🧬🔬🎥 @science.org Live-cell single-molecule dynamics of eukaryotic RNA polymerase machineries | Science www.science.org/doi/10.1126/...

Our company has a new name, Eira Bio (www.eirabio.com) (formerly K2 Therapeutics), but the same important mission to apply our advanced synthetic biology, directed evolution, and protein design technologies to discover and develop next-generation antibody-based medicines for a range of diseases!

This is a beautiful paper examining the molecular genetics of facultative multicellularity in a marine black yeast. I also love that they figure out the ecological context for the behavior (MC form when in sponges, where there are nutrients, & uni when starving!). www.nature.com/articles/s41...

Took us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ? doi.org/10.1093/nar/...

🚨 AIMBE calls on the scientific community to urge Congress to ensure timely passage of the FY2026 budget 👇 Strong, sustained funding for our nation's health and science agencies is essential for economic prosperity, U.S. global competitiveness, and public heath. takeaction.io/aimbe/protec...

Years ago, we set out to develop new synbio technology to solve a major drug discovery challenge: generating precision antibodies for challenging membrane proteins. It's a DREAM COME TRUE to report that we've launched K2 Therapeutics (k2-tx.com) to advance this into transformative medicines!

In today's issue of Cell-->if you are looking for a good distraction from the news (who isn't), check it out! www.cell.com/cell/fulltex...

We traveled to DC to talk to Congressional Staffers about the impact of NIH and NIBIB funding. It enables us to develop synthetic biology tools to advance cell & genetic medicines for patients in need. REPOST to deliver the message that SCIENCE saves lives & makes America GREAT!

7 years old! 🎂🎉🎈Happy birthday to our adventurous twins!

I hailed a Tesla Model 3, according to Uber-equivalent in Cairo, Egypt 😂😂

Excited to share that our work building in vivo biosensors for receptor tyrosine kinases (pYtags!) is now out www.cell.com/cell-reports...

1/n Morocco 🇲🇦 is magical. A few pics from our whirlwind tour through this beautiful country. Enjoy!

So cool, a novel archaeon with a super small genome and no metabolic genes! "An unprecedented level of metabolic dependence on a host, a condition that challenges the functional distinctions between minimal cellular life and viruses." www.biorxiv.org/content/10.1...

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social www.pnas.org/doi/10.1073/...

Furiously logging all the new budget news, laughing grimly that it landed *just after* we hit publish. Of course it did. Grateful that the entire point of @unbreaking.org is to give us a durable platform where we can keep integrating new developments. We'll digest, contextualize & update next week.

I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...

🧬🧫🦠 @science.org Bacterial reverse transcriptase synthesizes long poly-A–rich cDNA for antiphage defense | Science www.science.org/doi/10.1126/... #microbiology #bacteriophage #antiphage #immunity #DNA #RNAsky #RT #Cryo-EM #DRT9

Honored to be the 2025 recipient of the ACS Synthetic Biology Young Innovator Award. Hope to see you in Houston for #SEED2025!

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

I am 💔. We said goodbye to a beloved family member, our sweet dog Eloise. For 16+ years(!), she has been a constant source of joy, comfort, friendship, & humor. She was there for gradschool/postdoc, first jobs, wedding, 4 kids, ... She was my #1 companion. I will miss her dearly 😭. Pics/vids below

Super excited to be launching NimbusImage.com! Cloud-based image analysis to democratize machine learning! Documentation here! docs.nimbusimage.com

In this job, and especially these days, there is little that gives me more joy than watching one of your students crush their PhD defense. Huge congratulations to newly minted Dr. Colin Kunze -- we're all so proud of you!!

@science.org Telomeric transposons are pervasive in linear bacterial genomes | Science www.science.org/doi/10.1126/... @joepeterslab.bsky.social

HUGE congratulations to @kaitong25.bsky.social, @wcratcliff.bsky.social and team on this incredible discovery enabled by one of my favorite experiments — the multicellularity long-term evolution experiment (MuLTEE). Check out Will’s great tutorial below👇 (and v happy to have played a small role)

So we beat on. Gene/cell therapies would benefit many patients, but often use proteins that could be recognized as non-self by our immune system and cause problems. We combine algorithms to build proteins that are therapeutically relevant and can masquerade as our own parts doi.org/10.1101/2025...

The most achingly beautiful explanation of what science is, from @edyong209.bsky.social: “the idea that much of the world is hidden from us, that we don’t perceive it and don’t understand it, and that it is worth understanding and it is necessary to understand.” www.nytimes.com/2025/02/22/m...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

Excited to share James Jusuf's preprint: By integrating Micro-C with SuperRes Live-Imaging we can calibrate genomics&imaging to perform absolute quantification of looping (e.g. this loop is present 3%) We quantify mESC 36k loops: <loops> are generally rare (2.3%) www.biorxiv.org/content/10.1...

Proteases might serve as versatile control knobs for gene and cell therapies, but there looms the risk of immunogenicity as we and others have been using viral proteases. We now report a control system based on a an engineered human protease and its clinically approved inhibitor. rdcu.be/d6kVt

Just out in @natrevgenet.bsky.social, led by @amywebster.bsky.social: Epigenetics and individuality: from concepts to causality across timescales. Access available via the Sharedit Initiative. rdcu.be/d5LYh

Nora finished her paper with a sentence I like a lot "Our results show that even under extremely restrictive, competitive conditions, the simplest biological entities on Earth can still find paths to coexistence." There is a curious dichotomy in her experiments... 1/3 www.science.org/doi/10.1126/...

Holiday time when you’re married to an architect. Let’s go!

Excited to finally share Perceptein, a PERCEPtron made of proTEINs: www.science.org/doi/10.1126/...

For our inaugural @bsky.app post – 2 papers and the cover of Science @science.org!! Dr. Nish Reddy et al. built T cells that suppress inflammation in specific tissues bit.ly/4fX8JxN Dr. Milos Simic, Dr. Payal Watchmaker et al. built T cells that deliver therapies to the brain bit.ly/4g0I5Ej

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

I am ***absurdly*** excited to announce the launch of a new funding opportunity through Experiment dot com!!! You have one month to pitch something wonderful in the realm of plant biology/biotech research and education. $10,000 max grant. PLEASE RE-POST + SHARE!!! 1/3 experiment.com/programs/pla...

New here and excited to share our new paper on transcriptional effectors! Interested to discuss context-specificity of gene regulation? Or how to get CRISPRi/a working in new contexts? 👋 www.nature.com/articles/s41...

New paper from the lab out in Cell Systems. “Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut” www.cell.com/cell-systems...