Time-resolved tmFRET reveals GTP-coupled conformational changes in Mfn1 rupress.org/jcb/article-...

More organelle conversations! www.sciencedirect.com/science/arti...

Super excited to present out work at @mitotalks.bsky.social this Thursday!! Hope to see you there!

We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us: martinottlab.com Apply here: web103.reachmee.com/ext/I005/103...

5 years of MITOtalks! Feels like it was yesterday when @wanrooij20.bsky.social and @nunoraimundo.bsky.social opened the first MITOtalk to introduce @frezzalab.bsky.social. But it turns out FIVE YEARS have passed. That's 57 MITOtalks, 44 MITOchats, 6000+ followers. Onwards and upwards!

Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

We are hiring!. If you hold a PhD in natural science and are passionate about mitochondria, reach out!

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org. rdcu.be/eKKz1 🇨🇦

We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv: www.biorxiv.org/content/10.1...

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1

Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.

Congrats to ShuttLab PhD student Mashiat Zaman @mashiatzaman.bsky.social on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa

Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support. www.nature.com/articles/s41...

Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented @washubbsb.bsky.social graduate student Youmian Yan. A 🧵 www.biorxiv.org/content/10.1...

Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell great work by Martin Picard www.scientificamerican.com/article/why-...

Our Special Issue: Cell Biology of Mitochondria is complete. Explore our ToC: journals.biologists.com/jcs/issue/13... Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al. journals.biologists.com/jcs/article/... #JCSMitoSI #Mitochondria

Happy to see this fun piece finally out. Congrats to Laurie for bringing this all together and thanks to Martin for his contributions.

🚨New preprint!🚨 #teamtomo We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student, @mmedina300kv.bsky.social (defending Monday! 🍾) w/ @attychang.bsky.social @hamid13r.bsky.social & @tomo.science

Excited to call your attention to a new Fusion Conference this October in Malta. #IOSCD25 will cover: • Organelle Crosstalk • DNA Damage Responses & Inflammation • Organelles in Innate Immune Signaling • Organelle Communication in Disease and Aging More here: bit.ly/4jI458f @fusionconf.bsky.social

This work characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, and shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release and subsequent inflammation @mitomorph.bsky.social www.life-science-alliance.org/content/8/6/...

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩 @zidlab.bsky.social @tomo.science @hamid13r.bsky.social

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy www.life-science-alliance.org/content/8/6/...

Are u tired of reading about tariffs? Then take a look to our last work! @science.org www.science.org/doi/10.1126/...

A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A www.life-science-alliance.org/content/8/6/...

Our paper describing a novel MFN2 variant linked to mtDNA-mediated inflammation is now published at Life Science Alliance @lsajournal.org. doi.org/10.26508/lsa...

MITOtalks this week

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.org/10.1038/s415...htt

Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project! www.nature.com/naturecareer...

The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open. event.fourwaves.com/12cdb/pages

I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social Available in @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... #mito #mitochondria

New update on our preprint of the mt-HI-NESS reporter for imaging mtDNA nucleoids www.biorxiv.org/content/10.1...

Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer @science.org Huge THANKS to all the amazing collaborators + @salkinstitute, SBP www.science.org/doi/10.1126/...

There are now 19 thematic PCIs but many disciplines remain to be covered! We are therefore making a call for the creation of new thematic PCIs and giving some information on how to start:

🎉 This year is a big year for us as we celebrate 100 years of The Company of Biologists (and 100 years of supporting the community)! Join us at our celebratory conference (100yearsconference.biologists.com) and keep an eye out for exciting content throughout the year! #biologists100 #notforprofit

Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases www.medrxiv.org/content/10.1...

My first ever post on BlueSky, and it's to share my very first #FirstAuthor publication from my MSc in Calgary! I'm thrilled to finally share this work in Cell Death & Disease. Check it out here:: doi.org/10.1038/s414... Huge thanks to my amazing co-authors for making this work possible.

Happy to chat about this 👇 and the many other reasons to choose @jcellsci.bsky.social! I’ll be at the @biologists.bsky.social booth (517) during the poster sessions (…when I’m not whizzing around between the hundreds of sessions)! #CellBio2024

It's time 🙃!! The soon-to-be-open Bomba-Warczak Lab at UPenn is HIRING postdocs! If you're interested in mitochondria, proteomics, neurons and/or oocytes, and want to join a young & vibrant lab in a vibrant city - apply 👉 www.bombawarczaklab.com/people/now-h... #TeamMassSpec #mitochondria

Excited to co-chair a session on Cell Biology of Organelles with Laura Lackner @ascbiology.bsky.social #CellBio2024 on Monday, 12/16 at 5pm. We have a great line up of speakers.. check it out! 👇

Looking forward to catching up during ASCB. Will try to make it to the afternoon of this exciting workshop.

Hello science friends, we are in the market for a new -80C freezer. Any recommendations? Many thanks!

For all the metabolism lovers, we are excited (our recent manuscript) to demonstrate that mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways! www.life-science-alliance.org/content/7/12...

Hi everyone! Blue Sky seems alright! Check out our massive new review on Coenzyme Q that earned the cover 😉.

I just created a starter pack to collect accounts related to mtDNA research. Feel free to contact me if I should put someone on the list go.bsky.app/BiCguQz

Our opinion piece is out! My first published postdoc work with Lena Pernas. 🎉 Here, we speculate whether mitochondria can autonomously sense and elicit a response to microbes. 🤔🦠 #mitochondria #microbes dlvr.it/TGLcRm

I thought to start the BlueSky with our review in Annual Review of Biophysics describing mitochondrial dynamics, published early this year! t.co/MXpJnzAJ2T