Dying in the weather, but the views in Seoul are incredible

Very excited to be at the #KSBNS2025 in a few days! I’ll be presenting a poster in the first session (P-097) about our mScarlet based sensor for calcium PinkyCaMP and our developing mScarlet and 5HT1A based serotonin sensor. Stop by to talk and learn about this new generation of red sensors!

How many photons are in a GFP? — more than last year, and more than you thought. Here's a simple, cheap, and practical method to break a fundamental limit in fluorescence microscopy. But it only works in light sheet!

#OCaMP is now on bioRxiv and reagents are available on #Addgene! 🧪 A sensitive orange fluorescent calcium ion indicator for imaging neural activity www.biorxiv.org/content/10.1...

For those of you attending academic conferences in the U.S., after October 1, 2025 please note the following:

(1/3) Excited to introduce our new GRAB sensors for a series of steroid hormones! These tools enable real-time detection of steroid hormone dynamics in vivo🐭🧠. Happy to share these sensors and welcome any feedback! Please contact [email protected] for information.

A @csisingapore.bsky.social team showed D-I-Tasser can outperform AlphaFold2/3, elevating high-accuracy protein structure & function predictions. We wonder if this moves us closer to resolving protein–protein complex structure prediction? @natbiotech.nature.com www.nature.com/articles/s41...

New plasmids available from the @massecklab.bsky.social‬! PinkyCaMP, a mScarlet-based calcium sensor, can be leveraged for its exceptional brightness, photostability, and multiplexing capabilities. https://twp.ai/4iobS2

New tools! GreenPy and ApplePy are fluorescent biosensors for pyruvate with huge responses (20–40x in vitro) and a range of affinities (10s of μM to mM). These should be game changers for imaging of metabolism! Great work by Shosei Imai @sikmys.bsky.social and team 👏. www.biorxiv.org/content/10.1...

mScarlet3-H (aka mYongHong) is on the cover of Nature Methods! All plasmids are available for free from WeKwikGene wekwikgene.wllsb.edu.cn/publications...

New powerful article up in the New York Times on cancelled and delayed grants www.nytimes.com/interactive/...

Happy to see my Postdoc work out @natbiotech.nature.com. Using HaloTag and synthetic fluorophores instead of FPs enables us to shift the spectral properties of kinase activity reporters (KARs) to the far-red 🔬. Huge thanks to everyone involved @jinzhanglab.bsky.social! www.nature.com/articles/s41...

First PinkyCaMP plasmids are available via @addgene.bsky.social www.addgene.org/browse/artic... Cc @finkryan.bsky.social @massecklab.bsky.social

A highly photostable monomeric red fluorescent protein www.researchsquare.com/article/rs-5...

PinkyCaMP a mScarlet-based calcium sensor with exceptional brightness, photostability, and multiplexing capabilities https://www.biorxiv.org/content/10.1101/2024.12.16.628673v1

🎄PinkyCaMP- our christmas gift to you! 🎁: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with: ✨exceptional, brightness ✨phototability ✨and optogenetic compatability. Check out our new preprint: www.biorxiv.org/content/10.1...