New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦

We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1

Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.

Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell great work by Martin Picard www.scientificamerican.com/article/why-...

Our Special Issue: Cell Biology of Mitochondria is complete. Explore our ToC: journals.biologists.com/jcs/issue/13... Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al. journals.biologists.com/jcs/article/... #JCSMitoSI #Mitochondria

Happy to see this fun piece finally out. Congrats to Laurie for bringing this all together and thanks to Martin for his contributions.

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover: • Organelle Crosstalk • DNA Damage Responses & Inflammation • Organelles in Innate Immune Signaling • Organelle Communication in Disease and Aging More here: bit.ly/4jI458f @fusionconf.bsky.social

This work characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, and shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release and subsequent inflammation @mitomorph.bsky.social www.life-science-alliance.org/content/8/6/...

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩 @zidlab.bsky.social @tomo.science @hamid13r.bsky.social

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy www.life-science-alliance.org/content/8/6/...

Are u tired of reading about tariffs? Then take a look to our last work! @science.org www.science.org/doi/10.1126/...

A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A www.life-science-alliance.org/content/8/6/...

Our paper describing a novel MFN2 variant linked to mtDNA-mediated inflammation is now published at Life Science Alliance @lsajournal.org. doi.org/10.26508/lsa...

MITOtalks this week

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project! www.nature.com/naturecareer...

The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open. event.fourwaves.com/12cdb/pages

I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social Available in @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... #mito #mitochondria

New update on our preprint of the mt-HI-NESS reporter for imaging mtDNA nucleoids www.biorxiv.org/content/10.1...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

There are now 19 thematic PCIs but many disciplines remain to be covered! We are therefore making a call for the creation of new thematic PCIs and giving some information on how to start:

🎉 This year is a big year for us as we celebrate 100 years of The Company of Biologists (and 100 years of supporting the community)! Join us at our celebratory conference (100yearsconference.biologists.com) and keep an eye out for exciting content throughout the year! #biologists100 #notforprofit

Once again, 20 minutes of struggling to do something in R ends with me giving up and writing a Perl one-liner in less than a minute.

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases www.medrxiv.org/content/10.1...

My first ever post on BlueSky, and it's to share my very first #FirstAuthor publication from my MSc in Calgary! I'm thrilled to finally share this work in Cell Death & Disease. Check it out here:: doi.org/10.1038/s414... Huge thanks to my amazing co-authors for making this work possible.

Happy to chat about this 👇 and the many other reasons to choose @jcellsci.bsky.social! I’ll be at the @biologists.bsky.social booth (517) during the poster sessions (…when I’m not whizzing around between the hundreds of sessions)! #CellBio2024

It's time 🙃!! The soon-to-be-open Bomba-Warczak Lab at UPenn is HIRING postdocs! If you're interested in mitochondria, proteomics, neurons and/or oocytes, and want to join a young & vibrant lab in a vibrant city - apply 👉 www.bombawarczaklab.com/people/now-h... #TeamMassSpec #mitochondria

Excited to co-chair a session on Cell Biology of Organelles with Laura Lackner @ascbiology.bsky.social #CellBio2024 on Monday, 12/16 at 5pm. We have a great line up of speakers.. check it out! 👇

Looking forward to catching up during ASCB. Will try to make it to the afternoon of this exciting workshop.

Hello science friends, we are in the market for a new -80C freezer. Any recommendations? Many thanks!

For all the metabolism lovers, we are excited (our recent manuscript) to demonstrate that mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways! www.life-science-alliance.org/content/7/12...

Hi everyone! Blue Sky seems alright! Check out our massive new review on Coenzyme Q that earned the cover 😉.

I just created a starter pack to collect accounts related to mtDNA research. Feel free to contact me if I should put someone on the list go.bsky.app/BiCguQz

Our opinion piece is out! My first published postdoc work with Lena Pernas. 🎉 Here, we speculate whether mitochondria can autonomously sense and elicit a response to microbes. 🤔🦠 #mitochondria #microbes dlvr.it/TGLcRm

I thought to start the BlueSky with our review in Annual Review of Biophysics describing mitochondrial dynamics, published early this year! t.co/MXpJnzAJ2T

A community consensus paper about a contentious subject like the Last Eukaryotic Common Ancestor does feel very bluesky in late 2024 doesn't it? It was pretty fun to write. Hopefully you'll have fun reading it:) Kudos to @Tom Richards for his writing and cat herding abilities! plos.io/4g0alq4

Hello Bsky folks - here is a paper that we published earlier this year - great collaboration with the Bellen lab, Hyung-lok Chung, @okanca.bsky.social and others. Have a look if you're interested in Cdk8/19, mitochondria, Parkinsonism and Drosophila!

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪 www.annualreviews.org/content/jour... #Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

We have arrived. #mitochondria #MITOtalks #MITOchats

A PSA for PIs: If you have a light microscope, please have watch your lab watch these short practical videos on how to prevent damage to your objective lenses! Trust me on this one, they need it... #savetheobjectives youtube.com/playlist?lis...

Check out our new preprint characterizing the Q367H MFN2 variant, which we linked to mtDNA-mediated inflammation: www.medrxiv.org/content/10.1... Congrats to all the authors.

For anyone attending ASCB who wants to learn more about our new mtDNA probe - Co-author and Collaborator Pina Colarusso will be presenting a poster Tuesday afternoon: www.biorxiv.org/content/10.1...

We have a new pre-print up of a review paper by recently graduated MSc student Laurie Lee-Glover looking at how impaired mitochondrial protein import is sensed by multiple different mechanisms to activate different mitochondrial quality control responses: preprints.scielo.org/index.php/sc...