#WeekendRead! #MicrobiotaPower! Wang, Lin &co reveal @immunity-cp.bsky.social that a #GutSkinAxis that drives skin inflammation in psoriatic prone mice & patients caused by indole-producing gut bugs that increase host I3S driving AHR-dependent skin Th17 activation! www.cell.com/immunity/abs...

Original report on the regulators of TLR4 endocytosis and its importance in TRIF-IFN signaling. @lozanzi.bsky.social @harvardmed.bsky.social @harvardmicro.bsky.social www.cell.com/fulltext/S00...

This work derives from prior studies on the structure-function relationship between Bacteroides LPS and TLR4 endocytosis and signaling. www.sciencedirect.com/science/arti...

Fascinating discussion about cell death by several leaders in the field. If we get to understand cell death better, can we #LiveForever 😉?!👇👉 doi.org/10.1038/s41594-025-01646-x

Thank you @jem.org for the invite to participate in this Viewpoint alongside such inspiring scientists 🤩🤩

So happy to see the final version of our paper out today @jclinical-invest.bsky.social 🤗

How diet influences atherosclerosis in obesity… @aweinstock.bsky.social & team show short-term caloric restriction resolves atherosclerosis inflammation in obese mice, but weight regain accelerates its adverse effects: buff.ly/ieqwQ3O

An amazing resource written by the great Ivan Zanoni and Daniel Boehmer! 👏🏻

#InterferonPower! Li, Park &co show @cp-immunity.bsky.social that IL-15 negatively regulates CD103 expression on CD8 T cells allowing formation of effector T cells & that engagement of CD103 on CD8 T cells by E-cadherin+ dendritic cells is necessary to drive memory formation via type I IFNs & IL-12

#WeekendRead #InterferonPower! Hegde, @miriammerad.bsky.social &co show @nature.com that #tumor-derived factors drive NRF2 activation in bone marrow myeloid progenitors, dampening IFN-I/-III responses & favoring emergence of immunosuppressive monocyte-derived macrophages!

Pleased to update this - The paper is published in Cell Reports! A long road for this one, the paper grew exponentially and evolved over a couple of years. Thanks to @makris1.bsky.social for sticking with it to untangle all the new data! @cp-cellreports.bsky.social www.cell.com/cell-reports...

💥 #ImmunometabolismPower! Excited to have this officially out @cp-immunity.bsky.social 💥 We show that pathogens induce the host to produce oxidized lipids which rewire the #metabolism of #macrophages, causing #epigenetic modifications which dampen anti-inflammatory IL-10, exacerbating #inflammation!

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

#WeekendRead! #LiveForever! Gonzalez-Hurtado, Leveau, Dixit &co show @nataging.nature.com that adipose tissue macrophages #ATMs are central drivers of #inflammaging & loss of a sub population of nerve-associated ATMs in aging disrupts fat homeostasis impairing lipolysis!

#NoTimeToDie! Matthias Nahrendorf, Nina Kumowski &co show @science.org that after myocardial infraction, #neutrophils release antimicrobial resistin RELMg which forms pores in cardiomyocytes causing cell death & driving arrhythmias! www.science.org/doi/10.1126/...

If you've been looking for a big, juicy, up-to-date review on interferons, incorporating the latest understanding about how IFN-lambda fits into the picture... well, here it is!👇 (Thanks to @lozanzi.bsky.social and @danielboehmer.bsky.social for writing it!)

#MycobiotaPower! Exciting work @nature.com by Behnsen, Jaswal &co showing that #Salmonella uses type 3 secretion system to hijack #Candida_albicans to produce arginine in the gut, boosting Salmonella infectivity & reducing the immune response! www.nature.com/articles/s41...

Finally officially out in the latest issue of @cp-cell.bsky.social as a #free #featured #LeadingEdge paper: everything you wanted to know about #InterferonPower! ❤️ @danielboehmer.bsky.social @bostonchildrens.bsky.social @harvardmed.bsky.social www.cell.com/cell/fulltex...

Thanks Cytokine society for this interview in the Member Spotlight. Great honor to be featured here :) signals.cytokinesociety.org/2025/08/30/m...

#WeekendRead! #ImmunometabolismPower! Kunkemoeller @hannahprendeville.bsky.social @lydialynch.bsky.social &co show @natmetabolism.nature.com that not all fats are equal & that animal, & not plant, fats drive immune suppressive metabolites dampening NK & T cell anti #tumor responses!

#WeekendRead #NoTimeToDie! Pasparakis, Kaya &co show @cp-immunity.bluesky.social that ER stress sensor XBP1 potentiates #mucus production by intestinal globet cells preventing microbiota translocation & protecting against exacerbation of #colitis driven by intestinal epithelial cell necroptosis!

4 days left to submit late-breaking abstracts! #Cytokines2025

Data supports concept that pattern recognition receptors primarily sense the mistakes pathogens make, due to infidelities in their infectious cycle. The pathogens that are successful are immunologically silent. Original concept described here: www.science.org/doi/10.1126/...

#WeekendRead! #EveryCellIsAnImmuneCell! Artis @jazib.bsky.social &co show @natimmunol.nature.com that enteric neurons produce the neuropeptide ADM2 which acts directly on ILC2s limiting intestinal damage/#IBDs via amphiregulin production! www.nature.com/articles/s41...

Hot off the press!

Wonderful review on the biology of interferons by @lozanzi.bsky.social! www.cell.com/cell/fulltex...

Review @cellcellpress.bsky.social @danielboehmer.bsky.social @lozanzi.bsky.social Interferons in health and disease www.cell.com/cell/fulltex...

A must read for anyone interested in interferons, and beyond.

And a Review on interferons in health and disease www.cell.com/cell/fulltex...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

During this time we also published a paper "Exposure to bacterial PAMPs before RSV infection exacerbates innate in... www.sciencedirect.com/science/arti.... @mucosalimmunol.bsky.social. Well done to Amber Owen on getting the first paper from her PhD published.

Very excited that we are looking for a new lab member. If you are interested in viral immunology have a look at this job advert. You will work in 2 labs, ours and @prof-tregoning.bsky.social at @imperialnhli.bsky.social @imperialinfect.bsky.social

#WeekendRead! #MomIsAlwaysMom! Koch, Shenoy et al show @science.org that, in the first 7 days of life, breast milk IgGs (not IgAs!) recognize microbiota & limit, via Fc receptors, Tfh cell and B cell intestinal expansion, protecting against #colitis & #allergy during weaning!

Latest by us! An mRNA-based broad-spectrum antiviral inspired by ISG15 deficiency protects against viral infections in vitro and in vivo | Science Translational Medicine www.science.org/doi/10.1126/...

Seattle, here we come! 🌲 Cytokines 2025 (Nov 2-5) is THE place to be for cytokine researchers. 500+ scientists, cutting-edge science, amazing networking. @cytokinesociety.bsky.social: Registration closes Oct 10 - don't wait! seattle.cytokinesociety.org #Cytokines2025 #CytokineScience

Come join us in Seattle! seattle.cytokinesociety.org

#WeekendRead! #WeAreWhatWeEat, #MicrobiotaPower! Takeuchi, Ohno &co show @cp-cellmetabolism.bsky.social that acetylated cellulose reduces body weight gain in lean & obese mice by favoring utilization of simple sugars by the microbiota, forcing hepatic fatty acid utilization! dlvr.it/TMKzHY

#WeekendRead! #MicrobiotaPower! Deshmukh Stevens &co show @cp-cell.bsky.social that antibiotics in infant mice & humans decreases gut microbiota-driven inosine dampening anti-influenza A virus CD8 T cell effector functions & Trm formation in the lung via altered epigenetic reprogramming #GutLungAxis

#GlycoPower! @vijayrathinam.bsky.social @raflynn5.bsky.social @vinnieviruses.bsky.social &co show @nature.com that N-glycosylation of host small-RNAs present at cell surface prevents immune recognition by TLR3 and TLR7 upon apoptotic cells uptake avoiding autoinflammation!

#ImmunometabolismPower! Bombardieri, Mauro, Certo &co show @natmetabolism.nature.com that #lactate drives the formation of ectopic lymphoid structures which sustain #autoimmunity/ rheumatic disease activating T/B cells & that targeting lactate uptake is protective! www.nature.com/articles/s42...

#WeekendRead! #LiveForever & #MicrobiotaPower! Mittelbrun &co show @ Science Immunology that mitochondria alteration in T cells drives premature #inflammaging by decreasing Tfh & Treg cells which causes gut permeability & dysbiosis that can be corrected by T cell transfer! doi.org/10.1126/scii...

Very happy to share our favorite model for immune response initiation! @jclinical-invest.bsky.social @reisesousalab.bsky.social @lozanzi.bsky.social @caixaresearch.bsky.social @danieljdrucker.bsky.social @cp-immunity.bsky.social @cyrilpedia.bsky.social www.jci.org/articles/vie...

Delighted that our paper describing cDC1 states and their distribution in mouse tumours is out today in @eurjimmunol.bsky.social. Many congratulations to Cécile Piot who led this work and brought it to conclusion! onlinelibrary.wiley.com/doi/10.1002/...

#MustRead! @jkagan1.bsky.social & Joon Choi take a deep dive into the biology of host-derived oxidized lipids in health & disease!! 👇👇👇

Attending #Cytokines2025? Are you a grad student or an early career postdoc? Don't miss the opportunity to apply to the @jem.org Early Career Travel Award! More here👉 hubs.la/Q03yQFLq0

Such an honor and a pleasure to give a lecture at the Advanced Immunology course @aai.org! Tons of smart questions, and looking forward to meeting with participants in a couple of hours to chat more! #LoveScience #LoveInnateImmunity #InflammationPower

This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥 www.nature.com/articles/s42...

#WeekendRead! #EveryCellIsAnImmuneCell! #TollPower! Kaelberer Bohorquez &co show @nature.com that #TLR5 signaling in response to flagellin drives neuropeptide PYY release by gut colonic neuropod cells, activating vagal neurons that signal to #brain, reducing feeding via a “neurobiotic sense”!

MyD88 cell biology explored in yeast. The fantastic @VictorJCid and colleagues reveal an unexpected variety of organelles MyD88 can bind in budding yeast. Kudos to all authors on this exciting finding. link.springer.com/article/10.1...

🚨It’s out @embojournal.org 🚨 Cardiolipin inhibits Caspase-4/11! Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.