Nikola Grujic
@neuro-nik.bsky.social
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Neuroscientist extraodinaire PostDoc @ Burdakov Lab, ETH Zurich
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Nikola Grujic
Prachee Avasthi
23 days ago
Check out the latest from Mike and I on how to be a scientist in a post-journal world 9/9
thescientistpapers.substack.com/p/how-to-be-...
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How to be a scientist in a post-journal world
When we created this site to write about things in science that need to be fixed, we chose not to start with publishing, even though it has been our preoccupation for decades.
https://thescientistpapers.substack.com/p/how-to-be-a-scientist-in-a-post-journal
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Nikola Grujic
Konrad Kording
about 2 months ago
Planning your first scientific project as the term is about to start? Teaching a project based course? I am working on an app that should help.
planyourscience.com
Still looking for feedback. Much simpler than any previous version. Works on mobile. Good science, much AI.
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Scientific Paper Planner
Scientific Paper Planner Application
http://planyourscience.com
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Nikola Grujic
Dr. Robin Carhart-Harris
about 2 months ago
This principle of play and inquiry is something that truly motivates me in what I do 🔬 Science is a method, a way of scrutinizing the world. We shouldn’t take it too seriously; it is a discipline, but it is also playful. 🍄✨
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Nikola Grujic
Peter Rupprecht
about 2 months ago
New blog post, where I review some recent interesting papers on the role of cell organelles for neuronal calcium signaling:
gcamp6f.com/2025/08/11/i...
Featuring work by
@lorenabenedetti.bsky.social
, O'Hare et al. and Lin et al.!
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Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling
Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…
https://gcamp6f.com/2025/08/11/interesting-papers-on-the-role-of-cell-organelles-in-neuronal-dendrites-for-calcium-signaling/
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Nikola Grujic
Santiago Rompani
about 2 months ago
The lab's first paper is out! We find that pupil constriction in mice drives strong retinal activity in vivo, and that humans can also perceive pupil-shaped stimulus. This has repercussions for anybody using pupillometry. đź§µ1/n
www.nature.com/articles/s41...
#neuroskyence
#neuroscience
#neuro
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Pupil size modulation drives retinal activity in mice and shapes human perception - Nature Communications
The pupil is known to assist retinal adaptation to light level changes. Here, the authors find a mechanism for how the pupillary light reflex drives monocular and binocular retinal activity in mice an...
https://www.nature.com/articles/s41467-025-62736-4
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Nikola Grujic
Johannes Bohacek
7 months ago
How much analgesia is needed to manage pain levels in mice after brain surgeries? A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit. (in line with recent work from others, see cites in our preprint):
www.biorxiv.org/content/10.1...
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GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice
Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and aut...
https://www.biorxiv.org/content/10.1101/2025.03.07.642046v1
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Amazing work from our colleagues at ETH/UZH answering many unknowns about arousal during sleep. And congrats to their participants for being able to sleep with their eyes taped open!
www.nature.com/articles/s41...
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Pupil size reveals arousal level fluctuations in human sleep - Nature Communications
Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...
https://www.nature.com/articles/s41467-025-57289-5
7 months ago
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The arguments for scientific funding in a time of crisis are only weakened by research like this. I understand this was probably very fun for the authors, but was it really necessary?
#neuroskyence
pmc.ncbi.nlm.nih.gov/articles/PMC...
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Rats can distinguish (and generalize) among two white wine varieties
In the olfactory literature there is considerable debate about how differences in olfactory receptors across different species map onto variations in perceptual acuity and performance. Although humans...
https://pmc.ncbi.nlm.nih.gov/articles/PMC11842533/
7 months ago
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Sci-hub has been officially promoting a crypto shitcoin on their Facebook and official page sci-hub.se. It looks like it is going to zero. Did sci-hub just do a cheeky rugpull?? What a timeline
#academia
#openaccess
#neuroskyence
7 months ago
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Love me a good inbuilt forced pdf reader where no shortcuts I am used to work and it covers only a third of the screen. Thanks for nothing I will download it now pls
7 months ago
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I'm in contact with DOGE to see if they can get SFN to refund my abstract submission fees from the cancelled SFN meeting in 2021. Stay tuned
8 months ago
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Tired of not being eligible for postdoc funding schemes because I don't want to move to another country to start the project. The system where scientists are required to upend their life for vague reasons of changing scientific environments is shite. Just another pointless sacrifice
#neuroskyence
8 months ago
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Wanted just to follow and post science but you are relentless with political outrage posts. If whats happening now is what outrages you, you haven't been cynical enough
8 months ago
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Whens easter im tired
9 months ago
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Nikola Grujic
Thomas Andrillon
10 months ago
Amazing work from the team of Anita Lüthi! Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle
www.nature.com/articles/s41...
💤🧪đź§
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Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle - Nature Neuroscience
LĂĽthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...
https://www.nature.com/articles/s41593-024-01822-0
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too late to start a new analysis, yet too early to start predrinking the institute christmas party
10 months ago
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What happens if some journal company dies do the papers go down with them
10 months ago
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Need a journal where you can publish just one figure. Don't need to make up useless experiments / visualizations for another 4 figs
10 months ago
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You can just find pics from the concert you went to online afterwards and pretend you took them
10 months ago
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Nikola Grujic
eLife
10 months ago
🧵 1/10 How does the eLife Model work? After 10,000 submissions since launch, we highlighted some of the research published with us so far to demonstrate how our model works and how we’re changing research communication
#eLife10k
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The eLife Model for research publishing: How does it work?
eLife is driving a change in scientific publishing. Our approach brings together the immediacy and openness of preprints with the expert evaluation of peer r...
https://buff.ly/4gjgLRt
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Is it mathematically possible that every one of my masters students is in the top 5% of all the master students i supervised
10 months ago
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Nikola Grujic
Michael Eisen
10 months ago
I strongly suggest that academic publishers cease to exist.
add a skeleton here at some point
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Nikola Grujic
Johannes Bohacek
10 months ago
🔵 blue spot alert: Anita Luethi's team reports a dual role of
#locuscoeruleus
in
#sleep
in Nature Neuroscience
@natureportfolio.bsky.social
1) high LC activity facilitates cortical microarousals 2) low LC activity is required for NREMS-to-REMS transitions
doi.org/10.1038/s415...
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Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle - Nature Neuroscience
LĂĽthi and colleagues show that activity of the locus coeruleus (LC) is crucial for the cyclic alternation between non-rapid-eye-movement and rapid-eye-movement sleep. Stressful experiences during waki...
https://doi.org/10.1038/s41593-024-01822-0
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do you make a starter pack and share it to suck up to people on the said starter pack so that they will follow you or how does this thing work I wanna be popular
10 months ago
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Nikola Grujic
Zero-Noise Lab
10 months ago
Behold, our first
#Neuroskyence
thread! :) About one of our favourite questions: As a neuroscientist, should you average across trials to get pretty things like receptive fields and population vectors? Or should you resist the urge?
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Nikola Grujic
Josien
10 months ago
🧠🔬Using long GRIN lenses and notice that cells look good in the middle, but vague on the sides? My lab developed corrected lenses, which increases the FOV and thus number of neurons recorded! Check out this new publication:
elifesciences.org/reviewed-pre...
#microscopy
#inscopix
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I generate ~60gb a day in videos, yes I am keeping them all, but the stack of 20tb hard drives gets hard to manage
add a skeleton here at some point
10 months ago
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Nikola Grujic
Adrien Peyrache
10 months ago
Interesting discussion on whether or not keeping raw data (seems like we all agree we should!)
add a skeleton here at some point
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you reached the end!!
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