A new method for the precise insertion of large DNA sequences into the genome using engineered recombinases that don’t require DNA cutting or rely on the cell’s repair machinery. www.nature.com/articles/s41...

Charting somatic cell evolution www.biorxiv.org/content/10.1...

Prime editing can go far beyond single base pair edits producing, for example, 1MB deletions www.biorxiv.org/content/10.1...

Targeting of Cis-regulatory elements to up-regulate haploinsufficient genes www.biorxiv.org/content/10.1...

Visualization of chromatin at base pair resolution www.cell.com/cell/fulltex...

Engineering chloroplasts - an important paper for plant synthetic biology. share.google/W9d423qo1l1A...

I had a long conversation with MIT Tech Review’s @willdouglasheaven.bsky.social about AGI; it fed into this very good read on the rise of AGI orthodoxy

Reimagining nature with protein design www.cell.com/molecular-ce...

New safe harbors for genes www.cell.com/iscience/ful...

An extraordinary result for ipilimumab immunotherapy given as a first line therapy for glioblastoma share.google/485XFZxmBm26...

Discovery of an orthogonal translation system from metagenomic data. www.biorxiv.org/content/10.1...

CodonFM - learning the language of codon usage research.nvidia.com/labs/dbr/ass...

A molecular PC made out of DNA. DNA ‘antijunctions’ flip between states like tiny molecular switches. They can be programmed to make logic gates. One step closer to computers made from DNA. www.science.org/doi/10.1126/...

Another challenging day for gene therapy endpoints.news/biomarin-loo...

Perturbations in virtual cell models www.nature.com/articles/s41...

Multiplex epigenetic editing www.nature.com/articles/s41...

An AI model that doesn’t just predict biology, but helps design the next experiment. www.science.org/doi/10.1126/...

How a viral infection leads to striped tulips www.nature.com/articles/s42...

Baker lab builds a calcium channel entirely from scratch. This should enable cellular behaviors to be altered in entirely new ways. www.nature.com/articles/s41...

Wow! A Denisovan genome www.biorxiv.org/content/10.1...

Microscopic robots inspired by flowers www.nature.com/articles/s41...

Designing regulatory sequences that boost protein production using active learning. www.csbj.org/article/S200...

Molecular machine learning in action in the Stanford-Arc generative antibody design collaboration.

Great new piece by Andrew Hessel bigthink.com/life/the-nex...

Recombinase circuits in a cell-free system. www.cell.com/cell-systems...