The Selectivity Implications of Docking Libraries with Greater and Lesser Similarities to Bio-like Molecules pubmed.ncbi.nlm.nih.gov/42101975/

Characterizing Resting-State Brain Dynamics with Frequency-Resolved EEG Microstates: Parallel Analyses of Psilocybin Microdosing and Acute Inhaled DMT https://www.biorxiv.org/content/10.64898/2026.05.05.723034v1

LSD persistently disrupts affective pain processing https://www.biorxiv.org/content/10.64898/2026.05.06.723205v1

In 2003 I got a 5.2% and was told it would not be funded by NIMH…

A great day at the Met!

Serotonergic Polypharmacology of 2-Halogenated Tryptamines www.biorxiv.org/content/10.6...

Happy to share with you that we have a new preprint up on @biorxivpreprint.bsky.social " Biased signaling at NTSR1 differentially regulates inhibitory synaptic transmission in the extended amygdala and suppressess motivated feeding in mice" www.biorxiv.org/content/10.6...

TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine | Science Advances www.science.org/doi/10.1126/...

TrkB/mGluR5 cross-talk underlies a synaptic metaplasticity mechanism of ketamine | Science Advances www.science.org/doi/10.1126/...

Sharing the latest from the lab. Led by Yunlong Liu, this work explores how microglia and engram neurons interact during fear extinction in the hippocampus. rdcu.be/fgNH7

A new and fun interview www.youtube.com/watch?v=sEmm...

The polypharmacological profiles of xanomeline and N‐desmethylxanomeline - Sakamoto - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

The polypharmacological profiles of xanomeline and N‐desmethylxanomeline - Sakamoto - British Journal of Pharmacology - Wiley Online Library bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

Must read #psychedelics Acute dose-dependent effects of 4-bromo-2,5-dimethoxyphenethylamine (2C-B) compared with 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin in a double-blind, placebo-controlled study in healthy participants www.nature.com/articles/s41...

Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets: Cell www.cell.com/cell/fulltex...

A skin-hypothalamus axis couples heat stress and metabolic dysfunction: Cell www.cell.com/cell/fulltex...

No clear signal among professional investors WRT psychedelics.... open.substack.com/pub/zendudes...

Wow!! Molecular dissection of protein complexes isolated from sections of human brain www.biorxiv.org/content/10.6... Also complimentary: www.biorxiv.org/content/10.6...

Risk reshapes amygdala representation of choice: Neuron www.cell.com/neuron/fullt...

Risk reshapes amygdala representation of choice: Neuron www.cell.com/neuron/fullt...

Top-down control of the descending pain modulatory system drives multimodal placebo analgesia: Neuron www.cell.com/neuron/fullt...

I'm giving a talk on 'Molecular Glues and GPCRs' Dr. GPCR University with Dr. Bryan Roth Thursday, April 9 · 10:00 – 11:35 AM (America/New_York) meet.google.com/wam-ohcu-txt

This is yuuge! Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue www.biorxiv.org/content/10.6...

This is yuuge! Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue www.biorxiv.org/content/10.6...

This has to be a joke

Hmmmm....if I took advantage of this at the age of 55 and quit at the age of 65 there is so much exciting science that would never have seen the light of day. Among the most short-sighted notions I've ever encountered. I resonate with the idea that people can age out of science but let's get real.

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue Ka-Booom! Wait for it soon to be on @biorxiv-neursci.bsky.social #gpcr

Cryo-EM Structures of Brain-Derived G Protein-Coupled Receptors: The First Direct Visualization from Mammalian Brain Tissue Ka-Booom! Wait for it soon to be on @biorxiv-neursci.bsky.social #gpcr

Mechanistic insights into the therapeutic properties of delta opioid receptor | Science Advances www.science.org/doi/10.1126/...

It’s not all DAT: harnessing the potential of organic cation transporter 3 inhibition to selectively attenuate amphetamine reinforcement and dopamine release www.nature.com/articles/s41...

Intriguing finding: Pretreatment with the psychedelic DOI mitigates LPS-induced hippocampal inflammation and behavioral impairments in mice pubmed.ncbi.nlm.nih.gov/41872747/

Cool! www.nature.com/articles/s41...

Wow! Structural energetics of cold sensitivity www.nature.com/articles/s41...

Speaking of variable reporting on the impact or lack thereof of the estrous cycle on drug self-administration in rats, one factor I can’t recall seeing nailed down- light cycle.

Why it will be very difficult to demonstrate superiority of psychedelics vs conventional treatment for Treatment Resistant Depression (IMHO) open.substack.com/pub/zendudes...

Why it will be very difficult to demonstrate superiority of psychedelics vs conventional treatment for Treatment Resistant Depression (IMHO) open.substack.com/pub/zendudes...

That's a wrap!

That's a wrap!

Why 'success' with S-ketamine may not readily translate to psychedelics... open.substack.com/pub/zendudes...

Why 'success' with S-ketamine may not readily translate to psychedelics... open.substack.com/pub/zendudes...

Why I think investing in neuroplastogens for depression is a bad bet ....unless you have very deep pockets zendudest.substack.com/p/why-phase-...

How do I do science? open.substack.com/pub/zendudes...

How do I do science? open.substack.com/pub/zendudes...

Dose-response left-shifted...one now needs to be a very potent grant writer!

Xylazine's k-opioid agonist activity is not shared with other FDA-approved alpha2-adrenergic agonists https://www.biorxiv.org/content/10.64898/2026.03.04.709652v1

New paper inspired by @nanopharmnc.bsky.social Xylazine's k-opioid agonist activity is not shared with other FDA-approved alpha2-adrenergic agonists www.biorxiv.org/content/10.6...

New paper inspired by @nanopharmnc.bsky.social Xylazine's k-opioid agonist activity is not shared with other FDA-approved alpha2-adrenergic agonists www.biorxiv.org/content/10.6...