Nicolas Manel Lab
@manellab.bsky.social
📤 260
📥 83
📝 31
Institut Curie, Paris, France
https://minilien.curie.fr/ejggfa
pinned post!
🔥 Mark the date! 🗓️ Millésime 2026 of the
@embo.org
Workshop on Pathogen Immunity and Signaling has arrived. Terrific roster of speakers, many spots for talks, spectacular venue in Leiden. Submit your abstract. Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
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Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
https://meetings.embo.org/event/26-pathogen-immunity
about 1 month ago
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You bet. Thanks so much to the amazing
@erc.europa.eu
, the panel members and the reviewers!
add a skeleton here at some point
11 days ago
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🔥👇 The place to be.
add a skeleton here at some point
13 days ago
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reposted by
Nicolas Manel Lab
Iannacone Lab
about 1 month ago
Join us for this exciting meeting!
@embo.org
Workshop "Pathogen Immunity and Signalling", 8-12 June, 2026, Leiden, The Netherlands
meetings.embo.org/event/26-pat...
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🔥 Mark the date! 🗓️ Millésime 2026 of the
@embo.org
Workshop on Pathogen Immunity and Signaling has arrived. Terrific roster of speakers, many spots for talks, spectacular venue in Leiden. Submit your abstract. Join us on 8 – 11 June 2026.
meetings.embo.org/event/26-pat...
loading . . .
Pathogen Immunity and Signalling
Viruses, bacteria, and other pathogens pose a serious threat to human health, requiring a coordinated response from the innate and adaptive immune systems. Our immune system relies on pathogen recept…
https://meetings.embo.org/event/26-pathogen-immunity
about 1 month ago
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Fantastic seminar today by Norbert Pardi from
@upenn.edu
who did the pioneering work with Katalin Kariko and Drew Weissman to unlock mRNA nanoparticules. mRNA nanoparticules are the therapeutics of tomorrow!
about 2 months ago
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🔥Really cool work by our neighbors
@dfachinetti.bsky.social
together with Stanford's only
@naltemose.bsky.social
showcasing the ability to tune DNA methylation specifically in centromeric DNA, in turn affecting the identity and functionality of centromeres.
add a skeleton here at some point
2 months ago
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Erika Valeri & Moriz Gaidt
@impvienna.bsky.social
put together a very nice "Spotlights" piece in the latest issue of Molecular Cell
@cp-molcell.bsky.social
about the antiviral defense system VICAR and some of the avenues of research it opens. 🙏 to the authors
www.cell.com/molecular-ce...
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DIY innate immune sensing: Crafting fresh DNA to detect viruses
The innate immune receptor cGAS is geared toward detecting DNA from pathogens. In a recent Cell publication, Lahaye et al. discovered that viral infection triggers de novo synthesis of self-DNA-activa...
https://www.cell.com/molecular-cell/abstract/S1097-2765(25)00610-0
3 months ago
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Thrilled to be part of the late 2025 roster of
@globalimmuno.bsky.social
See you all on November 26th! Thanks so much to the organisers for putting this together.
add a skeleton here at some point
3 months ago
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Really cool highlight of our work
@cp-cell.bsky.social
describing VICAR, a novel antiviral defense system in humans, where centromeres take the center stage. Thank you so much Fumiko
@esashilab.bsky.social
for your insightful review and the beautiful working model.
add a skeleton here at some point
4 months ago
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reposted by
Nicolas Manel Lab
Esashi Lab
4 months ago
Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗
rdcu.be/eyOGc
- such a cool twist in the host–virus warfare. Many congrats to
@manellab.bsky.social
‬
add a skeleton here at some point
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Happy to let you know that the plasmids (except one, pending QC) from our study describing the VICAR antiviral defense system are now available through
@addgene.bsky.social
here:
www.addgene.org/browse/artic...
Thanks
@addgene.bsky.social
for making this possible!
add a skeleton here at some point
4 months ago
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Trans...genes! Celebrating upcoming publication from
@audeber.bsky.social
and Enzo Poirier at the unique Learning Center Institute in Paris
5 months ago
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Thrilled to share our latest
@cp-cell.bsky.social
. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS.
www.cell.com/cell/abstrac...
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Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS
Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...
https://www.cell.com/cell/abstract/S0092-8674(25)00556-2
6 months ago
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reposted by
Nicolas Manel Lab
IGMM-Montpellier
6 months ago
📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️
application.igmm.cnrs.fr
@cnrsbiologie.bsky.social
@cnrsoccitanieest.bsky.social
@umontpellier.bsky.social
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How does a cell detect infection by a DNA virus in its nucleus?
6 months ago
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Check out Randmice 2.0 from our colleagues @ Stimunity Biotech. It became an essential tool for us to optimize animal randomization for in vivo experiments. And it's free!
randmice.com
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Randmice - Optimize animal randomization
https://randmice.com/
6 months ago
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Soren Paludan
@civia-aarhus.bsky.social
kicks off a wonderful 2-day workshop on antiviral host defense. Looking forward to catching up will all the speakers and participants!
6 months ago
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So thrilled to participate in the
#EMBO
workshop on aneuploidy in the magnificient Stresa. Cheers to the many organizers including
@dfachinetti.bsky.social
7 months ago
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reposted by
Nicolas Manel Lab
Iannacone Lab
8 months ago
🚨 New EJI-EFIS Prize for ECRs! 🚨 🏆 €5,000 award for the best research article in EJI by an Early Career Researcher! 🎤 Winner presents at ECI + receives an EFIS–EJI travel grant! 🔗 Apply now:
onlinelibrary.wiley.com/page/journal...
#ECR
#Immunology
#EJI
#EFIS
#ScienceFunding
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European Journal of Immunology: EJI-EFIS Prize for the ECR Article of the Year
EJI and EFIS are thrilled to announce a new prize honoring Early Career Researchers (ECRs) whose work is published in EJI. This initiative aims to showcase the next generation of immunologists and encourage them to submit their excellent research to EJI.
https://onlinelibrary.wiley.com/page/journal/15214141/homepage/article-of-the-year
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@sufs-paris-rp.bsky.social
#StandUpForScience
felt really good to walk the streets of Paris for a couple of hours in support of science. We were thousands!
9 months ago
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#Macrophages
literally eat and live of dead
#bacteria
, while live bacteria stimulate inflammation. 🦠viability is sensed by an mTORC1 metabolic switch. Superb tour-de-force study
@nature.com
by the Garaude lab in Bordeaux, with help from
@sanderlab.bsky.social
www.nature.com/articles/s41...
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Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature
Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...
https://www.nature.com/articles/s41586-025-08629-4
9 months ago
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reposted by
Nicolas Manel Lab
Fondation ARC pour la recherche sur le cancer
9 months ago
📢 En 2025, nous renouvelons notre appel à projets « Passerelle » afin de soutenir des chercheurs non statutaires préparant les concours à un poste de chercheur au sein d’un EPST français. 🏆 Les lauréat(e)s recevront un soutien de 100 000 € pour un an. 👉
urlz.fr/pR3x
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Unexpected conservation: Rick Rubin interviews Richard Feynman. Loving this chat btwn 2 titans, defying the laws of time. Plenty of cool topics: curiosity, solving 'simple' problems, avoiding admin duties, teaching != research, religion, social studies....
www.tetragrammaton.com/content/rich...
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Richard Feynman - Tetragrammaton
52m 11.30.24
https://www.tetragrammaton.com/content/richard-feynman
9 months ago
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reposted by
Nicolas Manel Lab
Rebsamen Lab @UNIL
10 months ago
Confirmed speakers: A. Ablasser L. Andreeva
@audeber.bsky.social
@jelenalab.bsky.social
V. Dixit
@v-hornung.bsky.social
B. Lemaitre O. Majer
@manellab.bsky.social
E. Miao
@oliveiramann.bsky.social
M. Pasparakis
@inflammasomelab.bsky.social
@sparrerlab.bsky.social
R. Vance
@lozanzi.bsky.social
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On veut du fric pour la recherche publique ! Mr le Ministre présentait ses voeux au Collège de France, on était là .
10 months ago
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Showcasing this exciting paper from our good friends Fachinetti lab
@institutcurie.bsky.social
.
#Centromere
inactivation triggers
#senescence
: mis-segregated chromosomes deform the nuclear envelope and activate TORC2-ATR. We helped with
#cGAS
and some key suggestions.
doi.org/10.1038/s415...
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint - Nature Cell Biology
Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochrom...
https://doi.org/10.1038/s41556-024-01565-x
10 months ago
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