A review of my book #OnTheFutureOfSpecies on the conference of #AI and biology, was published in @science.org magazine today

Overton xkcd.com/3230/

The usefulness of useless knowledge timharford.com/2026/04/the-...

Sequence Display generates large-scale protein sequence–activity datasets by simultaneously reading out the sequence of interest and a downstream editing efficiency - perfect for data hungry ML methods! Happy to have played a small part in this!

If you are at @eutermis.bsky.social 2026, come to our symposium to learn more about “Engineering Living Materials: A New Frontier at the Intersection of Biology and Materials Science”. 24 April 12:00–13:30 at Porto PI Room.

blog post - State of the lab 13, part of yearly series, tracking our lab's progress in academia. This year I am mostly reflecting back on our slow adoption of DL methods, FOMO of new technologies and anxiety about the use of AI for research www.evocellnet.com/2026/04/stat...

The study key points: • #Meltelectrofibrillated nanofibrillar bundles mimic muscle topography •Scaffold #nanotopography enhances #ASCs adhesion and alignment •Robust #myotube formation, high expression of #myogenic markers •Microarchitectures for muscle #tissueengineering, adaptable to other tissues

Fantastic teamwork by Milica Mihailovic & Aleksandra Anisimova from the Karagöz lab @gekaragoz.bsky.social @maxperutzlabs.ac.at together with the @plantophagy.bsky.social lab — Another great collaboration 🙌 within our SFB program, published in @embojournal.org 🔗 link.springer.com/article/10.1...

How do you get a charged drug into a cell when charged molecules can't cross the membrane? You don't — you let the cell do the charging. Check our new paper "Charged molecular glue discovery enabled by targeted degron display" in Nature Chemical Biology. ❕Publication: www.nature.com/articles/s41...

What if AI could invent enzymes that nature hasn’t seen? 👩‍🔬🧑‍🔬 Introducing 🪩 DISCO: Diffusion for Sequence-structure CO-design 📝 Blog: disco-design.github.io 📄 Paper: arxiv.org/abs/2604.05181 💻 Code: github.com/DISCO-design...

🚨 Registration is open! 🚨 Join us for "Mitochondria Vol. 3: Mitochondrial Plasticity in Metabolism and Signalling", a free-of-charge international conference organized by the CRC 1218! 🗓 When: 05–07 October 2026 📍 Where: MTI, UzK Cologne, Germany 👉 Register now: mitochondria-volume3.uni-koeln.de

academic.oup.com/genetics/adv... Also thanks to Lyndall & @psarkies.bsky.social, @ahocher.bsky.social, and members of the lab for their comments and Francis Barr @oxfordbiochemistry.bsky.social for encouraging me to write down my thoughts. 2/2

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

Far-red kinase biosensors are applied to image kinase signaling networks at super resolution go.nature.com/3GfqrzL rdcu.be/faNLM

The lab of Johannes Zimmermann at Jena University has an opening for a PhD position - exciting research in a highly innovative group: www.jsmc-phd.de/admission/va...

Check out our latest work out today in @natmetabolism.nature.com in which we describe a new metabotype (metabolic phenotype): excess cysteine stress. We discovered novel cysteine conjugates and show how pyruvate modulates free intracellular cysteine levels. Grateful for an awesome team!!

Out Now! Advancing microbiology through foundational science #MicroSky

We have postdoc openings for data-driven modeling and information flows in living systems, with a focus on embryonic development. mattiaserra.com Requirements: PhD in Physics, Applied Math, or similar; prior exposure to biological data preferred. Please share with potential candidates. Thank you!

In mass spectrometry-based proteomics, peptides can fragment after chromatographic separation and before MS analysis. This phenomenon is called in-source fragmentation (ISF), and the resulting fragment peptides can be misinterpreted as biologically meaningful.

1/25 New paper out in PNAS! We show that the fitness costs of reproductive specialization, where somatic cells give up reproduction, scale inversely with organism size. Larger organisms can afford far more soma, removing a key barrier to multicellular complexity.

We've switched to a tailored implementation of Hypothes.is for commenting on bioRxiv/medRxiv. This alleviates any concerns people had about the Disqus plug-in used before. Great to partner on an open source project that other sites can consider integrating too 1/n openrxiv.org/hypothesis-c...

🚨New @lyssiotislab.bsky.social paper led by @radykm.bsky.social in @NatureMetabolism "NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions" 🧵Follow for a tweetorial... and bonus highlight of Vousden Lab co-published study and News & Views link from Wellen Lab!

Two (or more) PhD student positions are open with me in protein structure evolution (using AI). Please apply/spread the word. su.varbi.com/en/what:job/...

65 years after Peter Mitchell’s chemiosmotic theory, we report an association between ATP synthase and the electron transport chain. In the preprint led by @longzhou88.bsky.social, we describe a large supercomplex and show how the supramolecular organization contribute to oxidative phosphorylation 🧵

Structural principles of transcriptional collisions https://www.biorxiv.org/content/10.64898/2026.04.06.716678v1

Non-canonical histone H3.3 and its chaperones HIRA and DAXX participate in the regulation of KSHV latency https://www.biorxiv.org/content/10.64898/2026.04.02.716100v1

#Throwback 🧪 REVIEW | AMPK at the interface of nutrient sensing, metabolic flux and energy homeostasis MD Fullerton, GR Steinberg et al

🗃️From the archive: "When societal ignorance is rational motivated ignorance, the solution cannot be ordinary forms of knowledge dissemination" #SciComm #AcademicSky #PolSci

MitoAtlas: a Domain-Resolved Spatial Map of the HumanMitochondrial Proteome https://www.biorxiv.org/content/10.64898/2026.04.03.716438v1

Osmotic pressure gradients in E. coli biofilms revealed by in-situ sensors https://www.biorxiv.org/content/10.64898/2026.04.02.716217v1

(Academic) pedigree is a powerful facilitator of your career. I was the only person in my family with a high school degree, and now I know the impact of having educated parents and an academic (and professional) network.

RESEARCH | M Ahmadian, S Reilly et al @UCSDMedSchool, @weillcornell.bsky.social Free fatty acids drive uncoupled respiration in white adipocytes in obese thermoneutral-adapted mice 🧪

“first drafts of Results, Discussion, and Introduction should be the trainee’s own work. AI can help with grammar…tightening prose…critiquing the logic of an argument you’ve already made. But the hard part of forming the argument needs to be yours.’ blekhman.substack.com/p/you-need-t...

Very interesting new preprint from Patrick Murphy's group @pjmurphy249.bsky.social, finding that intergenic Pol II binding before zygotic genome activation is connected to repetitive element transcription. www.researchsquare.com/article/rs-9...

Happy Easter! Don't miss the latest publications on computational and analytical methods for #metabolomics and #lipidomics biomed.news/bims-metlip/... Pre-sorted by @biomednews.bsky.social

Join us this Wednesday to hear about fascinating research from @kashyapchhatbar.bsky.social and @a-radzisheuskaya.bsky.social! If you're not already registered, click here to sign up: us06web.zoom.us/webinar/regi... you can also join the conversation at our discord: discord.com/invite/dXqT89r

New research suggests that natural protein sequences haven’t evolved into as much diversity as what is theoretically possible. #chemsky 🧪

Check out the fantastic perspective by @jellevda.bsky.social & @prudentlab.bsky.social on our #pearling work, out in the same @science.org issue! www.science.org/doi/10.1126/...

Happy Easter!

#Autophagy and #mTOR papers from last week, enjoy with a chocolate egg or two 🐣 biomed.news/bims-auttor/...

Easter edition of #Mitochondria in #Health and #Disease! 🐰🐣 biomed.news/bims-mitdis/... @gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social Perling drives mtDNA nucleoid distribution www.science.org/doi/10.1126/...

Latest issue of curated #engineeredlivingmaterials feed: biomed.news/bims-enlima/... via @biomednews.bsky.social | #livingmaterials #ELMs includes research on: programmable soft matter, de novo-designed protein biomaterials, gradient multinozzle 3D Printing, bioelectronic interfaces, & more 🧪

My Easter books cartoon for @theguardian.com

“An MIT Media Lab study titled “Your Brain on ChatGPT” found that LLM users “consistently underperformed at neural, linguistic, and behavioral levels.” The tech oligarchs have somehow managed to enshittify *thinking*”

National labs generate large local knowledge spillovers, driving regional development by fostering non-lab patenting, wage gains and education compared to counterfactual locations, from Susan Helper, Resem Makan, and Daniel W. Shoag www.nber.org/papers/w35011

🧬 Characterized an unnamed #yeast #gene? 1. Name with 3 letters + number (ex. XYZ1) to reflect function. 2. Reserve your unique name at SGD while preparing manuscript www.yeastgenome.org/reserved_nam... 3. Include both ORF & gene names in your publication! 📝 Help: sites.google.com/view/yeastge...

Happy Yeaster!

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]