict sites. Read more: www.yeastgenome.org/reference/S1...

❄️The 2026 Winter Session of GIIN Webinars is here! Join us on the first Tuesday of each month at 5 PM (Rome) / 11 AM (NYC). No pre-registration needed, simply join via Zoom: uniroma1.zoom.us/j/95149984403 Want reminders? Subscribe here: docs.google.com/forms/d/e/1F...

New @natcomms.nature.com paper today from Tracy Bryan's lab @cmri.bsky.social: "Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase". Happy our lab could play a small part. Congrats Tracy, Ash Harman, Noa Lamm and the whole team. www.nature.com/articles/s41...

Registrations are now open!!

TODAY! Don’t miss it! 👇

New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...

How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1

Join us next Tuesday, December 2 at 5pm (Rome) / 11am (NYC) for an exciting GIIN webinar featuring @peterlylab.bsky.social and @alebrambati.bsky.social! Zoom link: uniroma1.zoom.us/j/95149984403 Register here to become part of our community: docs.google.com/forms/d/e/1F...

👏 Félicitations au Dr Enzo Poirier, chargé de recherche @inserm.fr et chef d'équipe à l’Institut Curie qui a reçu le prix de la Fondation Joannidès de l'@academiesciences.bsky.social, saluant ses travaux de recherche sur l'immunité innée.

👏 Félicitations au Dr Gudrun Schleiermacher, pédiatre oncologue à l’Institut Curie distinguée par l'@academiesciences.bsky.social par la médaille de Biologie humaine et sciences médicales pour ses travaux sur les mécanismes moléculaires des cancers pédiatriques et leur résistance aux traitements.

One name appears on an award, but it truly reflects the collective effort of an exceptionally talented team. All credit to @radoncdocgee.bsky.social, @szmyd-radoslaw.bsky.social, @drmelaniew.bsky.social, @annagmanjon.bsky.social, Lucy French, Sienna Casolin, Scott Page, & our awesome collaborators.

We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...

New study from the lab on genetic relationship between 53BP1-RIF1 and DNA-PKcs on DSB repair outcomes. Led by PhD student @kaelamakins.bsky.social www.nature.com/articles/s41...

Very excited and honored that our project CenAGE with @manellab.bsky.social and Elsa Logarinho was granted! Looking forward to discover how centromere instability affects the immune cells contributing to systemic ageing. More Info here: curie.fr/actualite/no... Open positions soon, stay tuned!

The 21st Course on Epigenetics which will take place from March 25th to April 1st, 2026 at the Institut Curie (Paris). The Course is open to M2 and PhD students. Application via the Advanced Training Office website before December 15th, 2025 at: minilien.curie.fr/3avv47

Happy to share the “International Symposium on Chromosome Dynamics: from Structure to Cellular Function” that will be held in Japan 31st of May 2026 www.fbs.osaka-u.ac.jp/labs/fukagaw.... Registrations will open on December 1st! Plenty of opportunities to present your work! Hope to seeing you

Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!

New research from Valerie Garcia and colleagues: Tel1 is recruited at chromosomal loop/axis contact sites to modulate meiotic DNA double-strand breaks interference journals.plos.org/plosgenetics...

Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 www.nature.com/articles/s41...

Brand new preprint from my lab, showing that TnpB, the ancestor of Cas12, acts as a gene drive in plasmids! And it turns out in conjugative plasmids that it acts as a primitive anti-self defense system, providing a potential link between its transposon effect and becoming CRISPR!

20 years already… It is true it looks like long ago when we started populating those empty rooms… and making the first agar plates look as normal ones…

POSTDOCTORAL POSITION IN STRUCTURAL BIOLOGY We need a structural biologist to work on several CryoEM datasets. For more information, please visit: www.antonylab.org Expertise in structure refinement and model-building are required. Please share.

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Why LLPS Scaffolds Cannot Exist – A Thermodynamic Thread If you consider arguments logical, please share. Else please expose logical faults 🧵👇

Back home after a truly inspiring trip where I had the honor to present at the Asian meeting on radiobiology at Hiroshima and at the VII Farm-DNA in São Paulo! Had the chance to connect with amazing scientists, old and new friends! Thanks so much to the organizers for these wonderful opportunities!

I'd also like to highlight a recent publication by @audeber.bsky.social, @enzopoirier.bsky.social, and colleagues showing FAM118B, which they term "SIRal", is essential for innate immune response in mammalian cellular models; they also have great phylogenetic analysis and insights into biochemistry.

Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.

📣 Discovery of a cellular resistance mechanism at the origin of relapses of triple-negative breast cancer: an essential step on the path towards more preventive medicine that is able to anticipate and avoid relapses. ▶️ institut-curie.org/news/relapse...

Come and join us here in Cambridge! Applications open for a new faculty position, for a researcher in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Happy to answer questions about research, teaching and working here. www.cam.ac.uk/jobs/faculty...

📢 Don't miss @groth-anja.bsky.social from the Danish Cancer Institute, who will present her research at the #Embryo2026 🧬 "How cells copy their epigenome" Register until Oct 31! 👇 www.molgen.mpg.de/embryo2026 Supported by the Weizmann Institute of Science

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

I am very proud to announce that our team has received an ERC synergy grant from @erc.europa.eu. A wonderful recognition of a truly collaborative effort with friends (Julius Lukes, Leos Valasek and Mark Osborn). Excited to begin this journey at @i2bcparissaclay.bsky.social @cnrs.fr

Please read the thoughtful Blog that @richardsever.bsky.social and the @openrxiv.bsky.social team wrote on integrating pre-prints with AI review openrxiv.org/enabling-rev...

Enabling options for review: bioRxiv authors now have the option to send their preprints directly to @qedscience.bsky.social , an authors-centered AI review platform, for automated feedback on their paper. openrxiv.org/enabling-rev... #OpenScience #Preprints #openrxiv #qedscience #biorxiv

Amazing view from the 24th floor of the Sorbonne tower at the 7th German-French DNA Repair Meeting! Excited to give my talk tomorrow!

🧬Register for the GRS on DNA Damage, Mutation & Cancer🧬 Feb 28–Mar 1 2026, Ventura CA Accepting abstracts for oral presentations! 
📍 Apply here 👉 grc.org/dna-damage-mutation-and-cancer-grs-conference/2026 (www.grc.org/dna-damage-m...) #DNADamage #GRC#GRS #CallForAbstracts

When the work of your colleagues really blows your mind 🤯🔥. Congratulations @jojdavies.bsky.social, team and collaborators! 🥂

My team is recruiting a Study Engineer (IE) with experience in mammalian cell culture - ideally human iPSCs - to work on a project exploring the role of aneuploidy and centromere regulation in neuroblastoma initiation and progression. info and application here institut-curie.org/job/study-en....

The latest work from ours and @vram142.bsky.social lab is out! True teamwork to visualize nascent chromatin with strand resolution, using a fully reconstituted system. Very proud of superstar-PhD student Bruna, and @palindromephd.bsky.social. Learning so much from Vijay’s amazing technologies! RT

The 33rd Fungal Genetics Conference is accepting abstracts - due December 4, 2025! genetics-gsa.org/fungal-2026/... #FUNGAL26