Always the same speakers… www.keystonesymposia.org/conferences/...

Our Department @imperialcollegeldn.bsky.social just received 546 applications for 3 Assistant/Associate Professor positions. Curious to see how many of these are American scientists trying to relocate

The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...

Hominoid-specific retrotransposons fuel regulatory novelty in early brain development , by @retrogenomics.bsky.social. ➡️ www.cell.com/cell-genomic...

It might be hard to convey to people outside economics just how seismic this is. The Trump effect has most certainly arrived to US academia.

That's right, folk! THREE TENURE TRACK JOBS IN BIOLOGY AT UMASS BOSTON! You might even be a good fit for more than one! Check 'em out! We'd love to have you!

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350.... A personal thread about the ups & downs of the journey we took to get to that point....1/n 🗣️🧬🧪

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids journals.biologists.com/dev/article/...

Explore gene-regulatory mechanisms that drive developmental reprogramming at EMBO Workshop "Awakening the Genome During Developmental Reprogramming: From Embryos to Organoids" in Seville, Spain, 4–7 May 2026. Deadline: 2 February meetings.embo.org/event/26-awa... #EMBOGenomeAwakening #EMBOevents 🧪

Hot off the press! Cell-type-specific functionality encoded within the intrinsically disordered regions of OCT4 www.nature.com/articles/s41...

Nice work from Val Wilson & co on neuromesodermal progenitors SOX2/TBXT co-expressing cells are self-propagating bipotent NMPs Increasing TBXT levels (not SOX2/TBXT ratio) switch NMPs from neural- to mesoderm-biased www.biorxiv.org/content/10.1...

New NIH structure for applications/awards with foreign components: Effective for due dates on or after 1/25/26, competing apps must use the PF5 activity code for grants (UF5 for cooperative agreements). Policy: grants.nih.gov/grants/guide... News news article: grants.nih.gov/news-events/...

This is very exciting! A small clinical trial using gene therapy for Huntington's disease has been successful. microRNAs were used to edit the Huntington mRNA, stopping it making mutant protein that can damage neurons. Huge hopes now for treating such a devastating condition

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

Our study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....

WDR5 and Myc Cooperate to Regulate Formation of Neural Crest Stem Cells https://www.biorxiv.org/content/10.1101/2025.09.19.677424v1

Any academic folks on H1B visas (even with stamps in passports) please get legal advice from your University attorneys before leaving the US.

✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...

Our new paper is out in Dev Biol! 🎉 🐸🧬 We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning 👉 Read more here: doi.org/10.1016/j.yd... @devbiol.bsky.social @biouea.bsky.social

What's the role of microglial chromatin-mediated processes? This study shows that loss of ATRX in #microglia disrupts #chromatin structure, leading to de-repression of #retroelements & a viral mimicry #inflammation response that impairs hippocampal neuron function @plosbiology.org 🧪 plos.io/46cBaE4

“Developmental Cell” and “Genes and Development”whenever we submit a paper to them

Seriously, not every paper needs to be an epic novel, modeled on Anna Karenina... www.embopress.org/doi/full/10....

🎵WHY DO ENHANCER! SUDDENLY APPEAR! EVERY TIME! THEY ARE NEAR!?! JUST LIKE ME! THEY LONG TO BE! CLOSE TO POLII! 🎵 www.nature.com/articles/s41...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

New preprint from my lab! We describe how transposable elements are activated in Parkinson’s disease, which is linked to an interferon response. We believe this study significantly advances our understanding of transposons and their role in human brains. www.biorxiv.org/content/10.1...

Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat! + @creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!

Multiple overlapping binding sites determine transcription factor occupancy @nature.com www.nature.com/articles/s41...

Look at this crazy thing! www.nature.com/articles/s41...

And mitochondrial challenges (cit.) too!

Happy to see our latest work out in @molbioevol.bsky.social. We revisit the evolution of 5-methylcytosine across neglected eukaryotic supergroups, establishing an ancestral repressive role silencing genome invaders, both transposons and viral elements👾: academic.oup.com/mbe/advance-... 🧵 1/7

CUT&TIME captures the history of open chromatin indeveloping neurons https://www.biorxiv.org/content/10.1101/2025.08.29.673195v1

A dual role for GLI3 signaling in neural crest development https://www.biorxiv.org/content/10.1101/2025.08.31.673339v1

Incredible scenes in Genoa, Italy as 50,000 people join a procession to bid farewell to the boats joining the Global Sumud Flotilla to Gaza. Over 50 boats from 44 countries, loaded with 100s of tons of food aid, have set sail to Gaza to attempt to break the Israeli siege. (📸 Hidden Palestine)

Check it out, Chromatin Kids! Chromatin remodeller does stuff to Transcription Factors! Functions where it is seldom seen! Both decreases and increases chromatin accessibility! How cool is that?

Applications are now open! We are recruiting 20 Assistant Professors in a wide range of subject areas. We're looking for early-career researchers with strong scientific merits and future potential. 🔗 All positions: ki.se/en/about-ki/...

30 years ago today, the greatest punk-rock album of all times was published. You might say London Calling is better but I wound not agree!

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10.... @imperiallifesci.bsky.social

Great work, congrats! It also lends further support to the hypothesis that (neuro)developmental disorders caused by haploinsufficiency of transcriptional regulators (such as CHD3) result from defects in cell fate determination: journals.biologists.com/bio/article/...

This preprint is now a published peer-reviewed paper! Thanks to all the co-authors involved, to the funders and to @reviewcommons.org and @embopress.org @emboreports.org for a smooth editorial process! Excited to see this in press! www.embopress.org/doi/full/10.... @imperiallifesci.bsky.social

Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...

#TEsky #RNAsky #RNAbiology

Now online! Composite transposons with bivalent histone marks function as RNA-dependent enhancers in cell fate regulation

Embryology! Neural crest! Looking for a postdoc? Job closes 25 Aug. Informal enquiries welcome, and anyone hanging out at the Xenopus meeting come say hi. #mouse #human #development #neuralcrest #chromatin @the-node.bsky.social @marcotrizzino.bsky.social

I'm sorry WHAT

Our next #DevPres webinar focusses on gene regulation with talks from 2025 Development PI fellows Anzy Miller @anzymiller.bsky.social and Marlies Oomen @marliesoomen.bsky.social, chaired by James Gahan @jgahan.bsky.social. 📆 27 August, 15:00 BST (UTC+1) Register here: us02web.zoom.us/webinar/regi...

The "You present for 6 min" part is highly optimistic! Especially in the epigenetics/chromatin field!

Next month starts Conference Season y'all

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

I believe one of the new mRNA vaccines was expected to treat colon cancer, and another had the potential to keep pancreatic cancer from recurring. That’s what they’re taking away.