Arindam Ghosh, PhD
@arindam92.bsky.social
📤 718
📥 1567
📝 26
Incoming Research Group Leader, DKFZ NCT WERA
#Biophysics
#Imaging
#Immunology
#Receptors
Happy to share that I will be starting my independent research career as a Research Group Leader at the German Cancer Research Center (DKFZ). Starting from January 2026, my group will be based at DKFZ National Center for Tumor Diseases (NCT WERA), Würzburg, Germany.
about 23 hours ago
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Arindam Ghosh, PhD
PicoQuant
about 2 months ago
👏 Congratulation to the 🏆 winners of Student Award held by
#PicoQuant
during 30th anniversary of our annual workshop on Single Molecule Spectroscopy and Ultra Sensitive Analysis in the Life Sciences.
#WS30
We were proud to once again support the next generation of scientists.
#PicoQuantStudentAward
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Arindam Ghosh, PhD
Sauer Lab
3 months ago
🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️
www.biorxiv.org/content/10.1...
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Arindam Ghosh, PhD
Kai Johnsson
4 months ago
Finally out in Nature Chem Bio: SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.
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SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology
SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kühn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...
https://www.nature.com/articles/s41589-025-01942-z
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reposted by
Arindam Ghosh, PhD
Andrey Klymchenko
5 months ago
Great news: I received ERC Advanced grant
#ERCAdG
@erc.europa.eu
CaptuRel! It aims at intelligent nanomaterials undergoing bioinspired cycle of capture and photorelease of bioactive molecules for sensing and controlling (bio)chemical gradients. Thanks to my Team,
@cnrs.fr
and
@unistra.fr
!
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Arindam Ghosh, PhD
Joachim Goedhart
5 months ago
De novo designed bright, hyperstable rhodamine binders for fluorescence microscopy by Bo Huang and team:
www.biorxiv.org/content/10.1...
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Arindam Ghosh, PhD
Paul & Virginie - Centriole Lab
5 months ago
🚨 New preprint! Using U-ExM + in situ cryo-ET, we show how C2CD3 builds an in-to-out radial architecture connecting the distal centriole lumen to its appendages. Great collab with
@cellarchlab.com
@chgenoud.bsky.social
@stearnslab.bsky.social
🙌.
#TeamTomo
#UExM
www.biorxiv.org/content/10.1...
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Arindam Ghosh, PhD
Erdinc Sezgin
6 months ago
New paper out! Would you like to fluorescently label the plasma membrane in live, fixed or permeabilized cells? I tested different lipid structures and labelling approaches to decide what makes a good membrane labelling probe for such imaging experiments!
www.biorxiv.org/content/10.1...
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Plasma membrane labelling efficiency, internalization and partitioning of functionalized fluorescent lipids as a function of lipid structure
Labeling the plasma membrane for advanced imaging remains a significant challenge. For time-lapse live cell imaging, probe internalization and photobleaching are major limitations affecting most membr...
https://www.biorxiv.org/content/10.1101/2025.05.07.652622v1
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reposted by
Arindam Ghosh, PhD
Luciano A. Masullo
6 months ago
Very excited to present our latest work: SPINNA, an analysis framework and software package for single-protein resolution data! 🖥️🤩 We can directly quantify stoichiometry and oligomerization from super-res (DNA-PAINT, RESI) images!! 🧬🎨
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reposted by
Arindam Ghosh, PhD
Anna-Karin Gustavsson
7 months ago
Collaborative work with the Shechtman Lab and
@heilemannlab.bsky.social
. Check it out here:
www.biorxiv.org/content/10.1...
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One-click image reconstruction in single-molecule localization microscopy via deep learning
Deep neural networks have led to significant advancements in microscopy image generation and analysis. In single-molecule localization based super-resolution microscopy, neural networks are capable of...
https://www.biorxiv.org/content/10.1101/2025.04.13.648574v1
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www.researchsquare.com/article/rs-6...
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Open-source Sub-Nanometer Stabilization System for Super-resolution Fluorescence Microscopy
Recent advances in fluorescence nanoscopy have pushed resolution to the 1-10 nm range, enabling the direct visualization of individual molecules even in crowded biological environments. Achieving this...
https://www.researchsquare.com/article/rs-6131181/v1
7 months ago
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Our work on lattice light-sheet TDI-DNA-PAINT and anti-CD20 immunotherapy antibodies is now featured in The Scientist magazine
www.the-scientist.com
. Many thanks to Sneha Khedkar for writing this fantastic piece.
www.the-scientist.com/new-microsco...
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New Microscopy Technique Challenges Therapeutic Antibody Classification
A super-resolution microscopy technique offers an unparalleled glimpse into how monoclonal antibodies bind to their targets on cancer cells to induce cell death.
https://www.the-scientist.com/new-microscopy-technique-challenges-therapeutic-antibody-classification-72829
8 months ago
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reposted by
Arindam Ghosh, PhD
Sandrine Lévêque Fort 🔬
8 months ago
🔬Happy to share our new preprint, where brightness is used to identify single molecule emission in 2D/3D, with a single camera ! Part of the PhD work of
@laurent-le.bsky.social
and Surabhi, great collaboration with
@emmanuelfort.bsky.social
from
@instlangevin.bsky.social
@ismolab.bsky.social
#SMLM
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Arindam Ghosh, PhD
Angel A. Martí
8 months ago
Congratulations to Rice Chemistry Prof. Anna-Karin Gustavsson for receiving the NSF CAREER.
@gustavssonlab.bsky.social
#NSFCAREER
#RiceChemistry
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Anna-Karin Gustavsson on LinkedIn: Rice’s Gustavsson receives NSF CAREER Award to investigate dynamics of…
Very honored and grateful to receive the NSF CAREER Award! Big thanks to the National Science Foundation (NSF) and to my fantastic research team and…
https://www.linkedin.com/feed/update/urn:li:activity:7302754443714777090/
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reposted by
Arindam Ghosh, PhD
Jörg Enderlein
8 months ago
Happy to share our newest paper in Ang. Chem. and big thanks to
@nkaredla.bsky.social
,
@faldalf.bsky.social
and
@tao-chen.bsky.social
🙏
onlinelibrary.wiley.com/doi/10.1002/...
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Leaflet‐specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers
Polymer-supported or tethered lipid bilayers serve as versatile platforms for mimicking plasma membrane structure and dynamics, yet the impact of polymer supports on lipid bilayers remains largely un...
https://onlinelibrary.wiley.com/doi/10.1002/anie.202423784
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reposted by
Arindam Ghosh, PhD
Dr. Romain Fernandez
8 months ago
🧪Paris Jussieu right now
#standupforscience
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reposted by
Arindam Ghosh, PhD
Institut Pasteur | 130 years of biomedical research
8 months ago
Science, research & public health face unprecedented attacks in the U.S. We stand with our American colleagues & support the Stand Up for Science call. Join the global march tomorrow, incl. in Paris! 🧪✊ 📍 March 7, 13:30 – Place Jussieu 🔗 More info:
standupforscience.fr
#StandUpForScience
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reposted by
Arindam Ghosh, PhD
Jörg Enderlein
9 months ago
I'm thrilled to share that our review article, "Molecular Level Super-Resolution Fluorescence Imaging," has now been published online (
www.annualreviews.org/content/jour...
)! We provide a comprehensive overview of fluorescence super-res methods that push the limits towards molecular-scale imaging.
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Molecular Level Super-Resolution Fluorescence Imaging | Annual Reviews
Over the last 30 years, fluorescence microscopy, renowned for its sensitivity and specificity, has undergone a revolution in resolving ever-smaller details. This advancement began with stimulated emis...
https://www.annualreviews.org/content/journals/10.1146/annurev-biophys-071524-105321
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Arindam Ghosh, PhD
Biophysical Reports
9 months ago
Online now! Fluorescent labeling strategies for molecular bioimaging. Marcel Streit, Made Budiarta, Marvin Jungblut, and Gerti Beliu.
www.cell.com/biophysrepor...
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Fluorescent labeling strategies for molecular bioimaging
Super-resolution microscopy (SRM) has transformed biological imaging by circumventing the diffraction limit of light and enabling the visualization of cellular structures and processes at the molecula...
https://www.cell.com/biophysreports/fulltext/S2667-0747(25)00005-9
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Arindam Ghosh, PhD
Sauer Lab
9 months ago
🆕 Our new functionalized docetaxel probe enables superior visualization of dense mitotic spindle structures during cell division by expansion microscopy! ▶️
pubs.acs.org/doi/10.1021/...
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Functionalized Docetaxel Probes for Refined Visualization of Mitotic Spindles by Expansion Microscopy
Visualizing the ultrastructure of mitotic spindles, the macromolecular machines that segregate chromosomes during mitosis, by fluorescence imaging remains challenging. Here we introduce an azido- and ...
https://pubs.acs.org/doi/10.1021/jacs.4c15608
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Arindam Ghosh, PhD
Carolyn Bertozzi
9 months ago
Check it out, powerful new method for optical imaging of the live ECM, from
@hhmijanelia.bsky.social
Group Leader Kayvon Pedram
#proudofalumni
#glycotime
www.nature.com/articles/s41...
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Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods
Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...
https://www.nature.com/articles/s41592-024-02590-2
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reposted by
Arindam Ghosh, PhD
UNSW Single Molecule Science
9 months ago
Aaaand that’s a wrap at Asia Pacific Microscopy Congress 2025 in sunny Brisbane, attended by a big team from Single Molecule Science. Lots of exciting new 🔬 tools and translation in biomedical investigations.
@ijayas.bsky.social
@arindam92.bsky.social
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reposted by
Arindam Ghosh, PhD
PicoQuant
9 months ago
Want to explore the world of time-resolved fluorescence
#microscopy
? Sign up for our online course and benefit from theoretical as well as practical sessions in an interactive format. Topics: data analysis, FCS, FRET, FLIM, and more. May 13-16, 2025. ➡️
www.microscopy-course.org
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reposted by
Arindam Ghosh, PhD
MichelleDigman
9 months ago
Thrilled and honored to present a plenary talk at the 13th Asia Pacific Microscopy Congress (APMC13) in Brisbane, Australia, on February 7, 2025, hosted by the Australian Microscopy and Microanalysis Society (AMMS).
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Arindam Ghosh, PhD
Erdinc Sezgin
10 months ago
New paper out💥 in Nano Letters
@pubs.acs.org
High throughput single particle profiler with simple confocal imaging. We used this new method to study protein-lipid interactions, drug membrane interactions and biophysics of small particles from human donors:
pubs.acs.org/doi/10.1021/...
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Imaging Single Particle Profiler to Study Nanoscale Bioparticles Using Conventional Confocal Microscopy
Single particle profiling (SPP) is a unique methodology to study nanoscale bioparticles such as liposomes, lipid nanoparticles, extracellular vesicles, and lipoproteins in a single particle and high t...
https://pubs.acs.org/doi/10.1021/acs.nanolett.4c05117
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Arindam Ghosh, PhD
Pratik Kumar
10 months ago
🧵Prepint alert! Optimizing Multifunctional Fluorescent Ligands for Intracellular Labeling |
tinyurl.com/3n55hvsc
. With Jason Vevea, Ed Chapman, and
@so-lets-kilab70.bsky.social
, we combined dye chemistry, HaloTag, microscopy and cell biology to make protein purification and manipulation tools.
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Arindam Ghosh, PhD
Heilemann Lab
10 months ago
If you have a passion for single-molecule super-resolution microscopy🔬, there are great news to share: the SMLMS conference series will continue this year and will be held in Bonn/Germany Aug 27th to 29th ✨- please save the date and join us, we are looking forward to meeting you there👇🏻
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Arindam Ghosh, PhD
Alexey Chizhik
10 months ago
How can you enhance the visibility of your next publication or increase your chances of getting your next research proposal accepted? How to get the illustration you need in just a few days? How to find an illustrator who is on the same wavelength with you?😉
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Arindam Ghosh, PhD
Jörg Enderlein
10 months ago
I am very proud to advertise our latest publication, "Super-Resolution Goes Viral: T4 Virus Particles as Versatile 3D-Bio-NanoRulers," in Adv. Materials:
advanced.onlinelibrary.wiley.com/doi/full/10....
. We propose to use T4 bacteriophages for calibrating 3D super-res fluorescence microscopy. 🧵
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Super‐Resolution Goes Viral: T4 Virus Particles as Versatile 3D‐Bio‐NanoRulers
Various super-resolution fluorescence microscopy methods achieve nanoscale resolution, vital for visualizing subcellular structures. Choosing suitable biological standards is challenging, demanding p...
https://advanced.onlinelibrary.wiley.com/doi/full/10.1002/adma.202403365
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Wow! Alexey
@alexeychizhik.bsky.social
, you never stop to amaze me. What a wonderful piece of sciart. Many congratulations 👏👏👏👏
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10 months ago
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Arindam Ghosh, PhD
Jörg Enderlein
10 months ago
Although
@ritastrack.bsky.social
has publicly declared that Superresolution Optical Imaging (SOFI) is dead 🤓 I am happy to share our newest review about it
rdcu.be/d52ak
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Super-resolution optical fluctuation imaging
Nature Photonics - The authors present a review of super-resolution optical fluctuation imaging (SOFI), including its core working principle, recent advances and remaining challenges.
https://rdcu.be/d52ak
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Lattice lightsheet two-dye imager DNA-PAINT (LLS-TDI-DNA-PAINT) example
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10 months ago
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Arindam Ghosh, PhD
Jörg Enderlein
10 months ago
Super happy to see the manuscript of my former PhD student and close friend Arindam Ghosh,
@arindam92.bsky.social
, and the Markus Sauer lab,
@sauer-lab.bsky.social
, being pblished in Science:
www.science.org/doi/10.1126/...
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Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy
Elucidating the interaction between membrane proteins and antibodies requires whole-cell imaging at high spatiotemporal resolution. Lattice light-sheet (LLS) microscopy offers fast volumetric imaging ...
https://www.science.org/doi/10.1126/science.adq4510
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Arindam Ghosh, PhD
Sauer Lab
10 months ago
🔬 Ever wondered how therapeutic antibodies work? 3D LLS-TDI-DNA-PAINT and live-cell LLS microscopy allow decoding of the molecular interplay of endogenous CD20 on B cells with therapeutic antibodies. 📄 Read more:
www.science.org/doi/10.1126/...
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I am super happy to share our latest article entitled "Decoding the molecular interplay of CD20 and therapeutic antibodies with fast volumetric nanoscopy", now published in Science
www.science.org/doi/10.1126/...
It was my postdoctoral work mit
@sauer-lab.bsky.social
Congrats to all the co-authors!
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10 months ago
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Glad to see this one out. It was a great interdisciplinary collaborative effort with the Das research group at Uni Bayreuth. Many congratulations to Tong Zhang,
@joergenderlein.bsky.social
, and all the co-authors.
pubs.acs.org/doi/10.1021/...
11 months ago
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Binding of an immunotherapeutic monoclonal antibody (magenta) to target receptor CD20 on B cell membrane imaged live using lattice light-sheet. Our 'Science' will appear online soon. Stay tuned for more details.
#FluorescenceFriday
#Latticelightsheet
#TDIDNAPAINT
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12 months ago
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