Happy #FluorescenceFriday. My lab is presenting a sneak peek of cancer-related transcription condensates in the nucleus of two human cell lines expressing a transcription factor fused with enhanced Green Fluorescent Protein. Prepared & imaged by my postdoc, Dr. Arpita Singh @arpitasingh.bsky.social.

It was wonderful to visit the Birla Institute of Technology and Science (BITS), Pilani, Rajasthan, to deliver a biology colloquium. I had a great interaction with the students & faculty members and learned about the amazing science being done at BITS Pilani. Thank you, Biological Sciences at BITS.

As part of our biophysics lab class, yesterday before experiments, I taught FRET (Förster resonance energy transfer). Shown here are two seminal papers: Theodor Förster (1946) & Stryer & Haugland (1967). My colleague, Amar Deep, took photos of me describing the 'kappa square' problem in FRET.

Happy #FluorescenceFriday. My lab is featuring fluorescence microscopy images of C. elegans worms expressing a stress granule-forming protein fused to RFP (Red Fluorescent Protein).🪱🔬 Left: A single worm. Right: An egg containing oxidative stress-induced granules in the embryo.

A beautiful work from my postdoc lab @ashokdeniz.bsky.social @scripps.edu in collaboration with @kerenlasker.bsky.social covered by @sciencex.bsky.social: phys.org/news/2025-12...

To all our dear friends, colleagues, students, staff, collaborators, supporters, well-wishers, and academic associates: Wish you and your family a very happy, prosperous, productive, peaceful, joyous, and healthy New Year 2026. - The Mukhopadhyay Lab

On this day, 17 years ago, December 29, 2008, I joined the IISER Mohali faculty. It's been an exciting journey. I learned a lot from many whom I interacted with. My students have made my scientific expedition very enjoyable. My experience has surpassed my expectations. Thank you all🙏

My 6-year term (two 3-year terms) on the editorial board of the Biophysical Journal @biophysj.bsky.social @biophysicalsoc.bsky.social will end on December 31. I truly enjoyed my role, which has immensely broadened my horizon. I thank all the reviewers and my amazing BJ colleagues. Thank you all!

It was wonderful to speak at the polypeptide folding & assembly symposium at the Pacifichem 2025 conference in Honolulu, Hawaii. Thanks to all the attendees for your kind words & for asking brilliant questions. It was nice to get an invitation to visit Seoul, South Korea, next year. Mahalo, Hawaii!

Arrived in Honolulu, Hawaii two days ago and greatly enjoying the Pacifichem 2025 conference at this stunning location. If you're attending Pacifichem, you're welcome to attend my talk tomorrow, Dec 17 (Wed) at 1:40 PM in Ilima Room at Sheraton Princess Kaiulani Waikiki Beach, Honolulu. See you!

Arrived in Honolulu, Hawaii two days ago and greatly enjoying the Pacifichem 2025 conference at this stunning location. If you're attending Pacifichem, you're welcome to attend my talk tomorrow, Dec 17 (Wed) at 1:40 PM in Ilima Room at Sheraton Princess Kaiulani Waikiki Beach, Honolulu. See you!

Looking forward to attending and speaking at Pacifichem 2025 @pacifichem.bsky.social, the International Chemical Congress of Pacific Basin Societies, next week in Honolulu, Hawaii. Thanks, Masaki Okumura (Tohoku Univ) and Takahiro Muraoka (Tokyo Univ), for the invitation. pacifichem.org

Congratulations to my PhD student, Anuja Walimbe @anujawalimbe.bsky.social, on receiving the Biophysical Society Travel Award to attend @biophysicalsoc.bsky.social meeting in San Francisco, California, in February 2026. She will present her exciting research on TDP-43, which is associated with ALS.

It was wonderful to host Shiv Grewal @grewalsh.bsky.social from NIH earlier this week. Shiv gave a beautiful talk on heterochromatin propagation and the epigenetic landscape. We had a stimulating discussion after his lecture. It was also great to have him visit my single-molecule biophysics lab.

Sonia Longhi @sonia-longhi.bsky.social from @cnrs.fr Marseille visited my lab at IISER Mohali as part of our Indo-French Centre for the Promotion of Advanced Research (IFCPAR/CEFIPRA) project. We had great scientific discussions and interactions with my students and colleagues.

It was a great honor to speak and chair a session in Prion 2025 held in Buzios, Rio de Janeiro, Brazil. I got great feedback on our prion phase separation work and learned a lot about biology, etiology, early diagnosis, and therapeutic strategies for fatal prion diseases (CJD/GSS/FFI). Goodbye, Rio!

What a terrific recognition of our research field! Dirk Görlich (Max Planck Institute Göttingen) and Steven McKnight (UT Southwestern) received the Lasker Award for their work on low-complexity domains and their phase separation. Read the perspective in PNAS: www.pnas.org/doi/epdf/10....

Last week, I started teaching the freshman biology class (BIO 101), which I'm very excited about. I'm sharing one of my introductory slides on the three pillars of modern biology - evolution, genetics and molecular nature of genetic material. Looking forward to teaching the first-year biology class!

Happy to share our community note published in Nature Communications @natcomms.nature.com. In this 14-page article (34 authors from 9 countries), we discuss current practices in phase separation. We hope it will be useful to the biomolecular condensate community. www.nature.com/articles/s41...

Breathtaking view of the Shivalik range of the Himalayas from the balcony of our apartment on the 7th floor at IISER Mohali: at 5:30 pm and 7 pm.

Happy to share a sneak peek of our foray into plant proteins: A fluorescence image of phase-separated condensates of an intrinsically disordered protein from Arabidopsis (prepared & imaged by my PhD students Snehasis Sarkar & Muskan Koundal). I'll share more details later. Happy Fluorescence Friday!

Yesterday, I had a great visit/seminar/discussion at the University of Lorraine, Metz, then arrived in Paris in the evening & had a breathtaking view of Paris from Eiffel Tower. Now at Paris CDG airport & will fly to Delhi. Had a wonderful time in France. Au revoir Paris/France/my friends in France!

Had an amazing 2-day stay in Montpellier & gave 2 seminars at IBMM, Université de Montpellier & CBS (Centre de Biologie Structurale), CNRS. Thanks to my amazing hosts, Joseph Chamieh (IBMM) & Emmanuel Margeat (CBS). I just arrived in Paris and on my way to Metz to visit the Université de Lorraine.

Goodbye, Marseille! Had an exciting scientific visit & enjoyed breathtaking views of the Mediterranean Sea! Now on the train to Montpellier to visit/speak at the Institut des Biomolécules Max Mousseron (IBMM) CNRS, Université de Montpellier in the next 4 hours. See you all at IBMM, CNRS Montpellier!

Yesterday, I taught biological phase separation at CNRS Marseille (photo credit: my former student, Harshita). Had an amazing lunch with students/postdocs of my host, Sonia Longhi. Had a wonderful dinner with Harshita near Marseille Port. Looking forward to visiting Nice & Cannes during the weekend.

Had busy last two days - gave a seminar at CNRS Marseille (photo credit: Harshita) & had discussions with scientists. Had a quick visit to Prado Beach & an amazing dinner at my host's (Sonia Longhi) beautiful house near Cassis (overlooking the Mediterranean Sea). Today, I'll teach phase separation.

Flying to Paris tomorrow. Looking forward to visiting and speaking at CNRS (Centre National de la Recherche Scientifique), Aix-Marseille Université, Institut des Biomolécules Max Mousseron, Centre de Biologie Structurale, CNRS/Université de Montpellier, and Université de Lorraine, Metz.

Congratulations to Lisha Arora @aroralisha20.bsky.social (15th PhD of my lab) and Rakshana, Ayush & Keshav (BS-MS) for receiving their degrees during commencement at IISER Mohali. We had a wonderful send-off dinner at The Lalit Chandigarh (where we also celebrated our latest Science Advances paper).

I'm so delighted to see my former PhD student, Priyanka Dogra, being featured by St. Jude Research @stjuderesearch.bsky.social. Priyanka's postdoctoral work at St. Jude aims to fight cancer at the cellular level by investigating nucleolar phase separation. www.stjude.org/research/pro...

Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social. www.science.org/doi/10.1126/...

Happy to share our latest paper published in Science Advances @aaas.org. Congratulations to my incredible students, Sandeep @sandeeprai.bsky.social, Roopali @roopsiek.bsky.social (co-first author), Anusha @anushasarbahi.bsky.social & Ashish @ashishjoshi.bsky.social. www.science.org/doi/10.1126/...

With @tanjamittag.bsky.social we asked if A1-LCD condensates are protective or crucibles for amyloid fibril formation. Their interfaces enable fibril nucleation but their interiors suppress fibril formation. Insights were transferrable to stress granules in cells. doi.org/10.1016/j.mo...

📢Stay tuned for our latest paper that will be published on June 6. We submitted the manuscript in July 2024. We had a 3-country, 4-time zone epic revision meeting in Oct 2024 (see the screenshot). This paper was accepted on May 1. I submitted proof corrections last week from Academia Sinica, Taiwan.

I had a lovely one-week stay at Academia Sinica, Taipei. I gave a seminar, taught phase separation/single-molecule FRET & gave a plenary lecture at Taiwan Biophysics conference. I enjoyed speaking/teaching/discussing science with very talented scientists here. Thanks to my incredible host Ruby Chen.

Check it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy! www.nature.com/articles/s41...

The 15th PhD from my lab: Today, Lisha Arora defended her PhD thesis. Congratulations to Dr. Arora! @aroralisha20.bsky.social Thanks to Samir Maji (Indian Institute of Technology Bombay) for serving as the external examiner, and the doctoral committee members, Sanchita Sengupta and Raj Kumar Roy.

My former PhD student, Ashish Joshi, visited our lab last week. He just reached San Diego to join Keren Lasker's lab at The Scripps Research Institute @scripps.edu It's amazing; now 3 of my former PhD students, including Debapriya Das & Anamika Avni, are postdocs at Scripps, my postdoc alma mater.

Today, I was super excited to see live C. elegans worms with my students using our new stereomicroscope in my lab. Thanks to my colleague Jogender Singh & his lab for providing us with a plate. My students, Deepti, Snehasis, and my postdoc, Arpita, taught me how to watch worms. Exciting times ahead!

Attn. Participants of the IDP Subgroup Symposium at the Biophysical Society meeting TODAY at 1:30 PM PST: I'm happy to share the latest program (Venue: Petree Hall C, Los Angeles Convention Center). We'll have our subgroup dinner tonight at Sol Agave L.A. LIVE. See you soon!

We had a wonderful my lab alumni dinner at a Southern Thai food restaurant in Hollywood yesterday (Feb 14). Thanks to Priyanka, Debapriya, Ashish & Anamika, and my better half, Mily, for joining us at an exciting dinner. Now gearing up for the Biophysical Society meeting in Los Angeles!

Arrived in Los Angeles after 35 h. A technical snag delayed the Delhi-San Francisco flight. Managed to get the LA connection. Mt. Fuji (flew over Japan) & LA downtown before/after landing. Tonight I'm hosting my lab alumni dinner in Hollywood before Biophysical Society meeting kick-starts tomorrow.

Happy to share my interview with Pavan Kumar (Professor of Physics at IISER Pune) for his channel. In this podcast, I share some hitherto untold stories of my academic journey from my childhood, PhD, postdoc to professor at IISER Mohali. The YouTube link is below (1h:40m): youtu.be/UrQJbuhv1s0?...

Happy to share the final program of the 2025 Intrinsically Disordered Proteins Subgroup Symposium at the Biophysical Society Meeting to be held in Los Angeles on February 15. Looking forward to seeing you all in less than a week @biophysicalsoc.bsky.social.

Ancient human genomes offer clues about the earliest migrations out of Africa www.nature.com/articles/d41...

Dear Intrinsically Disordered Proteins Subgroup (IDP Subgroup) members of the Biophysical Society: I can't wait to see you at the IDP Subgroup symposium in Los Angeles on Feb 15. You can buy a symposium dinner ticket from the Biophysical Society store: www.biophysics.org/store/produc...

Attn. Intrinsically Disordered Proteins Subgroup members: We are excited to host our IDP subgroup dinner on Feb 15 after the IDP symposium at a Mexican restaurant in Los Angeles: Sol Agave L.A. LIVE. www.solagave.com/los-angeles You can purchase a dinner ticket: www.biophysics.org/store/produc...

To all the attendees of the Biophysical Society meeting to be held in Los Angeles (Feb 15-19): As a member of the Committee on Sustainability, I invite you to attend the President's Symposium on "Biophysics for a Sustainable Future" on Sunday, Feb 16 at 10:45 AM. www.biophysics.org/2025meeting/...

A fluorescence image of fusing protein droplets we prepared in vitro from a key protein involved in the formation of cellular stress granules prepared/recorded by PhD students in our lab (Snehasis, Deepti, and Anuja). #FluorescenceFriday. Stay tuned for our exciting updates on protein-RNA granules.

We welcome two new PhD students to our lab at IISER Mohali - Muskan Koundal and Poorva Grover. They will work on some fascinating and emerging aspects of biological condensates. We also have a new group photograph taken today by Kanika Sharma.

Homo-FRET (Förster resonance energy transfer), a special case of the more commonly used hetero-FRET, can be employed to study biomolecular organization by probing the depolarization of fluorescence anisotropy. Homo-FRET was first introduced by Gregorio Weber in 1954. pubs.rsc.org/en/content/a...