🚀 Excited to share our new work: Absolute Stability Predictor! 📊: forms.gle/4ZnXZSnTBvay... Built the MGnify Stability Dataset (1.8M+ measurements) and developed stability prediction models, together with @grocklin.bsky.social @KotaroTsuboyama, @sokrypton.org and teams.

We've actually been working on this very actively and have quite promising results on larger/higher stability proteins using an improved method. Looking for funding to buy some (a lot of) oligos... any pointers? It's within reach...

Another banger

Thread coming later but I think people will like this!! 2 million stability measurements plus a predictive model for deltaG (not ddG)

Accurate protein stability prediction for small domains using mega-scale experiments https://www.biorxiv.org/content/10.64898/2026.05.19.726285v1

Happy to share this in its published form! More than any project I've worked on, this was a huge team effort, so thank you so much to that team! Especially @ajrferrari.bsky.social www.nature.com/articles/s41...

If you missed the preprint, now is a good time to read the journal version of @grocklin.bsky.social et al’s fantastic paper on multiplexed HDX measurements Large-scale discovery, analysis and design of protein energy landscapes doi.org/10.1038/s415...

Another example demonstrating that the federal science and research ecosystem is being seriously damaged regardless of what’s ultimately appropriated

NIGMS is signed onto the F31 NOFO. grants.nih.gov/grants/guide...

New lab preprint: if ML struggles with extrapolation, let's expand the diversity of training data with gene synth, DNA shuffling, and ML gen.... also lots of #FluorescentProteins #ProteinEngineering #MachineLearning #SyntheticBiology 1/n

High Diversity Gene Libraries Facilitate Machine Learning Guided Exploration of Fluorescent Protein Sequence Space https://www.biorxiv.org/content/10.64898/2026.03.01.706892v1

I’m looking to hire a research technician for my lab at Harvard & DFCI, who would primarily work in the wet lab expressing and characterizing designed proteins, starting this summer. A great role for a recent college grad looking for an immersive research experience before grad school.

Here’s a preprint from the Keating Lab: www.biorxiv.org/content/10.6.... Foster Birnbaum and Amy E. Keating demonstrate that sequence design models, such as ProteinMPNN, are limited because they were trained only on native sequences.

The final Calvin and Hobbes, which appeared in papers 30 years ago today.

Large scale prospective evaluation of co-folding across 557 Mac1-ligand complexes and three virtual screens [new] Mac1 co-folding eval: Pose prediction, conform. change, & hit ID post-training.

The most precious commodity you have is your attention. You don’t have to waste it on poor-faith debates or arguments with strangers if you don’t think they’ll be productive. You can prioritize the things that matter to you and make your life richer.

Excited to share our newest manuscript on antigen discovery and vaccine design for tuberculosis lead by Owen Leddy (everyone hiring new faculty in a few years, remember this name!) www.science.org/doi/10.1126/... #TBsky

New preprint! We measured temperature- and pH-induced aggregation for over 18,000 natural and de novo designed protein domains!

Global Analysis of Aggregation Determinants in Small Protein Domains https://www.biorxiv.org/content/10.1101/2025.11.11.687847v1

quick reminder to come see @grocklin.bsky.social tonight at @mit.edu!

Join us in Room 181, Building 68 @mit.edu on October 22nd 2025 @ 7pm EDT to see @grocklin.bsky.social present a mind blowing amount of data and learn what becomes possible at this scale "Predicting protein folding stability and aggregation propensity using large-scale experiments" bpdmc.org

Announcing such a major change to NSF GRFP this late in the cycle is incredibly cruel. 2nd yr students (mine included) have been working so hard on their proposals despite ongoing uncertainty. They are driven and passionate about being outstanding scientists and helping those coming up behind them.

Cecilia Payne-Gaposchkin ✨ figured out what stars are made of ✨ when she was just 25. 🔭🧪 Her PhD thesis basically established the Harvard astro department — at a time when Harvard didn't officially allow woman students. I wrote this little profile to mark the 100th anniversary of her thesis:

Vought and his “no more NIH money out the door” footnote is a power struggle. Between R’s getting antsy about hard votes and Senate signaling support for science funding, Vought had to signal his dominance in some way. Now is the real test: are R’s more afraid of Trump et al. or their constituents?

The NIH can’t award ANY grants to outside researchers under new WH restriction, reports @wsj.com. The pause came in the form of a footnote from OMB Director Vought, in a document that doles out federal funds to the NIH. Prelude to rescissions, especially after his comments over the weekend?

One might think, oh the fiscal year is only two months. But many of our grants are already delayed by weeks to months and we are on borrowed time as is. This is devastating and heralds darker times ahead.

PO just confirmed that our 5th percentile R01 is not getting funded. Past NCI Payline at 4 percent. Cant believe it.

NCI's payline will be the 4th percentile. The Trump administration has effectively killed Cancer Research in the US www.cancer.gov/grants-train...

A motivating quote from @carolynbertozzi.bskyverified.social: “…You are discovering knowledge and gifting that to humanity for all of posterity. Once you learn something no one can take that away. It is not an object. It is an intellectual currency that will be shared throughout the generations…”

#MorganLabatND is hiring a research technician!! We are looking for an aspiring biochemistry researcher that shares our community values, is curious about the world around them, and brings a unique perspective to our team. (1/2) jobs.smartrecruiters.com/UniversityOf...

Chicago!

Although 500 new NSF GRFPs were added in June, the total number of fellowships in 2025 remains ~500 fewer than in 2024. Some fields—like CS and Physics—still saw net increases in total awards. But others, including Life Sciences & Psychology, have taken hits of 50% or more compared to last year.

Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation. It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology

We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) www.biorxiv.org/content/10.1...

Keep in mind: these are AWARDED grants, with Notice of Awards. The federal government is not honoring existing contracts with this university, refusing to reimburse for costs charge on awarded grants.

Funding freeze at Northwestern from Emma Mairson at grant-watch.us. Data from USAspending. Normally, ~$70 M per month. Now, bupkis. Northwestern is keeping research moving and must be spending ~$40 M per month. Clearly not sustainable for too long.

Note that this (exceptional) visualization does not appear to account for the Harvard, Brown, Northwestern terminations. This is a major underestimate

Do you love flow cytometry, cell sorting and other quantitative, biophysical approaches for measuring cells and their biomolecules? Join our team at Notre Dame! www.linkedin.com/posts/ndbic_...

our lab is blessed to have 3 new postdoctoral fellow positions. we would welcome scientists interested in...

The notion that private institutions need to toe the party line is so fundamentally un-American it is almost unbelievable

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

Good cover @economist.com

The Ivy League should be preparing mutual defense agreements that would allow students to transfer, even just nominally, to any other Ivy. Then the Big10 should do the same. We succeed together, we fail apart.

This is especially important: “We call upon our fellow institutions of higher education in the United States to declare their willingness to facilitate the immediate co-enrollment of Harvard’s international students, including formal acceptance of transfer for immigration purposes.”

Three things made the US a rich and powerful nation: the rule of law, its science & innovation system, and openness to foreign talent. Remarkable how Trump has taken a sledgehammer to all three. No enemy of this country could do more.

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

“However, the NIH General Counsel’s office was very clear that this was not possible. The statutory authority for NIH is to support research and NIH does not have a say in how this is accomplished (as long as it is legal).” /fin

Should say "How the federal government became so deppendent on academic research labs"

Sources have shared 2 important pieces of information about NIH grant payments (although I am trying to get further confirmation). Hang on... (1) ALL payments to Columbia, Brown, Northwestern, Cornell, Weill-Cornell, Harvard are frozen. 1/3