How to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...

Thank you Radiohead you will always be the best for me!

Now “The Big Beautiful Bill” makes a lot more sense

Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...

This image shows a mass of human stem cells, collectively known as an ‘organoid’. We stained the neural crest cells of this organoid to better understand diseases related to defects in their development, such as Hirschsprung's disease and Neuroblastoma. Image credit: @carmenmorenogon.bsky.social

“I want you to understand what it is like to live in Chicago during this time.” aphyr.com/posts/397-i-...

Congratulations @fueyoraquel.bsky.social !!

The new album by Rosalia is MIND BLOWING.

Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...

I have been living in the UK for several years, and still can't wrap my head around the fact that half the country calls lunch "dinner" and dinner "tea", while the other half of the country calls lunch "lunch" and dinner "dinner" with the exception of school lunches, that are called school dinners

One month left for early-career researchers to apply for a funded place at our Workshop 'Novelty, Co-option and Divergence During Gene Network Evolution' organised by James Hombría & Antónia Monteiro Deadline 5 Dec. biologists.com/workshops/ju... @isabelalmudi.bsky.social @jlopezrios.bsky.social

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct

@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS. Get in touch for any questions and apply by 2 December: my.corehr.com/pls/kclrecru...

Current situation in my household (we have a 6 year old girl)

How does life evolve to adapt to modern cities? Out now in Science, my PhD work with @lindymcbr.bsky.social uncovers the ancient origin of the “London Underground mosquito” – one of the most iconic examples of urban adaptation. 🧵(1/n) @science.org www.science.org/doi/10.1126/science.ady4515

Check out our new preprint on the evolution of enhancer loss. Turns out there are 50 ways to lose a function. We found four of them. www.biorxiv.org/content/10.1...

Spread the word! There is a professor position opening at our University @upcite.bsky.social. There are several possible (great) labs to join, but if you are interested in DNA methylation and epigenetics in mammals, don't hesitate to contact me directly!

Sign up now for EMBO Workshop "Molecular mechanisms of selfish elements and strategies" in Bern, Switzerland, 8–11 February 2026. Abstract submission/Registration by: 15 December 2025/15 January 2026 https://meetings.embo.org/event/26-selfish-elements #EMBOselfishElements #GeneSky #EMBOevents 🧪

TET knockout cells transit between pluripotent states and exhibit precocious germline entry Ian Chambers and collaborators www.embopress.org/doi/full/10....

Here, we show that the unique regulatory landscape of ecDNA enables an ancient LINE to resurrect and act as an enhancer of Myc. This was so fun with @katerinakraft.bsky.social and @mattjones.bsky.social and others. www.nature.com/articles/s41...

We are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3

Out now! 🎉 Check the thread & preprint to see why we think E–P specificity is real in mammals — and, well, a few other interesting things popped up too 👀 Huge thanks to @danielibrahim.bsky.social, @arnaudkr.bsky.social & @stemundi.bsky.social and fantastic people in their labs — what a journey! 🧪🔬

Did transposable elements shape brain evolution — and if so, which ones, and in which cell states and lineages? Led by @tyamadat.bsky.social, we explored this question in cerebellum development using sequence-based deep learning models! www.biorxiv.org/content/10.1...

Following the announcement of YourParty, support for 'Others' in opinion polls increased from 3.7% to 6.0%. It has since dropped back to 3.7%, with the Greens seemingly gaining, reaching a peak of 10.7%. electionmaps.uk/polling/vi

DNA methylation is one of the most studied epigenetic modification associated with regulation of gene expression. Bisulfite-converted genomic DNA sequencing has been the current gold standard in the field for building genome-wide DNAm maps at base pair resolution.

Always the same speakers… www.keystonesymposia.org/conferences/...

Our Department @imperialcollegeldn.bsky.social just received 546 applications for 3 Assistant/Associate Professor positions. Curious to see how many of these are American scientists trying to relocate

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social. ➡️ www.cell.com/cell-genomic...

It might be hard to convey to people outside economics just how seismic this is. The Trump effect has most certainly arrived to US academia.

That's right, folk! THREE TENURE TRACK JOBS IN BIOLOGY AT UMASS BOSTON! You might even be a good fit for more than one! Check 'em out! We'd love to have you!

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350.... A personal thread about the ups & downs of the journey we took to get to that point....1/n 🗣️🧬🧪

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids journals.biologists.com/dev/article/...

Explore gene-regulatory mechanisms that drive developmental reprogramming at EMBO Workshop "Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids" in Seville, Spain, 4–7 May 2026. Deadline: 2 February meetings.embo.org/event/26-awa... #EMBOGenomeAwakening #EMBOevents 🧪

Hot off the press! Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 www.nature.com/articles/s41...

Nice work from Val Wilson & co on neuromesodermal progenitors SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased www.biorxiv.org/content/10.1...

New NIH structure for applications/awards with foreign components: Effective for due dates on or after 1/25/26, competing apps must use the PF5 activity code for grants (UF5 for cooperative agreements). Policy: grants.nih.gov/grants/guide... News news article: grants.nih.gov/news-events/...

This is very exciting! A small clinical trial using gene therapy for Huntington's disease has been successful. microRNAs were used to edit the Huntington mRNA, stopping it making mutant protein that can damage neurons. Huge hopes now for treating such a devastating condition

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

WDR5 and Myc Cooperate to Regulate Formation of Neural Crest Stem Cells https://www.biorxiv.org/content/10.1101/2025.09.19.677424v1

Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

Our new paper is out in Dev Biol! 🎉 🐸🧬 We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning 👉 Read more here: doi.org/10.1016/j.yd... @devbiol.bsky.social @biouea.bsky.social

What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @plosbiology.org 🧪 plos.io/46cBaE4

“Developmental Cell” and “Genes and Development”whenever we submit a paper to them

Seriously, not every paper needs to be an epic novel, modeled on Anna Karenina... www.embopress.org/doi/full/10....

🎵WHY DO ENHANCER! SUDDENLY APPEAR! EVERY TIME! THEY ARE NEAR!?! JUST LIKE ME! THEY LONG TO BE! CLOSE TO POLII! 🎵 www.nature.com/articles/s41...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...