Trends in Immunology
@cp-trendsimmuno.bsky.social
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đĽ 51
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Cell Press Reviews journal covering Immunology. Posts by Editor-in-Chief, Claudia Burrello.
KLHL6: a proteostatic guardian against T-cell exhaustion
#immunology
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KLHL6: a proteostatic guardian against T-cell exhaustion
Cheng et al.'s recent study identifies the Cullin3-RING E3 ubiquitin ligase complexes (CRL3) adaptor protein Kelch-like protein 6 (KLHL6) as a proteostasis regulator whose downregulation in chronically stimulated T cells leads to the accumulation of thymocyte selection-associated high mobility group box protein and phosphoglycerate mutase family member 5, driving T-cell dysfunction. This work positions T-cell exhaustion as a proteostatic disorder and highlights KLHL6 as a promising target for cancer immunotherapy.
http://dlvr.it/TRY1JC
about 11 hours ago
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The importance of long-lived IgE plasma cells for protracted allergies
#immunology
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The importance of long-lived IgE plasma cells for protracted allergies
IgE contributes to allergy, but its cellular sources are rare and hard to identify. Genetic fate mapping and single-cell sequencing approaches have now revealed that two cell populations maintain IgE: long-lived IgE plasma cells (PCs) and âtype 2â memory B cells. This forum piece discusses recent discoveries on long-lived IgE PCs.
http://dlvr.it/TRXK91
about 23 hours ago
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Barrier breakdown: insights into the skinâgut axis in psoriatic arthritis
#immunology
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Barrier breakdown: insights into the skinâgut axis in psoriatic arthritis
Psoriatic arthritis (PsA) is a chronic inflammatory disease that primarily affects the skin, joints, and entheses. Growing evidence implicates alterations at the gut and skin barriers in PsA pathogenesis. These sites play a crucial role in tissue homeostasis, and their disruption can contribute to the translocation of immune cells and bacterial products, resulting in systemic inflammation. Crosstalk between barrier sites and joints can promote or exacerbate disease development, with barriers also being a potential target of disease. This review article provides a barrier-centered perspective across gut, skin, and synovium, with a specific focus on new concepts about intertissue communication involving immune and microbial mediators that can propagate inflammation in PsA.
http://dlvr.it/TRSCQc
5 days ago
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reposted by
Trends in Immunology
Barriers in Inflammation lab
about 1 month ago
đ§ Excited to share our review in Trends in Immunology (
@cp-trendsimmuno.bsky.social
): âDecoding brain border immunity to enable future therapeutic avenues.â by Lien Van Hoecke,
@lorevanacker.bsky.social
, and
@roosvdb.bsky.social
www.cell.com/trends/immun...
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Decoding brain border immunity to enable future therapeutic avenues
The brain is no longer viewed as immunologically isolated but as an organ surrounded by dynamic border compartments that coordinate surveillance, drainage, and communication with the periphery. Key in...
https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00315-1
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reposted by
Trends in Immunology
Cell Press
19 days ago
Lactation supports babies' immune health and reduces the risk of breast cancer for the mother.
spkl.io/63327Avl8f
Abigail Jaquish & Deepshika Ramanan
@cp-trendsimmuno.bsky.social
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Tumor-derived cystatin C enables amyloid clearance
#immunology
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Tumor-derived cystatin C enables amyloid clearance
Li et al. described a tumor-derived neuroimmune mechanism that promotes clearance of established amyloid pathology in Alzheimerâs disease. Tumor-secreted cystatin C activates TREM2-dependent microglial phagocytosis, reducing plaques and improving cognition. This work introduces a context-dependent neuroimmune-modulatory strategy that shifts Alzheimerâs therapy from broad immune activation toward substrate-coupled amyloid clearance.
http://dlvr.it/TRR4xJ
6 days ago
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Stealth designs to overcome allorejection in engineered cell therapy
#immunology
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Stealth designs to overcome allorejection in engineered cell therapy
The rapid development of allogeneic engineered therapeutic cells has intensified the challenge of host immune-mediated rejection. Advances in molecular immunology, genetic engineering, and induced pluripotent stem cellâbased multigene editing have enabled the creation of âstealthâ allogeneic cells designed to evade immune detection while maintaining function. Key strategies include the deletion of human leukocyte antigen class I and class II molecules to limit T cell recognition, the expression of natural killer (NK) cell inhibitory ligands to prevent NK cell-mediated killing, and the upregulation of CD47 to suppress phagocytosis. An expanding repertoire of immune-modulatory molecules, receptorâligand interactions, and experimental assays is refining these approaches. Together, stealth designs are accelerating the translation of allogeneic cell therapies toward more durable and broadly applicable clinical use.
http://dlvr.it/TRQhz6
7 days ago
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Integration of biochemical and physical cues by patrolling CD8+ T cells
#immunology
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Integration of biochemical and physical cues by patrolling CD8+ T cells
CD8+ T cell migration is central to host defense, enabling clonal selection, tissue infiltration, and elimination of infected cells. While chemokines guide these cells by activating Rac for F-actin polymerization, recent studies reveal a complementary mechanism through Rho activation. This pathway relies on tissue confinement, which deforms the nucleus, activates the actomyosin network, and allows CD8+ T cells to use physical cues for surveillance without external signals. In this review article, we explore how chemokine- and mechanosensing-dependent pathways guide CD8+ T cell surveillance and introduce a âfront-â versus ârear-drivenâ motility model to illustrate their integration for effective tissue monitoring. Ultimately, the interplay of biochemical and physical cues ensures tissue-specific protection by T cells during homeostasis and inflammation.
http://dlvr.it/TRLq43
11 days ago
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Weâre offering exclusive in-person 1:1 meetings with Cell Press editors for participants of @CellSymposia #CSImmuneHomeostasis26 in Shanghai, China (May 11â13, 2026). Early bird registration ends today!
http://dlvr.it/TRKq2z
12 days ago
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Two models, one question: how does respiratory syncytial virus cause asthma?
#immunology
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Two models, one question: how does respiratory syncytial virus cause asthma?
De Leeuw et al. conducted human observational and murine studies to establish the combined role of parental aeroallergen sensitization and early-life respiratory syncytial virus infection in asthma development. The findings reveal synergistic effects driving immunological, pathological, and physiological changes resembling asthma, advancing the understanding of disease mechanisms and potential preventive targets.
http://dlvr.it/TRJjM9
13 days ago
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Secondary bile acids as immune and metabolic mediators
#immunology
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Secondary bile acids as immune and metabolic mediators
Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota is the source of hundreds of secondary bile acids and microbially conjugated bile acids. Secondary bile acids regulate immune function throughout the body, promote the conversion of thyroid hormone, and regulate energy expenditure in muscle and adipose tissues, ultimately contributing to the beneficial effects of calorie restriction on human health and longevity. Here, we discuss recent advances in our understanding of secondary bile acids, the intestinal microbiota generating them, and their role in immune disorders.
http://dlvr.it/TRGmBC
14 days ago
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Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity
#immunology
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Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity
During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of key EVT ligands, promotes placentation, tolerance, and immunity.
http://dlvr.it/TRDxjv
16 days ago
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Cytokine specificity in macrophages: JAK-STAT and beyond
#immunology
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Cytokine specificity in macrophages: JAK-STAT and beyond
Macrophages are key in maintaining tissue homeostasis and controlling inflammation. To rapidly adapt their phenotype, they rely on JAK-STAT signaling pathways to convert extracellular cytokine cues into transcriptional responses. Understanding how macrophages interpret disease-associated cytokine environments is therefore key for deciphering how inflammation is resolved or sustained.
http://dlvr.it/TRC2z8
18 days ago
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Got milk? how T cells shape lactation and beyond
#immunology
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Got milk? how T cells shape lactation and beyond
Lactation is increasingly recognized as an immune-regulated process. Immune cells shape mammary gland development, coordinate tissue remodeling, and aid in milk production with lasting consequences for maternal health. Here, we summarize recent advances on the roles and dynamics of T cells in the mammary gland during lactation and beyond.
http://dlvr.it/TR9pKZ
20 days ago
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Flt3L from interfollicular stroma maintains resident dendritic cells
#immunology
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Flt3L from interfollicular stroma maintains resident dendritic cells
Dendritic cell (DC) maintenance and positioning are essential for their function in lymph nodes. Wu et al. identify gremlin1 (Grem1)+ fibroblastic reticular cells as critical source of niche-specific Fms-like tyrosine kinase 3 ligand (Flt3L) for conventional DC maintenance in health and disease, highlighting stromal cells as key regulators of immunity.
http://dlvr.it/TQpj38
about 1 month ago
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Last chance to submit an abstract and be considered for a short talk @CellSymposia #CSImmuneHomeostasis26 taking place on May 11â13, 2026 in Shanghai, China Submit here:
http://dlvr.it/TQWYrt
about 2 months ago
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Bruce Koppelman @cp-immunity.bsky.social speaks with Dr. Bing Su (Shanghai Jiao Tong University) about the vision behind @CellSymposia #CSImmuneHomeostasis26 taking place May 11â13, 2026, Shanghai, China. Watch the interview:
http://dlvr.it/TQLQcK
2 months ago
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Decoding brain border immunity to enable future therapeutic avenues
#immunology
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Decoding brain border immunity to enable future therapeutic avenues
The brain is no longer viewed as immunologically isolated but as an organ surrounded by dynamic border compartments that coordinate surveillance, drainage, and communication with the periphery. Key interfaces â including the meninges, bloodâbrain barrier, choroid plexus (ChP), and skull bone marrow â host specialized immune niches that regulate antigen sampling, leukocyte trafficking, and neuroimmune signaling. Recent advances in imaging and in single-cell and spatial profiling have revealed previously unrecognized cell types, migration routes, and barrier specializations that shape central nervous system (CNS) immunity in health and disease. Understanding how these border tissues sense, integrate, and modulate immune activity opens opportunities for therapeutically tuning neuroimmune responses at the brainâs periphery while preserving parenchymal integrity.
http://dlvr.it/TQD3wz
2 months ago
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Resident T cells in the healthy and multiple sclerosis brain
#immunology
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Resident T cells in the healthy and multiple sclerosis brain
Insights into T-cell biology in the central nervous system (CNS) have evolved from early neuroinflammatory models demonstrating the pathogenic potential of autoreactive T cells to recent human studies defining resident T-cell populations in the healthy and diseased brain. We here discuss advances in postmortem brain tissue processing, flow cytometry, and transcriptional profiling revealing that human brain CD8+ and CD4+ T cells are tissue-resident memory T cells with distinct phenotypes shaped by CNS borders and parenchymal niches. These findings refine our understanding of CNS immune surveillance and provide a framework for dissecting T-cell contributions to multiple sclerosis.
http://dlvr.it/TQCdps
2 months ago
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Microglia in systemic neuroimmune communication: functions beyond phagocytosis
#immunology
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Microglia in systemic neuroimmune communication: functions beyond phagocytosis
Bidirectional crosstalk between the immune and nervous systems, via âneuroimmune circuitsâ, regulates homeostatic and inflammatory responses essential for health. Microglia, long-lived brain macrophages, act as key hubs integrating immune signals into coordinated brain responses by shifting into distinct functional states in response to local and systemic cues. In this review, we focus on how environmental signals shape these microglial states, how microglia influence other brain cells through both direct and indirect mechanisms, and emerging evidence of how microglia are impacted by, and respond to, peripheral changes. We highlight microglia as central players in systemic neuroimmune communication, influencing both brain and peripheral health, while outlining recent tools and key knowledge gaps to guide future research into mechanisms of neuroimmune circuit communication.
http://dlvr.it/TQCG4V
2 months ago
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Tissue-resident regulatory T cells: modulators of local immunity
#immunology
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Tissue-resident regulatory T cells: modulators of local immunity
Regulatory T cells (Tregs) have gained renewed attention for their diverse roles beyond immune suppression. This review integrates recent discoveries on how tissue-resident Tregs integrate immune, metabolic, and neural cues to maintain organ homeostasis and regeneration. Across adipose tissue, intestine, brain, and skin, Tregs coordinate local networks that couple immune tolerance with metabolic balance and tissue repair. We further discuss therapeutic advances â including antigen-specific chimeric antigen receptor (CAR)/T cell receptor (TCR) Tregs, interleukin 2 (IL-2) muteins, and metabolic modulation â that aim to harness Tregs for treating autoimmunity and chronic inflammation. Together, these insights highlight Tregs as central interpreters of tissue context and as promising targets for next-generation precision immunotherapy.
http://dlvr.it/TQCG3m
2 months ago
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Interleukin-23 biology linking mucosal immunity to autoimmune diseases and cancer
#immunology
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Interleukin-23 biology linking mucosal immunity to autoimmune diseases and cancer
Interleukin-23 (IL-23) is a pleiotropic cytokine that maintains the delicate balance between tolerance to commensal microbiota and defense against pathogens at mucosal barriers. When dysregulated, IL-23 becomes a key driver of chronic inflammation, with therapeutics blocking this pathway being successfully harnessed in the clinic. In this review, we discuss recently uncovered biology of IL-23 in the context of mucosal immunity, which intimately links the role of this pathway to the pathophysiology of autoimmunity, chronic inflammation, and emerging functions in cancer. Through the lens of the cell types that respond to IL-23, the engaged effector programs, and the key functions in health and disease, we highlight recent advances and opportunities to better understand the dichotomous outcomes mediated by this cytokine.
http://dlvr.it/TQ7JC3
2 months ago
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Lactation, tissue-resident immunity, and protection against breast cancer
#immunology
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Lactation, tissue-resident immunity, and protection against breast cancer
Parity and lactation have long been recognised as protective factors in breast cancer, with notable risk reduction in triple negative breast cancer (TNBC). Recent work by Virassamy et al. suggests a tissue-specific, persistent immune surveillance underpins this effect, particularly in women who have also breastfed.
http://dlvr.it/TQ4v1V
3 months ago
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Targeting γδ T cells for immunotherapies against colorectal cancer
#immunology
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Targeting γδ T cells for immunotherapies against colorectal cancer
The advancement of immunotherapy faces significant challenges, including extending its benefits to a growing number of patients and enhancing its efficacy across different tumor types. In this context, γδ T cells emerge as particularly promising candidates owing to their distinctive biological features such as MHC-independent activation, potent cytotoxicity, and capacity to bridge innate and adaptive immunity. Recently, advanced single-cell techniques have allowed detailed γδ T cell characterization in the tumor microenvironment (TME) and have emphasized their heterogeneity, mechanisms of activation, and response to immune checkpoint blockade (ICB). This review provides a comprehensive summary of recent advances in understanding γδ T cells in colorectal cancer (CRC), with a particular emphasis on their prognostic and therapeutic relevance in both primary tumors and metastatic disease.
http://dlvr.it/TPwj7P
3 months ago
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Group 3 innate lymphoid cells: guardians of intestinal homeostasis
#immunology
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Group 3 innate lymphoid cells: guardians of intestinal homeostasis
Intestinal homeostasis is crucial for overall health, and its maintenance relies on a complex and delicate interplay between intestinal epithelial cells, the gut microbiota, and the immune system. Among immune components, group 3 innate lymphoid cells (ILC3s), which primarily reside in the intestinal microenvironment, play a crucial role in maintaining gut homeostasis. Through the expression of multiple effector molecules such as interleukin (IL)-22 and major histocompatibility complex class II (MHCII), ILC3s orchestrate intestinal epithelial responses and regulate innate and adaptive immunity, thereby collectively promoting a symbiotic hostâmicrobiota relationship, supporting immune tolerance, and providing protection against pathogens. This review summarizes current understanding of ILC3 functions in gut homeostasis, highlights their interactions with the microbiota and other cell types, and outlines how aberrant ILC3 activity contributes to disease pathogenesis.
http://dlvr.it/TPw8BH
3 months ago
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A novel mechanism of immunoevasion by ER+ breast cancer
#immunology
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A novel mechanism of immunoevasion by ER+ breast cancer
Estrogen receptor (ER)+ breast malignancies are poorly infiltrated by immune cells, hence exhibiting limited sensitivity to immune checkpoint inhibitors (ICIs). Recent data from Palomeque et al. demonstrate that ER signaling actively contributes to such an immunoevasive phenotype by preventing the nuclear factor LCOR from establishing an ICI-sensitive tumor microenvironment.
http://dlvr.it/TPsZtP
3 months ago
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Immune cellular homeostasis and its breakdown at the maternalâfetal interface
#immunology
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Immune cellular homeostasis and its breakdown at the maternalâfetal interface
Pregnancy requires dynamic immune adaptations that balance tolerance, homeostasis, and defense at the maternalâfetal interface. Recent advances integrating findings from human placental samples with those from refined animal models now enable a detailed analysis of how cellular responses in mid and late gestation contribute to major obstetrical complications - with distinct clinical manifestations - such as preterm birth, fetal growth restriction, and pre-eclampsia. In this Opinion article we propose a unifying paradigm: the breakdown of maternalâfetal immune homeostasis. We highlight regulatory T cells and decidual macrophages as complementary regulators of antigen-specific tolerance and nonspecific homeostasis, whereas effector T cell infiltration in chronic placental inflammation and neutrophil-driven inflammation in acute chorioamnionitis exemplify pathological immune activation. Together, these examples illustrate how immune programs that sustain mid-to-late pregnancy, when dysregulated, drive pathology and open new therapeutic opportunities.
http://dlvr.it/TPrvF9
3 months ago
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Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis
#immunology
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Neuronal inflammasomes: balancing immunity, neuroinflammation, and homeostasis
Recent discoveries reveal that inflammasome signaling in neurons extends beyond host defense to influence fundamental aspects of brain function, including synaptic plasticity, axon remodeling, and exosome-mediated intercellular communication. This review explores how basal neuronal inflammasome activity contributes to central nervous system (CNS) homeostasis and how heightened signaling in neurons drives neuroinflammatory and degenerative processes. Understanding these dual roles of neuronal inflammasomes provides new insights into neuroimmune crosstalk and identifies potential targets for modulating repair and inflammation in CNS injury and disease.
http://dlvr.it/TPnT8x
3 months ago
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reposted by
Trends in Immunology
Cell Press
3 months ago
To effectively treat long #COVID, we must learn from historical chronic illnesses, medical researchers say.
spkl.io/63328AgJFr
#COVID
Akiko Iwasaki, Christine Miller, Janna Moen @cp-trendsimmuno.bsky.social
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reposted by
Trends in Immunology
Tom Kindlon
3 months ago
News Release 4-Dec-2025 To treat long COVID, we must learn from historical chronic illnesses, medical researchers say
www.eurekalert.org/news-release...
Lots of discussion of ME/CFS in full paper
#PAIS
#MEcfs
#LongCovid
add a skeleton here at some point
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reposted by
Trends in Immunology
Mass Lab
3 months ago
đ§Źđ˝ď¸ Your macrophages may be carrying your motherâs metabolic history! In our
@cp-trendsimmuno.bsky.social
article, we discuss how maternal diet programs lifelong immune function.
authors.elsevier.com/sd/article/S...
#ImmuneMemory
#Macrophages
#MaternalNutrition
#DOHaD
#EarlyLifeProgramming
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Maternal diet shapes the development and identity of tissue-resident macrophages
#immunology
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Maternal diet shapes the development and identity of tissue-resident macrophages
The developmental origins of health and diseases concept posits that early-life exposure to environmental adversities increases risks for diverse noncommunicable and infectious diseases. Among these adversities, maternal malnutrition is a critical determinant of offspring health trajectories. Maternal malnutrition from preconception to lactation can durably alter cellular and tissue function in the offspring. We propose that tissue-resident macrophages (TRMs) act as central mediators of this developmental programming. Seeding tissues during embryogenesis, integrating metabolic and hormonal signals, and persisting throughout life, TRMs can encode maternal nutritional states into lasting tissue adaptations. We summarize how specific maternal diets program distinct TRM subsets and how programmed TRMs link maternal nutritional statuses to disease susceptibility. TRMs may offer early intervention targets to improve offspring health.
http://dlvr.it/TPg2HT
3 months ago
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IELâIEC circuit in barrier immunity and beyond
#immunology
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IELâIEC circuit in barrier immunity and beyond
The intestinal epithelium functions as an immuneâmetabolic interface, integrating environmental signals to maintain systemic homeostasis. Intraepithelial lymphocytes (IELs), interspersed within the epithelial layer, form a highly interactive network with intestinal epithelial cells (IECs) to coordinate barrier defense, immune tolerance, and metabolic regulation. IECs orchestrate IEL development, positioning, and functional programming. Reciprocally, IELs modulate epithelial physiology, nutrient uptake, and epithelial repair. Dysregulation of the IELâIEC unit contributes to intestinal and extraintestinal pathologies. This review discusses current advances in IELâIEC bidirectional communication, highlighting the influences of diet, microbial metabolites, and immune checkpoints on this interface. We propose a paradigm in which the IELâIEC interplay functions as a key immunometabolic regulatory unit and represents a promising therapeutic target for systemic diseases.
http://dlvr.it/TPfHNf
3 months ago
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The lingering shadow of epidemics: post-acute sequelae across history
#immunology
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The lingering shadow of epidemics: post-acute sequelae across history
The SARS-CoV-2 pandemic has drawn global attention to post-acute infection syndromes (PAIS), with millions affected by post-acute sequelae of COVID-19 (PASC, or Long COVID). While Long COVID is newly defined, PAIS have been described for over a century following epidemic infections. Multiple pathogens â including influenza, Epstein-Barr virus, and Borrelia burgdorferi, among others â can precipitate persistent, poorly understood symptoms. Chronic illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have long been linked to infectious triggers. This recurring association highlights critical knowledge gaps and underscores the need for systematic investigation. Unlike prior pandemics, the current era offers advanced technologies and analytic tools to address these gaps. Defining the biology of Long COVID may yield broader insights into hostâpathogen interactions and mechanisms of chronic illness.
http://dlvr.it/TPdMyr
3 months ago
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Glycolytic diversity drives immune complexity in cancer
#immunology
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Glycolytic diversity drives immune complexity in cancer
The interaction between the tumor immune microenvironment (TIME) and the tumor determines whether immune evasion or antitumor immunity prevails. Metabolic reprogramming is increasingly recognized as a critical factor shaping the tumor immune response. Glucose metabolism regulates the intrinsic cellular states of both immune and tumor cells, while simultaneously shaping the surrounding microenvironment. The glycolytic diversity of immune and tumor cells drives the complexity of the TIME. In this Review, we explore how glucose metabolism remodels the TIME and how these metabolic alterations influence immune effector function and immune evasion. We also highlight the potential for integrating microenvironmental modulation as a promising therapeutic strategy in glucose-targeted cancer therapies.
http://dlvr.it/TPZJVp
4 months ago
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Auguries of adaptivity: LES γδ TCR ligand recognition revisited
#immunology
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Auguries of adaptivity: LES γδ TCR ligand recognition revisited
Identification of antigenic ligands for the γδ T cell receptor (TCR) has remained a highly challenging goal since the emergence in the 1980s of γδ T cells as a distinct immune compartment. In a significant advance more than 12 years ago, endothelial protein C receptor (EPCR), a cell-surface-expressed major histocompatibility complex (MHC)-like protein that binds phospholipids, was identified as the first ligand for a human γδ TCR to be validated by direct binding experiments: a finding that undoubtedly posed more questions than it answered. In this review we discuss how features of this single clonotypic specificity anticipated insights into adaptive-like human γδ T cell biology that emerged in subsequent investigations, and we highlight recent findings about EPCR that point towards the relevance of such responses in anti-pathogen and potentially anti-tumour immunity.
http://dlvr.it/TPYdKn
4 months ago
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Get with the program: regulation of T cell death
#immunology
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Get with the program: regulation of T cell death
Programmed cell death (PCD) encompasses several tightly regulated molecular signalling pathways, leading to the controlled destruction of cells. Apoptosis is a non-immunogenic form of cell death that regulates homeostasis to cell stressors. In contrast, lytic forms of cell death â necroptosis, pyroptosis, and ferroptosis â promote inflammation, alerting the immune system to danger. As adaptive immune responders, T cells clonally expand in response to antigenic stimulation and rapidly contract following the clearance of infection. While the role of apoptosis in regulating these processes is relatively well understood, evidence for lytic death activity in T cells is emerging. This review provides an update on recent advances in the understanding of PCD pathways in conventional and unconventional T cells in diverse immune contexts.
http://dlvr.it/TPSGz4
4 months ago
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Cell intrinsic versus cell extrinsic control of plasma cell longevity
#immunology
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Cell intrinsic versus cell extrinsic control of plasma cell longevity
The maintenance of serum antibodies requires the persistence of plasma cells within the bone marrow (BM). However, little is understood about why relatively few BM plasma cells live for extended periods. We consider two opposing viewpoints. We first consider the notion that sustained antibody titers requires localization of plasma cells to specialized BM niches where they access cell extrinsic survival factors, including extracellular ATP (eATP). We then consider the alternative possibility that plasma cell survival requires optimized cell intrinsic control of antibody synthesis supported by eATP stimulation of purinergic receptors. Based on the latter view we propose that many BM plasma cells fail to achieve maximal longevity due to suboptimal protein homeostasis rather than compromised access to cell extrinsic survival cues.
http://dlvr.it/TPRc23
4 months ago
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reposted by
Trends in Immunology
Hannah Garner
4 months ago
Excited to share this highlight of a beautiful study into how myeloperoxidase acts as a chromatin transformer
add a skeleton here at some point
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7
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reposted by
Trends in Immunology
Iannacone Lab
4 months ago
New review out in
@cp-trendsimmuno.bsky.social
! With
@valentinavenzin.bsky.social
, we revisit IL-27 as a central regulator of CD8âş T cell fate â integrating insights from infection, cancer, and autoimmunity, and outlining its therapeutic potential.
www.sciencedirect.com/science/arti...
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Reframing IL-27: a central regulator of CD8+ T cell immunity
Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies reâŚ
https://www.sciencedirect.com/science/article/pii/S1471490625002698
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Beyond the innate immune system: rethinking inflammasomes in multiple sclerosis
#immunology
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Beyond the innate immune system: rethinking inflammasomes in multiple sclerosis
Inflammasomes have emerged as central regulators of (auto)immune pathology, including multiple sclerosis (MS). Once exclusively considered in the domain of myeloid cells, both canonical and noncanonical inflammasomes are now recognized in diverse immune and nonimmune populations relevant to MS, including T lymphocytes, bloodâbrain barrier (BBB) endothelial cells (EnC), and oligodendrocytes (ODCs). Elevated inflammasome activity is evident in patient-derived samples, particularly within active brain lesions. Experimental autoimmune encephalomyelitis (EAE) models confirm the pathogenic contribution of inflammasomes, as genetic deletion or pharmacological inhibition of inflammasomes mitigate disease. These advances position inflammasomes at the intersection of neuroinflammation and neurodegeneration, and highlight inflammasome inhibition as a promising therapeutic avenue currently under investigation in preclinical and early clinical studies.
http://dlvr.it/TPMYDW
4 months ago
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Reframing IL-27: a central regulator of CD8+ T cell immunity
#immunology
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Reframing IL-27: a central regulator of CD8+ T cell immunity
Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies revealed that IL-27 also directly modulates CD8+ T cells, displaying both stimulatory and inhibitory potential. Recent work extends this earlier literature, showing that IL-27 in infection and cancer can promote effector differentiation, sustain survival, and reverse dysfunction, often without the systemic toxicity associated with related cytokines. This review outlines the molecular features, signaling mechanisms, and cellular sources of IL-27, integrating emerging evidence from viral, tumor, and autoimmune settings. We propose that IL-27 operates not as an inherently pro- or anti-inflammatory cytokine but as a context-dependent tuner of CD8+ T cell cytotoxic immunity, offering new opportunities for therapeutic exploitation.
http://dlvr.it/TPMYCj
4 months ago
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Interleukin-22: the hub bridging gut homeostasis and metabolism
#immunology
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Interleukin-22: the hub bridging gut homeostasis and metabolism
IL-22, produced by various cell types including T helper (Th) 17 cells and group 3 innate lymphoid cells (ILC3s), plays a pivotal role in gut homeostasis by acting on non-hematopoietic cells. It promotes epithelial barrier integrity, tissue repair, and antimicrobial defense. Beyond its established function in mucosal immunity, emerging evidence reveals IL-22âs involvement in regulating intestinal metabolism and protecting against systemic metabolic dysregulation. This review highlights recent advances in preclinical mouse models and human clinical data in IL-22 biology, focusing on its dual role in immune defense and metabolic control. Given the strong link between inflammatory bowel disease (IBD) and metabolic disorders, we further discuss IL-22âs therapeutic potential in mitigating both intestinal inflammation and related metabolic complications.
http://dlvr.it/TPMPKL
4 months ago
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Regulation of intestinal injury via dietary cysteine
#immunology
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Regulation of intestinal injury via dietary cysteine
Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8ιβ+ T cells that secrete IL-22. This epithelialâimmune crosstalk potentiates ISC repair after injury, highlighting a metabolismâimmune axis linking cysteine sensing to tissue regeneration.
http://dlvr.it/TPLKd0
4 months ago
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Myeloperoxidase transforms chromatin into an immune weapon
#immunology
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Myeloperoxidase transforms chromatin into an immune weapon
Burn et al. reveal a previously unrecognised, non-catalytic function of myeloperoxidase (MPO) in neutrophil extracellular trap (NET) formation; integrating super-resolution microscopy and biochemical approaches, they demonstrated that MPOâs oligomeric state governs chromatin decondensation, redefining MPO as a structural chromatin modifier with implications for diseases driven by dysregulated NETosis.
http://dlvr.it/TPJNfg
4 months ago
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Early life determinants of skin-resident T cells
#immunology
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Early life determinants of skin-resident T cells
Recent research has shown that sequential colonization of the skin by various subsets of immune cells, particularly T cells, during perinatal stages forms layered surveillance networks crucial for maintaining skin tissue integrity and function. Here, we review our current understanding of key epigenetic and molecular mechanisms, along with maternal/external environmental factors, that regulate the sequential colonization of skin by different T cell subsets and their roles in establishing and maintaining skin tissue homeostasis. We propose that establishment of a skin-resident T cell system is developmentally programmed in coordination with maturation of skin structural barriers to adapt to environmental changes during perinatal stages, while dysregulation during this critical âwindow of opportunityâ could have lifelong impacts on the health of both the skin and body.
http://dlvr.it/TPFrnB
4 months ago
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Our November issue is online! Check it out đhttps://www.cell.com/issue/S1471-4906(24)X0012-5
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Current issue: Trends in Immunology
https://www.cell.com/issue/S1471-4906(24)X0012-5
4 months ago
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reposted by
Trends in Immunology
Ivan Zanoni
4 months ago
#ToPrimeOrNotToPrime
, this is the question! Excited for our new review
@cp-trendsimmuno.bsky.social
with
@oceanedufies.bsky.social
in which we discuss what is âprimingâ for the
#NLRP3
#inflammasome
& how we can harness this knowledge to better control human diseases!
#InflammasomePower
!
#Free
đđđ
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ScienceDirect.com | Science, health and medical journals, full text articles and books.
https://authors.elsevier.com/sd/article/S1471-4906(25)00252-2
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Are you working on research that challenges the classical function of the immune system? Submit an abstract to @CellSymposia #CSImmuneHomeostasis26 and be considered for a poster or short talk at the meeting in Shanghai, China, May 11â13, 2026
http://dlvr.it/TPFG1G
4 months ago
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Post-translational modifications of NLRP3: to prime or not to prime?
#immunology
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Post-translational modifications of NLRP3: to prime or not to prime?
The NLRP3 inflammasome plays a central role in host defense against microbial infections but also contributes to inflammatory diseases. Functioning of NLRP3 strictly relies on two signals: a âpriming signalâ that licenses NLRP3 activity and an âactivation signalâ that triggers inflammasome assembly and downstream caspase-1 activation. The priming signal involves transcriptional upregulation of NLRP3 and diverse post-translational modifications that regulate its stability, subcellular localization, and proteinâprotein interactions. This multilayered regulation prevents untimely inflammasome activation while enabling its rapid assembly when both priming and activation signals are present. Here, we focus on the complexity of the priming signal and critically analyze and discuss how diverse post-translational modifications cooperate to prime NLRP3, controlling its activity in health and disease.
http://dlvr.it/TPBMl3
4 months ago
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