Can we control cells by forcing TFs to collaborate? Interested? Read our preprint! An awesome collaboration with @cgersbach.bsky.social, @igvfconsortium.bsky.social, Christian McRoberts Amador, @rachel-savage.bsky.social: www.biorxiv.org/content/10.6... 🧵

New preprint in which we built and simulated full-length models of α-Synuclein fibrils to reveal how the fuzzy coat mediates selective binding of peptides to amyloid fibrils Work led by Carlos Pintado-Grima in a nice collaboration with Salvador Ventura's lab doi.org/10.64898/202...

Nature research paper: Continuously tunable coherent pulse generation in a semiconductor laser go.nature.com/4vrshCt

Out in @natmethods.nature.com: More dyes. They work. Quite well. And blink. Pick the one that fits your target, your technique, and your labeling density. With too many collaborators and institutes to list, but anchored at @hhmijanelia.bsky.social www.nature.com/articles/s41...

Our latest work on shape-programmable tissues is out in @science.org. By positioning topological defects in cellular nematics, we encode frustrated 2D force fields that relax into predictable 3D shapes. Collaboration with Marino Arroyo’s lab, led by @pauguillamat.bsky.social at @ibecbarcelona.eu.

1/ Excited to share our preprint! 🥳 Degradation of aromatic compounds, including BTEX pollutants, requires highly endergonic aromatic ring reduction. Using #cryoEM and in situ #cryoET, we show how BCRII couples electron bifurcation modules in one giant redox machine www.biorxiv.org/content/10.6...

🥳 Excited to share our #diatom work out in @pnas.org. In a great collaboration with @nic-poulsen.bsky.social and @ulrichschwarz.bsky.social we show that diatoms modulate the curvature of their paths by dynamic switching of their cell–substrate contact sites. doi.org/10.1073/pnas.2506122123

Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/ www.pnas.org/doi/10.1073/...

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Congrats to Chunyu Li, Dr Xu-cheng Gan, Yu (Hannah) Irie and Dr Milo Smith for their paper appearing today in Science!

Some molecular machines, like ribosomes, can persist for long periods of time in cells. Could molecular aging of ribosomes shape how proteins are made? In our new preprint we track ribosomes as they age in cells and uncover unexpected effects on translation (1/10) www.biorxiv.org/content/10.6...

Pulsed #lasers integrated with #cryoEM: @fitzpatricklab.bsky.social postdoc Daniel Du aims to boost contrast in #cryoET zuckermaninstitute.columbia.edu/making-world-s-best-microscopes-biology-better zuckermaninstitute.columbia.edu/science-life-daniel-du elifesciences.org/reviewed-preprints/109793v1

Evolution navigated billions of challenges to get to us to where we are today. Directed evolution compresses this to a 1D axis. Imagine if you could sample 200 dimensions at once, with data to boot 📈 First @chorylab.bsky.social PACE preprint on our new system to tackle this: bit.ly/turboprance

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

Papers are like buses... You wait for ages, then two come along at once. Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published! www.nature.com/articles/s41...

Have you ever wanted to do single-molecule biophysics in high-throughput? @matt-dejong.bsky.social (amazing joint grad student with @dunnlab.bsky.social) invented a way & measured >100,000 single molecules across 241 different sequences. (1/3) www.biorxiv.org/content/10.6...

Thanks so much Samrat!

Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com. www.nature.com/articles/s41... Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇 www.biorxiv.org/content/10.6...

What a thrill to see this out! Our prospective, scalable, and target-centric solution for molecular glue discovery. More thoughts and details here: www.linkedin.com/posts/activi... Paper here: www.nature.com/articles/s41...

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now? www.nature.com/articles/s41... More functional data, many thousands of words removed, and a few other updates from last year's preprint.

A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09... #KeioMedicalSciencePrize

Curious how biomolecular condensates can localize ions? Using NMR, we found that condensates selectively bind and localize both chaotropic anions and kosmotropic cations. This alters the condensate composition, interface potential and RNA duplex stability inside. By @irissmokers.bsky.social

I am super happy to share our latest article entitled "Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy", now published in Science www.science.org/doi/10.1126/... It was my postdoctoral work mit @sauer-lab.bsky.social Congrats to all the co-authors!

Happy new year! Our new preprint is live! We use single molecule imaging in live cells to show that activation domains can control how transcription factors bind to chromatin. SMT 1 TF Dogma 0 www.biorxiv.org/content/10.1...

Happy to be on BlueSky! For my first post, I am excited to share a new collaborative paper combining experiments and simulations, where we used circadian clock proteins to engineer biomaterials with time-programmed self-assembly and disassembly www.nature.com/articles/s41...

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

After a remarkable 300 columns, David Goodsell has retired from the Molecule of the Month. We are very grateful for his service. @jiwasa.bsky.social will continue the series, beginning with January's article on Assembly Line Polyketide Synthases Details: cdn.rcsb.org/rcsb-pd...

Rayleigh-Plateau instability in mitochondria? Exciting analysis of physics of mitochondria dynamics

For inspiration, here are the papers we discussed in 2023:

Visualizing Single V-ATPase Rotation Using Janus Nanoparticles pubs.acs.org/doi/full/10....

1/ 🚨We’re thrilled to share our latest study: "Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟 www.biorxiv.org/content/10.1... How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

Excited to share our preprint, work by Anthony Gurunian, showing that #condensates can induce localized potentials in membranes + an analytical framework, with important biological implications, collaboration with @kerenlasker biorxiv.org/cgi/content/...

Interesting porous material - rhodium metal-organic polyhedra (MOP) with tethered polymers. Tunable phase transition/gas adsorption-diffusion properties, applied to gas separation membranes. www.nature.com/articles/s41...

Our latest work is out in Nature today! Using smFRET, we directly visualized recruitment of the eIF4F complex to the 5' cap of eukaryotic mRNAs and formation of an activated mRNA. Our findings reveal new and surprising roles for each eIF4F component. 1/3 www.nature.com/articles/s41...

Interesting biomaterial engineering!- leveraging physical and chemical properties of gallium www.nature.com/articles/s41...

First paper of our lab today @natureportfolio.bsky.social by Nussi! We provide a real-time movie on how #transcription and #translation cooperate using #single-molecule FM: we find long-range #ribosome/ RNAP communication mediated by #RNA looping! @embl.org #RNAbiology #RNASky t.co/a24Xxcxdo0

Important advance + cool method/Physics www.science.org/doi/10.1126/...

Published in @science.org, scientists at Scripps Research have uncovered a mutation in the H5N1 “bird flu” virus that enhances its ability to bind to human cells—emphasizing the need to monitor H5N1 to prepare for potential pandemic threats. More:

Do you find yourself curious about the eating habits of macrophages? Check out our new preprint to discover the biophysical principles that guide macrophage behavior. www.biorxiv.org/content/10.1...

Nice work! Also includes some interesting work with lipid chirality/racemic mixtures.

Neat!

We’re pleased to share our substantially updated (more below on that…) version of our manuscript exploring the relationship between conservation in sequence/function for intrinsically disordered regions (IDRs) www.biorxiv.org/content/10.1...

As the chair of the Intrinsically Disordered Proteins Subgroup of @biophysicalsoc.bsky.social I'm happy to announce the exciting scientific program put together by program co-chairs Dorothee Dormann & Lukasz Joachimiak. Looking forward to seeing you in Los Angeles! www.biophysics.org/2025meeting/...

Happy to share that my former PhD student, Debapriya Das (now doing her postdoc with my postdoc advisor, Ashok Deniz, at the Scripps Research Institute, California) has been selected for a platform talk at the Biophysical Society meeting to be held in Los Angeles in Feb 2025. Congrats, Debapriya!

Latest #CDlab paper: Synchronization of E. coli Bacteria Moving in Coupled Microwells: onlinelibrary.wiley.com/doi/epdf/10.... E. coli bacteria swim in sync in weakly coupled neighboring microcavities! Great work led by @AleksandreJapa from from Farbod Alijani's lab, to which I also contributed

We did this crazy project where we tried to see if proteins could interact with their mirror image ligand. Seems impossible when proteins need to form 3D structures to interact. But what about if the interaction remains disordered??? www.nature.com/articles/s41...

Delighted to share our new paper, exciting collaboration with Racki, Park and Grotjahn Labs @scripps.edu. Reentrant DNA shells tune polyphosphate condensate size. Congrats Jenna and Ravi, Tumara, all other authors! @natureportfolio.bsky.social #Condensates #Biophysics #SoftMatterPhysics