King L Hung
@kinglhung.bsky.social
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Biologist at Scripps, PhD at Stanford. Dynamics of genomes and cells.
https://kinglhung.org
pinned post!
Our paper is out in
@nature.com
! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
www.nature.com/articles/s41...
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Genetic elements promote retention of extrachromosomal DNA in cancer cells - Nature
A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing ...
https://www.nature.com/articles/s41586-025-09764-8
25 days ago
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King L Hung
Rose Z. Hill, Ph.D.
10 days ago
Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘
www.sciencedirect.com:5037/science/arti...
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https://www.sciencedirect.com:5037/science/article/pii/S0092867425013091
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Very nice news coverage on my scientific journey by Christie Wilcox in
@science.org
and
#ScienceAdviser
:
www.science.org/content/arti...
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ScienceAdviser: Unassuming frogs snack on murder hornets
Today in Science and science: An impressive bugbot, extrachromosomal DNA in cancer, and more
https://www.science.org/content/article/scienceadviser-unassuming-frogs-snack-murder-hornets#protostar
10 days ago
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Our paper is out in
@nature.com
! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11
www.nature.com/articles/s41...
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Genetic elements promote retention of extrachromosomal DNA in cancer cells - Nature
A combination of genome-wide functional screening, imaging and chromatin profiling identifies a new class of highly prevalent genomic elements that help retain extrachromosomal DNA copies in dividing ...
https://www.nature.com/articles/s41586-025-09764-8
25 days ago
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King L Hung
Cancer Grand Challenges
26 days ago
🎉 Congratulations to
@kinglhung.bsky.social
from team eDyNAmiC for receiving the prestigious prize and for having his essay, “Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes”, published in
@science.org
. 📖 Read more -
lnkd.in/ekMqXC6J
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King L Hung
Carolyn Bertozzi
30 days ago
Congrats King Hung, Science & SciLifeLabs award winner
@stanfordmedicine.bsky.social
, collaborating with
@stanford-chemh.bsky.social
institute scholar
@paulmischel.bsky.social
www.science.org/doi/10.1126/...
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Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes
Cancer genes break free from the regulatory constraints of chromosomes
https://www.science.org/doi/10.1126/science.aec9588
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Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in
@science.org
about my PhD thesis research on extrachromosomal DNA at Stanford
@stanfordmedicine.bsky.social
.
www.science.org/doi/10.1126/...
30 days ago
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King L Hung
Ardem Patapoutian
about 1 month ago
And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces:
www.science.org/doi/10.1126/...
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King L Hung
Mark Peifer (He, him)
4 months ago
The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community,
@flybase.bsky.social
, is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share
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King L Hung
Ardem Patapoutian
8 months ago
Published an op-ed for
@cnn.com
: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...
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Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN
Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...
https://www.cnn.com/2025/04/09/health/nobel-laureate-research-funding-patapoutian/index.html
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Cool approach to isolate extrachromosomal DNA: karyotyping by FACS! Wish I had thought of it.
www.biorxiv.org/content/10.1...
9 months ago
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King L Hung
Maya Voichek
9 months ago
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
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King L Hung
Katherine J. Wu
9 months ago
if you've had an NIH grant terminated, I want to hear about it. Signal: katherinejwu.12
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King L Hung
Ardem Patapoutian
10 months ago
The Patapoutian lab started 25 years ago on March 1, 2000. A quarter-century of science with brilliant trainees, colleagues & collaborators. Cheers to my mentors & mentees! Excited to celebrate with past & present lab members in November. Here’s to more great science 🧪 and better times ahead!
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King L Hung
Sonya Neal
10 months ago
Flooding BlueSky with good news today. Neal lab received a NoA! Grateful our NIH R35 MIRA renewal is funded to support our ongoing work on membrane protein quality! 🙏🙏
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Opportunity to work with an amazing scientist!
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11 months ago
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King L Hung
Ardem Patapoutian
12 months ago
Join our lab! We're hiring a research technician—a great opportunity for individuals with a Bachelor's degree who want to gain valuable research experience before heading to medical or graduate school.
recruiting2.ultipro.com/SCR1003TSRI/...
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https://recruiting2.ultipro.com/SCR1003TSRI/JobBoard/98759e7d-7ede-4c0b-ac7b-2c6293c7b522/OpportunityDetail?opportunityId=31fe2066-b3cb-49f5-80ad-44a4c5df6575
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Hi bluesky! A re-introduction: I am a cell biologist interested in cellular signaling logic and decision making. I worked on cancer genomes in my PhD at Stanford, and am now a postdoc working on how cells interpret force at Scripps in the Patapoutian lab. Excited to reconnect here!
about 1 year ago
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King L Hung
Susan Gasser
about 1 year ago
Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.
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King L Hung
Anton Henssen
about 1 year ago
First re-post on
@bsky.app
. Great collaboration between
@kinglhung.bsky.social
and team eDyNAmiC !! 🔥🔥👇🏻👇🏻
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King L Hung
Trevor Graham
about 1 year ago
Lovely paper showing co-segregation and co-selection of multiple species of ecDNA within cancer cells. Nice computational modelling and inference of segregation and selection coefficients too
@benjaminwerner.bsky.social
and Weini Huang!
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Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
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Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature
Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.
https://www.nature.com/articles/s41586-024-07861-8
about 1 year ago
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King L Hung
Çağrı Çevrim
about 1 year ago
Now we're all here; I think this paper need more attention!
journals.biologists.com/dev/article/...
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The case against simplistic genetic explanations of evolution
Summary: Extreme traits in animals, from the origin of limbs to the loss of tails, capture public attention. This Review argues that scientists should not seek simple explanations for how they evolved...
https://journals.biologists.com/dev/article/151/20/dev203077/362254/The-case-against-simplistic-genetic-explanations
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King L Hung
Henry De Belly
about 1 year ago
Sharing my latest preprint as a re-introduction to bsky!
biorxiv.org/content/10.1...
---- Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?
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King L Hung
Eric Topol
about 1 year ago
High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths. It's free, open-access.
erictopol.substack.com/p/cancer-sci...
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Cancer Science in On a Tear
New insights on evolution, resistance, and therapies
https://erictopol.substack.com/p/cancer-science-in-on-a-tear
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King L Hung
Matthew Freeman
about 1 year ago
Waves of new BlueSky arrivals in last few days! I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology Hope it’s helpful but warning: now a v long thread! Probably the last time I can do this...
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King L Hung
Ron L Shanderson, PhD 🦀
about 1 year ago
Republicizing my preprint from earlier this year! We found that mitochondrial Raf1 upregulates glutamine catabolism in cancer cells.
www.biorxiv.org/content/10.1...
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Mitochondrial Raf1 Regulates Glutamine Catabolism
Raf1 is present within the mitochondrial matrix, where it binds GLS to regulate glutamine catabolism and tumorigenesis. In cancer, Raf1 activation occurs via mechanisms that include mutation of upstr...
https://www.biorxiv.org/content/10.1101/2024.03.08.581297v1.full
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