My PhD work is out as a preprint! Have a read 😊👇🏻

New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...

When the work of your colleagues really blows your mind 🤯🔥. Congratulations @jojdavies.bsky.social, team and collaborators! 🥂

Thanks Shan Zha for hosting my Social DNA’ing on Thursday. Was a honour to celebrate the 5th anniversary of this epic series. If you didn’t catch it, pls check out the recorded webinar to find out what we’ve been up to with research support from @cruk-ci.bsky.social! fast.wistia.com/embed/channe...

Congrats Kelly! 🥂

Excited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...

A new treatment significantly improves survival rates for women with aggressive, inherited breast cancer involving BRCA1 or BRCA2 gene mutations. Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back. 🧪🧬💊 #medsky www.bbc.com/news/article...

Don’t miss the 2025 César Milstein Lecture, by David Pellman from the Dana-Farber Cancer Institute and Harvard University. Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes” More details: www2.mrc-lmb.cam.ac.uk/news-and-eve... #LMBSeminar

Please repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email [email protected] for info

Register and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...

BRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...

We show transcriptomic buffering of tumour suppressor loss via syn. lethal genes is not anecdotal but a cancer hallmark. Buffering also seen in BRCAness, predicts penetrant syn leth effects and outcome. @icr.ac.uk @cancerresearchuk.org @breastcancernow.bsky.social www.nature.com/articles/s41...

Really cool work, demonstrating TRF2-RAP1 mediated inhibition of the NHEJ machinery at chromosome ends! www.biorxiv.org/content/10.1...

Few better ways to end the year with the team than over a few pints (& mini Guinness’s) in the @StarPubOxford

In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇