Osman Lab
@osman-lab.bsky.social
π€ 236
π₯ 217
π 33
Studying the mysteries that surround the genome of the cell's powerhouse
https://www.osman-lab.de
pinned post!
𧬠Introducing the
#mtDNA
Lab Intel Pipeline! Our system daily scans PubMed and bioRxiv to bring you: π
#Gemini
generated Daily Dossiers (PDF) and ποΈ
#NotebookLM
generated Podcasts with a focus on
#mtDNA-QC
and
#mtDNA-copy-number
π Full Archive:
drive.google.com/drive/folder...
about 1 month ago
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Daily #mtDNA intel: β’ Structural partitioning improves phylogenetic signals 𧬠⒠Transmembrane helices show conserved thymine/hydrophobic bias π¬ β’ New #nematode mitogenome data.
π Full Dossier
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ποΈ Podcast
1 day ago
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Daily #mtDNA intel: β’ PS1 in inner membrane regulates cristae & mtDNA stability 𧬠⒠MitoMetrics refines forensic likelihood ratios β’ SMC loss linked to MELAS dysmotility π¬ #Genetics
π Full Dossier
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ποΈ Podcast
3 days ago
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Daily #mtDNA intel: β’ Most axonal mitochondria lack mtDNA/ATP 𧬠⒠ROS impairs lysosomal flux in human APOE4 cells β’ Mitogenome variants impact Parkinson's progression π¬ #Neuro
π Full Dossier
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ποΈ Podcast
5 days ago
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Daily #mtDNA intel: β’ Fumarate loss activates cGAS-STING 𧬠⒠MT-CO2 m.8024G>A drives bioenergetic failure β’ mtDNA background impacts pS65-Ub in Lewy body disease π¬ #genetics
π Full Dossier
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ποΈ Podcast
7 days ago
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Daily #mtDNA intel: β’ C24-Ceramide-VDAC1 binding triggers hypoxic mtDNA release 𧬠⒠TFAM roles mapped across pan-cancer types β’ Melatonin identified as a mitochondrial radioprotectant π¬
π Full Dossier
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ποΈ Podcast
8 days ago
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Daily #mtDNA intel: ⒠Liver mitochondria drive systemic inter-organ aging 𧬠⒠cGAS-STING blockade preserves tendon stem cell fitness ⒠ZBP1 promotes RIPK1-dependent apoptosis
π Full Dossier
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ποΈ Podcast
9 days ago
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reposted by
Osman Lab
TDvaliLab
10 days ago
#C.elegans
is about to join the 'centriolar satellites' club. Check out our new preprint
#centriolarsatellites
:
www.biorxiv.org/content/10.6...
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Daily #mtDNA intel: β’ MAF1 inhibits AIM2 by sequestering host mtDNA 𧬠⒠Cytoskeleton loss dysfunctions B-ALL mitochondria β’ LRRK2 G2019S drives oxidative DNA damage π¬ #CellBio #Genetics
π Full Dossier
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ποΈ Podcast
10 days ago
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reposted by
Osman Lab
Nature Structural & Molecular Biology
13 days ago
New online: Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
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Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
Nature Structural & Molecular Biology, Published online: 27 February 2026; doi:10.1038/s41594-026-01756-0Kroczek et al show that degradation of DNAJC15 by OMA1 and AFG3L2 under stress limits mitochondrial protein import and OXPHOS biogenesis. Non-imported proteins lead to the induction of the unfolded protein responses from the endoplasmic reticulum.
http://dlvr.it/TRBzwf
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Daily #mtDNA intel: β’ APOL3 mediates mtDNA efflux via lysosomal damage β’ ALS blood/CSF mtDNA indices profiled 𧬠⒠CRISPR-guided biogenesis in iPSC-CMs π¬
π Full Dossier
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ποΈ Podcast
13 days ago
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Daily #mtDNA intel: ⒠TFAM replication vital for oocyte competence 𧬠⒠Hypoxia triggers APOBEC3A-mediated DNA damage ⒠Aging reduces muscle resilience after disuse #MitoSci
π Full Dossier
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ποΈ Podcast
14 days ago
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Daily #mtDNA intel: β’ PRMT5 regulates stability via TFAM methylation 𧬠⒠Leakage triggers cGAS-STING neuroinflammation β’ Mitophagy failure promotes release in selenium deficiency π¬
π Full Dossier
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ποΈ Podcast
15 days ago
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Daily #mtDNA intel: β’ 4,5-DHA validated as robust disease marker β’ Single-cell lineage tracing via inheritance modeling β’ ROS quenching suppresses cGAS-STING signaling π§¬π¬
π Full Dossier
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ποΈ Podcast
16 days ago
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Check out today's mtDNA research briefing!
π Full Dossier
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ποΈ Podcast
17 days ago
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Daily #mtDNA intel: β’ Cardiospecific POLG loss drives cardiomyopathy 𧬠⒠EV-mediated mtDNA transfer triggers osteoarthritis β’ Gstk1 inhibits cGAS/STING in sepsis π¬ #genetics
π Full Dossier
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ποΈ Podcast
20 days ago
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reposted by
Osman Lab
Kurianlab
20 days ago
www.science.org/doi/10.1126/...
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Rapid directed evolution guided by protein language models and epistatic interactions
Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...
https://www.science.org/doi/10.1126/science.aea1820
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reposted by
Osman Lab
Andreas P.M. Weber πΎπ±π§¬
20 days ago
This argues against the hydrogen hypothesis of mitochondrial origin. π
www.nature.com/articles/s41...
See also this excellent context (including a microscopy π¬movie of crawling Asgards) by
@carlzimmer.com
:
www.nytimes.com/2026/02/18/s...
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Oxygen metabolism in descendants of the archaeal-eukaryotic ancestor - Nature
Sequencing of marine sediments finds 136 newly identified Heimdallarchaeia and several novel lineages, and indicates that Heimdallarchaeia evolved distinct metabolic capabilities from other Asgar...
https://www.nature.com/articles/s41586-026-10128-z
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Daily #mtDNA intel: β’ Single-cell lineage tracing via inheritance 𧬠⒠USP10-MTX2 axis regulates cGAS-STING signaling β’ EV mtDNA transfers drive osteoarthritis π¬
π Full Dossier
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ποΈ Podcast
21 days ago
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reposted by
Osman Lab
Carl Zimmer
22 days ago
One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link:
nyti.ms/4qMbo22
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reposted by
Osman Lab
Martin Ott lab
about 1 month ago
We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us:
martinottlab.com
Apply here:
web103.reachmee.com/ext/I005/103...
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Daily #mtDNA intel: β’ Mito transfer fuels tumor pyrimidine synthesis 𧬠⒠mtDNA dsRNA drives aging-associated cognitive decline β’ Novel 12244G>A variant linked to MELAS phenotype π¬
π Full Dossier
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ποΈ Podcast
23 days ago
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reposted by
Osman Lab
Florian FrΓΆhlich
24 days ago
New preprint from the lab together with
@labvanni.bsky.social
. We looked what happens to ER generated free very long chain fatty acids.. VLCFAs are partionig into lipid droplets and are extracted from the hydrophobic core by Fat1.
www.biorxiv.org/content/bior...
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https://bsky.app/profile/labvanni.bsky.social
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Daily #mtDNA intel: β’ dsRNA drives aging-linked cognitive decline 𧬠⒠EV mtDNA transfer triggers osteoarthritis β’ ANOMALY pipeline identifies NuMTs in long-read data π¬ #Bio #Genetics
π Full Dossier
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ποΈ Podcast
24 days ago
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Daily #mtDNA intel: β’ Gstk1 inhibits cGAS/STING in septic hearts 𧬠⒠LL37-mediated mtDNA stress drives rosacea π¬ β’ Nanosystems enable mtDNA control for wound repair
π Full Dossier
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ποΈ Podcast
25 days ago
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Daily #mtDNA intel: β’ mtDNA inheritance enables lineage tracing 𧬠⒠LONP1 variants linked to diverse phenotypes β’ HSP90Ξ±/DRP1 axis triggers sepsis brain injury π¬ #mitochondria
π Full Dossier
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ποΈ Podcast
26 days ago
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reposted by
Osman Lab
Amanda Moehring
27 days ago
Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.
www.science.org/doi/10.1126/...
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A small polymerase ribozyme that can synthesize itself and its complementary strand
The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...
https://www.science.org/doi/10.1126/science.adt2760
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Daily #mtDNA intel: β’ RNA G-quadruplexes brake OXPHOS assembly 𧬠⒠EV-mediated mtDNA transfer drives osteoarthritis β’ Photoactivatable POLRMT inhibition targets cancer π¬ #CellBio
π Full Dossier
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ποΈ Podcast
27 days ago
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reposted by
Osman Lab
Joanna Chustecki
28 days ago
All together now π£οΈπ£οΈ : mitochondrial dynamics are vital *even in plants*! π£οΈπ£οΈ Fantastic work looking looking at the prime candidate for the mysterious & elusive plant mito fusion factors: MIRO1 The momentum for plant mito dynamics is picking up πͺπ»
www.nature.com/articles/s41...
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Mitochondrial fusion safeguards stomatal defence in plants - Nature Plants
Plants close their stomata to block pathogen entry, but how this defence is supported at the organelle level remains unclear. Our study reveals that immune signalling promotes MIRO1-dependent mitochon...
https://www.nature.com/articles/s41477-026-02233-8
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Daily #mtDNA intel: ⒠Nanosystems modulate mtDNA levels for healing ⒠LONP1 variants linked to diverse phenotypes ⒠MBD5/6 loss impairs respiration via chromatin 𧬠#genetics #biology
π Full Dossier
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ποΈ Podcast
28 days ago
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reposted by
Osman Lab
Hana Antonicka
29 days ago
To all
#mitochondria
lovers: Euromit 2026 early-bird registration is coming up!
add a skeleton here at some point
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reposted by
Osman Lab
Andreas P.M. Weber πΎπ±π§¬
30 days ago
π§¬β‘ Call for abstracts & participants | GRC 2026 β‘𧬠Together with Vamsi Mootha, Iβm chairing the 2026 Gordon Research Conference on Mitochondria & Chloroplasts (July 19 - 24, 2026). Weβd love to see your application. Thread π§΅π
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Daily #mtDNA intel: ⒠Ageing drives indel accumulation in energetic tissues ⒠Cytosolic mtDNA triggers NLRP3 in Parkinson's models ⒠ANOMALY pipeline improves NuMT detection 𧬠#genetics
π Full Dossier
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ποΈ Podcast
29 days ago
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Daily #mtDNA intel: β’ Molybdenum blocks cGAS-STING in pancreatitis π¬ β’ EV-mediated mtDNA transfer drives osteoarthritis β’ ANOMALY tool detects NuMTs via long-read seq 𧬠#Genetics
π Full Dossier
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ποΈ Podcast
about 1 month ago
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reposted by
Osman Lab
LMU MΓΌnchen
about 1 month ago
#Photosynthesis
πΏ: A team led by
#LMU
biologist Hans-Henning Kunz has now deciphered the chloroplast ionome of various plant species. Their findings form an important basis for elucidating the regulation of mineral homeostasis in chloroplasts & developing new biotech strategies.
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Photosynthesis: new insights into mineral homeostasis of chloroplasts
LMU biologists decipher the ionome of chloroplasts and create the foundations for new biotech strategies.
https://www.lmu.de/en/newsroom/news-overview/news/photosynthesis-new-insights-into-mineral-homeostasis-of-chloroplasts-0fe03b0c.html
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reposted by
Osman Lab
LSM
about 1 year ago
Check out our new newsletter!!πβ€οΈ Kudos to the newsletter team for their efforts!π
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Daily #mtDNA intel: β’ #NanoDel detects large mtDNA deletions via long-read seq π¬ β’ Damage markers link to Long COVID cognition β’ Mito mechanisms central to gentamicin nephrotoxicity.
π Full Dossier
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ποΈ Podcast
about 1 month ago
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reposted by
Osman Lab
BrunetLab
about 1 month ago
Interested in the mechanisms of aging and 'rejuvenation'? Our lab at Stanford has a Research Assistant/Lab manager position open!! Apply and join our awesome team! π (please share)
careersearch.stanford.edu/jobs/life-sc...
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Life Science Research Professional 1 in School of Medicine, Stanford, California, United States
The Brunet lab in the Department of Genetics at Stanford University (https://web.stanford.edu/group/brunet/) is seeking an independent and motivated.....
https://careersearch.stanford.edu/jobs/life-science-research-professional-1-29900
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Daily #mtDNA intel: 𧬠⒠TFAM modulation suppresses interferon signaling in SSc models. ⒠Astaxanthin targets pyroptosis via cGAS-STING inhibition. ⒠Archaic mtDNA fragments alter nuclear genome function in m...
π Full Dossier
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ποΈ Podcast
about 1 month ago
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Daily #mtDNA intel: β’ Acridine ligand selectively targets mtG4s, triggering cancer apoptosis. β’ CLIPPER regulates LPIN1 biogenesis for heart regeneration. β’ BLM helicase inhibition disrupts caprine oocyte ma...
π Full Dossier
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ποΈ Podcast
about 1 month ago
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reposted by
Osman Lab
Lorena Oli
about 1 month ago
Check out my first
@prelights.bsky.social
article, based on some great work done by Dr. Tejashree Waingankar &
@samlewis.bsky.social
at UC Berkeley π¬π§¬π§
prelights.biologists.com/highlights/s...
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Self-renewal of neuronal mitochondria through asymmetric division - preLights
Neurons contain βhotspotsβ for mitochondrial biogenesis at distal branch points
https://prelights.biologists.com/highlights/self-renewal-of-neuronal-mitochondria-through-asymmetric-division/
2
9
7
𧬠Introducing the
#mtDNA
Lab Intel Pipeline! Our system daily scans PubMed and bioRxiv to bring you: π
#Gemini
generated Daily Dossiers (PDF) and ποΈ
#NotebookLM
generated Podcasts with a focus on
#mtDNA-QC
and
#mtDNA-copy-number
π Full Archive:
drive.google.com/drive/folder...
about 1 month ago
0
8
5
reposted by
Osman Lab
KunzLab@LMU
about 1 month ago
Plz read our study by
@lmumuenchen.bsky.social
PhD cand. Lorenz. He describes chloroplast ionomes for several π±species & shows how plastid iron can be massively increased. Terrific help by peers from
@ruhr-uni-bochum.de
,
@mizzouid.bsky.social
and
@uni-saarland.de
academic.oup.com/plcell/artic...
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The chloroplast ionome shines light on the dynamics of organellar iron homeostasis
Loss of chloroplast iron (Fe) ferritin storage leads to Fe re-shuttling into the vacuole and reduced leaf tissue Fe content.
https://academic.oup.com/plcell/article/doi/10.1093/plcell/koag017/8444747
2
20
13
Our new paper is out π in
@narjournal.bsky.social
A fascinating complex composed of Mrx6, Mam33, and Pim1 controls
#mtDNA
copy number by regulating Lon-dependent substrate turnover in
#yeast
. Congrats to
@simonrecyclable.bsky.social
, all co-authors and collaborators!
academic.oup.com/nar/article/...
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Mrx6 binds the Lon protease Pim1Β N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Abstract. Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces c
https://academic.oup.com/nar/article/54/2/gkaf1390/8425365
about 2 months ago
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How do cells assess mtDNA quality? Local ATP and membrane-potential gradients reflect mtDNA integrity and drive intracellular purifying selection. We introduce FAST, a scalable mtDNA QC assay in S. cerevisiae. Great collaboration with the Schmoller Lab.
journals.plos.org/plosgenetics...
π§¬β‘
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Local mitochondrial physiology defined by mtDNA quality guides purifying selection
Author summary Mitochondria are essential organelles in our cells that convert nutrients into usable cellular energy. They contain their own DNA, and mutations in this DNA can compromise mitochondrial...
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1011836
2 months ago
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reposted by
Osman Lab
7 months ago
π¨ Preprint alert! π¨ My first first-author manuscript is out on bioRxiv! We developed a new method to monitor mtDNA quality control in yeast, and found that a functional respiratory chain is crucial for the process.
@osman-lab.bsky.social
#mtDNA
#mitochondria
www.biorxiv.org/content/10.1...
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Local Mitochondrial Physiology Defined by mtDNA Quality Guides Purifying Selection
The mitochondrial genome (mtDNA) encodes essential subunits of the electron transport chain and ATP synthase. Mutations in these genes impair oxidative phosphorylation, compromise mitochondrial ATP pr...
https://www.biorxiv.org/content/10.1101/2025.08.08.669275v1
1
12
4
reposted by
Osman Lab
KunzLab@LMU
about 1 year ago
Lost in translation? Chloroplasts can handle slang! New study from our group at
@lmumuenchen.bsky.social
with great collabs
@plantproteomics-ms.bsky.social
@ifink-lab.bsky.social
bsky.socialβ¬
@hhu.
d
e @wsupullman.bsky.soci
a
l https://www.biorxiv.org/content/10.1101/2025.03.07.642005
v1 π§΅Often assumed
1
20
9
π Excited to share our latest work on Mrx6 and mtDNA copy number regulation, now available on
@biorxivpreprint.bsky.social
! We uncover how Mrx6 and Mam33 interact with the Lon protease Pim1 to control substrate degradation. π¬ Check it out here:
www.biorxiv.org/content/10.1...
#mitochondria
#mtDNA
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Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Mitochondrial DNA (mtDNA) copy number regulation remains incompletely understood, despite its importance in cellular function. In Saccharomyces cerevisiae, Mrx6 belongs to the Pet20-domain-containing ...
https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1
about 1 year ago
0
19
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reposted by
Osman Lab
bioRxivpreprint
about 1 year ago
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
https://www.biorxiv.org/content/10.1101/2025.02.14.638270v1
0
1
1
reposted by
Osman Lab
EMBO Reports
about 1 year ago
Akshaya Seshadri and Anjana Badrinarayanan
@anjbadri.bsky.social
@ncbsbangalore.bsky.social
@tifrscience.bsky.social
show that exonuclease action of replicative
#polymerase
gamma drives damage-induced
#mitochondria
#DNA
clearance. New mechanism of mtDNA clearance.
www.embopress.org/doi/full/10....
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