“The entire National Science Foundation budget is less than what we spent in the first week of the war with Iran. The National Institutes of Health,… accounts for a fraction of 1 percent of all federal spending” www.nytimes.com/2026/06/20/o...

New NIH Request for Information regarding capping the number of Research Project Grants allowed per investigator. grants.nih.gov/grants/guide... Open for comments until August 3rd, 2026

A 14-protein plasma signature identifies individuals benefiting from anti-IL-1β-based lung cancer risk reduction @cellcellpress.bsky.social @charlesswanton.bsky.social @clareweeden.bsky.social @wehi-research.bsky.social www.cell.com/cell/fulltex... @crick.ac.uk

Interested in autoinflammatory diseases? Read our review on Variants of Uncertain Significance (VUS) in @natrevrheum.nature.com with @alessandracarbone.bsky.social, Guilaine Boursier & Sinisa Savic. How to decode VUS through genetic, in silico, functional approaches and clinic! rdcu.be/fkOJM

A glycan-based adjuvant expands the breadth and duration of protection of mRNA-based vaccines www.nature.com/articles/s41... @lozanzi.bsky.social @harvardmed.bsky.social @natimmunol.nature.com

#InterferonPower #InflammasomePower! Thrilled for our 💥#NewPaper💥 @natimmunol.nature.com spearheaded by Kautilya Jena showing that our #fungal adjuvant #Mannadjuvant prolongs & potentiates protection of mRNA vaccines via #IL1b & #IFNs, broadening it to new variants & overcoming antigenic imprinting!

I'm so delighted to share that I have been awarded a K99/R00 from NIH/NIAID to study the priming and activation mechanisms of NLRP3 against inflammatory diseases 🥳 !! This would never have been possible without the amazing mentoring and support from Ivan @lozanzi.bsky.social !!

#EveryCellIsAnImmuneCell! 💥#NewPaperAlert💥 Excited to share our latest review with @agharrison.bsky.social about molecular, cellular & #spatial control of the immune response regulated by #stromal, #innate, & #adaptive immune cells in the lymph node! Free link👉 www.sciencedirect.com/science/arti...

Please check out our latest publication where we find that caspase-3, which mediates what is thought to be an immunologically silent form of cell death is important for protecting against bacterial infections. Congrats to the whole team for making this possible. journals.plos.org/plospathogen...

I will start my own research group at @ipblncsic.bsky.social, and I am already available to support fellowship applications!! A dream come true thanks to my mentors' continuous support: J-M Ruysschaert, @ppelegrin.bsky.social, Kate @inflammasomelab.bsky.social, @clarebryant.bsky.social Thank you!

I’m stoked to share my postdoc work with @sunnyshinlab.bsky.social, a collaborative effort with @metabailism.bsky.social & Brian Goldspiel, aided by many valued collaborators: Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly. Some big takeaways:

📣 Job opening in our lab! We're looking for a technician with experience in murine models. More details about the job description here 👇 www.linkedin.com/jobs/view/4353643662/

Bronnec, @cinflammasome.bsky.social et al. @ciri-lyon.bsky.social developed SpeckSeq to evaluate the pathogenicity of 228 MEFV variants. SpeckSeq leads to a revised classification of MEFV variants, new diagnoses, & novel insights on pyrin structure–function relationship. rupress.org/jem/article/...

November is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....

www.nature.com/articles/s41... Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy

#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#ThatIsTheQuestion Post-translational modifications of NLRP3: to prime or not to prime? Thrilled to have had the opportunity to write this review with @lozanzi.bsky.social 🤩! We discuss how PTMs coordinate during priming to control NLRP3 stability, location & partners. tinyurl.com/35dy5rcc

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

#EveryCellIsAnImmuneCell! Luchetti @rauchlab.bksy.social Dixit &co show @nature.com that enteropathogenic bacteria evolved a virulence factor that degrades non-canonical #inflammasome & targets ROCKs necessary for luminal extrusion of infected intestinal #epithelial cells, favoring bacterial growth!

#InflammaZoom free Webinar is back on Monday October 20th! With James Murphy (WEHI, Melbourne, Australia) @pseudokinase.bsky.social and Jonathan Maelfait (VIB-UGent, Ghent, Belgium) Register now: bit.ly/4iXGqjw

💡Our webinars are back! Don’t miss our session on macrophage metabolism this September 18th at 1:00 PM CET. Stoyan Ivanov (Research Director; C3M, Nice) and Malvina Seradj (Postdoc; Institute of Cancer Research, London). 🔗 Register here: tinyurl.com/2feve67c

#InterferonPower Immensely honored and excited to share our new review on all things Interferons out now in @cp-cell.bsky.social. Grateful to the brilliant & inspiring @lozanzi.bsky.social for the chance to contribute! Check it out! authors.elsevier.com/c/1leKGL7PXu...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more. Kudos to Joon Choi for his exceptional work. royalsocietypublishing.org/doi/10.1098/...

‼️ Congratulations to @malvinapiz.bsky.social on her cool work published today @embopress.org on Cardiolipin inhibiting Casp4 non-canonical inflammasome signaling outputs 👻 a lot of fun to work with Malvina and Mercedes @inflammasomelab.bsky.social on this project www.embopress.org/doi/full/10....

#EpigeneticPower! 💥 #NewPaperAlert! We show @cp-immunity.bsky.social that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2 & blocking #IL10!

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

Are you interested in #immunometabolism but not sure where to start? Introducing our new book “Metabolites as Signals in Immunity and Inflammation”, co-edited with Zbigniew Zasłona and @lukeanthonyoneill.bsky.social (@tcddublin.bsky.social), available now. shop.elsevier.com/books/metabo... (1/n)

Thrilled that our latest paper showing that DCs undergo either pyroptosis or apoptosis upon bacterial blockade of host translation to restrict Legionella is now online at the @asm.org journal mBio! Congrats to 1st author @vvazquez.bsky.social & co-authors! 🎉 journals.asm.org/doi/10.1128/...

NINJ1 regulates plasma membrane fragility under mechanical strain @nature.com www.nature.com/articles/s41...

Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...

Ever wondered where NLRP3 needs to be in the cell to activate the #inflammasome? Turns out, it does not really matter. Check out our latest study in @natcomms.nature.com: nature.com/articles/s41... See 🧵👇 1/9

Great work by the @inflammasomelab.bsky.social @s-burgener.bsky.social and colleagues showing in vivo the importance of caspase-1 inactivation in controlling inflammation! Impressive amount of work behind it, glad to see this out! www.biorxiv.org/content/10.1...

The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells. www.science.org/doi/10.1126/...

One of the coolest studies of last year would not be funded by the current NIH policy. By studying people undergoing gender affirming testosterone treatment, they discovered how sex hormones shape the #immune response, with important consequences for everyone! www.nature.com/articles/s41...

Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA. Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...

🚀 Call for Applications 🌍🔬 L'Oréal Germany, the German UNESCO Commission, and the Humboldt Network are awarding €25,000 to outstanding early-career female scientists in STEM and natural sciences. 📅 Apply by: 10 March 2025 More info: www.forwomeninscience.com/challenge/sh...

Proud to share our lab’s latest work on innate Immunity, led by Orane Visvikis Incredible work by @juangarciasanchez.bsky.social, with key contributions from Estelle Bonnet, Céline Loubatier and the whole team @univcotedazur.bsky.social @C3M @Inserm www.cell.com/iscience/ful...

#NoTimeToDie! Lien, @fitzgeraldkate.bsky.social &co show @pnas.org that Raver1 controls the splicing of RIPK1, impacting caspase-8 activation, gasdermin D & E cleavage, IL1 & IL18 production & pyroptic cell death in the context of Yersinia infection in vivo! #ScienceSavesLives

Excited to share our latest preprint! We find that DCs undergo heterogeneous cell death- either pyroptosis or apoptosis upon bacterial blockade of host translation- to restrict Legionella infection. Congrats to my PhD student @vvazquez.bsky.social & co-authors! Check out his bluetorial 🧵 below! 👇

Portimine A #toxin causes #SkinInflammation through ZAKα-dependent #NLRP1 inflammasome activation By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues 🗞️https://doi.org/10.1038/s44321-025-00197-4

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants www.nature.com/articles/s41... @natimmunol.bsky.social @sethlucianmasters.bsky.social

“...to care is an act not of weakness, but of strength.” The Lancet response: bit.ly/4jRb5Av

#JoinUs! Today 4pm, Modell Center, I’ll be giving the @harvardmed.bsky.social @harvard.edu #Immunology seminar, tons of unpublished data, all about how we sense & respond to microbial & host-derived inflammatory signals during infections & sterile inflammatory diseases!

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful...

Our paper out @Nature: CARD domains mediate anti-phage defense in bacterial gasdermin systems CARDs are essential for caspase recruitment during human inflammasome activation. We now find them in bacterial immune systems Congrats Tana Wein! Thank you Kranzusch lab! www.nature.com/articles/s41...

Return to Europe Marie Curie fellowship....if you want to come back to the old continent while it's still not fascist, think about it. If you want to study gut immunity, interferons, metabolism...let's talk about it 😀🧪 #interferosky marie-sklodowska-curie-actions.ec.europa.eu/actions/post...

If you want to see our work presented directly from the primary source, @julienmambu.bsky.social will be giving a free webinar on Feb 6th at 5 PM CET as part of the Thursday seminar series of the French Society of Immunology #SFI sign up here: zoom.us/webinar/regi...

We are recruiting one postdoc and one PhD student to join our lab on #Drosophila #innate immunity in Lausanne (Switzerland). More info: www.epfl.ch/labs/lemaitr...