Interested in autoinflammatory diseases? Read our review on Variants of Uncertain Significance (VUS) in @natrevrheum.nature.com with @alessandracarbone.bsky.social, Guilaine Boursier & Sinisa Savic. How to decode VUS through genetic, in silico, functional approaches and clinic! rdcu.be/fkOJM

The Trojan Horse is real, and it’s microscopic! 🐴🦠 Our paper is out today in @cellcellpress.bsky.social! We discovered that deltaviruses physically hide INSIDE helper viruses to sneak into new cells. And to prove it, we had to image them from every angle. 🧵👇 www.sciencedirect.com/science/arti...

Université Grenoble Alpes has opened a full professorship in microbiology. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. For more information 👉🏻 liphy.univ-grenoble-alpes.fr/sites/defaul...

Ground-breaking studies reveal the mechanism of "natural CRISPRa" 🤩 Looking forward to seeing all the technological applications !

🎉 We are thrilled to share our latest study revealing a new mechanism by which Legionella pneumophila evades antibiotic killing via reversible genetic variation mediated by integrative and conjugative elements (ICEs). 📖 Here for the full story: www.biorxiv.org/content/10.6...

PAPER ALERT! I am excited to share that our study describing the molecular mechanism of caspase-4 activation has just been published in Immunity. www.cell.com/immunity/ful... I would like to thank all the co-authors for their valuable contributions. Well done guys! Link for short summary below👇

IRF2 regulates both GSDMD expression and NK cells antibacterial functions. Check the latest paper from the lab @ciri-lyon.bsky.social published in @emboreports.org. IRF2 as a key immune regulator against our favorite bug, #Francisella tularensis! #inflammasome link.springer.com/article/10.1...

Rhinoviruses cause common cold & asthma attacks but are also often benign. Using nasal organoids, we learned how the community of cells in the lining the nasal passages coordinates to respond to rhinovirus and which responses lead to excess mucus & inflammation. www.cell.com/cell-press-b...

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET

📢 Recruitment of an Associate Professor (Maître de conférences) in Bacteriology at CIRI and ENS de Lyon. Research at @ciri-lyon.bsky.social @francoisrousset.bsky.social @labxc.bsky.social Anti-phage Immunity, Horizontal gene/ MGE transfer 📚 Teaching at ENS de Lyon within the Department of Biology.

I'm humbled to receive the Paoletti Prize awarded by @cnrsbiologie.bsky.social 😌 and very grateful to present and past mentors !

"Don’t mourn his loss—be grateful that you knew him". Bacteriologist at Pasteur then at INEM, Alain Charbit spent most of his career working on Intracellular bacteria and notably Francisella tularensis to decipher the role of its metabolism in virulence. He was a colleague and a friend.

🌟 New preprint alert! 🌟 We’re excited to share the latest work from @francoisleulier.bsky.social lab, now on bioRxiv!

An ERC Consolidator Grant for Lucie ETIENNE @lucievirevolte.bsky.social, Researcher PI at the CIRI (@cnrs-rhoneauvergne.bsky.social, @ensdelyon.bsky.social, @insermaura.bsky.social, UCBL, @hospicescivilslyon.bsky.social , UJM-Saint Etienne)! CONGRATULATIONS!!🎉👏 www.insb.cnrs.fr/fr/personne/...

Join our online BoltzGen presentation and Q&A on Wed. Dec. 17th at noon ET! A few new results, many new insights, and lots of good discussion, I am sure! Paper: www.biorxiv.org/content/10.1... Presentation sign up + Zoom: luma.com/b24bd37m

Here is the latest paper of the lab @ciri-lyon.bsky.social on the pyrin #inflammasome, the MEFV gene variants and the associated autoinflammatory diseases, Familial Mediteranean fever (FMF) and PAAND.

International Call: recruitment of an Early-Career Team Leader in Virology at CIRI! For further information: ciri.ens-lyon.fr/nous-rejoind...

Our latest work from @brozlab.bsky.social and led by @alexandraboegli.bsky.social is out now in @embojournal.org. Check out our findings on how the intestinal #inflammasome NLRP6 senses lysosomal damage to trigger pyroptotic cell death.

So excited that this study is now online! It's been a pleasure to work with BioAge Labs and our collaborators on this story. We characterise a new class of #NLRP3 inhibitors with translational potential for so many inflammatory diseases.

Paper(s) alert from our RESOLUTE project – In a compilation of four papers in @molsystbiol.org we show how we were deciphering cellular logistics and present a comprehensive systematic blueprint of chemical transport pathways with #SoluteCarrier transporters

We are excited to have our new paper out: Tethering of the pathogen sensor caspase-4 to the endomembrane damage sensor galectin-8 poises the host to rapidly detect pathogens that breach the endolysosomal network. www.cell.com/cell-reports... #innate_immunity #inflammasome #celldeath #immunoSky 1/2

#LocationLocationLocation! #NewVirusSensingModality! Lahaye, @manellab.bsky.social &co show @cp-cell.bsky.social that nuclear cGAS senses viruses by recognizing centromeric DNA amplification caused by viral effectors that degrade centromere proteins! www.cell.com/cell/abstrac...

Review: Spaan, Boisson, and @sethlucianmasters.bsky.social review the known primary disorders of the polyubiquitination pathways in humans that lead to #autoinflammation and/or #immunodeficiency rupress.org/jem/article/...

🔥 Open postdoc position in human inflammation-driven control of infection! 🔥 Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! (1/5) Please share!

Another link between RHO GTPases and inflammasomes. RAC2 GoF variants activate the NLRP3 inflammasome, Congrats to the Boyer group @lauboye.bsky.social! bsky.app/profile/jem....

Many phages encode "sponge" proteins that catch immune signaling molecules to block bacterial immunity. Two preprints report a defense system plugged the other way around: the signaling molecule constitutively inhibits the effector, so that sponges trigger effector activity 🤯 what a wild mechanism!

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Portimine A #toxin causes #SkinInflammation through ZAKα-dependent #NLRP1 inflammasome activation By P. Brehmer, F. Roca, F. Zhong, J. Common, @etienne-meunier.bsky.social, P. Hess & colleagues 🗞️https://doi.org/10.1038/s44321-025-00197-4

A large dataset we hope is helpful for patients who may have CAPS, an #autoinflammatory condition associated with genetic variants in NLRP3. Lots of "variants of uncertain significance" now have a specific readout from our in vitro assay which can help with clinical diagnosis. rdcu.be/d9iRG