Spiros Makris
@makris1.bsky.social
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Postdoc @actonlab @LMCB_UCL @UCL |Stromal Immunology|
Our latest paper is finally out! We are showing the significance of the podoplanin/CLEC-2 signaling axis beyond controlling cellular mechanics and actomyosin contractility.
#fibroblasts
#podoplanin
#stroma
#inflammation
@actonlab.bsky.social
www.cell.com/cell-reports...
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Lymph node fibroblast phenotypes and immune crosstalk regulated by podoplanin activity
Makris et al. show that podoplanin regulates the transcription profile of lymph node fibroblasts. Podoplanin deletion drives inflammation, disrupts lymph node architecture, and attenuates stromal/immu...
https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00679-5
3 months ago
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reposted by
Spiros Makris
Seth Coffelt
8 months ago
#hiring
#postdoc
We are looking for a postdoc to work on anti-tumor gamma delta T cells in breast cancer metastasis mouse models. Apply here:
www.gla.ac.uk/explore/jobs...
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University of Glasgow - Explore - Jobs at Glasgow - Appointments - Research Associate (Breast Cancer Now) [164192]Search iconClose menu iconMenu icon bar 1Menu icon bar 2Menu icon bar 3
https://www.gla.ac.uk/explore/jobs/appointments/164192/
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Spiros Makris
Nature Reviews Immunology
8 months ago
NEW
@preprintclub.bsky.social
Journal Club of
@biorxiv-immuno.bsky.social
paper by
@makris1.bsky.social
@actonlab.bsky.social
showing that loss of podoplanin in fibroblastic reticular cells results in decreased antibody levels and smaller germinal centres after immunization
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Podoplanin mediates stromal–immune crosstalk in the lymph node - Nature Reviews Immunology
A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.
https://www.nature.com/articles/s41577-025-01140-x?utm_source=bluesky&utm_medium=social&utm_campaign=nri
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reposted by
Spiros Makris
Madelon de Jong
10 months ago
Share and help fill this one up! Suggestions via comments or DM!
#stroma
#fibroblast
#MSC
go.bsky.app/KPJMU4
add a skeleton here at some point
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reposted by
Spiros Makris
Sophie Acton
10 months ago
Our latest preprint! - led by
@makris1.bsky.social
we find that Podoplanin expression in lymphoid tissue fibroblasts regulated their inflammatory signalling and crosstalk with immune cell populations
doi.org/10.1101/2022...
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