BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

"Imagine if we can apply the same approach across the entire world and start to map to capture the true diversity of the human immune system so we can build predictive models and figure out interventions." 🔆 Don't miss David Ewing Duncan's new substack: davideduncan.substack.com/p/welcome-to...

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas. This was a collaboration between Julie Cheung and Brian Hunt in the lab Thanks to Cancer Cell for publishing our work. www.cell.com/cancer-cell/...

If the immune system is an army... ... would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest? I’d go with the team. Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...

@biorxivpreprint.bsky.social STAT3 operates as an inflammation-dependent transcriptional switch @josephsunlab.bsky.social @simongrassmann.bsky.social @mskcancercenter.bsky.social www.biorxiv.org/content/10.1...

The Vahedi Lab is seeking a highly motivated Research Specialist A/B to join our dynamic research group studying the mechanisms of immune regulation. Apply here: wd1.myworkdaysite.com/recruiting/u...

Thrilled to have our latest research @wehi-research.bsky.social published in @natimmunol.nature.com www.nature.com/articles/s41... This work was an outstanding partnership between talented PhD student Len Dalit (now postdoc, no 🦋) and bioinformatician @chinweetan.bsky.social Thread below...

One more thing to mention: we are thrilled to be joining the vibrant and growing Systems Immunology community here, led by @tsanglab.bsky.social. There will be much collaborative work with the vision of understanding and rebuilding the immune system from the ground up, so stay tuned!

We have some news to share: The Kueh lab is moving to ‪Yale this fall!‬ We will be joining the Yale Center for Systems and Engineering Immunology ‪@yalecsei.bsky.social‬ and the Department of Immunobiology. medicine.yale.edu/systems-engi...

This week @science.org examines the wonders of the immune system! From molecular defences that co-evolved with pathogens to specialised cells that are intricately linked with physiology, the immune system is attuned to biological sex and different stages of life.

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

EPIGENETIC HULK READY TO SMASH AGAIN! GET IN LOSERS!

Excited to share that our study, on how T cells selectively sense foreign antigens with single-molecule sensitivity, is out! This work was led by the brilliant Will White, and done in collaboration with Jay Groves and David Baker @uwproteindesign.bsky.social www.pnas.org/doi/10.1073/...

First Phase 2 randomized trial of engineered T cells for a solid tumor—GI cancer— with some encouraging results www.thelancet.com/journals/lan... @thelancet.com

🚨 New #preprint alert! We're excited to share our latest work: "Single-Allele Chromatin Tracing Reveals Genomic Clustering of Paralogous Transcription Factors as a Mechanism for Developmental Robustness in T Cells"🔗 tinyurl.com/4ve26tbd

Check out this new study and TCR Tg mouse generated by Endi Santosa @endicytosis.bsky.social. If you are interested in studying classic and inflationary CD8+ T cell memory to MCMV infection, we’re happy to share this mouse, and @laboxenius.bsky.social is extremely generous with her Tg lines as well.

(1/n) New preprint from @claricehongky.bsky.social Fan Fang Varshini Ramanathan in collab w Jie Liu. Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps at ultra-high resolution.

Check out this great resource of single cell multiome data, cell annotations, regulatory DNA models of cell type resolved chromatin accessibility & comprehensive annotation of motifs & sequence syntax for multiple tissues in early human development 1/

1. For the past thirty years I've had the best job in the world. 
I've had the opportunity to follow my curiosity; explore the workings of nature and society; mentor students and junior colleagues in the same process; and teach generations of students about it all.

Delighted to have our Perturb-multiome paper, led by #JorgeMartinRufino and @hemagene.bsky.social from our lab, published today in @science.org. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: www.science.org/doi/10.1126/...

Powerful new Washington Post story up... wapo.st/426d9fT (Gift link) 1/n

It’s the economy stupid- “There is no better investment than one that saves lives, supports local economies and drives America’s global leadership in biomedical innovation” www.forbes.com/sites/michae...

Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis www.nature.com/articles/s41...

I am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social

I'm going to Stand Up for Science 2025 in Seattle. Seattle friends, come join! Fri March 7. Mural Amphitheatre at Seattle Center. 305 Harrison Street, Seattle. 12-3pm PST.

Rubio terminated 5800 USAID contracts – more than 90% of its foreign aid programs – in defiance of the courts. Here’s a list of just some of the lifesaving awards that were terminated. Nearly all were Congressionally mandated. They’ve saved millions of lives. 🧵

This is a powerful (and accurate) speech both about curiosity driven research and about which institutions would be most hurt by a 15% cap on indirect cost rates (smaller academic med centers) and who would benefit (China). 1/2

Important editorial: the "existential moment requiring careful and consistent action to preserve the values and ambitions of science." "The weeks ahead may be the greatest test that the US scientific community has ever faced" By @holdenthorp.bsky.social @science.org www.science.org/doi/full/10....

I have been trying to find the time to move away from the polical hellscape we find ourselves in to finish and share a bluetorial about science. This helps me remember what this is all about. Ironically, it is about the treatment of pain.

NIH-supported research saves lives: here are two "poster" human beings to prove it. Emily Whitehead: cured of her leukemia by CAR-T developed at Penn. Victoria Gray: major symptoms of her sickle cell disease resolved following CRISPR gene editing - path paved at Boston Childrens, UW, UC Berkeley.

More and more scientists are joining the ranks of fired federal workers—and fighting back through protests, appeals, and legal challenges.

I have a NYT essay out this morning. There is very little that Americans can agree on these days. Not religion, not sports, and certainly not politics. But there is one thing nearly everyone agrees on: Vaccines are good. (Gift link) www.nytimes.com/2025/02/16/o...

ATTENTION (PLEASE SHARE) If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread. There are lots of talented and accomplished people who may be looking for new opportunities.

Checking in with sources this morning... The total from NIH was apparently slightly more than 1500 people (out of 5200 HHS Department-wide) 1/n

Speak up!!! Please email & call you Congress Reps today to oppose these cuts to NIH-especially if you are a scientist living in a red state. Here’s where to find them: www.congress.gov/members/find...

It’s been buried in all the news today, but every scientist in the US should pay attention to this: Mike Lauer went out on a limb for us all, sending out a memo saying institutes should start awarding grants. And it looks like Trump/Musk fired him for that. 🧪

I've met with many cabinet nominees across many admins, and my meeting with RFK Jr. was by far the most troubling. He rattled off debunked conspiracy theories & lied to my face—denying his own statements he'd made on record. We cannot confirm an anti-vaxxer as Secretary of Health.

There will be devastating consequences if RFK Jr. is confirmed. Senate Republicans need to show some courage, show some conscience, and say NO to a vaccine denier becoming our highest-ranking health official.

A Direct Hit, by @holdenthorp.bsky.social @science.org www.science.org/doi/full/10.... "This is a moment to unite."

JUST IN: Federal judges orders HHS, CDC, and FDA to restore “by no later than 11:59 pm” today their websites and datasets to pre-January 30th status. storage.courtlistener.com/recap/gov.us...

Just got the dreaded email. University of Iowa is halting all NIH grant submissions. Losing a generation of scientists here will send the state backwards. What a travesty.

The American Bar Association has just called upon every attorney, regardless of their political views, to join them & stand up for the rule of law & at minimum insist that our government "follow the law." Every lawyer has an ethical responsibility to do so. www.americanbar.org/news/abanews...

NIH Updates Good news: It appears that at least of the submitted F31 diversity supplements for which the study section had disappeared from eRA commons are reappearing with the original study section. Still uncertain future, but it's a step. 1/2

JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants. storage.courtlistener.com/recap/gov.us...

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Hero lawyers in state AG offices busted their asses over the weekend to get this done. Now do your part: call your Representative and Senators TODAY. Call your AG AND governor and voice your support for these lawsuits.

BREAKING: 22 states sue NIH over Trump administration's new 15% cap on overhead for federal research grants. Suit filed federal court in Boston contends lifesaving research 'will grind to a halt' under the policy. Doc: storage.courtlistener.com/recap/gov.us...

Made some slides for scientists to talk about what's been happening & what we should do next. There are probably many people better qualified than me to talk about these issues. If that's you, please, please, please consider holding some virtual advocacy training sessions for researchers this week.

Press release by the appropriations subcommittee on NIH budget slashing by @delauro.house.gov 🙏

A useful tool and a great thing to do... 5calls.org/issue/nih-ns...