Our new paper is out 🎉 in @narjournal.bsky.social A fascinating complex composed of Mrx6, Mam33, and Pim1 controls #mtDNA copy number by regulating Lon-dependent substrate turnover in #yeast. Congrats to @simonrecyclable.bsky.social, all co-authors and collaborators! academic.oup.com/nar/article/...

How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab. journals.plos.org/plosgenetics... 🧬⚡

🚨 Preprint alert! 🚨 My first first-author manuscript is out on bioRxiv! We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process. @osman-lab.bsky.social #mtDNA #mitochondria www.biorxiv.org/content/10.1...

Lost in translation? Chloroplasts can handle slang! New study from our group at @lmumuenchen.bsky.social with great collabs @plantproteomics-ms.bsky.social @ifink-lab.bsky.social bsky.social‬ @hhu.de @wsupullman.bsky.social https://www.biorxiv.org/content/10.1101/2025.03.07.642005v1 🧵Often assumed

🚀 Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on @biorxivpreprint.bsky.social ! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. 🔬 Check it out here: www.biorxiv.org/content/10.1... #mitochondria #mtDNA

Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1

Akshaya Seshadri and Anjana Badrinarayanan @anjbadri.bsky.social @ncbsbangalore.bsky.social @tifrscience.bsky.social show that exonuclease action of replicative #polymerase gamma drives damage-induced #mitochondria #DNA clearance. New mechanism of mtDNA clearance. www.embopress.org/doi/full/10....

Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1...

And here's the thread by @gavsturm.bsky.social explaining their herculean and fascinating work on #pearling #biophysics!

@osman-lab.bsky.social < is that you > @osman_lab on 𝕏 ? @felix_thoma on 𝕏 Apr 25, 2022 "Mitochondrial dynamics in budding yeast. A picture was taken every 3 min for 5 h. I used mKate2 targeted to the mitos, and imaged the cells in a microfluidic chamber with a Nikon Ti2e Eclipse" need this here!