I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

📣 Job opening in our lab! We're looking for a technician with experience in murine models. More details about the job description here 👇 www.linkedin.com/jobs/view/4353643662/

Bronnec, @cinflammasome.bsky.social et al. @ciri-lyon.bsky.social developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#ThatIsTheQuestion Post-translational modifications of NLRP3: to prime or not to prime? Thrilled to have had the opportunity to write this review with @lozanzi.bsky.social 🤩! We discuss how PTMs coordinate during priming to control NLRP3 stability, location & partners. tinyurl.com/35dy5rcc

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

💡Our webinars are back! Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET. Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London). 🔗 Register here: tinyurl.com/2feve67c

#InterferonPower Immensely honored and excited to share our new review on all things Interferons out now in @cp-cell.bsky.social. Grateful to the brilliant & inspiring @lozanzi.bsky.social for the chance to contribute! Check it out! authors.elsevier.com/c/1leKGL7PXu...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more. Kudos to Joon Choi for his exceptional work. royalsocietypublishing.org/doi/10.1098/...

‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project www.embopress.org/doi/full/10....

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

Are you interested in #immunometabolism but not sure where to start? Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now. shop.elsevier.com/books/metabo... (1/n)

Thrilled that our latest paper showing that DCs undergo either pyroptosis or apoptosis upon bacterial blockade of host translation to restrict Legionella is now online at the @asm.org journal mBio! Congrats to 1st author @vvazquez.bsky.social & co-authors! 🎉 journals.asm.org/doi/10.1128/...

NINJ1 regulates plasma membrane fragility under mechanical strain @nature.com www.nature.com/articles/s41...

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in @natcomms.nature.com: nature.com/articles/s41... See 🧵👇 1/9

Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out! www.biorxiv.org/content/10.1...

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

One of the coolest studies of last year would not be funded by the current NIH policy. By studying people undergoing gender affirming testosterone treatment, they discovered how sex hormones shape the #immune response, with important consequences for everyone! www.nature.com/articles/s41...

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

🚀 Call for Applications 🌍🔬 L'Oréal Germany, the German UNESCO Commission, and the Humboldt Network are awarding €25,000 to outstanding early-career female scientists in STEM and natural sciences. 📅 Apply by: 10 March 2025 More info: www.forwomeninscience.com/challenge/sh...

Proud to share our lab’s latest work on innate Immunity, led by Orane Visvikis Incredible work by @juangarciasanchez.bsky.social, with key contributions from Estelle Bonnet, Céline Loubatier and the whole team @univcotedazur.bsky.social @C3M @Inserm www.cell.com/iscience/ful...

#NoTimeToDie! Lien, @fitzgeraldkate.bsky.social &co show @pnas.org that Raver1 controls the splicing of RIPK1, impacting caspase-8 activation, gasdermin D & E cleavage, IL1 & IL18 production & pyroptic cell death in the context of Yersinia infection in vivo! #ScienceSavesLives

Excited to share our latest preprint! We find that DCs undergo heterogeneous cell death- either pyroptosis or apoptosis upon bacterial blockade of host translation- to restrict Legionella infection. Congrats to my PhD student @vvazquez.bsky.social & co-authors! Check out his bluetorial 🧵 below! 👇

Portimine A #toxin causes #SkinInflammation through ZAKα-dependent #NLRP1 inflammasome activation By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues 🗞️https://doi.org/10.1038/s44321-025-00197-4

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants www.nature.com/articles/s41... @natimmunol.bsky.social @sethlucianmasters.bsky.social

“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av

#JoinUs! Today 4pm, Modell Center, I’ll be giving the @harvardmed.bsky.social @harvard.edu #Immunology seminar, tons of unpublished data, all about how we sense & respond to microbial & host-derived inflammatory signals during infections & sterile inflammatory diseases!

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful...

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab! www.nature.com/articles/s41...

Return to Europe Marie Curie fellowship....if you want to come back to the old continent while it's still not fascist, think about it. If you want to study gut immunity, interferons, metabolism...let's talk about it 😀🧪 #interferosky marie-sklodowska-curie-actions.ec.europa.eu/actions/post...

If you want to see our work presented directly from the primary source, @julienmambu.bsky.social will be giving a free webinar on Feb 6th at 5 PM CET as part of the Thursday seminar series of the French Society of Immunology #SFI sign up here: zoom.us/webinar/regi...

We are recruiting one postdoc and one PhD student to join our lab on #Drosophila #innate immunity in Lausanne (Switzerland). More info: www.epfl.ch/labs/lemaitr...

So excited to have our new paper out now! Pyroptotic EVs “transplant” gasdermin pores from dying cells onto bystander cells, propagating pyroptosis and inflammation. t.co/XgU6jt15aF 1/3 #innate_immunity #immunoSky #celldeath #ExtracellularVesicles @uconnresearch.bsky.social

#NoTimeToDie! @inflammasomelab, Holley, Monteleone &co show @natimmunol.bsky.social that cells that die by #pyroptosis, or #necroptosis, are crowned with F-actin filopodia that makes them visible by dendritic cells via CLEC9A to initiate adaptive immunity! www.nature.com/articles/s41...

#Bittersweet! Today we say goodbye to Tomi Kostevc, an amazingly talented international PhD student in the lab that did an amazing work on #DendriticCell biology (#FirstLove!)! Physically back to @ChariteBerlin @CharitePhdnet, but we will keep doing more cool #science together 😎!!

Thrilled to share our latest collaborative study with @brodskyigorlab.bsky.social showing that TLR priming licenses murine NAIP/NLRC4 inflammasome activation by immunoevasive bacterial ligands! Congrats to postdocs James Grayczyk, Luying Liu, former grad student @marisaegan.bsky.social & co-authors!

Hi everyone! New to Bluesky, but happy to share the final chapter of my PhD @uconnhealth.bsky.social out today in Nature Immunology! Here, we uncovered a noncanonical function of the glucose transporter GLUT4 in regulating RLR signaling in muscle and adipocytes www.nature.com/articles/s41...

Our 1st paper post (skeet?) on 🦋: So excited and thankful to have this out! www.pnas.org/doi/abs/10.1.... This study was spearheaded by a fantastic former postdoc - James Grayczyk w/ much help from the talented Luying Liu who helped get it through the revision process and over the finish line

📢 Postdoc opening! 📢 @soreklab.bsky.social and we are looking for outstanding candidates for a position at the intersection of computational biology & innate immunity. Dive into impactful research in two dynamic fields. Interested? Let’s connect! 👇 www.genzentrum.uni-muenchen.de/career/postd...

With the deluge of new friends - if you are or know someone who is a looking for a position as computational scientist (any level) in #pancreaticcancer, #macrophages #spatialbiology #singlecell... we might have something for you. Will also consider wet lab ppl, send email if interested. pls repost!