Our story on mechanosensation in baroreceptor cells of the kidney is finally out! Well worth the wait on this project we began in 2020 that turned into a massive collaborative effort within the kidney field. 🫘 www.sciencedirect.com:5037/science/arti...

Very nice news coverage on my scientific journey by Christie Wilcox in @science.org and #ScienceAdviser: www.science.org/content/arti...

Our paper is out in @nature.com! Oncogenes are often copy-number amplified on extrachromosomal DNA (ecDNA) in cancer, but how is ecDNA inherited by dividing cells? Here we identified elements within ecDNA that promote its retention in dividing cells. 1/11 www.nature.com/articles/s41...

🎉 Congratulations to @kinglhung.bsky.social‬ from team eDyNAmiC for receiving the prestigious prize and for having his essay, “Oncogenes out of context: Cancer genes break free from the regulatory constraints of chromosomes”, published in @science.org. 📖 Read more - lnkd.in/ekMqXC6J

Congrats King Hung, Science & SciLifeLabs award winner @stanfordmedicine.bsky.social, collaborating with @stanford-chemh.bsky.social institute scholar @paulmischel.bsky.social www.science.org/doi/10.1126/...

Honored to receive the Science & SciLifeLab Prize! Very grateful to all my mentors and colleagues. I wrote an article in @science.org about my PhD thesis research on extrachromosomal DNA at Stanford @stanfordmedicine.bsky.social. www.science.org/doi/10.1126/...

And here is the story after peer review. This work highlights our current approach, which is to use Piezo channels to uncover new areas of biology that are shaped by mechanical forces: www.science.org/doi/10.1126/...

The community of Drosophila researchers is amazing, mutually supportive and collaborative. Right now a key resource for our community, @flybase.bsky.social , is threatened by the cancellation of its NIH grant and is seeking community help in raising short term funds 1/n 🧪 please share

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Cool approach to isolate extrachromosomal DNA: karyotyping by FACS! Wish I had thought of it. www.biorxiv.org/content/10.1...

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬 But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯 Our new study reveals how retrotransposons invade the germline directly from somatic cells. www.biorxiv.org/content/10.1... A short thread 🧵👇

if you've had an NIH grant terminated, I want to hear about it. Signal: katherinejwu.12

The Patapoutian lab started 25 years ago on March 1, 2000. A quarter-century of science with brilliant trainees, colleagues & collaborators. Cheers to my mentors & mentees! Excited to celebrate with past & present lab members in November. Here’s to more great science 🧪 and better times ahead!

Flooding BlueSky with good news today. Neal lab received a NoA! Grateful our NIH R35 MIRA renewal is funded to support our ongoing work on membrane protein quality! 🙏🙏

Opportunity to work with an amazing scientist!

Join our lab! We're hiring a research technician—a great opportunity for individuals with a Bachelor's degree who want to gain valuable research experience before heading to medical or graduate school. recruiting2.ultipro.com/SCR1003TSRI/...

Hi bluesky! A re-introduction: I am a cell biologist interested in cellular signaling logic and decision making. I worked on cancer genomes in my PhD at Stanford, and am now a postdoc working on how cells interpret force at Scripps in the Patapoutian lab. Excited to reconnect here!

Two back-to-back papers in Nature comms from mylab explore the link between destabilization of the actin cytoskeleton and aberrant base excision repair - passing through nuclear actin and the actin-dependent nucleosome remodeler INO80C.

First re-post on @bsky.app . Great collaboration between @kinglhung.bsky.social and team eDyNAmiC !! 🔥🔥👇🏻👇🏻

Lovely paper showing co-segregation and co-selection of multiple species of ecDNA within cancer cells. Nice computational modelling and inference of segregation and selection coefficients too @benjaminwerner.bsky.social and Weini Huang!

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/ www.nature.com/articles/s41...

Now we're all here; I think this paper need more attention! journals.biologists.com/dev/article/...

Sharing my latest preprint as a re-introduction to bsky! biorxiv.org/content/10.1... ---- Everyday, cells like this crawl through your body to protect you. While we know that their front 🔴 and back 🔵 polarity programs work together, how exactly do these two processes communicate?

High-resolution of cancer. Unprecedented. A brief review of what we've just learned from 17 new papers in the latest edition of Ground Truths. It's free, open-access. erictopol.substack.com/p/cancer-sci...

Waves of new BlueSky arrivals in last few days! I’ve been tracking starter packs relevant to molecular/mechanistic/genetic/cellular…etc biology Hope it’s helpful but warning: now a v long thread! Probably the last time I can do this...

Republicizing my preprint from earlier this year! We found that mitochondrial Raf1 upregulates glutamine catabolism in cancer cells. www.biorxiv.org/content/10.1...