This one feels special: our latest work on subtelomeric heterochromatin is now on www.biorxiv.org/content/10.1.... This story was driven by the virtuoso PhD work of Agnisrota Mazumder @agnisrota.bsky.social, co-mentored with @al-sadylab.bsky.social, and grew out of our #MSCA Cell2Cell network.

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

I am excited to announce that we are looking for a Lab Manager @fmiscience.bsky.social in Basel. If you want to be part of a growing team investigating development and tissue formation, and are enthusiastic about helping set up a new lab, please check out the role: www.fmi.ch/education-ca...

We are hiring-join us!

Massive congratulations to @canaztekin.bsky.social for being awarded an ERC Starting Grant @erc.europa.eu ! 🎉 His "Signal to Regeneration" (SigReg) project will explore the potential of limb regeneration in mammals. Read more and watch Can introduce his project: s.gwdg.de/cLAmJE

What a special moment!🙌🙌🙌

Excited and very grateful to announce that I have been awarded an ERC Starting Grant by @erc.europa.eu! 🎉 This is a fantastic opportunity to further build my team at the Max Planck Institute of Immunobiology and Epigenetics (@mpi-ie.bsky.social) exploring new grounds in fundamental research:

🥳 Thrilled to share that our lab has been awarded an ERC StGrant for our project SigReg: Signal to Regeneration! How can we unlock limb regeneration in adult mammals? It’s time to apply what we learned from 🐸 ➡️ 🐭 Thank you @erc.europa.eu for supporting ambitious science!!!

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Last week, we bid farewell to our Summer student Jean.🍹👋 It was great having you in the lab and we wish you all the best finishing your studies!🍀 See you soon!🥳

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...

Director at Max Planck - a unique position! The Open Call for Expressions of Interest in Max Planck Directorships is open now and can be submitted by the 31st of October 2025. ➡️ mpg.de/directors - Please share the Open Call among potential candidates.

To all post-docs: The Genome Biology dept ‪@embl.org has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

STUDY: Denmark tracked over a million children for 21 years, and found vaccines linked to zero extra cases of autism, asthma, or 48 other conditions. Vaccines are safe, effective, and the best way to eradicate preventable disease. Period.

We found a new asymmetry in the large-scale chromosome structure: sister chromatids are systematically shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! The work was led by Flavia Corsi, in close collaboration with the Daniel Gerlich lab. www.biorxiv.org/content/10.1... 1/

Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5

All about the 2026 ERC grant application and evaluation process! ✍️ Are you new to ERC grants? Then join us for a live webinar on 10 July at 15:00 CEST, tailored for researchers who are just starting out in their attempt to get an ERC grant. Watch 👉 europa.eu/!3rGdWB

📖 Happy to share our recent preprint! www.biorxiv.org/content/10.1... We discovered how SINEs are kept silent: the ChAHP protein complex acts as a molecular brake on POL III transcription retrotransposons. A 🧵:

If you are interested in working on chromatin and oogenesis in the mouse in beautiful Copenhagen, we are recruiting a postdoc! jobportal.ku.dk/videnskabeli... Please share!

also anyone with an apt/house for rent in #freiburg, 4+ rooms, preferably Herdern, Güterbahnhof, Wiehre, ANY time, ANY price, SEND IT MY WAY

📣 I will take up a Professorship at @uni-freiburg.de, Faculty of Biology. With amazing funding news coming in, we'll be in a position to establish a major research program around Epigenetics, Signaling and Synthetic Biology at the Signalhaus @cibss.bsky.social. More news and job ads to come soon!

🚨 Only a few more days to REGISTER for the TriRhena Gene Regulation Club in Freiburg. Whether you are new or an established researcher in the Basel-Freiburg-Strasbourg region, this is your meeting when working in transcription, chromatin & gene regulation! ✍️ www.ie-freiburg.mpg.de/gene-regulat...

📣 We are recruiting new group leaders in Innovative Biology! RNA biology Epigenetic regulation Cell cycle regulation Cancer, immunology Virology Application and information ⬇️ application.igmm.cnrs.fr @cnrsbiologie.bsky.social @cnrsoccitanieest.bsky.social @umontpellier.bsky.social

We are thrilled to have just found out: CIBSS has secured continued funding under the #ExcellenceStrategy! This major boost will enable us to accelerate our research into biological signalling and lay the groundwork for next-generation insights from 2026 to 2032!

Calling all #LifeSciences #PhDs and #PostDocs worldwide, ready to join us in #Freiburg: The Freiburg Rising Stars Academy is #Now accepting applications for the 2025-2026 cohort. Apply for a #ResearchStay in a #CIBSS lab and collaborate with one of our host PIs! Please share 🔄 kurzlinks.de/87z5

Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF

Cell cycle duration determines oncogenic transformation capacity Tumours usually originate from a specific cell type in a given tissue; cell types that have faster cycles are more likely to become cancerous 🧪 www.nature.com/articles/s41...

Join us!!!

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

It has been bittersweet last week, when we bid farewell to Pedro and Prasanthi who are embarking on a new adventure!🥹 Thanks a lot for all the hard work and high spirit!🙏

IMBA is recruiting a Junior Group Leader! Are you interested in starting your own lab, pursuing curiosity-driven basic research in the life sciences? Apply now to our group leader position. The deadline is May 28. Link is below.

We are seeking a new colleague to join us at the Vienna BioCenter, specifically at my beloved home institution, IMBA @imbavienna.bsky.social we value collegiality and a passion for curiosity driven science. Being a great and fun human being also helps!

Don't miss this exciting conference dedicated to the study of gene expression regulation, one molecule at a time! Technologies ranging from (epi)genomics, (epi)transcriptomics, to functional (epi)genetics and imaging! @stirlingchurchman.bsky.social @laghalab.bsky.social @arnaudkr.bsky.social

📢 Job Alert! The Faculty of #Biology of the @uni-freiburg.de is seeking for a researcher with a competitive, internationally visible profile in #ChemicalBiology focusing on #BiologicalSignallingResearch. Join us and apply by 28 February, 25! More info: uni-freiburg.de/stellenangeb...

Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters www.science.org/doi/10.1126/...

✨ Excited to share my latest preprint on how H3K4 methylation promotes transcriptional memory from gametes to embryos across a transcriptionally silent window — crucial for proper zygotic genome activation and development. 🐸🧬✨ 📄 Check it out here:
doi.org/10.1101/2025... 👇 Highlights below

Big congrats and welcome to Freiburg!🤗 Exciting times ahead!🤩

Happy holidays from the very first @flurylab.bsky.social christmas dinner! We had lots of fun and even more cheese😅

We are looking for new group leaders. If RNA is your thing, and/or computational biology and you want to start your own group, check out these links. Feel free to contact me about these! And, please help me spread this. Thanks! www.imb.de/jobs/jobdeta... www.imb.de/jobs/jobdeta...

… and by Jumana AlHaj Abed & Valentin Flury (@flurylab.bsky.social), both MPI group leaders as well as @jamiehackett.bsky.social and Joyce Man (Heard lab) from @embl.org … 14/X

Many other super lab members not (yet) on Bluesky! So finally, two postdocs that just moved on... @denbobalab.bsky.social has established his group at MPI on #microbiome-germline axis. @mdura.bsky.social has just preprinted on #intergenerational-inheritance and is on the market! Check them out!

Fascinating talk on chromatin replication by @flurylab.bsky.social of @mpi-ie.bsky.social today. Thanks for organizing @cibss.bsky.social @biologyunifreiburg.bsky.social!

Please join this starter pack for everyone working from chromatin replication to epigenetic inheritance and cell fate! Now still small, but we hope to gather everyone interested in joining. Please message us to be added, go.bsky.app/ALFFRUN

My first post on Blue Sky - moving over ! For all post-docs out there - fantastic opportunity @EMBL. Independent group leader position: Core funding, state-of-the-art core facilities, access to fantastic Ph.D. students, and of course amazing colleagues. Please apply www.embl.org/jobs/positio...

We are establishing an open access infrastructure for optical pooled screening and looking for a computational scientist to join us for this great adventure. Come to Copenhagen and be part of a great scientific community: candidate.hr-manager.net/ApplicationI...

The latest from our group, led by Megan Ostrowski and @martyyang.bsky.social, is now published in final form (www.cell.com/cell/fulltex...! Many thanks to our excellent peer reviewers for suggesting several experiments (including CAF-1 perturbation) to really improve the study =) #epigenetics

Polycomb restores H2A ubiquitin By read-write action #ChromatinHaiku #ncPRC1-RYBP www.nature.com/articles/s41...

Please see our paper in Nature on read-write mechanisms of H2AK119 ubiquitination by Polycomb repressive complex I. Congrats to the whole team, especially Victoria and huge thanks to our collaborator JP Armache! Also big thanks to Mark Foundation for Cancer Research for the support! rdcu.be/dZ5HZ

The peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉 And don’t miss the chromatin haiku! www.cell.com/molecular-ce...