What a great first day at the GfG symposium on epigenetics & chromatin. Fantastic talks by @akispapantonis.bsky.social , @apombo1.bsky.social, @marcusbuschbeck.bsky.social and Philipp Korber. And Peter Becker giving the Max-Delbrueck lecture. A real treat for the audience!

Looking forward to exciting talks at the GfG Symposium in Gießen. Already found a poster, featuring my favourite gene: SMARCAD1, by Jacqueline Mermoud #epigenomics @diagenode.bsky.social @gfgenetik.bsky.social

Please re-post: Interested in chromatin and its evolution? Good news! There's still time to join us in beautiful Catalonia (9-12 Dec) to discuss eukaryotic, bacterial, archaeal, and viral chromatin and how it all hangs together meetings.embo.org/event/24-evo... Abstract deadline: 30 September

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

Useful data set: www.nature.com/articles/s41...

What makes genes burst www.cell.com/trends/cell-...

out today: my labmate Shubham developed a super clever new technique to profile TF-DNA interactions with unprecedented resolution of low-affinity binding sites, revealing patterns in how these sites are organized in the genome to modulate TF occupancy: www.nature.com/articles/s41...

In a new study, FMI researchers show that two enzymes—KDM2A and KDM2B—act as safeguards in eggs, preventing excessive DNA methylation at gene regions. Without them, abnormal methylation is passed to embryos, repressing genes needed for early development. www.cell.com/developmenta...

Please share! PhD projects available through @gw4biomeddtp.bsky.social Please get in touch if you are interested in studying chromatin biology in stem cell models gw4biomed.ac.uk/architects-o... gw4biomed.ac.uk/risk-vs-prot... gw4biomed.ac.uk/rna-dependen... gw4biomed.ac.uk/investigatin...

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social! register here for the entire series: us06web.zoom.us/webinar/regi...

Please re-post: If you know (or are!) somebody who might fancy doing a PhD (Oct 2026 start) in my group @oxfordbiochemistry.bsky.social, working on chromatin evolution in prokaryotes (or other things we're interested in), please have a look at www.bioch.ox.ac.uk/supervisors-...

Two new druggable targets in ERG-driven prostate cancer - KMT2A and DOT1L www.nature.com/articles/s41...

Every so often, a paper lands at exactly the right moment. This one’s a gem. Can’t wait to try out this new strategy for delivering CRISPRoff chromatin-editing tools into our favorite cellular model system. Congrats to James K Nuñez and his team: www.nature.com/articles/s41...

One more movie! Using the RL algorithm (from pnas.org/doi/10.1073/...), @masaashimazoe.bsky.social analyzed our nucleosome tracking data and classified them by their mobility. Hotter color = faster motion (Slow🔵→ 🟢 → 🟡 → 🟠 Fast)

If you like transcription regulation and its mechanisms, this WIP list is for you. I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list. go.bsky.app/8vTgeXB

Excited to share our newest results on ZNF512B: It not only regulates chromatin organization, binds NuRD and H2A.Z, and acts as transcriptional repressor (Wunderlich et al., NAR, 2024), it also participates in mitosis and is crucial for stem cell differentiation. www.biorxiv.org/content/10.1...

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10.... @imperiallifesci.bsky.social

Congratulations, Dr. Kalita!!!

Join us!!!!! THE Symposium for all Chromatin and Epigenetics experts and 'lovers' this year!!!

Deadline approaching fast (June 30th, 2025)! Do not miss this fantastic opportunity: prestigious 3.000 € award for best PhD thesis!

It was a privilege to be part of the Allis lab. Dave fostered an environment of rigor, curiosity, and kindness- his impact lives on in the many he mentored. Grateful to reconnect at Rockefeller with this extraordinary group. Thank you to the organizers for an inspiring symposium.

Elisabeth-Gateff Award Alert! Great opportunity for all German PhDs or PhDs, who worked on their thesis in Germany: 3.000 € award for best thesis in the area of genetics/epigenetics/molecular biology! Apply till June 30th, 2025! Please RT!

What a fantastic achievement! @jlugiessen.bsky.social got three excellence clusters! Many congratulations to all organisers! Extremely happy about the continued success of @cpi-exstra.bsky.social. I am overjoyed to be a – small - part of this cluster with its amazing team of researchers!

Join us!!!

As organizer, I can highly recommend this Symposium! Come and join us! Please RT!

#ChromatinDays – Join Us! SFB 1064's final annual meeting! Talks, reunion & BBQ Bash 🍖 on May 26-27. Guest speakers: former SFB & IRTG members. Alumni, don’t miss the BBQ & IRTG Satellite Session! 📢 Register now! Scan the QR code or visit: www.sfb1064.med.uni-muenchen.de/chromatin-da... 🐝 there!

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

Exciting times ahead! We visited the laboratories and offices that we will be moving into at the end of this year after complete renovation (still a lot to do). Thank you @jlugiessen.bsky.social for finding a new home for us!

Marsh family on point, as always but this is epic! #SlavaUkraine youtu.be/pvT3aQjLxdE?...

Ukraine is Europe! We stand by Ukraine. We will step up our support to Ukraine so that they can continue to fight back the agressor. Today, it became clear that the free world needs a new leader. It’s up to us, Europeans, to take this challenge.

Finally! The outstanding review by Felix Diegmüller(@felixdiegmueller.bsky.social) & Jörg Leers is out in JBC! Written for a special issue honoring C. David Allis, it highlights his groundbreaking work on histone variants and recent discoveries in H2A.Z biology! #Epigenetics #Histones #Chromatin

*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer

We are doing our best! Hope the vast majority of Germans has not forgotten our dark past and how everything started… Never again!!! Really scared about what is happening in the USA right now.

#Oncohistone #H3 #Histone #Chromatin #Cancer #BuddingYeast academic.oup.com/nar/article/...

New paper from our lab is out! We investigated the function of the NuRD subunit CHD3 in cranial neural crest specification. CHD3 variants are the cause of Snijder-Block-Campeau Syndrome, which manifests with craniofacial anomalies and intellectual disability 1/n

(6/6) #Epigenetics #StemCells Check out the preprint: www.biorxiv.org/content/10.1...

!THREE OPPORTUNITIES TO JOIN US! We are looking for 3 (!!!) PhD students interested in: How Metabolism affects Genome Regulation. Join us at @carrerasijc.bsky.social as Marie Sklodowska Curie network fellow. More info: 2 x experimental: www.nuclear-dn.eu 1 x computational: www.hubmol.eu

Together with more than 13.000 people, my husband (mirrored in my sun glasses) and I were demonstrating in the city Gießen against right extremism and hate but for inclusion and equality. There is still hope in a crazy world!

In our new paper, we uncover a damaged chromatin marking mechanism that drives the non-random segregation of UV damage through mitosis. Chromatin alterations impinge on genome stability by controlling DNA damage segregation See Ferrand*, Dabin* et al., Nat Commun 2025.

Our latest work: how can compartmentalization emerge in a eukaryotic genome lacking canonical heterochromatin? By investigating bacterial genomes put in yeast, we show that the presence or absence of transcription is sufficient! #chromatin #3Dgenome #generegulation www.science.org/doi/10.1126/... 👇

Incredibly cool paper linking Acetyl-CoA synthesis and HATs in T cells, with differing mechanisms in 'exhausted' T-cells! Another publication showing the link between metabolism and chromatin modifications driving cellular phenotypes www.science.org/doi/10.1126/...

Long-read sequencing just got an upgrade. 📢 Genome, methylome, epigenome & transcriptome in one go—haplotype-resolved & at single-molecule resolution. 🔥

Our story on the mechanism of co-transcriptional histone mark deposition is now officially out: www.science.org/doi/10.1126/...

Super happy to see our latest work on the opposite effects of DOT1L on gene expression published ! #chromatin #DOT1L #sexchromosomes #malegermcells www.nature.com/articles/s42...

When 2 males have a baby that reaches adulthood (mice with extensive genome editng)) www.cell.com/cell-stem-ce...

Our collaboration with the Muir lab revealed that N-terminal histone modifications can 'detoxify' K27M inhibition by altering PRC2-substrate interactions. Acetylation showed the greatest impact, supported by xenograft data from the Monje group. pubs.acs.org/doi/epdf/10....

A mechanism for maintaining and spreading H3K9me3 in heterochromatin from the Fejes Toth and Aravin labs that depends on the local H3K9me3 density: HP1 dimers recruit SetDB1 to chromatin by simultaneously binding H3K9me3 on histone H3 and auto-methylated SetDB1. www.biorxiv.org/content/10.1...

Our group has a new Dr. rer. nat.! 🎉 Tim Wunderlich defended his excellent dissertation on ZNF512B with distinction. This fantastic achievement was afterwards celebrated appropriately with colleagues, friends, examiners and family! Congratulations, Dr. Wunderlich! We are so proud!