Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment: iScience www.cell.com/iscience/ful...

Our recent work showing that tau phosphorylation alters cooperative binding and organelle transport in neurons is now posted at @elife.bsky.social. A big thanks to the reviewers and editors for their thoughtful assessment. doi.org/10.7554/eLif...

Help me spread the word about an opening for the Furino Chair in Bioengineering in the Department of Bioengineering at McGill University. We seek candidates focused on developing biotherapeutic approaches to cancer, including but not limited to mRNA vaccines, CAR-T, and immunotherapy. (1/3)

A few highlights from our new preprint: On taxol-stabilized microtubules In vitro, wild-type (WT) and phosphor-resistive (AP) tau form well-defined envelopes, while phosphomimetic (E14) tau does not bind cooperatively.

Very happy to share our latest work on tau. We show that tau binds cooperatively in living neurons. Phosphorylation disrupts tau envelopes, and misregulates axonal transport. www.biorxiv.org/content/10.1...

Steven M. Block | 2025 Benjamin Franklin Medal in Life Science fi.edu/en/awards/la... youtu.be/yeZJXeQo3JQ?... via @YouTube

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

Competition for microtubule lattice spacing between a microtubule expander and compactor. https://www.biorxiv.org/content/10.1101/2025.02.28.640185v1