Protein complex, the retromer, promotes recycling/disposal of damaged mitochondrial DNA 📷 Parisa Kakanj & Mari Bonse et al @dplamartin.bsky.social lab University of Cologne, Cologne, Germany in @science.org Science Advances ➡️ bpod.org.uk/archive/2025... with @rooph.bsky.social

Small molecules restore mutant mitochondrial DNA polymerase activity www.nature.com/articles/s41...

What a lovely paper from @dplamartin.bsky.social and his team! Mechanistic insight to mtDNA turnover at the lysosomes. 📬

www.hhu.de/en/news-arti... @hhu.de

Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...

Are u tired of reading about tariffs? Then take a look to our last work! @science.org www.science.org/doi/10.1126/...

Tomorrow will be a good day! I can’t wait to show you what we have…

A novel pathomechanism connected to mtDNA-mediated inflammation for CMT2A www.life-science-alliance.org/content/8/6/...

Being a PI is hard, we have to deal with one rejection after another, hours of work amounting to nothing because someone thinks our ideas aren’t cool enough. But then, suddenly, you get a yes! And life shines again. Thanks, @dfg.de , for your support!

I'm super happy that our story is now published! 📖 www.science.org/doi/10.1126/... But what changed compared to the original preprint? Also, I feel i should post Movie 1 🎥, that inspired the cover. Back when I did the original bluesky thread, movies were not available.

Whoa - are a significant proportion of sporadic ALS/motor neuron disease cases a mitochondrial DNA disease?! #mitochondria www.nature.com/articles/s41...

Big news: we are setting up a new non-profit organization to run bioRxiv and medRxiv. It's called openRxiv [no it's not a new preprint server; it's dedicated organization to oversee the servers] openrxiv.org 1/n

Great job! Many have tried, many have failed.

Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...

Engineering mtDNA deletions by reconstituting end joining in human mitochondria: Cell www.cell.com/cell/fulltex...

mtDNA goes places, and sometimes nucleoids end up in stressful situations. Our next speaker @lauraenewmanphd.bsky.social is keeping an eye (or two) on this, and will tell us all about it. This week, usual time and place.

Today is Rare disease day! There are over 6000 rare diseases that present with a variety of symptoms affecting all organs. Although we call them rare, they affect over 300 millions of individuals world-wide. Help raise awareness, so we, scientists, can search for cures.

That looks like something I must read

Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....

Dual regulation of mitochondrial fusion by Parkin–PINK1 and OMA1 www.nature.com/articles/s41...

Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA www.nature.com/articles/d41...

Putting the brakes on mitochondrial fusion to prevent escape of mitochondrial DNA www.nature.com/articles/d41...

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Such a great pleasure to host @dplamartin.bsky.social at UoB! A day full of cool science about #mitochondria, #endosomes and #mtDNA! Thank you for the visit!

Lovely visit to @unibirmingham.bsky.social . Thanks to my host @sofiaahola.bsky.social and to the best campus tour guide possible @jonwolfmueller.bsky.social. See you soon!

On way ✈️ to Birmingham! So excited to meet @sofiaahola.bsky.social and to show these guys our last research!

Time for some mito-business. Or should we say methyl-business?? Let's ask our speaker Thomas MacVicar. This thursday, usual time and place.

Thanks to Désirée Schatton and Christian Frezza @frezzalab.bsky.social for the great News and Views @naturecancer.bsky.social www.nature.com/articles/s43...

Fine-tuning tumor immunogenicity with mitochondrial complex I Our views on a very cool paper from @ppuigserverb.bsky.social we hope you like it! www.nature.com/articles/s43...

A cell photographed through a microscope. The powerhouses/overlords of the cell, mitochondria (pink), the Golgi apparatus (blue), and the actin filament cytoskeleton (orange) are shown. #Science #Biology #CellBiology #microscopy

“We're pleased to inform you that the editors are interested in publishing your paper; however….” I got too excited too quick

With two complete starter packs (in my profile), here is a 3rd one for the ever-growing metabolism community. Please contact me if you are working (prerequisite) on metabolism and want to be included here; there is still some space. I will keep updating it. go.bsky.app/7Uwa6fb

Let's make 2025 the "Year of the Mitochondria," to stimulate more research for mitochondrial and other diseases, incite curiosity and commitment from funders to invest in mitochondria as the heart of health and a key to solving resistant diseases and conditions. @MitoWorld.org / Image: Rehman Lab

For all the metabolism lovers, we are excited (our recent manuscript) to demonstrate that mitochondrial apolipoprotein MIC26 is a metabolic rheostat regulating central cellular fuel pathways! www.life-science-alliance.org/content/7/12...

Quite accurate

THUNDEROUS APPLAUSE

On the cover #MolecularCell. In this issue Acharya and Demetriades show how #mTORC1 🎈activation mediates its own release from the #lysosomes 🪐🌎. It was my pleasure to bring to life the grand idea from Aishwarya and Costas!

If your are having issues receiving strains from the CGC in Europe, this can really help,…Launch of the European Hub for CGC strain distribution community.alliancegenome.org/t/european-s...

Stressed mitochondrial RNA granules from our recent work on the cover of PNAS! A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1. #mitochondria #dsRNA

I am very excited to share this preprint led by Cissy Yong. 🧪 This study shows how tumour sampling conditions during surgery can alter the metabolic profile of ccRCC tissues, with major research implications #Metabolomics (now with the correct link) www.researchsquare.com/article/rs-5...

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪 www.annualreviews.org/content/jour... #Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

We have arrived. #mitochondria #MITOtalks #MITOchats

Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

Hi all! We’re excited to see this community grow. One of our main goals is to highlight the work and voices of women in mitochondrial research. Please tag us in any relevant posts so we can help to amplify these contributions!!

#StartPack for the #Ferroptosis researchers community. A small but growing list—let’s expand it together! Please, feel free to reach out if you'd like to be added or removed. 🧪🔬 go.bsky.app/35UvtTi

I didn't post it on the day of, but I did have my TEN YEAR ANNIVERSARY at Nature Methods last week. 🥳 My benchwork and the tools I made are the professional legacy of my twenties. My work at the journal is the legacy of my thirties. No big plans for change, but I do ponder what the future holds.

Recycling for #fluorescencefriday

One of my favourite videos that deserves to be here also. Mitochondria and mtDNA on the move!