Dysfunction of cortical GABAergic projection neurons as a major hallmark in a model of neuropsychiatric syndrome: Neuron www.cell.com/neuron/fullt...

So glad to hear I’m potentially qualified to be an Assistant Professor!

Submedius Thalamus Modulates Orbitofrontal Cortex Representations During Maternal Behavior in Mice https://www.biorxiv.org/content/10.1101/2025.09.18.677207v1

It's #FluorescenceFriday! Another movie from our preprint, showing exocytosis of VAMP2-pHluorin (live-cell TIRF, blue) correlated with 2-color STORM of spectrins (green) and clathrin-coated pits (magenta). www.biorxiv.org/content/10.1...

Grin2b-mutant mice exhibit heightened remote fear via suppressed extinction and chronic amygdalar synaptic and neuronal dysfunction | Science Advances www.science.org/doi/10.1126/...

Grin2b-mutant mice exhibit heightened remote fear via suppressed extinction and chronic amygdalar synaptic and neuronal dysfunction | Science Advances www.science.org/doi/10.1126/...

Now this is useful! PRESTO-TANGO selectivity data on chemical probes freely available! Please RT #gpcr www.opnme.com/news/pdsp-ne...

Identification of a neural basis for energy expenditure in the mouse arcuate hypothalamus: Neuron www.cell.com/neuron/fullt...

My thoughts on grant writing hell open.substack.com/pub/zendudes...

Why the reports that cancer cells are modulated by neuronal activity is a really, really old finding open.substack.com/pub/zendudes...

Why the reports that cancer cells are modulated by neuronal activity is a really, really old finding open.substack.com/pub/zendudes...

Yes, I've been out of grad school a long time, but I owe a lot to my PhD supervisor, Dale Ramsden. Big congrats to Dale on this well-deserved award (and I was pleasantly surprised my own ATM/V(D)J recombination research was mentioned in this article!). unclineberger.org/news/ramsden...

Cool! www.science.org/doi/10.1126/...

Here’s something important www.biorxiv.org/content/10.1...

Blurb for our latest paper: ct.moreover.com?a=5758890516...

new work from @zenbrainest.bsky.social and lab.

Here’s something important www.biorxiv.org/content/10.1...

5-O-Me-DMT's pharmacology elucidated: #psychedelics open.substack.com/pub/zendudes...

This is an AMAZING PAPER!! Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity: Cell www.cell.com/cell/fulltex...

A neural entero-pancreatic pathway that regulates insulin secretion and glucose tolerance www.biorxiv.org/content/10.1...

An Anterior Cingulate Cortex Neuronal Ensemble Controls Contextual Opioid Analgesic Tolerance www.biorxiv.org/content/10.1...

There is nothing special about DMT's affinity for sigma receptors: zendudest.substack.com/p/dmt-and-th...

There is nothing special about DMT's affinity for sigma receptors: zendudest.substack.com/p/dmt-and-th...

Take a deep breath and begin the week. #MountainMonday #BlueSkyMonday #Montana #GlacierNationalPark

I guess by controversial I could instead say “thin evidence” though the question would be “What is thin?” For a therapeutic hypothesis any data are “thin” until multiple, placebo controlled and adequately powered clinical trials are performed to test the hypothesis.

I understand that Herb Meltzer has officially retired at northwestern. Herb was a fantastic mentor and colleague and I wish him all the best. Fundamental contributions to schizophrenia treatment and he trained a yuuge number of scientists.

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-expressing hindbrain neurons https://www.biorxiv.org/content/10.1101/2025.08.12.668772v1

This is tres cool: www.science.org/doi/10.1126/...

Safety and Efficacy of the NMDA‐2b‐Selective Negative Allosteric Modulator BI 1569912: A Phase Ib Randomized Trial in Major Depressive Disorder - McIntyre - Clinical Pharmacology & Therapeutics - Wiley Online Library ascpt.onlinelibrary.wiley.com/doi/10.1002/...

This is where I disagree--setting aside a small pot of $$ to attempt to replicate controversial findings (I'm thinking of something like this www.science.org/doi/10.1126/... ) would be $$ well spent provided the results were disseminated in 'real time'.

Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism: Cell Metabolism www.cell.com/cell-metabol...

'We are exploring various mechanisms to support scientists focused on replication work, to publish negative findings, and to elevate replication research.' Now I can publish all my 'non-replications' and, perhaps, receive credit from NIH for these!!

Today, Bhattacharya sent a document entitled "NIH Priorities and Internal Review of Intramural and Extramural Programs" to Institute and Center Directors and other leaders. I am trying to get a clean copy. These "Priorities" will likely be "Agency Priorities" for grant funding and termination.

Over 20 years after Julius’s lab and mine cloned TRPM8, it is rewarding to see this science helping patients. The TRPM8 agonist Tryptyr treats dry eye by increasing tear production. A reminder that NIH-funded curiosity-driven research translates to medicines. tryptyr.myalcon.com?gad_source=1...

My hero, my friend and colleague. A must read for all. Thanks!!

Molecular and neural control of social hierarchy by a forebrain-thalamocortical circuit: Cell www.cell.com/cell/fulltex...

Molecular and neural control of social hierarchy by a forebrain-thalamocortical circuit: Cell www.cell.com/cell/fulltex...

Changes in the season are beginning in the high country. #MountainMonday #Montana #NaturePhotography

My unvarnished thoughts on psychedelics open.substack.com/pub/zendudes...

A Genome-wide CRISPR Screen Reveals ZDHHC8-Dependent Gαq Palmitoylation as a Key Regulator of GPCR Signaling Muhammad Ahmad, Norbert Perrimon, Raghuvir Viswanatha, Ah-Ram Kim bioRxiv 2025.08.06.668953; doi: doi.org/10.1101/2025...

NIH no cost extensions no longer require a prior approval request grants.nih.gov/grants/guide...

@alexkwan.bsky.social Periodically folks in the lab urge me to let them get started on 'the circuitry of #psychedelics'. I always dissuade them because I know there are folks like you out there who are going to do this waaaaayyy better than we could. Congrats--cool work.

New preprint + thread 🧵 #Psychedelics induce the formation of new synapses, but where do they connect? Our rabies tracing study reveals that #psilocybin shifts connectivity across specific cortical networks. www.biorxiv.org/content/10.1... 1/12

Wow! www.biorxiv.org/content/10.1...

JCI - Distinct nucleus accumbens neural pathways underlie separate behavioral features of chronic pain and comorbid depression www.jci.org/articles/vie...

My recent email to @NIHDirector_Jay @RobertKennedyJr Please RT!

My recent email to @NIHDirector_Jay @RobertKennedyJr Please RT!

My modest solution for revolutionizing drug discovery in an 'animal-free' manner: open.substack.com/pub/zendudes...