Osman Lab
@osman-lab.bsky.social
π€ 275
π₯ 285
π 36
Studying the mysteries that surround the genome of the cell's powerhouse
https://www.osman-lab.de
pinned post!
We have officially launched our new lab website. π₯³ The site includes the automated literature curation on
#mtDNA
quality control and copy number regulation, which will appear on Mondays and Thursdays. Listen to the latest
#NotebookLM
generated podcast. 𧬠Explore the new site:
osman-lab.de
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The Osman Lab | LMU Munich
Mitochondrial research and genome maintenance at Ludwig-Maximilians-University.
https://osman-lab.de/
3 months ago
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reposted by
Osman Lab
Mokranjac Lab
2 months ago
Interested to know how
#mtHsp70
looks inside
#mitochondria
and what that means for
#mitochondrial
#proteostasis
and
#stress
#signalling
? Take a look at our latest publication in
@pnas.org
π₯³π₯³
@osman-lab.bsky.social
doi.org/10.1073/pnas...
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reposted by
Osman Lab
Juan C. Landoni
3 months ago
Our paper is now out in Science! Super excited to share our discovery that
#mitochondria
#pearling
is the elusive mechanism driving the regular distribution and inheritance of
#mtDNA
nucleoids 𧬠[1/6]
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reposted by
Osman Lab
Stella Hurtley
2 months ago
Out now in
@science.org
Pearling drives mitochondrial DNA nucleoid distribution | Science
www.science.org/doi/10.1126/...
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Pearling drives mitochondrial DNA nucleoid distribution
The distribution of mitochondrial DNAβcontaining nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...
https://www.science.org/doi/10.1126/science.adu5646
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Osman Lab
The EMBO Journal
3 months ago
What are the roles of UFMylation during ribosome-associated quality control?
@gekaragoz.bsky.social
@plantophagy.bsky.social
and colleagues find it to cooperate with RQC factors in promoting clearance of arrested nascent polypeptides at the ER
link.springer.com/article/10.1...
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The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
https://link.springer.com/article/10.1038/s44318-026-00753-9
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reposted by
Osman Lab
Yasin Dagdas
3 months ago
Congrats Milica
@alessandrick.bsky.social
& everyone
@gekaragoz.bsky.social
lab. Glad we could contribute to this awesome story on
#UFMylation
&
#RQC
crosstalk
@embojournal.org
link.springer.com/article/10.1...
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The coordinated action of UFMylation and the RQC pathways clears arrested polypeptides at the ER - The EMBO Journal
Clearance of arrested nascent polypeptides resulting from ribosomal stalling is essential for proteostasis. Stalled endoplasmic reticulum (ER)-bound ribosomes are marked by ubiquitin-fold modifier 1 (...
https://link.springer.com/article/10.1038/s44318-026-00753-9
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reposted by
Osman Lab
Elif KaragΓΆz
3 months ago
Our work on the role of Ufmylation on ribosome quality control on the ER is out! Great work of two terrific first authors Milica and
@alessandrick.bsky.social
together with our wonderful collaborators, the one and only Dagdas lab
@plantophagy.bsky.social
!
add a skeleton here at some point
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reposted by
Osman Lab
Hansi Weissensteiner
3 months ago
Emerging mechanisms of genome degradation during the mtDNA life cycle
www.nature.com/articles/s41...
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Emerging mechanisms of genome degradation during the mtDNA life cycle - Nature Cell Biology
Mitochondrial DNA (mtDNA) is not static but undergoes a regulated βlife cycleβ that encompasses replication, maintenance, spatial distribution and turnover. Here, we update emerging mtDNA degradative ...
https://www.nature.com/articles/s41556-026-01903-1
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reposted by
Osman Lab
New Phytologist
3 months ago
The New Phytologist Foundation is pleased to sponsor the 39th Molecular Biology of Plants Conference! The conference takes place in Hennef, Germany, this week.
www.pflanzen-molekularbiologie.de/conference-m...
@molplantsci.bsky.social
#PlantScience
#MBP2026
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Conference
Conference "Molecular Biology of Plants" - Annual meeting of the Section Plant Physiology and Molecular Biology in the German Society for Plant Sciences (DBG)
https://www.pflanzen-molekularbiologie.de/conference-molecular-biology-of-plants
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We have officially launched our new lab website. π₯³ The site includes the automated literature curation on
#mtDNA
quality control and copy number regulation, which will appear on Mondays and Thursdays. Listen to the latest
#NotebookLM
generated podcast. 𧬠Explore the new site:
osman-lab.de
loading . . .
The Osman Lab | LMU Munich
Mitochondrial research and genome maintenance at Ludwig-Maximilians-University.
https://osman-lab.de/
3 months ago
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Daily #mtDNA intel: β’ AK4-mediated synthesis fuels macrophage immunity 𧬠⒠T cell mutations found post-chemotherapy β’ Osteomodulin suppresses osteoclast respiration π¬ #genetics
π Full Dossier
|
ποΈ Podcast
3 months ago
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1
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Daily #mtDNA intel: β’ Structural partitioning improves phylogenetic signals 𧬠⒠Transmembrane helices show conserved thymine/hydrophobic bias π¬ β’ New #nematode mitogenome data.
π Full Dossier
|
ποΈ Podcast
3 months ago
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Daily #mtDNA intel: β’ PS1 in inner membrane regulates cristae & mtDNA stability 𧬠⒠MitoMetrics refines forensic likelihood ratios β’ SMC loss linked to MELAS dysmotility π¬ #Genetics
π Full Dossier
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ποΈ Podcast
3 months ago
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Daily #mtDNA intel: β’ Most axonal mitochondria lack mtDNA/ATP 𧬠⒠ROS impairs lysosomal flux in human APOE4 cells β’ Mitogenome variants impact Parkinson's progression π¬ #Neuro
π Full Dossier
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ποΈ Podcast
3 months ago
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Daily #mtDNA intel: β’ Fumarate loss activates cGAS-STING 𧬠⒠MT-CO2 m.8024G>A drives bioenergetic failure β’ mtDNA background impacts pS65-Ub in Lewy body disease π¬ #genetics
π Full Dossier
|
ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ C24-Ceramide-VDAC1 binding triggers hypoxic mtDNA release 𧬠⒠TFAM roles mapped across pan-cancer types β’ Melatonin identified as a mitochondrial radioprotectant π¬
π Full Dossier
|
ποΈ Podcast
4 months ago
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Daily #mtDNA intel: ⒠Liver mitochondria drive systemic inter-organ aging 𧬠⒠cGAS-STING blockade preserves tendon stem cell fitness ⒠ZBP1 promotes RIPK1-dependent apoptosis
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
TDvaliLab
4 months ago
#C.elegans
is about to join the 'centriolar satellites' club. Check out our new preprint
#centriolarsatellites
:
www.biorxiv.org/content/10.6...
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Daily #mtDNA intel: β’ MAF1 inhibits AIM2 by sequestering host mtDNA 𧬠⒠Cytoskeleton loss dysfunctions B-ALL mitochondria β’ LRRK2 G2019S drives oxidative DNA damage π¬ #CellBio #Genetics
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
Nature Structural & Molecular Biology
4 months ago
New online: Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
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Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Nature Structural & Molecular Biology, Published online: 27 February 2026; doi:10.1038/s41594-026-01756-0Kroczek et al show that degradation of DNAJC15 by OMA1 and AFG3L2 under stress limits mitochondrial protein import and OXPHOS biogenesis. Non-imported proteins lead to the induction of the unfolded protein responses from the endoplasmic reticulum.
http://dlvr.it/TRBzwf
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Daily #mtDNA intel: β’ APOL3 mediates mtDNA efflux via lysosomal damage β’ ALS blood/CSF mtDNA indices profiled 𧬠⒠CRISPR-guided biogenesis in iPSC-CMs π¬
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: ⒠TFAM replication vital for oocyte competence 𧬠⒠Hypoxia triggers APOBEC3A-mediated DNA damage ⒠Aging reduces muscle resilience after disuse #MitoSci
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ PRMT5 regulates stability via TFAM methylation 𧬠⒠Leakage triggers cGAS-STING neuroinflammation β’ Mitophagy failure promotes release in selenium deficiency π¬
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ 4,5-DHA validated as robust disease marker β’ Single-cell lineage tracing via inheritance modeling β’ ROS quenching suppresses cGAS-STING signaling π§¬π¬
π Full Dossier
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ποΈ Podcast
4 months ago
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Check out today's mtDNA research briefing!
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ Cardiospecific POLG loss drives cardiomyopathy 𧬠⒠EV-mediated mtDNA transfer triggers osteoarthritis β’ Gstk1 inhibits cGAS/STING in sepsis π¬ #genetics
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
Kurianlab
4 months ago
www.science.org/doi/10.1126/...
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Rapid directed evolution guided by protein language models and epistatic interactions
Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...
https://www.science.org/doi/10.1126/science.aea1820
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reposted by
Osman Lab
Andreas P.M. Weber πΎπ±π§¬
4 months ago
This argues against the hydrogen hypothesis of mitochondrial origin. π
www.nature.com/articles/s41...
See also this excellent context (including a microscopy π¬movie of crawling Asgards) by
@carlzimmer.com
:
www.nytimes.com/2026/02/18/s...
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Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature
Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgar...
https://www.nature.com/articles/s41586-026-10128-z
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Daily #mtDNA intel: β’ Single-cell lineage tracing via inheritance 𧬠⒠USP10-MTX2 axis regulates cGAS-STING signaling β’ EV mtDNA transfers drive osteoarthritis π¬
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
Carl Zimmer
4 months ago
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link:
nyti.ms/4qMbo22
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Osman Lab
Martin Ott lab
5 months ago
We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us:
martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
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Daily #mtDNA intel: β’ Mito transfer fuels tumor pyrimidine synthesis 𧬠⒠mtDNA dsRNA drives aging-associated cognitive decline β’ Novel 12244G>A variant linked to MELAS phenotype π¬
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
Florian FrΓΆhlich
4 months ago
New preprint from the lab together with
@labvanni.bsky.social
. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1.
www.biorxiv.org/content/bior...
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https://bsky.app/profile/labvanni.bsky.social
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Daily #mtDNA intel: β’ dsRNA drives aging-linked cognitive decline 𧬠⒠EV mtDNA transfer triggers osteoarthritis β’ ANOMALY pipeline identifies NuMTs in long-read data π¬ #Bio #Genetics
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ Gstk1 inhibits cGAS/STING in septic hearts 𧬠⒠LL37-mediated mtDNA stress drives rosacea π¬ β’ Nanosystems enable mtDNA control for wound repair
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ mtDNA inheritance enables lineage tracing 𧬠⒠LONP1 variants linked to diverse phenotypes β’ HSP90Ξ±/DRP1 axis triggers sepsis brain injury π¬ #mitochondria
π Full Dossier
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ποΈ Podcast
4 months ago
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3
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reposted by
Osman Lab
Amanda Moehring
4 months ago
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
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A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
https://www.science.org/doi/10.1126/science.adt2760
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Daily #mtDNA intel: β’ RNA G-quadruplexes brake OXPHOS assembly 𧬠⒠EV-mediated mtDNA transfer drives osteoarthritis β’ Photoactivatable POLRMT inhibition targets cancer π¬ #CellBio
π Full Dossier
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ποΈ Podcast
4 months ago
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2
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reposted by
Osman Lab
Joanna Chustecki
4 months ago
All together now π£οΈπ£οΈ : mitochondrial dynamics are vital *even in plants*! π£οΈπ£οΈ Fantastic work looking looking at the prime candidate for the mysterious & elusive plant mito fusion factors: MIRO1 The momentum for plant mito dynamics is picking up πͺπ»
www.nature.com/articles/s41...
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Mitochondrial fusion safeguards stomatal defence in plants - Nature Plants
Plants close their stomata to block pathogen entry, but how this defence is supported at the organelle level remains unclear. Our study reveals that immune signalling promotes MIRO1-dependent mitochon...
https://www.nature.com/articles/s41477-026-02233-8
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Daily #mtDNA intel: ⒠Nanosystems modulate mtDNA levels for healing ⒠LONP1 variants linked to diverse phenotypes ⒠MBD5/6 loss impairs respiration via chromatin 𧬠#genetics #biology
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
Hana Antonicka
4 months ago
To all
#mitochondria
lovers: Euromit 2026 early-bird registration is coming up!
add a skeleton here at some point
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reposted by
Osman Lab
Andreas P.M. Weber πΎπ±π§¬
4 months ago
π§¬β‘ Call for abstracts & participants | GRC 2026 β‘𧬠Together with Vamsi Mootha, Iβm chairing the 2026 Gordon Research Conference on Mitochondria & Chloroplasts (July 19 - 24, 2026). Weβd love to see your application. Thread π§΅π
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Daily #mtDNA intel: ⒠Ageing drives indel accumulation in energetic tissues ⒠Cytosolic mtDNA triggers NLRP3 in Parkinson's models ⒠ANOMALY pipeline improves NuMT detection 𧬠#genetics
π Full Dossier
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ποΈ Podcast
4 months ago
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Daily #mtDNA intel: β’ Molybdenum blocks cGAS-STING in pancreatitis π¬ β’ EV-mediated mtDNA transfer drives osteoarthritis β’ ANOMALY tool detects NuMTs via long-read seq 𧬠#Genetics
π Full Dossier
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ποΈ Podcast
4 months ago
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3
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reposted by
Osman Lab
LMU MΓΌnchen
4 months ago
#Photosynthesis
πΏ: A team led by
#LMU
biologist Hans-Henning Kunz has now deciphered the chloroplast ionome of various plant species. Their findings form an important basis for elucidating the regulation of mineral homeostasis in chloroplasts & developing new biotech strategies.
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Photosynthesis: new insights into mineral homeostasis of chloroplasts
LMU biologists decipher the ionome of chloroplasts and create the foundations for new biotech strategies.
https://www.lmu.de/en/newsroom/news-overview/news/photosynthesis-new-insights-into-mineral-homeostasis-of-chloroplasts-0fe03b0c.html
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Osman Lab
LSM
over 1 year ago
Check out our new newsletter!!πβ€οΈ Kudos to the newsletter team for their efforts!π
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Daily #mtDNA intel: β’ #NanoDel detects large mtDNA deletions via long-read seq π¬ β’ Damage markers link to Long COVID cognition β’ Mito mechanisms central to gentamicin nephrotoxicity.
π Full Dossier
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ποΈ Podcast
4 months ago
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reposted by
Osman Lab
BrunetLab
4 months ago
Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! π (please share)
careersearch.stanford.edu/jobs/life-sc...
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Life Science Research Professional 1 in School of Medicine, Stanford, California, United States
The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....
https://careersearch.stanford.edu/jobs/life-science-research-professional-1-29900
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Daily #mtDNA intel: 𧬠⒠TFAM modulation suppresses interferon signaling in SSc models. ⒠Astaxanthin targets pyroptosis via cGAS-STING inhibition. ⒠Archaic mtDNA fragments alter nuclear genome function in m...
π Full Dossier
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ποΈ Podcast
4 months ago
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5
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Daily #mtDNA intel: β’ Acridine ligand selectively targets mtG4s, triggering cancer apoptosis. β’ CLIPPER regulates LPIN1 biogenesis for heart regeneration. β’ BLM helicase inhibition disrupts caprine oocyte ma...
π Full Dossier
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ποΈ Podcast
4 months ago
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2
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reposted by
Osman Lab
Lorena Oli
4 months ago
Check out my first
@prelights.bsky.social
article, based on some great work done by Dr. Tejashree Waingankar &
@samlewis.bsky.social
at UC Berkeley π¬π§¬π§
prelights.biologists.com/highlights/s...
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Self-renewal of neuronal mitochondria through asymmetric division - preLights
Neurons contain βhotspotsβ for mitochondrial biogenesis at distal branch points
https://prelights.biologists.com/highlights/self-renewal-of-neuronal-mitochondria-through-asymmetric-division/
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