Luc-Alban Vuillemenot (@lavuillemenot.bsky.social)

New lab preprint! We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook www.biorxiv.org/cgi/content/...

loading . . .

Wee1 opposes APC/C(Cdh1) activity to promote S-phase entry Wee1 phosphorylates and inhibits CDK activity to inhibit mitotic entry and establish a G2 DNA damage checkpoint. Consequently, Wee1 inhibitors are in clinical trials, developed to be synthetically let... https://www.biorxiv.org/cgi/content/short/2025.12.01.691493v1