Shutt Lab
@mitomorph.bsky.social
📤 1171
📥 356
📝 59
Associate Professor at University of Calgary studying mitochondria.
reposted by
Shutt Lab
Heidi M McBride
about 2 months ago
New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful!
@mitocollier.bsky.social
Funded by
#CIHR
,
@asapresearch.parkinsonsroadmap.org
.
rdcu.be/eKKz1
🇨🇦
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Shutt Lab
Thompson Lab
3 months ago
We have a new preprint! A major part of Taylor's PhD research is now available to read on bioRxiv:
www.biorxiv.org/content/10.1...
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Hyper-proliferation of Adipose Progenitors During Developmental Adipogenesis Programs Higher Adipocyte Number and Early-onset Obesity in Offspring Born to Obese Dams
Being born to a mother who was obese during pregnancy is one of the strongest predictors of early onset obesity and metabolic syndrome. To identify the developmental mechanism linking maternal obesity...
https://www.biorxiv.org/content/10.1101/2025.09.13.676029v1
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Shutt Lab
bioRxiv Cell Biology
5 months ago
Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells
https://www.biorxiv.org/content/10.1101/2025.06.23.660251v1
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Thanks for including us in this exciting work! Looking forward to the next stages of this fun collaboration.
add a skeleton here at some point
5 months ago
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Congrats to ShuttLab PhD student Mashiat Zaman
@mashiatzaman.bsky.social
on receiving an award for his short talk at the recent CSMB-PRinCE meeting in Ottawa
6 months ago
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Shutt Lab
A. Phillip West
6 months ago
Delighted to share our paper describing how type I interferon promotes caspase-11 hyperactivity in models of PolG-related mitochondrial disease. Thanks to all co-authors and the POLG Foundation for for their support.
www.nature.com/articles/s41...
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Caspase-11 drives macrophage hyperinflammation in models of Polg-related mitochondrial disease - Nature Communications
Mitochondrial diseases lead to chronic health impairment, aggravated by infections and other environmental exposures. Here authors show, in a mouse model of polymerase gamma (Polg)-related mitochondri...
https://www.nature.com/articles/s41467-025-59907-8
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Shutt Lab
Natalie Niemi
6 months ago
Very excited to share our latest work, “Mitochondrial presequences harbor variable strengths to maintain organellar function,” led by the fantastically talented
@washubbsb.bsky.social
graduate student Youmian Yan. A 🧵
www.biorxiv.org/content/10.1...
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Mitochondrial presequences harbor variable strengths to maintain organellar function
Hundreds of mitochondrial-destined proteins rely on N-terminal presequences for organellar targeting and import. While generally described as positively charged amphipathic helices, presequences lack ...
https://www.biorxiv.org/content/10.1101/2025.05.26.655807v1
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Shutt Lab
Hansi Weissensteiner
7 months ago
Mitochondria Are More Than Powerhouses—They’re the Motherboard of the Cell great work by Martin Picard
www.scientificamerican.com/article/why-...
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The Hidden Social Lives of Mitochondria
When these energy-giving organelles thrive, so do we
https://www.scientificamerican.com/article/why-mitochondria-are-more-like-a-motherboard-than-the-powerhouse-of-the-cell/
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Shutt Lab
Journal of Cell Science
7 months ago
Our Special Issue: Cell Biology of Mitochondria is complete. Explore our ToC:
journals.biologists.com/jcs/issue/13...
Our cover image highlights mitochondria (magenta) and DNA (cyan) in glioblastoma cells from Buckley et al.
journals.biologists.com/jcs/article/...
#JCSMitoSI
#Mitochondria
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Happy to see this fun piece finally out. Congrats to Laurie for bringing this all together and thanks to Martin for his contributions.
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7 months ago
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Shutt Lab
Danielle Grotjahn
7 months ago
🚨New preprint!🚨
#teamtomo
We expanded Surface Morphometrics to quantify membrane thickness from cryo-ET—revealing local variation across organelles. Led by the lab’s first grad student,
@mmedina300kv.bsky.social
(defending Monday! 🍾) w/
@attychang.bsky.social
@hamid13r.bsky.social
&
@tomo.science
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Shutt Lab
A. Phillip West
7 months ago
Excited to call your attention to a new Fusion Conference this October in Malta.
#IOSCD25
will cover: • Organelle Crosstalk • DNA Damage Responses & Inflammation • Organelles in Innate Immune Signaling • Organelle Communication in Disease and Aging More here:
bit.ly/4jI458f
@fusionconf.bsky.social
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Inter-organelle Stress Communication in Inflammation & Disease Conference | Fusion Conferences
Our scientific research conferences support the development of physical, medical and life sciences, providing a powerful platform that encourages discussion and collaboration in luxury locations acros...
https://bit.ly/4jI458f
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reposted by
Shutt Lab
Life Science Alliance
8 months ago
This work characterizes the Q367H variant in MFN2, identified in a patient with myopathy but no peripheral, and shows a novel way in which MFN2 dysfunction causes disease by promoting mtDNA release and subsequent inflammation
@mitomorph.bsky.social
www.life-science-alliance.org/content/8/6/...
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reposted by
Shutt Lab
Danielle Grotjahn
8 months ago
I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant
@attychang.bsky.social
—landed the cover of the April issue of JCB! 🤩
@zidlab.bsky.social
@tomo.science
@hamid13r.bsky.social
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reposted by
Shutt Lab
Life Science Alliance
8 months ago
New work from Zaman et al., in the Shutt Lab
@mitomorph.bsky.social
, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...
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reposted by
Shutt Lab
David Pla Martin
8 months ago
Are u tired of reading about tariffs? Then take a look to our last work!
@science.org
www.science.org/doi/10.1126/...
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Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
https://www.science.org/doi/10.1126/sciadv.adr6415
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reposted by
Shutt Lab
David Pla Martin
8 months ago
A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A
www.life-science-alliance.org/content/8/6/...
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The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation
Pathogenic variants in the mitochondrial protein MFN2 are typically associated with a peripheral neuropathy phenotype, but can also cause a variety of additional pathologies including myopathy. Here, ...
https://www.life-science-alliance.org/content/8/6/e202402921
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Our paper describing a novel MFN2 variant linked to mtDNA-mediated inflammation is now published at Life Science Alliance
@lsajournal.org
.
doi.org/10.26508/lsa...
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8 months ago
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Shutt Lab
8 months ago
MITOtalks this week
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Great chance for Canadian researchers to attend a great scientific meeting in Canada!
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8 months ago
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reposted by
Shutt Lab
Andrew Roger
9 months ago
I'm pleased to introduce our new paper rooting the eukaryote Tree of Life (eToL) that resulted from a collaboration led by PhD student Kelsey Williamson and a large group of collaborators doi.or
g/10.1038/s415...htt
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A robustly rooted tree of eukaryotes reveals their excavate ancestry - Nature
The root of the eukaryote Tree of Life is estimated from a new, larger dataset of mitochondrial proteins including all known eukaryotic supergroups, showing it lies between two multi-supergroup assemb...
https://doi.org/10.1038/s41586-025-08709-5
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reposted by
Shutt Lab
Martin Ott lab
9 months ago
Less than a week left to apply to the open post doc position in our lab. Join us in beautiful Gothenburg to work on an exciting project!
www.nature.com/naturecareer...
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Postdoc on Mitochondrial Biogenesis and Quality Control - Gothenburg (Stad), Västra Götaland (SE) job with University of Gothenburg | 12835658
Investigating the molecular connectivity of mitochondrial gene expression, protein biogenesis and quality control Background: Mitochondria convert ...
https://www.nature.com/naturecareers/job/12835658/postdoc-on-mitochondrial-biogenesis-and-quality-control/?_gl=1*1a5b67z*_up*MQ..*_gs*MQ..*_ga*MjExMTA5Mjg0Mi4xNzM4NjYxODg2*_ga_ZPPY0FP3YS*MTczODY2MTg4NS4xLjEuMTczODY2MzQxNy4wLjAuMA..*_ga_ERRNTNZ807*MTczODY2MTg4NS4xLjEuMTczODY2MzQxNy4wLjAuNzAwNDAzMjY1&gclid=Cj0KCQiAkoe9BhDYARIsAH85cDOeioEaSDbw0Y4v3JHasY_a9d1Wt5EYmVFnvgV9ToiJKozPxyKqUrsaAimCEALw_wcB
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reposted by
Shutt Lab
Peng Huang
9 months ago
The 12th Canadian Developmental Biology Conference will take place in the beautiful city of Kelowna, British Columbia, Canada, in May 25-28, 2025. The registration is still open.
event.fourwaves.com/12cdb/pages
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reposted by
Shutt Lab
Isi Molina-Riquelme
10 months ago
I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing
@jmacuada.bsky.social
Available in
@cp-trendscellbio.bsky.social
www.cell.com/trends/cell-...
#mito
#mitochondria
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How are mitochondrial nucleoids trafficked?
Mitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding inner mitochondrial membrane (...
https://www.cell.com/trends/cell-biology/abstract/S0962-8924(24)00272-1
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New update on our preprint of the mt-HI-NESS reporter for imaging mtDNA nucleoids
www.biorxiv.org/content/10.1...
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A novel genetic fluorescent reporter to visualize mitochondrial nucleoids
Mitochondria have their own genome (mtDNA), which is present in hundreds of copies per cell and organized into nucleoid structures that are distributed throughout the dynamic mitochondrial network. Be...
https://www.biorxiv.org/content/10.1101/2023.10.23.563667v2
10 months ago
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Shutt Lab
Tcellogic (Sue Kaech)
11 months ago
Interested in how T cells are regulated in a tissue-specific manner? Karthik Varanasi’s exciting work shows Bile Acid synthesis impedes tumor-specific T cell responses during liver cancer
@science.org
Huge THANKS to all the amazing collaborators + @salkinstitute, SBP
www.science.org/doi/10.1126/...
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Bile acid synthesis impedes tumor-specific T cell responses during liver cancer
The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that...
https://www.science.org/doi/10.1126/science.adl4100
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Shutt Lab
Peer Community In
11 months ago
There are now 19 thematic PCIs but many disciplines remain to be covered! We are therefore making a call for the creation of new thematic PCIs and giving some information on how to start:
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Call for the creation of new PCIs - Peer Community In
Here is the list of the different Peer Communities In already created, hosting recommendations and peer-reviews of preprints and ready to receive your submissions
https://buff.ly/40azLuY
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Shutt Lab
Seema Grewal
11 months ago
🎉 This year is a big year for us as we celebrate 100 years of The Company of Biologists (and 100 years of supporting the community)! Join us at our celebratory conference (100yearsconference.biologists.com) and keep an eye out for exciting content throughout the year!
#biologists100
#notforprofit
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reposted by
Shutt Lab
Ian Holmes
11 months ago
Once again, 20 minutes of struggling to do something in R ends with me giving up and writing a Perl one-liner in less than a minute.
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Shutt Lab
Anupam Patgiri
11 months ago
Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases
www.medrxiv.org/content/10.1...
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Mitochondrial DNA variant detection in over 6,500 rare disease families by the systematic analysis of exome and genome sequencing data resolves undiagnosed cases
Background Variants in the mitochondrial genome (mtDNA) cause a diverse collection of mitochondrial diseases and have extensive phenotypic overlap with Mendelian diseases encoded on the nuclear genome...
https://www.medrxiv.org/content/10.1101/2024.12.22.24319370v1.full
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Shutt Lab
James Sousa
12 months ago
My first ever post on BlueSky, and it's to share my very first
#FirstAuthor
publication from my MSc in Calgary! I'm thrilled to finally share this work in Cell Death & Disease. Check it out here::
doi.org/10.1038/s414...
Huge thanks to my amazing co-authors for making this work possible.
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GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease - Cell Death & Disease
Cell Death & Disease - GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn’s disease
https://doi.org/10.1038/s41419-024-07289-y
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Shutt Lab
Seema Grewal
12 months ago
Happy to chat about this 👇 and the many other reasons to choose
@jcellsci.bsky.social
! I’ll be at the
@biologists.bsky.social
booth (517) during the poster sessions (…when I’m not whizzing around between the hundreds of sessions)!
#CellBio2024
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Shutt Lab
Ewa Bomba-Warczak
12 months ago
It's time 🙃!! The soon-to-be-open Bomba-Warczak Lab at UPenn is HIRING postdocs! If you're interested in mitochondria, proteomics, neurons and/or oocytes, and want to join a young & vibrant lab in a vibrant city - apply 👉
www.bombawarczaklab.com/people/now-h...
#TeamMassSpec
#mitochondria
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Bomba Lab
https://www.bombawarczaklab.com
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Shutt Lab
Amit Joshi
12 months ago
Excited to co-chair a session on Cell Biology of Organelles with Laura Lackner
@ascbiology.bsky.social
#CellBio2024
on Monday, 12/16 at 5pm. We have a great line up of speakers.. check it out! 👇
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Looking forward to catching up during ASCB. Will try to make it to the afternoon of this exciting workshop.
add a skeleton here at some point
12 months ago
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reposted by
Shutt Lab
Markus Mukenhirn
12 months ago
journals.biologists.com/jcs/article-...
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Myosin II tension sensors visualize force generation within the actin cytoskeleton in living cells
Summary: Design and characterization of a novel FRET-based tension sensor that can detect myosin-associated forces in living cells.
https://journals.biologists.com/jcs/article-abstract/137/20/jcs262281/362544/Myosin-II-tension-sensors-visualize-force
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reposted by
Shutt Lab
Peng Huang
about 1 year ago
Hello science friends, we are in the market for a new -80C freezer. Any recommendations? Many thanks!
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Shutt Lab
Kondadi Lab
about 1 year ago
For all the metabolism lovers, we are excited (our recent manuscript) to demonstrate that mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways!
www.life-science-alliance.org/content/7/12...
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Mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways
Mitochondria play central roles in metabolism and metabolic disorders such as type 2 diabetes. MIC26, a mitochondrial contact site and cristae organising system complex subunit, was linked to diabetes...
https://www.life-science-alliance.org/content/7/12/e202403038
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Shutt Lab
Siegfried Hekimi
about 1 year ago
Hi everyone! Blue Sky seems alright! Check out our massive new review on Coenzyme Q that earned the cover 😉.
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Shutt Lab
Hansi Weissensteiner
about 1 year ago
I just created a starter pack to collect accounts related to mtDNA research. Feel free to contact me if I should put someone on the list
go.bsky.app/BiCguQz
add a skeleton here at some point
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Shutt Lab
José Delgado, Ph.D.
about 1 year ago
Our opinion piece is out! My first published postdoc work with Lena Pernas. 🎉 Here, we speculate whether mitochondria can autonomously sense and elicit a response to microbes. 🤔🦠
#mitochondria
#microbes
dlvr.it/TGLcRm
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Mitochondria as sensors of intracellular pathogens
Mitochondria must sense their environment to enable cells and organisms to adapt to diverse environments and survive during stress. However, during microbial infection, an evolutionary pressure since ...
http://dlvr.it/TGLcRm
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Shutt Lab
Kondadi Lab
about 1 year ago
I thought to start the BlueSky with our review in Annual Review of Biophysics describing mitochondrial dynamics, published early this year!
t.co/MXpJnzAJ2T
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https://www.annualreviews.org/doi/pdf/10.1146/annurev-biophys-030822-020736
https://t.co/MXpJnzAJ2T
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Shutt Lab
Dacks Lab (Evolutionary Cell Biology)
about 1 year ago
A community consensus paper about a contentious subject like the Last Eukaryotic Common Ancestor does feel very bluesky in late 2024 doesn't it? It was pretty fun to write. Hopefully you'll have fun reading it:) Kudos to @Tom Richards for his writing and cat herding abilities!
plos.io/4g0alq4
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Reconstructing the last common ancestor of all eukaryotes
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. This Consensus View lays out guidelines to identify the gene repertoire of the Last Eukaryotic Com...
https://plos.io/4g0alq4
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Shutt Lab
Esther Verheyen 🇨🇦
about 1 year ago
Hello Bsky folks - here is a paper that we published earlier this year - great collaboration with the Bellen lab, Hyung-lok Chung,
@okanca.bsky.social
and others. Have a look if you're interested in Cdk8/19, mitochondria, Parkinsonism and Drosophila!
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Shutt Lab
Juan C. Landoni 🔬
about 1 year ago
🔬 Curious about
#mitochondria
#imaging
but unsure where to begin? Our review might help! 🚀📜🧪
www.annualreviews.org/content/jour...
#Quantitative
#Microscopy
#SuperResolution
#AcademicSky
#ScienceSky
#CellBiology
#mtDNA
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reposted by
Shutt Lab
about 1 year ago
We have arrived.
#mitochondria
#MITOtalks
#MITOchats
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Shutt Lab
Jennifer Waters
about 1 year ago
A PSA for PIs: If you have a light microscope, please have watch your lab watch these short practical videos on how to prevent damage to your objective lenses! Trust me on this one, they need it...
#savetheobjectives
youtube.com/playlist?lis...
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Objective Lenses - YouTube
https://youtube.com/playlist?list=PL7Y2NBzyw8AhH8JHjPJEsnLKEUacGrGHZ&si=VBxhhjpE6irQrOku
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Check out our new preprint characterizing the Q367H MFN2 variant, which we linked to mtDNA-mediated inflammation:
www.medrxiv.org/content/10.1...
Congrats to all the authors.
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The MFN2 Q367H variant from a patient with late-onset distal myopathy reveals a novel pathomechanism connected to mtDNA-mediated inflammation
medRxiv - The Preprint Server for Health Sciences
https://www.medrxiv.org/content/10.1101/2024.06.20.24309123v1
over 1 year ago
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For anyone attending ASCB who wants to learn more about our new mtDNA probe - Co-author and Collaborator Pina Colarusso will be presenting a poster Tuesday afternoon:
www.biorxiv.org/content/10.1...
about 2 years ago
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We have a new pre-print up of a review paper by recently graduated MSc student Laurie Lee-Glover looking at how impaired mitochondrial protein import is sensed by multiple different mechanisms to activate different mitochondrial quality control responses:
preprints.scielo.org/index.php/sc...
about 2 years ago
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