A review of AI-designed protein binders www.cell.com/action/showP...

Great new paper from the David Baker lab www.biorxiv.org/content/10.1...

A landmark paper from Brian Hie’s group at the Arc Institute. The de novo design of the synthetic genome of an entirely novel biological entity www.biorxiv.org/content/10.1...

The potential future production of light using plants www.cell.com/matter/abstr...

What’s it like to date a chatbot? Patricia Marx tries out some A.I. relationships.

I’m greatly enjoying the meticulously researched new Crick biography by @matthewcobb.bsky.social published by @profilebooks.bsky.social in November, which I am reviewing for @science.org. It’s set to become the definitive biography of the mercurial, enigmatic and brilliant Francis Crick.

Innervation of SCLC tumors www.nature.com/articles/s41...

Combined single cell DNA-RNA sequencing (SDR-seq) www.nature.com/articles/s41...

Wonderful review on the role of lncRNAs in brain development, function and disease www.nature.com/articles/s41...

The treatment of previously incurable mitochondrial disease using IVF-based mitochondrial donor treatment www.nature.com/articles/s41...

Neomers are short (13 to 17 base pair) segments missing from the genomes of healthy individuals that can be used to diagnose cancer www.nature.com/articles/s43...

Nice paper from the Tom Ellis lab @proftomellis.bsky.social pubs.acs.org/doi/10.1021/...

A scalable DNA computing platform dl.acm.org/doi/pdf/10.1...

One metastatic colon cancer patient who failed immunotherapy with a complete response share.google/X1CqnzyHn8Eg...

The artificial evolution of synthetic yeast strains that are able to incorporate non-natural amino acids more efficiently. The deletion of specific ribosomal protein genes markedly improves the efficiency of the production of proteins containing ncAAs. www.biorxiv.org/content/10.1...

The UK Biobank has released the full genome sequences of 490,640 individuals www.nature.com/articles/s41...

Engineering disease and drought-resistant tomatoes btiscience.org/explore-bti/...

An internal map of species relationships derived using Evo2 www.goodfire.ai/papers/phylo...

A proof of concept for engineered plant-based lighting solutions. www.cell.com/matter/fullt...

Biologically-derived machine learning hardware www.biorxiv.org/content/10.1...

Looking forward to tucking into Matthew Cobb’s meticulously research new biography of Francis Crick @matthewcobb.bsky.social which I am reviewing for @science.org