#ToPrimeOrNotToPrime, this is the question! Excited for our new review @cp-trendsimmuno.bsky.social with @oceanedufies.bsky.social in which we discuss what is “priming” for the #NLRP3 #inflammasome & how we can harness this knowledge to better control human diseases! #InflammasomePower! #Free 👇👇👇

#Nature #NewsFeature 7 basic science discoveries that changed the world. Ozempic, MRI machines and flat screen televisions all emerged out of fundamental research decades earlier. www.nature.com/articles/d41... cc @lluismontoliu.bsky.social

#InflammasomePower! 💥New paper alert💥 How is NLPR3 primed & activated in chronic non-communicable inflammatory diseases? With @oceanedufies.bsky.social &co we show that chronic exposure to oxPAPC drives NRF2 activation that primes & activates NLRP3 sustaining #atherosclerosis in mice & humans! 👇👇👇

#SpookyInflammasome 🎃 With @lozanzi.bsky.social &co, we show that sustained NRF2 activation by endogenous oxidized phospholipids primes and activates the NLRP3 inflammasome 🔥 to drive atherosclerosis. ... more to come on the priming !

Thank you to our editor, Kirsty Minton, and the staff at NRI for the opportunity to share our thoughts on this emerging topic.

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

Looking for passionate candidate to apply to PhD fellowship to University of Murcia call: www.um.es/documents/d/... Interested students contact me!

Cheng, Qiu et al @jhu.edu provide new insights into the molecular mechanism of #phagosome maturation and the dynamics of host defense response following phagosome-mediated bacterial degradation in peritoneal #macrophages. rupress.org/jem/article/... #InnateImmunity #inflammation #InfectiousDisease

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

#NLRP3 is a target for antiinflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @colllab.bsky.social et al characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. rupress.org/jem/article/... #Inflammasome

Review @natimmunol.nature.com The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets www.nature.com/articles/s41...

#InterferonPower! Thrilled for our latest work @cp-cell.bsky.social! With @danielboehmer.bsky.social, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free👉 authors.elsevier.com/a/1leKGL7PXu...

🚨It’s out @embojournal.org 🚨 Cardiolipin inhibits Caspase-4/11! Huge thanks to my brilliant supervisors Kate & Pablo, to @s-burgener.bsky.social & Mercedes and all the @inflammasomelab.bsky.social, it was a joy working and laughing with you, and to @brozlab.bsky.social & Si Ming lab.

Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Bluetorial (1/13)👇with movies! Link: rdcu.be/d2mjm