Bryan Roth
@zenbrainest.bsky.social
📤 772
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📝 417
James Black: 'the prismatic qualities of the assay distort our view in obscure ways and degrees'
pinned post!
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease:
open.substack.com/pub/zendudes...
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Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
https://open.substack.com/pub/zendudest/p/psychedelics-can-both-cause-brain?r=g3vpk&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
about 1 month ago
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Nice review! Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin: Cell
www.cell.com/cell/fulltex...
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Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin
Sympathetic nerves regulate skin immunity by engaging keratinocytes to modulate the density of tissue-resident memory T cells. This neuro-epithelial axis can enable the nervous system to dynamically t...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901492-8
1 day ago
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A triple-node heart-brain neuroimmune loop underlying myocardial infarction: Cell
www.cell.com/cell/fulltex...
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A triple-node heart-brain neuroimmune loop underlying myocardial infarction
This study explores the dissection of a neuroimmune pathway involving the sensory vagus nerve, the hypothalamic paraventricular nucleus, and the sympathetic superior cervical ganglia underlying myocar...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901506-5
2 days ago
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A triple-node heart-brain neuroimmune loop underlying myocardial infarction: Cell
www.cell.com/cell/fulltex...
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A triple-node heart-brain neuroimmune loop underlying myocardial infarction
This study explores the dissection of a neuroimmune pathway involving the sensory vagus nerve, the hypothalamic paraventricular nucleus, and the sympathetic superior cervical ganglia underlying myocar...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901506-5
2 days ago
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cool! Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance
www.nature.com/articles/s42...
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Distinct sympathetic projections to brown fat regulate thermogenesis and glucose tolerance - Nature Metabolism
Neri et al. develop elegant tools to understand how the sympathetic nervous system regulates intrascapular brown adipose tissue (iBAT) function. Using these tools, they find that sympathetic nerves ta...
https://www.nature.com/articles/s42255-025-01429-0
8 days ago
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Wow!
www.cell.com/cell/abstrac...
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Identification of Or5v1/Olfr110 as an oxylipin receptor and anti-obesity target
Or5v1/Olfr110, a high-affinity odor receptor, detects an oxylipin signal to boost liver fat burning and glucose control, and a synthetic agonist can amplify this metabolic benefit.
https://www.cell.com/cell/abstract/S0092-8674(25)01429-1
8 days ago
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Bryan Roth
bioRxiv Neuroscience
23 days ago
Revisiting the SSRI-TRKB Mechanism: Lack of Evidence for Interaction in the Human Brain
https://www.biorxiv.org/content/10.64898/2026.01.07.698082v1
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Bryan Roth
Nikolai Slavov
22 days ago
It includes results from this preprint:
www.biorxiv.org/content/10.1...
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Principles of protein abundance regulation across single cells in a mammalian tissue
Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...
https://www.biorxiv.org/content/10.1101/2025.09.17.676955v2.full
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27 days ago
What is the computational role of dendritic excitations? Byung Hun Lee and team mapped voltage dynamics throughout the dendritic trees of CA1 pyramidal neurons in mice navigating in virtual reality.
www.biorxiv.org/content/10.6...
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An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice: Cell Reports
www.cell.com/cell-reports...
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An NTS-expressing inhibitory circuit from interpeduncular nucleus to dorsal raphe nucleus controls pain and comorbid depression in male mice
Song et al. find a subpopulation of neurotensin (NTS)-expressing neurons in the interpeduncular nucleus (IPN) that co-release NTS and GABA in the dorsal raphe nucleus, and they demonstrate the neurons...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2901491-3
29 days ago
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The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice: Cell Reports
www.cell.com/cell-reports...
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The medial shell of nucleus accumbens regulates chronic pain and comorbid depression via separate downstream targets in male mice
Xia et al. reveal two separate pathways that regulate chronic pain and comorbid depression. They demonstrate that NAcMedD1-MSNs regulate comorbid depressive symptoms via the NAcMedD1-MSNs→MD circuit, ...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2901488-3
29 days ago
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The sigma enigma revealed:
www.nature.com/articles/s41...
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SigmaR1 is an auxiliary translocon factor with lipid-binding activity that regulates protein and lipid droplet homeostasis - Nature Communications
This study identifies the ER sheet protein SigmaR1 as an auxiliary translocon factor. By directly binding phosphatidylcholine and specific translocon components, SigmaR1 maintains protein and lipid ho...
https://www.nature.com/articles/s41467-025-68157-7
29 days ago
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reposted by
Bryan Roth
Jeremy Berg
about 1 month ago
This is an outstanding essay describing some of the important roles and influences of NIH program officers (from an insider perspective). Read!
elizabethginexi.substack.com/p/the-quiet-...
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The Quiet Power of Program Officers
How invisible decisions shape what science gets done—and whether it matters
https://elizabethginexi.substack.com/p/the-quiet-power-of-program-officers
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Bryan Roth
A fun interview about the polypharmacology of
#psychedelics
www.youtube.com/watch?v=v4kn...
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Is the 5-HT2A Receptor the Key to Psychedelic Effects?
YouTube video by Xylo Bio
https://www.youtube.com/watch?v=v4knKrarl9w
about 1 month ago
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Bryan Roth
Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC Please RT
about 1 month ago
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Postdoctoral fellowship available in structure guided drug discovery in @RothLabUNC Please RT
about 1 month ago
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reposted by
Bryan Roth
bioRxiv Neuroscience
about 1 month ago
Psilocybin decreases reward-seeking behavior accompanied by increased activity of parvalbumin neurons with perineuronal nets in the medial prefrontal cortex
https://www.biorxiv.org/content/10.64898/2025.12.22.696123v1
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A fun interview about the polypharmacology of
#psychedelics
www.youtube.com/watch?v=v4kn...
loading . . .
Is the 5-HT2A Receptor the Key to Psychedelic Effects?
YouTube video by Xylo Bio
https://www.youtube.com/watch?v=v4knKrarl9w
about 1 month ago
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Mapping cellular targets of covalent cancer drugs in the entire mammalian body: Cell
www.cell.com/cell/fulltex...
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Mapping cellular targets of covalent cancer drugs in the entire mammalian body
vCATCH is a volumetric tissue labeling technique enabling cellular-resolution mapping of covalent drug targets throughout the entire mammalian body.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901365-0
about 1 month ago
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Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
www.jneurosci.org/content/earl...
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Neurochemical and Neurophysiological Effects of Intravenous Administration of N,N-Dimethyltryptamine in Rats
N , N -dimethyltryptamine (DMT) is a serotonergic psychedelic that is being investigated clinically for the treatment of psychiatric disorders. Although the neurophysiological effects of DMT in humans...
https://www.jneurosci.org/content/early/2025/12/17/JNEUROSCI.0742-24.2025
about 1 month ago
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Bryan Roth
Kate Nautiyal
about 1 month ago
New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice.
www.nature.com/articles/s41...
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The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice - Molecular Psychiatry
Molecular Psychiatry - The serotonin 1B receptor is required for some of the behavioral effects of psilocybin in mice
https://www.nature.com/articles/s41380-025-03387-1
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Bryan Roth
bioRxiv Neuroscience
about 1 month ago
Lysergic acid diethylamide pretreatment prolongs brain-stimulation induced neural activity
https://www.biorxiv.org/content/10.64898/2025.12.16.694720v1
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Bryan Roth
My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease:
open.substack.com/pub/zendudes...
loading . . .
Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
https://open.substack.com/pub/zendudest/p/psychedelics-can-both-cause-brain?r=g3vpk&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
about 1 month ago
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My thoughts on psychedelic drugs and the risk of brain cancer and valvular heart diesease:
open.substack.com/pub/zendudes...
loading . . .
Psychedelics can both cause brain cancer and heart disease?
Perhaps.....
https://open.substack.com/pub/zendudest/p/psychedelics-can-both-cause-brain?r=g3vpk&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
about 1 month ago
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reposted by
Bryan Roth
Microbiology Society
about 1 month ago
Born
#OnThisDay
in 1922, Esther Lederberg was the first to isolate the lambda phage in 1951. She characterised the lysogenic phase, whereby the phage are able to integrate into the bacterial genome, staying dormant. This discovery made them a model tool of study, leading to many more breakthroughs.
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Bryan Roth
Nikolai Slavov
about 1 month ago
This article suggests that cancer treatment contributes to mutagenesis: "More than 25% of driver mutations in normal tissue exposed to systemic anti-cancer therapy, including in TP53, could be attributed to treatment."
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Brainstem circuit for sickness-induced sleep | Science Advances
www.science.org/doi/10.1126/...
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Brainstem circuit for sickness-induced sleep
Brainstem circuit mediates sickness-induced NREM sleep.
https://www.science.org/doi/10.1126/sciadv.ady0245
about 2 months ago
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Bryan Roth
The YouTube lectures
add a skeleton here at some point
about 2 months ago
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The YouTube lectures
add a skeleton here at some point
about 2 months ago
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Relates to this paper:
www.biorxiv.org/content/10.6...
add a skeleton here at some point
about 2 months ago
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Bryan Roth
Intriguing--YES! Surprising--perhaps not so much One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
about 2 months ago
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Intriguing--YES! Surprising--perhaps not so much One implication: do not take psychedelics if you have glioma.....
www.biorxiv.org/content/10.6...
about 2 months ago
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reposted by
Bryan Roth
bioRxiv Neuroscience
about 2 months ago
Serotonergic neuron-glioma interactions drive high-grade glioma pathophysiology
https://www.biorxiv.org/content/10.64898/2025.12.10.693579v1
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Bryan Roth
bioRxiv Neuroscience
about 2 months ago
Artificial hibernation uncovers distinct synaptic engram architecture for memory retention
https://www.biorxiv.org/content/10.64898/2025.12.09.692927v1
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Sympathetic functional units encoded by genetically defined postganglionic neurons: Neuron
www.cell.com/neuron/fullt...
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Sympathetic functional units encoded by genetically defined postganglionic neurons
Wei et al. found two CG-SMG sympathetic subpopulations: Calb2-positive neurons project to gut muscle, forming endings at myenteric ganglia to regulate motility, and Nxph4-positive neurons innervate or...
https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900809-8
about 2 months ago
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Bryan Roth
bioRxiv Neuroscience
about 2 months ago
Serotonin Engages Divergent 5-HT Receptor Pathways for Cell Type-Resolved Modulation of Prefrontal Layer 5 Microcircuits
https://www.biorxiv.org/content/10.64898/2025.12.03.691770v1
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Cool!
add a skeleton here at some point
about 2 months ago
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A useful technique!
add a skeleton here at some point
about 2 months ago
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Wow--pretty amazing story here!
add a skeleton here at some point
about 2 months ago
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Ultra-large virtual screening unveils potent agonists of the neuromodulatory orphan receptor GPR139
www.nature.com/articles/s41...
about 2 months ago
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reposted by
Bryan Roth
Babli Adhikary
about 2 months ago
Attending
#Cellbio2025
? I am presenting two posters, stop by if you are interested in epithelial dynamics. Looking forward to all the amazing conversations and feedback!!
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Avoiding common errors in psychedelic drug discovery!
open.substack.com/pub/zendudes...
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Avoiding common errors in psychedelic researh
D'Oh
https://open.substack.com/pub/zendudest/p/avoiding-common-errors-in-psychedelic?r=g3vpk&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
about 2 months ago
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Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks: Cell
www.cell.com/cell/fulltex...
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Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks
Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901305-4
about 2 months ago
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Huge implications for
#GPCR-based
drug and sensor design Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors |
pubs.acs.org/doi/full/10....
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Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors
Sodium ions are classically conceptualized as negative allosteric modulators for G protein-coupled receptors, although there have been reports of either positive allosteric modulation or no effect of ...
https://pubs.acs.org/doi/full/10.1021/acs.biochem.5c00526
about 2 months ago
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Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex
www.jneurosci.org/content/45/4...
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Ventral Striatal Cholinergic Interneurons Regulate Decision-Making or Motor Impulsivity Differentially across Learning and Biological Sex
Dopaminergic transmission within the ventral striatum is broadly implicated in risk/reward decision-making and impulse control, and the rat gambling task (rGT) measures both behaviors concurrently. Wh...
https://www.jneurosci.org/content/45/49/e0764252025
about 2 months ago
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Bryan Roth
Star Trek Minus Context
2 months ago
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Bryan Roth
Alaina Jaster, PhD
2 months ago
Sorry that I don’t think famous white people (who are mostly horrible people) should be able to pay large amounts of $ to go to an ibogaine or ayahuasca retreat and claim they’ve found healing while the US continues to not care about Indigenous People or access to healthcare 🙃
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Biased histamine signaling selectively gates fat preference: Neuron
www.cell.com/neuron/fullt...
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Biased histamine signaling selectively gates fat preference
Zheng et al. uncover the neural basis for specific food preferences, showing that separate thalamic populations mediate intake of high-fat and high-sugar diets. They identify a histamine H3 receptor-m...
https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900842-6
2 months ago
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Biased histamine signaling selectively gates fat preference: Neuron
www.cell.com/neuron/fullt...
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Biased histamine signaling selectively gates fat preference
Zheng et al. uncover the neural basis for specific food preferences, showing that separate thalamic populations mediate intake of high-fat and high-sugar diets. They identify a histamine H3 receptor-m...
https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900842-6
2 months ago
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IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness: Cell
www.cell.com/cell/fulltex...
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IL-1R1-positive dorsal raphe neurons drive self-imposed social withdrawal in sickness
During sickness, animals exhibit prolonged social withdrawal, a response that may limit disease spread. Elevated IL-1β levels during inflammation activate IL-1R1-expressing neurons in the dorsal raphe...
https://www.cell.com/cell/fulltext/S0092-8674%2825%2901245-0
2 months ago
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Bryan Roth
Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states: Neuron
www.cell.com/neuron/fullt...
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Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states
Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex send distinct feedback signals to the primary visual cortex. These pathways differentially modulate visual proces...
https://www.cell.com/neuron/fulltext/S0896-6273%2825%2900844-X
2 months ago
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