New lab preprint! We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook www.biorxiv.org/cgi/content/...

So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...

Thank you to @cp-devcell.bsky.social for selecting our story to feature on the cover of today’s issue of Developmental Cell! Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...

Thrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...

We had a blast tonight at the ‘Curious about the Crick’ event showcasing the science in our lab. Lots of enthusiasm and so many interesting questions. Was awesome to share this with my wonderful lab from brainstorming to communicating the science we love. Thank you to @crick.ac.uk for having us

The Crick PhD program is open and there are amazing projects including our lab's. I couldn't recommend enough joining the program: brilliant community and excellent training and mentorship. Specific project with us will be decided based on your interests. Apply here www.crick.ac.uk/careers-stud...

Very saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.

Just over one week until this opportunity closes! If you’re an ambitious computational scientist looking for a Postdoc position, apply now

🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights. 🔗 www.biorxiv.org/content/10.1...

Farewell dinner for @oliveringe.bsky.social with our wonderful Santos lab family. Ollie was our 1st Crick PhD student! Lots to celebrate and many fun memories. We are so grateful to have had Ollie in the lab and cannot wait to see what’s next for him in the Morris lab at Harvard! Best of luck,Ollie!

@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

It was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...

Fresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...

This is Mirjam, Santos Lab’ PhD student presenting her work at the EMBL meeting on Developmental Metabolism 🫶. Conference was incredible and Mirjam had an amazing time!

1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!

Drs. @dbenzinger.bsky.social‬ and @jamesbriscoe.bsky.social at the @crick.ac.uk established an #optogenetic system for the precise spatiotemporal control in vitro of Sonic hedgehog morphogen production. 🦔 📄 - https://bit.ly/3Vxf0rf 🎙️ - https://bit.ly/3JWWpT9

Researchers have found that early embryonic cells start to specialise via converging developmental paths, rather than following linear trajectories as was previously believed. www.crick.ac.uk/news/2025-09...

1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...

Latest on Waddington Landscapes: Computational methods to fit dynamical landscapes directly to single cell data Applied to neural tube patterning shows morphogen-signalling landscapes can be linearly interpolated Connects interpretable landscape models with data www.biorxiv.org/content/10.1...

Thrilled to bits to see our latest work online in Dev Cell! 🥳 We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n tinyurl.com/cell-stretch

So happy to finally see this work published! We reveal that an in vitro system mimics specification of extra-embryonic mesoderm into the visceral yolk-sac and allantois, and use this model alongside in vivo experiments to study the role of Eomes and T in these tissues. Big thanks to all co-authors 🥳

New work with Saunders & Charras labs Physical boundaries guide cell fate decisions during human trunk development Reaction Diffusion model shows how geometry shapes biology with TBXT expression forming consistent domains regardless of colony size & shape www.biorxiv.org/content/10.1...

New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...

Amazing work by Afnan @stochastalive.bsky.social and our lab satellite colleagues @crick.ac.uk, comparing human vs mouse forebrain signalling centres & progenitor diversity in nascent embryonic telencephalon. Outcome of exploration soon on bioRxiv. @kingsioppn.bsky.social @devneuro.bsky.social

Was so lovely to be part of this work with @borzogharibi.bsky.social @santoslab.bsky.social ! Read below to learn more about this cool new model of extra-embryonic development.

Now online! Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development