Anthony A. Hyman will become EMBL’s next Director General. He joins EMBL from @mpi-cbg.de in Dresden. He is also Professor of Molecular Biology @tudresden.bsky.social, and was a group leader at EMBL Heidelberg from 1993 to 1999. www.embl.org/news/people-...

Some hardcore mechanism, for the aficionados (from Peter Jones @vai.org and Ting-Hai Xu @slu-official.bsky.social labs) @natsmb.nature.com www.nature.com/articles/s41...

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass... I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands) #WesternBlot #cellsky

The first rule of the Phillies And The World Series is that We. Do. Not. Talk. About. The. Phillies. And. The. World. Series. Also, 89% of <Phillies> fans are optimistic? 🤔 #RingTheBell but come on, do it responsibly & honestly 😂

I still get chills Meet Mike *30+ years severe depression *first hospitalized @ 13y *20 meds *3 rounds of ECT *2 near-fatal suicide attempts Mike felt joy for the first time in decades after we turned on his new brain pacemaker or PACE see videos, read paper, follow thread doi.org/10.31234/osf...

Tres cool! A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons: Cell www.cell.com/cell/fulltex...

Hippocampal ensembles regulate circuit-induced relapse of extinguished fear www.nature.com/articles/s41...

Molecular Underpinnings of Memory Persistence and Forgetting doi.org/10.1111/jnc....

Neural activity in the brain when a #zebrafish recognizes food (paramecium). Credit to Dr. Akira Muto. #ZebrafishZunday 🧪

Thrilled to share our latest study out in @natureportfolio.nature.com led by the fantastically talented Jing Liu. Our study provides insight into a long standing question in biology: What molecular features make us uniquely human and how do these function? www.nature.com/articles/s41...

🧠 New in Nature from the fabulous Silver Lab @ Duke: A human-specific enhancer, HARE5, boosts radial glia proliferation, expanding neocortical size and connectivity. Knock-in mice showed enlarged cortices and more neurons. This highlights how regulatory DNA changes shaped human brain evolution.

➡️ Delighted to contribute to this piece on the mechanisms underlying memory reconsolidation and persistence, together with Hugo Bayer, Cristina Stern and @stevemaren.bsky.social www.sciencedirect.com/science/arti...

I think about this comic at least once a week

Love this. I'm always puzzled by physiological v pathological abeta, tau, & ptau. This is a cool study looking at physiological v pathological abeta on synapses. www.nature.com/articles/s41...

Over 50 yrs since the discovery of protein kinases, 80% of human kinases still have ≤20 known substrates, and many are “dark.” I'm EXCITED to announce our new work towards solving this- combining (1) deep learning with (2) proximity proteomics in vivo! ➡️ www.biorxiv.org/content/10.1...

In-depth investigation of proteomic changes in plaque-associated axonal swellings 😮

transcriptionally similar cells can be functionally diverse

I am very proud to announce that my PhD paper finally came out in Cell! In this *very* collaborative study, we develop and release a deep-learning approach to predict neuron type identity from their electrical signature. doi.org/10.1016/j.ce... 1/16 🧵

#keepNIHstrong Research is a virtuous cycle that brings hope to those hurting. Researchers and physicians are front line warriors for the greatest medical problems of our time. Research fuels engines of innovation and drives economic growth. www.unitedformedicalresearch.org/annual-econo...

Parents matter - important study for modeling amyloid accumulation 🐭

Spiny night for #FluorescenceFriday! Trying some out of left field ways to visualize busy samples. Actin (rainbow depth-color coded) and microtubules (gray) along mature dendrites. projection of a 3D-SIM stack with some undisclosed tricks

Happy New Year, blue-sci-peeps! My piece in Annual Review of Biophysics on chromatin replication is now available online. doi.org/10.1146/annu... If you have paywall issues, try this link: madhanilab.ucsf.edu/s/annurev-bi...

Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S

crosstalk between mRNA export and transcription

Epigenetic memory that couples 5mC and H3K9 methylation, enables chromatin state inheritance across lifetimes and evolution. New excellent review by @hitenmadhani.bsky.social highlights inheritance mechanisms including roles for histone chaperones and nucleosome recycling. tinyurl.com/42ddhj4a

Apparently "functional connectivity" was first used to correlate the activity of individual neurons over time Gerstein, G. L., & Perkel, D. H. (1969). Simultaneously recorded trains of action potentials: analysis and functional interpretation. Science, 164(3881), 828-830.

long-term memory without short-term memory

Delighted to highlight our new paper in @natureportfolio.bsky.social entitled 'Synaptic basis of feature selectivity in hippocampal neurons' (thread below 👇): www.nature.com/articles/s41...

Thrilled to see this well-deserved honor for long-time friend and colleague @apombo1.bsky.social - a warm congratulations to Ana and Pombo lab members

Congratulations to our alum Dr. Ji Hun Kim who has started his own laboratory at KAIST and just won his first independent grant. Ji Hun is the co-inventor of LADL and will build out the technology to understand condensates in disease. pubmed.ncbi.nlm.nih.gov/31235883/

Ten years. Together we built a warm, tight-knit, international community, shared new computational and experimental technologies around the the world, posted >400 preprints, and catalyzed understanding of the mechanisms and functions of chromatin in development and disease.

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵

Best way to cap off 4DN meeting is Karaoke with Bing, @creminslab.bsky.social and many others! So much fun, and most songs sung were Chinese!

San Diego hotpot! With @creminslab.bsky.social and many others. Featuring for this heart guy: aortae!

Outstanding talks from the next generation of chromatin researchers - excited for the future @gracebower.bsky.social of @evgenykvon.bsky.social lab @sedonamurphy.bsky.social of Yale Cell Bio Tessa Pompay of Dixon lab Zoe Grant of @benoitbruneau.bsky.social lab Quan Zhu of Shen & Ren labs & others

From our recent paper: 7-color Tetbow image of the neocortex🌈 We can distinguish hundreds of neurons based on the combinatorial expression of 7 FPs. Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...

Antagonistic ties in village social network: an interesting read and 🧵

“Acanthocystis turfacea with ingested rotifer” From the beautiful Hudson transparency collection at the University of Exeter. specialcollectionsarchive.exeter.ac.uk/collections/...

Absolutely fascinating survey from Pew Research on public trust in science came out today. If you are wanting to reach across the aisle and help restore trust in science, the very first step is knowing your audience. Here's what they found. www.pewresearch.org/science/2024...

Join us in Banff for the Keystone Interplay of Chromatin Architecture and Transcriptional Regulation meeting next spring (joint with Epigenetics in Development and Disease): www.keystonesymposia.org/conferences/... Short talk abstract coming up - Jan 9

Well that's a spanner in the works. Transient CaMKII inhibition in the amygdala blocks the short term memory (1h) but the long term memory (>1 day) still forms!!!! Brilliant work from the Yasuda lab #neuroscience #biophysics www.nature.com/articles/s41...

Hallo! Does anyone have a robust protocol for coupling DNA oligos to proteins? The oligo will be fairly long, and so protocols that require lower mass inputs are preferred. We have free-rein over the oligo chemistry, but the protein is from a commercial source. Feel free to PM. Thanks in advance! 🙏

Thank you @creminslab.bsky.social!! I am super excited for the work to come, and extremely grateful to the NIH, NHGRI, and the reviewers for believing in my work!

Most of the talks from our Oct meeting are now online, with a few more to come: www.precisionmedicine.columbia.edu/videos

Congratulations to PhD student Rohan Patel @rohaniopatel.bsky.social: Awarded a new NIH F31 fellowship for his work to computationally explore chromatin patterns and mechanisms of loop extrusion in sequential oligopaints imaging data. doi.org/10.1101/2024... x.com/PatelRohanD/...

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

We designed MS2 and PP7 binding coat proteins that are degraded in cells except when bound by their hairpin RNAs. You can check out our pre-print here: tinyurl.com/27p7hyt9, and listen to a Google AI-generated podcast on it here: notebooklm.google.com/notebook/d71...

New paper out in @ScienceMagazine! In 8 studies (multiple platforms, methods, time periods) we find: misinformation evokes more outrage than trustworthy news, when it does it's shared more + ppl are less likely to read before sharing. w/ @killianmcl1 @Klonick @mollycrockett 🧵👇

ÅNGSTRÖM-RESOLUTION FLUORESCENCE MICROSCOPY. Can we do structural biology with an optical microscope? Yes! Check out how we resolved *single bases of DNA* and much more using fluorescence microscopy, out on 24.05.2023 in Nature! @natureportfolio.bsky.social [re-post from Twitter]

Neat thread on perturbing DNA methylation and the real challenges and spinning them into insight. Happy to see deep discussions about science take center stage. Kudos @maxvcg.bsky.social and team