I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...

‼️ Excited to share our new paper out now in @science.org ‼️ We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments. Link: www.science.org/doi/epdf/10.... Thread ⬇️ (1/8)

New review out on molecular glues: turning serendipitous hits into smartly designed drugs that tag cancer-linked proteins for destruction 🧬💥💊 www.tandfonline.com/doi/full/10....

Postdoc positions open in my lab (Francis Crick Institute) to study 1. initiation of DNA replication. 2. chromatin replication/epigenetic inheritance. Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists. Deadline 3 August 2025. crick.wd3.myworkdayjobs.com/External/job...

A photo from the recombination mechanisms conference in Crete last week. Thanks to the @fusionconf.bsky.social team, speakers, poster presenters and attendees for a great meeting!

Update on #Recombination25 Conference! 🚨 📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT! 🌟Grants are available for students, postdocs & junior investigators!🌟 For more details, visit bit.ly/41v8IuK or email Felicity at 📧[email protected] @westlabcrick.bsky.social

Talk submission deadline coming up on 10th February 2025!

The West lab @crick.ac.uk has finally joined bluesky! Looking forward to sharing (and discovering!) new work 🧬 #recombination #dnarepair #BRCA #cryoEM #cellbiology