Today we swapped pipettes for putters. Day 2 retreat highlight: realizing that hitting the fairway is way harder than hitting a replication fork 😅

Off to Nord Sjælland with the Miller lab @tcr-miller.bsky.social for our joint retreat! Exciting brainstorming, bonding, and a little hygge ahead. First challenge: design your next @natureportfolio.nature.com article 🚀

What makes #cshldnarep special isn’t just the cutting-edge, top-notch science; it’s the chance to meet the authors of the papers we build on every day, exchange ideas, and feel part of this community. Heading home exhausted, grateful, full of ideas and renewed motivation to push my project forward!

Our PhD student @martaolivasantiago.bsky.social and postdoc @amitash.bsky.social presented their posters on #cshldnarep, turning data into an insightful dialogue. Huge thanks to everyone who stopped by our poster!

This week we’re at CSHL #cshldnarep where the DNA replication & genome maintenance community has gathered for a week of science, discussions, and late-night brainstorming.

Sometimes DNA replication hits a 🛑 roadblock. Cells don’t stop; they take clever detours (DNA damage tolerance) 🚗💨 to keep genomes intact. That’s the focus of our new review in @cp-trendsbiochem.bsky.social: “Just bypass it: mechanisms of DNA damage tolerance” 🔗 doi.org/10.1016/j.ti...

New cool research alert! Tita Sixma #RepliFate lab uncovered the preferred exo-cleavage mechanism by which USP1/UAF1 can cleave ubiquitin chains on polyubiquitinated PCNA and temporarily enrich for monoubiquitinated PCNA. Read the full study: doi.org/10.1038/s414...

It is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...

Just published! Lecona (@emlecona.bsky.social ) & Méndez #RepliFate labs show that VCP/p97 removes Pol α/primase from chromatin to avoid excess ATR activation during normal #DNAreplication VCP/p97 = checkpoint gatekeeper! Read the full study: doi.org/10.1038/s414...

🎉 Congratulations to SUND's new professors! The Faculty of Health and Medical Sciences, @ucph.bsky.social celebrated 23 newly appointed professors. Through their dedicated work, they contribute every day to the development of the university, the healthcare system, and society at large.

🌿 Off to Hillerød for the 2025 MoMeD Summer School! Our PI Julien Duxin -as head of the MoMeD PhD Programme at @ucph.bsky.social- joins our PhD students and many others for 2 packed days of science, networking, and inspiration. Looking forward to connecting and exchanging ideas across fields!

Frogs in the lab? Yep! 🐸 This week, RepliFate PhD students are diving into the Xenopus egg extract system at the @duxinlab.bsky.social (@bric-ucph.bsky.social, @ucph.bsky.social) -where test tubes meet frog magic to unravel the mysteries of DNA replication and genome integrity.

Our lab’s a little more crowded (and a lot more curious) this week! 🧠🐸 We’re thrilled to welcome @RepliFate students for a hands-on course in Xenopus egg extracts. They're diving into the Xenopus world and learning how this powerful system helps us explore DNA replication and genome stability.

🎯 A tenure-track group leader position in translational cancer research is now open at Finsen Laboratory. Come join an excellent and friendly research environment combining both the Rigshospitalet and the KU @ucph.bsky.social affiliated groups candidate.hr-manager.net/ApplicationI...

Chromosome Biology Club is back today! Join us for two exciting talks: 🧬 Christian Nielsen (CCS/ICMM) on the distinct roles of condensins I & II in mitotic chromosome mechanics 🧬 Judit Pilmark (BRIC) on mutational signatures linked to NER deficiency Starting at 4.45 pm Followed by pizzas and beer

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ @natcomms.nature.com BRCT domain in recruitment and activity of two Pol X members in NHEJ: a unified model for the interaction of Pol X with Ku70/80. www.nature.com/articles/s41...

The FEBS | EMBO Women in Science Award aims to highlight the major contributions made by female scientists to #LifeSciences research. Winners of the award are inspiring role models for future generations of #WomenInScience Nominate a scientist by 15 May: www.embo.org/the-embo-com... 🧪

New preprint from the lab @kaelamakins.bsky.social Genetic interactions between 53BP1-RIF1 and DNA-PKcs for DSB repair outcomes. www.biorxiv.org/content/10.1...

Our study highlights RNA as a direct template for DNA repair, revealing RT-DSBR as a previously unrecognized and potentially mutagenic pathway. Huge thanks to the incredible team who made this work possible! (5/5) 🔗 www.nature.com/articles/s41... #GenomeInstability #DNARepair #RNA #CRISPR #DSB

Today we celebrated #EuropeDay2025 showing the work we do at the RepliFate Doctoral Network in the public library Eugenio Trías @cbm-csic-uam.bsky.social @genomefun.bsky.social

🧬 New research discovers sequential phosphorylation of MRE11 by ATM and ATR prevents extensive DNA degradation at stalled replication forks www.pnas.org/doi/abs/10.1...

🌍 #ClimateActionDay is here! For the first time, the University of Copenhagen @ucph.bsky.social is joining forces to take real steps toward a greener future At BRIC @bric-ucph.bsky.social, we’re putting words into action! Small changes can make a big impact 🌱 #GreenLabs #SustainableScience

this week 20 years ago, Nature published two seminal papers showing for the first time that BRCA-mutant cells were selectively sensitive to PARP inhibitors, paving the way for clinical trials and approval of PARP inhibitors for patients with BRCA-mutant ovarian and breast cancers, and beyond.

A must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com

We had the pleasure of hosting Prof. Andrew Jackson from the University of Edinburgh, who gave a brilliant and thought-provoking talk on how single-gene mutations can lead to microcephaly—bridging genome integrity and stem cell biology. Looking forward to potential synergies between our labs!

#WomenInScience KU @ucph.bsky.social is marking 150 years since women were first allowed to study at the university! Nielsine Nielsen was Denmark’s first female doctor, marking a major milestone in the path toward gender equality. The full program of events and celebrations here: kvinder150.ku.dk

📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP

It’s time for new duo: Julius Thomas & his PI Lorenza Penengo from the University of Zurich. They study the ISG15 system in DNA replication—but there’s more! One could be found scaling alpine peaks, while the other might just trade the lab for the thrill of mushroom hunting. Curious to know more? 🍄

🚨#CBC is happening today! Don’t forget—our next Chromosome Biology Club is today at 16:45 at the Biocenter! Three great speakers and exciting science await, followed by beer and pizza. See you there!

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability. doi.org/10.1093/nar/...

Thrilled to share our lab's first preprint, led by an exceptional PhD student Gita Chhetri and with the support of wonderful collaborators, we find that replisome function is rate-limited by strand-specific PCNA dynamics. Hope you will enjoy reading. www.biorxiv.org/content/10.1... Brief teaser:

Pre-print alert from @hopfnerlab.bsky.social! Great job! Read more about it here: www.biorxiv.org/content/10.1... #DNArepair #SFB1361

📅 Our next Chromosome Biology Club is next week! Join us on March 25th at the Biocenter for exciting talks from: ◉ Johanna Kliche (Nilsson group, @nilssonlab.bsky.social) ◉ Oline Pade Jensen (Lisby group) ◉ Luke Greenhough (Steve West group, @xrnchew.bsky.social) Mark your calendars! #CBC

📅 The Evil Within: Regulation and Repair of Endogenous DNA Damage conference is coming to @imbmainz.bsky.social, Germany on March 10–13, 2026. Registration opens late summer 2025! Follow @sfb1361.bsky.social for updates. #ISC26DNArepair #DNARepair #DNADamage

We’re kicking off our RepliFate introductions with @Phuc and her PI, @sylvie-noordermeer.bsky.social ! As part of the RepliFate network, they are contributing to exciting research in double-strand break (DSB) repair. Wanna know more about their work, hobbies, and fun facts? Check out their profiles!

We'll be hosting Peter Martin (Niedzwiedz Lab, ICR London) tomorrow to discuss his recently baked preprint: "The mitotic CIP2A-TOPBP1 axis facilitates mitotic pathway choice between MiDAS and MMEJ" (buff.ly/4hYnS2u). Thanks for accepting our invitation, we're looking forward to this JC!

This week we had the pleasure of hosting Pei-Ying Lin in our lab as part of the @replifate.bsky.social Artists in Residency program. Together with Pei, we explored how scientific discovery can fuel creativity and new perspectives #SciArt 🧠🧶🎨

Tomorrow is the last day to submit your application for the INTERACT PhD Programme! Apply now: https://buff.ly/4hj1bGh

Xpandomer is a nice searchable word. 🧪 🧬

Exciting news! The INTERACT PhD Programme is now accepting the first round of applications until February 20, 2025. 🎯 Cutting-edge research, interdisciplinary collaboration, and fully funded fellowships. Interested? Learn more & apply ➡️ https://buff.ly/4hj1bGh

Dead line is approaching. Have a look on the prg.

Our PhD student Stella @stellamk.bsky.social presented her project on ‘Replication-Coupled Resolution of Formaldehyde-Induced Histone Crosslinks’ yesterday at the #GRS prior to the #GRC on Mammalian DNA Repair. Huge thanks to everyone for the great questions and discussions afterward at her poster!

🌟 The 2024 Nobel Prize in Chemistry was awarded to AlphaFold, an AI tool transforming protein research 🧬 Australian researchers can access it for free via GalaxyAustralia. Dive into protein research and drive innovation! 💡🔬 #NCRISimpact bioplatforms.com/news/alphafo...

We had our first BRIC Day! 🚀 A fantastic poster session where we explored the diverse research projects at @bric-ucph.bsky.social and discovered what drives our colleagues to come to the lab every day. Science thrives on curiosity, collaboration, and shared passion—this event was all about that!

Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td

On Monday we had a first joint lab meeting with Thomas Miller team @tcr-miller.bsky.social 💡As Helen Keller said, 'alone we can do so little; together we can do so much.' Here’s to fostering open communication and impactful collaborations across projects!

Mark your calendar: the next Egmond DNA repair meeting will take place in 2026 from April 19 - 24! You can pre-register to receive announcement here: forms.lumc.nl/lumc2/Egmond Registration will open by June 2025/

New discovery from our #CDlab reported in Cell @cp-cell.bsky.social today: SMC motor proteins have a left-right ‘gearbox’ and can switch direction in DNA loop extrusion! www.sciencedirect.com/science/arti... 1/

Are you: - Scientifically curious and determined to pursue a PhD degree? - Eager to work on interdisciplinary research projects related to cancer or neurological diseases? - Driven to strengthen your scientific creativity and independent thinking? www.linkedin.com/feed/update/...